Indian J Chest Dis Allied Sci 2008 Jan-Mar;50(1):67-78
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Sputum smear-negative pulmonary tuberculosis (SSN-PTB) is a common problem faced by clinicians. Performing fibreoptic bronchoscopy (FOB), and subjecting the bronchoscopic secretions/transbronchial lung biopsy (TBLB) material to conventional diagnostic methods of smear, mycobacterial culture and histopathology appears to be helpful in the diagnosis of SSN-PTB. Application of polymerase chain reaction (PCR) may be helpful as an adjunctive method in the appropriate clinical setting. Read More