15,017 results match your criteria ssc


Astaxanthin Relieves Busulfan-Induced Oxidative Apoptosis in Cultured Human Spermatogonial Stem Cells by Activating the Nrf-2/HO-1 pathway.

Reprod Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Anatomy, School of Medicine, Medical School, Tehran University of Medical Sciences, Tehran, Iran.

Many child cancer patients endure anticancer therapy containing alkylating agents before sexual maturity. Busulfan (BU), as an alkylating agent, is a chemotherapy drug, causing DNA damage and cytotoxicity in germ cells. In the present study, we aimed to investigate the protective effect of astaxanthin (AST), as a potent antioxidant and powerful reactive oxygen species (ROS) scavenger, on BU-induced toxicity in human spermatogonial stem cells. Read More

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Immunosuppression does not prevent severe gastrointestinal tract involvement in systemic sclerosis.

Clin Exp Rheumatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, McGill University, Montreal, Quebec; Division of Rheumatology, Jewish General Hospital, Montreal, Quebec, and Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.

Objectives: We aimed to test the hypothesis that exposure to immunosuppression in early systemic sclerosis (SSc) could modify the risk of developing new onset severe gastrointestinal (GIT) involvement.

Methods: A total of 762 subjects with <3 years of disease duration and without severe GIT disease at baseline study visit were identified from combined longitudinal cohort data from the Canadian Scleroderma Research Group (CSRG) and Australian Scleroderma Interest Group (ASIG). The primary exposure was ever use of methotrexate, cyclophosphamide, mycophenolate mofetil and/or azathioprine during the study period. Read More

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Application of substitution box of present cipher for automated detection of snoring sounds.

Artif Intell Med 2021 Jul 6;117:102085. Epub 2021 May 6.

Ngee Ann Polytechnic, Department of Electronics and Computer Engineering, 599489, Singapore; Department of Biomedical Engineering, School of Science and Technology, SUSS University, Singapore; Department of Biomedical Informatics and Medical Engineering, Asia University, Taichung, Taiwan.

Background And Purpose: Snoring is one of the sleep disorders, and snoring sounds have been used to diagnose many sleep-related diseases. However, the snoring sound classification is done manually which is time-consuming and prone to human errors. An automated snoring sound classification model is proposed to overcome these problems. Read More

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Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort.

Arthritis Res Ther 2021 Jun 14;23(1):170. Epub 2021 Jun 14.

Division of Rheumatology and Scleroderma Program, Department of Internal Medicine, University of Michigan, Suite 7C27 300 North Ingalls Street, SPC 5422, Ann Arbor, MI, 48109, USA.

Background: Early diffuse cutaneous systemic sclerosis (dcSSc) has the highest case fatality among rheumatic diseases. We report baseline characteristics, current immunosuppressive therapies, progression of skin and internal organ involvement, and mortality in a multicenter prospective cohort from the United States (US) of America.

Methods: We performed a longitudinal analysis of participants from 12 US centers, from April 2012 to July 2020. Read More

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Advances at the Interface of Cancer and Systemic Sclerosis.

J Scleroderma Relat Disord 2021 Feb 17;6(1):50-57. Epub 2020 Mar 17.

Johns Hopkins University School of Medicine, Baltimore, MD.

The interface between systemic sclerosis (SSc) and cancer has offered valuable insights into our understanding of SSc disease pathogenesis. Defining SSc subgroups both temporally and serologically has been instrumental in stratifying cancer risk, with autoantibodies to RNA polymerase 3 (RNApol3), RNA polymerase I large subunit (RPA194), RNA Binding Region Containing 3 (RNPC3), and centromere identifying subgroups at increased or decreased risk of cancer. Clinically, improved subgrouping of SSc patients provides the opportunity to detect cancer at earlier stages of disease while increasing our efficiency of cancer assessment. Read More

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February 2021

The complete chloroplast genome of .

Mitochondrial DNA B Resour 2021 Jun 4;6(7):1855-1856. Epub 2021 Jun 4.

Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, PR China.

is one of the Agave cultivars for sisal fiber production around the tropical areas of the world. In the present study, we successfully sequenced and assembled its chloroplast genome. The full size of the genome is 157,268 bp with a GC content at 37. Read More

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The complete chloroplast genome sequence of (Benth.) S. Moore. (Asteraceae).

Mitochondrial DNA B Resour 2021 Jun 3;6(7):1834-1836. Epub 2021 Jun 3.

Kunming Medical University Haiyuan College, Kunming, China.

The complete chloroplast (cp) genome of was sequenced and assembled for the first time. In this study, the total genome size is 150,596 bp in length and demonstrates a typical quadripartite structure containing a large single copy (LSC, 82,575 bp) and a small single copy (SSC, 18,293 bp), separated by a pair of inverted repeats (IRa, IRb) of 24,864 bp. The G + C content of this cp genome was 37. Read More

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The complete chloroplast genome sequence of (Verbenaceae).

Mitochondrial DNA B Resour 2021 Jun 3;6(7):1832-1833. Epub 2021 Jun 3.

College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, China.

In this study, the complete chloroplast (cp) genome of was assembled using Illumina sequencing data. The complete cp genome is 149,869 bp in length, including a pair of invert repeats (IRA and IRB) regions of 22,839 bp, large single-copy (LSC) region of 86,201 bp, and small single-copy (SSC) region of 17,990 bp. The G + C content of this cp genome was 38. Read More

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The complete chloroplast genome and phylogenetic analysis of subsp. (Rupr.) P.S.Green & M.C.Chang from Qinghai Province, China.

Mitochondrial DNA B Resour 2021 Jun 3;6(7):1829-1831. Epub 2021 Jun 3.

Key Laboratory of Restoration Ecology in Cold Region of Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.

subsp. (Rupr.) P. Read More

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Complete chloroplast genome of by sequencing.

Mitochondrial DNA B Resour 2021 Jun 4;6(7):1826-1828. Epub 2021 Jun 4.

College of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, P. R. China.

(Mart.) () is an important herbage species, which could provide high-quality feed for livestock and poultry breeding. This paper is the first to report the chloroplast genomes, which were detected by sequencing. Read More

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The complete chloroplast genome of .

Mitochondrial DNA B Resour 2021 Jun 3;6(7):1824-1825. Epub 2021 Jun 3.

Chengdu Academy of Agricultural and Forestry Sciences, Chengdu, Sichuan, China.

is of the unique edible bamboo specie of high quality in China. We studied the complete chloroplast(cp) genome of in this study. The cp genome of (GenBank accession: MW186792) was 138,911 bp in length, including a large single-copy (LSC) region of 82,498 bp, a small single-copy (SSC) region of 12,743 bp and a pair of inverted repeated (IR) regions of 21,835 bp. Read More

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The complete chloroplast genome sequence of Sieb. & Zucc. (Lythraceae).

Mitochondrial DNA B Resour 2021 Jun 2;6(6):1732-1733. Epub 2021 Jun 2.

Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, P. R. China.

L., an annual floating-leaved herb, is widely distributed in the old world and has important edible and medicinal values. However, the taxonomy and phylogeny of are unclear. Read More

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Gut Microbiota Aberration in Patients of Systemic Sclerosis and Bleomycin-Induced Mice Model.

Front Cell Infect Microbiol 2021 28;11:647201. Epub 2021 May 28.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Systemic sclerosis (SSc) is an immune-mediated systemic autoimmune disease with unknown etiology, which has high morbidity and mortality. Current treatments to dispose of this disorder are limited. And there are still no ideal animal models that can fully replicate the four basic pathophysiological features of SSc, including vascular lesions, fibrosis, inflammation, and autoimmunity, let alone animal models specifically designed to study gastrointestinal lesions. Read More

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Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis.

Front Immunol 2021 27;12:674343. Epub 2021 May 27.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Autoimmune diseases (ADs) are characterized by immune-mediated tissue damage, in which angiogenesis is a prominent pathogenic mechanism. Vascular endothelial growth factor (VEGF), an angiogenesis modulator, is significantly elevated in several ADs including rheumatoid arthritis (RA), systemic sclerosis (SSc), and systemic lupus erythematosus (SLE). We determined whether circulating VEGF levels were associated with ADs based on pooled evidence. Read More

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Relationship Between Social Motivation in Children With Autism Spectrum Disorder and Their Parents.

Front Neurosci 2021 26;15:660330. Epub 2021 May 26.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.

Impairment in social motivation (SM) has been suggested as a key mechanism underlying social communication deficits observed in autism spectrum disorder (ASD). However, the factors accounting for variability in SM remain poorly described and understood. The current study aimed to characterize the relationship between parental and proband SM. Read More

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Correlation between irreversible organ damage and the quality of life of patients with systemic lupus erythematosus: The Kyoto Lupus Cohort survey.

Lupus 2021 Jun 14:9612033211025614. Epub 2021 Jun 14.

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objectives: It is important to clarify the relationship between irreversible organ damage and the quality of life (QOL) by considering the unique factors of patients with systemic lupus erythematosus (SLE). We aimed to clarify their correlation using SLE-specific QOL assessment tools. We also aimed to identify which type of organ damage is adversely correlated with the QOL. Read More

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Rational design of 2D/1D ZnCo-LDH hierarchical structure with high rate performance as advanced symmetric supercapacitors.

J Colloid Interface Sci 2021 Jun 3;602:177-186. Epub 2021 Jun 3.

School of Material Science and Engineering, Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science and Technology, Xi'an 710021, PR China.

Hierarchical microstructures of electrode materials for supercapacitors have attracted strong attention owing to the enlarged surface area, fast charge transportation and enhanced volume expansion. All these advantages of hierarchical structures are available for facilitating the electrochemical performances and stability of electrode materials for advanced supercapacitors. However, few reports focused on the development of transition metal-based homogeneous 2D/1D hierarchical structures use the same material. Read More

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Identification and profiles of microRNAs in different development stages of miniature pig secondary palate.

Genomics 2021 Jun 9;113(4):2634-2644. Epub 2021 Jun 9.

Department of geriatric dentistry, Capital Medical University School of Stomatology, Tiantan Xili No.4, Beijing 100050, China; Laboratory of Molecular Signaling and Stem Cells Therapy, Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Tiantan Xili No.4, Beijing 100050, China. Electronic address:

Cleft palate is one of the most frequent craniofacial malformation birth defects. Miniature pigs (Sus scrofa) are a valuable alternative large animal model to explore human palate development. Presently, the microRNA (miRNA) expression profiles in miniature pigs during palatogenesis from embryonic day (E) 30 to 50 were identified. Read More

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Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients.

Rheumatology (Oxford) 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Pharmacy, Université de Montréal, Québec, Canada.

Objective: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by inflammation and fibrosis. Although constitutive activation of fibroblasts is proposed to be responsible for the fibrotic and inflammatory features of the disease, the underlying mechanism remains elusive and, effective therapeutic targets are still lacking. The aim of this study was to evaluate the role of oxidative stress-induced senescence and its contribution to the pro-fibrotic and pro-inflammatory phenotypes of fibroblasts from SSc patients. Read More

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Survival of stainless steel crowns and composite resin restorations in molars affected by Molar-Incisor Hypomineralization (MIH).

Int J Paediatr Dent 2021 Jun 11. Epub 2021 Jun 11.

Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.

Background: Currently, there is no consensus on the superiority of any material for the restorative treatment of molars affected by Molar-Incisor Hypomineralization (MIH).

Aim: To evaluate the survival of restorations with stainless steel crown (SSC) or composite resin (CR) in first permanent molars affected by MIH for 24 months.

Design: In this retrospective cohort study, 61 CR and 54 SSC restorations performed on molars affected by MIH of patients, aged between 7 and 10, that were treated and overseen at a university dental clinic in the period of 2017-2020 were evaluated. Read More

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Combining multi-antigenic immunodot with indirect immunofluorescence on HEp-2 cells improves the diagnosis of systemic sclerosis.

Clin Immunol 2021 Jun 7;229:108774. Epub 2021 Jun 7.

Immunology laboratory, Institut Fédératif de Biologie, Toulouse University Hospital Center, France; INSERM U1043, CNRS UMR 5282, Toulouse III University, Center for Pathophysiology Toulouse Purpan, Toulouse, France. Electronic address:

Systemic sclerosis (SSc) is associated, in nearly all patients, with autoantibodies (Ab). Accordingly, and in order to identify major (anti-CEN A/B and anti-Topo I) but also minor Abs, the usefulness of combining indirect immunofluorescence (IIF) on HEp-2 cells with an 11 multi-antigenic SSc immunodot was explored. 1689 samples tested at the request of clinicians, were evaluated retrospectively. Read More

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Design, physico-chemical characterization and biological activity of organogold(III) glycoconjugates.

Dalton Trans 2021 Jun 10. Epub 2021 Jun 10.

National University of Ireland Galway, School of Chemistry, University Road, H91 TK33 Galway, Co. Galway, Ireland.

To develop new metal-based glycoconjugates as potential anticancer agents, four organometallic gold(iii)-dithiocarbamato glycoconjugates of the type [AuIII(2-Bnpy)(SSC-Inp-GlcN)](PF6) (2-Bnpy: 2-benzylpyridine; Inp: isonipecotic moiety; GlcN: amino-glucose scaffold; Au3-Au6) and the corresponding model non-glycosylated counterparts [AuIII(2-Bnpy)(SSC-Inp-R)](PF6) (R: OEt (Au1), NH2 (Au2)) have been generated and characterized by means of several analytical techniques (elemental analysis, FT-IR, 1H-/13C-NMR, ESI-MS, UV-Vis, X-ray crystallography). Their stability under physiologically-relevant conditions (PBS solution) and n-octanol/PBS distribution coefficient (D7.4) have also been evaluated. Read More

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Current advances in cardiac magnetic resonance imaging in systemic sclerosis.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3718-3736

Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Systemic sclerosis (SSc) is a systemic autoimmune disorder characterized by inflammation, fibroproliferative vasculopathy, and progressive fibrosis. Cardiac involvement is common in SSc and may affect the myocardium, pericardium, heart valves, conduction system, as well as coronary arteries. However, it remains asymptomatic for a long time, which leads to delayed diagnosis and poor prognosis. Read More

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Long term outcomes of the French ASTIS systemic sclerosis cohort using the global rank composite score.

Bone Marrow Transplant 2021 Jun 9. Epub 2021 Jun 9.

Unité de Médecine Interne: Maladies Auto-immunes et Pathologie Vasculaire (UF 04), Centre de Référence des Maladies auto-immunes systémiques Rares d'Ile-de-France MATHEC, AP-HP, Hôpital Saint-Louis, Paris, France.

Two randomised trials (ASTIS, SCOT) of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) versus monthly Cyclophosphamide for severe Systemic Sclerosis (SSc) patients used similar inclusion criteria, but different primary endpoints: event-free-survival (EFS) at 24 months in ASTIS versus the global rank composite score (GRCS) at 54 months in SCOT. Here we analysed the French ASTIS cohort (n = 49) outcome using the same GRCS endpoint as reported in SCOT. All patients, randomised to AHSCT (n = 26) or Cyclophosphamide (n = 23), were evaluated for the non-parametric GRCS endpoint based on: death, EFS, forced vital capacity (FVC), Health Assessment Questionnaire Disability Index (HAQ-DI) and modified Rodnan skin score (mRSS) at 60 months. Read More

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Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial.

BMJ 2021 06 9;373:n1205. Epub 2021 Jun 9.

Department of Medicine, McGill University, Montreal, QC, Canada.

Objective: To determine the efficacy and safety of dalteparin postoperative bridging treatment versus placebo for patients with atrial fibrillation or mechanical heart valves when warfarin is temporarily interrupted for a planned procedure.

Design: Prospective, double blind, randomised controlled trial.

Setting: 10 thrombosis research sites in Canada and India between February 2007 and March 2016. Read More

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Dualities of the vitamin D in systemic sclerosis: a systematic literature review.

Adv Rheumatol 2021 Jun 9;61(1):34. Epub 2021 Jun 9.

Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 2350 Ramiro Barcelos St, Room 645, Porto Alegre, RS, 90035-903, Brazil.

Background: Systemic sclerosis (SSc) is a chronic disease characterized by autoimmunity, vasculopathy, and visceral and cutaneous fibrosis. Vitamin D has several functions in the immunological system, and different studies have suggested a potential role in triggering autoimmune diseases. Patients with SSc may present with low serum levels of vitamin D, but the association between hypovitaminosis D and disease onset or any clinical manifestation is still obscure. Read More

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MicroRNA-30a-5p promotes differentiation in neonatal mouse spermatogonial stem cells (SSCs).

Reprod Biol Endocrinol 2021 Jun 9;19(1):85. Epub 2021 Jun 9.

Department of Anatomy, School of Medicine, Tehran University of Medical Science, Tehran, Iran.

Background: The importance of spermatogonial stem cells (SSCs) in spermatogenesis is crucial and intrinsic factors and extrinsic signals mediate fate decisions of SSCs. Among endogenous regulators, microRNAs (miRNAs) play critical role in spermatogenesis. However, the mechanisms which individual miRNAs regulate self- renewal and differentiation of SSCs are unknown. Read More

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Effect of nintedanib on lung function in patients with systemic sclerosis-associated interstitial lung disease: further analyses of a randomized, double-blind, placebo-controlled trial.

Arthritis Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.

Following the publication of further analyses of the effects of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) in the SENSCIS trial (1), Dr Bredemeier queried whether the occurrence of gastrointestinal adverse events in subjects treated with nintedanib may have reduced the effectiveness of masking and so introduced bias (2). Read More

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Clinical and methodological considerations on the results of the SENSCIS trial: Comment on the article by Maher et al.

Arthritis Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Rheumatology Service at Hospital Nossa Senhora da Conceição, Grupo Hospitalar Conceição, Porto Alegre, RS, Brazil.

I read with interest the reanalysis of the results of the SENSCIS trial, published by Maher et al (1). The article may represent an advance in the knowledge of the effects of nintedanib in systemic sclerosis-associated interstitial lung disease (SSc-ILD), but there are aspects that deserve additional comments. Read More

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Characterization of the complete chloroplast genome of D. Don (Elaeagnaceae).

Mitochondrial DNA B Resour 2021 May 31;6(7):1818-1820. Epub 2021 May 31.

School of Life Sciences, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, Fudan University, Shanghai, China.

Seabuckthorn ( L.) is a pioneer species widely distributed in Eurasia. We assembled and annotated the chloroplast genome of from Illumina pair-end data, which was 155,420 bp in length with 36. Read More

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