28,950 results match your criteria sri

Harms to children from the financial effects of others' drinking.

Int J Drug Policy 2021 Apr 19;94:103254. Epub 2021 Apr 19.

Centre for Alcohol Policy Research, La Trobe University, Australia; Melbourne School of Population and Global Health, University of Melbourne, Australia.

Background: Many children live with parents who drink and experience little impact, but risky or heavy drinking by caregivers can result in a range of harms to children. Alcohol-related financial harms which directly impact children's needs in general populations have been seldom studied.

Objective: The study aims to identify the prevalence and correlates of financial harms from others' drinking affecting children's needs in nine lower- and middle-income (LMICs) and high-income countries (HICs). Read More

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Unilateral auditory deprivation in humans: Effects on frequency discrimination and auditory memory span in the normal ear.

Hear Res 2021 Apr 9;405:108245. Epub 2021 Apr 9.

Department of Ear, Nose and Throat, GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab 151203, India.

Hearing with one ear is associated with auditory deprivation leading to cortical neuronal reorganization. Despite evidence for substantial effects of unilateral input on cortical and sub-cortical structures, the functional consequences of such alterations on human hearing is underexplored. Unilateral hearing impairment offers a unique model to study the perceptual consequences of cortical reorganization. Read More

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Magnetic Recyclable Heterogeneous Catalyst FeO/g-CN for Tetracycline Hydrochloride Degradation via Photo-Fenton Process Under Visible Light.

Environ Technol 2021 Apr 22:1-44. Epub 2021 Apr 22.

Key Laboratory of Nanominerals and Pollution Control of Higher Education Institutes, School of Resources and Environmental Engineering, Hefei University of Technology, Hefei 230009, P. R. China.

Antibiotic pollution of water resources is a global problem, and the development of new treatments for destroying antibiotics in water is a priority research. We successfully manufactured recyclable magnetic FeO/g-CN through the electrostatic self-assembly method. Selecting tetracycline (TC) as the target pollutant, using FeO/g-CN and HO developed a heterogeneous optical Fenton system to remove TC under visible light. Read More

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Admission ultrasonography as a predictive tool for thrombocytopenia and disease severity in dengue infection.

Trans R Soc Trop Med Hyg 2021 Apr 22. Epub 2021 Apr 22.

Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka.

Background: Ultrasound (US) is an investigation available in many acute care settings. Thrombocytopenia is a well-described complication of dengue infection and has been shown to correlate with disease severity. The purpose of this study was to assess the utility of admission ultrasonography in predicting thrombocytopenia and disease severity in patients infected with dengue virus. Read More

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Remineralization efficacy of nonfluoride versus herbal-based pediatric dentifrice in demineralized primary teeth.

J Indian Soc Pedod Prev Dent 2021 Jan-Mar;39(1):67-73

Department of Pedodontics and Preventive Dentistry, Sri Siddhartha Dental College and Hospital, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India.

Background: Dental caries is one of the most prevalent posteruptive bacterial infections worldwide, characterized by a progressive demineralization process that affects the mineralized dental tissues. Although the decline of dental caries prevalence can be attributed to the widespread use of dentifrices that contain fluoride, yet there is a need for an advanced alternative nonfluoride remineralizing dentifrice. Yet, there is a need for an advanced alternative nonfluoride remineralizing dentifrice. Read More

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Pulsatile flow in descending aorta: Can coarctation of aorta be ruled out by transesophageal echocardiography?

Ann Card Anaesth 2021 Apr-Jun;24(2):253-255

Department of Cardiology, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

A 5-year-old child with L posed great arteries, large subpulmonic ventricular septal defect (VSD), atrial septal defect (ASD), and a large patent ductus arteriosus (PDA) with mild isthmic narrowing was scheduled for surgical correction. Intraoperatively, it was a case of anatomically corrected malposition of great arteries. Due to abnormal positioning of great vessels, the isthmus was ligated instead of the large PDA. Read More

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Psychiatric hospital reform in low- and middle-income countries: a systematic review of literature.

Soc Psychiatry Psychiatr Epidemiol 2021 Apr 21. Epub 2021 Apr 21.

Centre for Mental Health and Wellbeing Research, University of Warwick, Coventry, England.

Purpose: Psychiatric hospitals or mental asylums grew across the world in the colonial era. Despite concerns over quality of care and human rights violations, these hospitals continue to provide the majority of mental health care in most low- and middle-income countries (LMICs). We sought to review the evidence of reform of mental hospitals and associated patient outcomes. Read More

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A Challenge for a Unique Dengue Vector Control Programme: Assessment of the Spatial Variation of Insecticide Resistance Status amongst and Populations in Gampaha District, Sri Lanka.

Biomed Res Int 2021 2;2021:6619175. Epub 2021 Apr 2.

Department of Biosystems Engineering, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makadura, Sri Lanka.

Background: To date, dengue is considered an important public health problem in Sri Lanka. Irrational use of insecticides without evidence-based applications has primed the development of resistance in mosquito vectors.

Method: The present study investigated the resistance status of and to commonly used insecticides in three selected Medical Officer of Health (MOH) areas (i. Read More

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Measuring Students' Ability to Engage in Scientific Inquiry: A New Instrument to Assess Data Analysis, Explanation, and Argumentation.

Educ Assess 2020 7;25(2):112-135. Epub 2020 May 7.

University of Washington, Seattle, WA, USA.

We describe the conceptualization, design, development, validation, and testing of a summative instrument that measures high school students' ability to analyze and evaluate data, construct scientific explanations, and formulate scientific arguments in biology and chemistry disciplinary contexts. Data from 1,405 students were analyzed to evaluate the properties of the instrument. Student measurement separation reliability was 0. Read More

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Strategy for COVID-19 vaccination in India: the country with the second highest population and number of cases.

NPJ Vaccines 2021 Apr 21;6(1):60. Epub 2021 Apr 21.

Sri Ramachandra Institute of Higher Education and Research (Deemed University), Porur, Chennai, Tamil Nadu, India.

Free vaccination against COVID-19 commenced in India on January 16, 2021, and the government is urging all of its citizens to be immunized, in what is expected to be the largest vaccination program in the world. Out of the eight COVID-19 vaccines that are currently under various stages of clinical trials in India, four were developed in the country. India's drug regulator has approved restricted emergency use of Covishield (the name employed in India for the Oxford-AstraZeneca vaccine) and Covaxin, the home-grown vaccine produced by Bharat Biotech. Read More

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The BioCyc Metabolic Network Explorer.

BMC Bioinformatics 2021 Apr 21;22(1):208. Epub 2021 Apr 21.

Bioinformatics Research Group, SRI International, 333 Ravenswood Ave, Menlo Park, CA, 94025, USA.

Background: The Metabolic Network Explorer is a new addition to the BioCyc.org website and the Pathway Tools software suite that supports the interactive exploration of metabolic networks. Any metabolic network visualization tool must by necessity show only a subset of all possible metabolite connections, or the results will be visually overwhelming. Read More

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Efficacy and safety of hydroxychloroquine in osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.

Korean J Intern Med 2021 Apr 22. Epub 2021 Apr 22.

Department of Musculoskeletal Health and Disease, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Background/aims: Conventional disease-modifying anti-rheumatic drugs have been trialed in osteoarthritis (OA). Hydroxychloroquine (HCQ), which has shown its effectiveness in rheumatoid arthritis, has been trialed for the treatment of OA; however, its efficacy and safety remain unclear. This systematic review and meta-analysis evaluate efficacy and safety of HCQ for the treatment of OA. Read More

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Using Open Source, Open Data, and Civic Technology to Address the COVID-19 Pandemic and Infodemic.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Objectives: The emerging COVID-19 pandemic has caused one of the world's worst health disasters compounded by social confusion with misinformation, the so-called "Infodemic". In this paper, we discuss how open technology approaches - including data sharing, visualization, and tooling - can address the COVID-19 pandemic and infodemic.

Methods: In response to the call for participation in the 2020 International Medical Informatics Association (IMIA) Yearbook theme issue on Medical Informatics and the Pandemic, the IMIA Open Source Working Group surveyed recent works related to the use of Free/Libre/Open Source Software (FLOSS) for this pandemic. Read More

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Telehealth and the COVID-19 Pandemic: International Perspectives and a Health Systems Framework for Telehealth Implementation to Support Critical Response.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Sri Sathya Sai Central Trust, Puttaparthi, India.

Objectives: Telehealth implementation is a complex systems-based endeavour. This paper compares telehealth responses to (COrona VIrus Disease 2019) COVID-19 across ten countries to identify lessons learned about the complexity of telehealth during critical response such as in response to a global pandemic. Our overall objective is to develop a health systems-based framework for telehealth implementation to support critical response. Read More

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Longitudinal self-supervised learning.

Med Image Anal 2021 Apr 4;71:102051. Epub 2021 Apr 4.

Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Center for Biomedical Sciences, SRI International, Menlo Park, CA 95025, USA. Electronic address:

Machine learning analysis of longitudinal neuroimaging data is typically based on supervised learning, which requires large number of ground-truth labels to be informative. As ground-truth labels are often missing or expensive to obtain in neuroscience, we avoid them in our analysis by combing factor disentanglement with self-supervised learning to identify changes and consistencies across the multiple MRIs acquired of each individual over time. Specifically, we propose a new definition of disentanglement by formulating a multivariate mapping between factors (e. Read More

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Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme.

Curr Mol Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Central Inter-Disciplinary Research Facility, School of Biological Sciences, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, India.

Background: Glioblastoma multiforme is one of the most heterogenous primary brain tumor with high mortality. Nevertheless, of the current therapeutic approaches, survival rate remains poor with 12 to 15 months following preliminary diagnosis, this warrants the need for effective treatment modality. Wnt/β-catenin pathway is presumably the most noteworthy pathway up-regulated in almost 80% GBM cases contributing to tumor-initiation, progression and survival. Read More

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Emerging role of non-coding RNA in health and disease.

Metab Brain Dis 2021 Apr 21. Epub 2021 Apr 21.

Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, India.

Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progression, and therapy is more rational and authentic pave than a macroscopic approach. Read More

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A Spiderweb-Like Fibrinous Reaction.

JAMA Ophthalmol 2021 Apr 21;139(4):e210697. Epub 2021 Apr 21.

Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

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An Intratumoral Aneurysm and an Extrarenal Synchronous Cystic Tumour in a Case of a Renal Cell Carcinoma.

Case Rep Urol 2021 6;2021:8878429. Epub 2021 Apr 6.

Department of Pathology, Faculty of Medicine, University of Colombo, Sri Lanka.

Background: Renal cell carcinoma is a heterogeneous group of malignant tumors originating from the kidney. We report a case of a renal cell carcinoma with two very rare associates, i.e. Read More

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Kirkwood-Buff-Derived Force Field for Peptides and Proteins: Philosophy and Development of KBFF20.

J Chem Theory Comput 2021 Apr 20. Epub 2021 Apr 20.

Department of Chemistry, Kansas State University, 213 CBC Building, 1212 Mid-Campus Drive North, Manhattan, Kansas 66506, United States.

A new classical nonpolarizable force field, KBFF20, for the simulation of peptides and proteins is presented. The force field relies heavily on the use of Kirkwood-Buff theory to provide a comparison of simulated and experimental Kirkwood-Buff integrals for solutes containing the functional groups common in proteins, thus ensuring intermolecular interactions that provide a good balance between the peptide-peptide, peptide-solvent, and solvent-solvent distributions observed in solution mixtures. In this way, it differs significantly from other biomolecular force fields. Read More

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Management of late-onset hypogonadism: person-centred thresholds, targets, techniques and tools.

J R Coll Physicians Edinb 2021 Mar;51(1):79-84

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College & Hospital, Vellore, Tamil Nadu, India; Non communicable disease unit, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Australia.

Late-onset hypogonadism (LOH) is a complex and highly debatable syndrome in ageing men, which is characterised by reduced testosterone levels associated with classical symptoms of androgen deficiency. This article discusses the complex issues surrounding its management related to patient-centric thresholds and therapeutic targets. It specifically highlights the need to consider symptoms as the starting point, the key milestones in the management and the target of treatment, while ensuring safety at all times. Read More

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Hypnale coagulopathy: snake envenomation of a different kind.

J R Coll Physicians Edinb 2021 Mar;51(1):31-36

Alva's Health Centre, Moodabidri-574227, Karnataka, India, Email:

Hypnale hypnale is a small pit viper that is known as the hump-nosed pit viper (HNV) or 'Merrem's hump-nosed pit viper' and is endemic to Sri Lanka and the Western Ghats of South India. Previously, it was thought that this viper bite would result in mild systemic or local envenomation, however, we now know that HNV bites could cause severe systemic toxicity and mortality. The most common systemic toxicity of this viper envenomation is coagulopathy, which is known as 'Hypnale coagulopathy'. Read More

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Pharmacogenetic evaluation of 6-mercaptopurine-mediated toxicity in pediatric acute lymphoblastic leukemia patients from a South Indian population.

Pharmacogenomics 2021 Apr 20. Epub 2021 Apr 20.

Department of Human Genetics, Sri Ramachandra Institute of Higher Education & Research, Chennai, India.

To evaluate the variants in the genes coding for the proteins involved in thiopurine and folate metabolism with treatment related adverse effects (TRAEs). Eleven variants in seven candidate genes were genotyped in 127 pediatric acute lymphoblastic leukemia patients under 6-mercaptopurine (6-MP) treatment to infer the association of selected genotypes with TRAEs. Among the genotypes inspected, (c. Read More

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Impact of pmrA on Cronobacter sakazakii planktonic and biofilm cells: A comprehensive transcriptomic study.

Food Microbiol 2021 Sep 11;98:103785. Epub 2021 Mar 11.

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Xihu District, Hangzhou, 310024, Zhejiang Province, China. Electronic address:

Cronobacter sakazakii is an emerging opportunistic foodborne pathogen causing rare but severe infections in neonates. Furthermore, the formation of biofilm allows C. sakazakii to persist in different environments. Read More

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September 2021

MedFused: A framework to discover the relationships between drug chemical functional group impacts and side effects.

Comput Biol Med 2021 Apr 11;133:104361. Epub 2021 Apr 11.

College of Science, Health and Engineering, La Trobe University, Melbourne, Australia. Electronic address:

It is a well-known fact that there are often side effects to the long-term use of certain medications. These side effects can vary from mild dizziness to, at its most serious, death. The main factors that cause these side effects are the chemical composition, the mode of treatment, and the dose. Read More

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High Anxiety and Depression Scores and Mental Health Service Use Among South Asian Advanced Cancer Patients: A Multi-country Study.

J Pain Symptom Manage 2021 Apr 16. Epub 2021 Apr 16.

Lien Centre for Palliative Care, Duke-NUS Medical School, Singapore; Programme for Health Services & Systems Research, Duke-NUS Medical School, Singapore.

Context: Addressing symptoms of anxiety and depression is important in cancer palliative care. However, little information exists on the prevalence of high anxiety and depression scores and mental health service use among advanced cancer patients in South Asia.

Objectives: To examine among South Asian advanced cancer patients, the 1) prevalence of high anxiety and depression scores, 2) factors associated with high anxiety and depression scores, and 3) mental health service use. Read More

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Assessing the impacts of Amphan cyclone over West Bengal, India: a multi-sensor approach.

Environ Monit Assess 2021 Apr 19;193(5):283. Epub 2021 Apr 19.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.

Landfall of the Amphan (very severe cyclonic storm) occurred at 1730 hrs Indian Standard Time (IST) on May 20, 2020, near the West Bengal (W.B.) coast of India. Read More

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NK-Cell Biofactory as an Off-the-Shelf Cell-based Vector for Targeted In Situ Synthesis of Engineered Proteins.

Adv Biol (Weinh) 2021 Apr 19:e2000298. Epub 2021 Apr 19.

Biosciences Division SRI International, Menlo Park, CA, 94025, USA.

The NK-92MI, a fast-growing cytolytic cell line with a track record of exerting clinical efficacy, is transformed into a vector for synthesizing calibrated amounts of desired engineered proteins at our disease site, that is, NK-cell Biofactory. This provides an allogeneic option to the previously published T-cell-based living vector that is limited by high manufacturing cost and product variability. The modularity of this pathway, which combines a "target" receptor with an "effector" function, enables reprogramming of the NK-cell Biofactory to target diseases with specific molecular biomarkers, such as cancer, viral infections, or auto-immune disorders, and overcome barriers that may affect the advancement of NK-cell therapies. Read More

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A Novel Green Approach to Synthesize Curcuminoid-Layered Double Hydroxide Nanohybrids: Adroit Biomaterials for Future Antimicrobial Applications.

ACS Omega 2021 Apr 30;6(14):9600-9608. Epub 2021 Mar 30.

Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Soratha Mawatha, Nugegoda 10250, Sri Lanka.

Thermal instability, photodegradation, and poor bioavailability of natural active ingredients are major drawbacks in developing effective natural product-based antimicrobial formulations. These inherited issues could be fruitfully mitigated by the introduction of natural active ingredients into various nanostructures. This study focuses on the development of a novel green mechanochemical synthetic route to incorporate curcuminoids into Mg-Al-layered double hydroxides. Read More

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