1,355 results match your criteria sr-bi


Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.

FEBS Open Bio 2021 Apr 8. Epub 2021 Apr 8.

Clinical Medical Research Center, Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Apolipoprotein M (ApoM) exhibits various anti-atherosclerotic functions as a component of high-density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR-BI) is a classic HDL receptor that mediates selective cholesterol uptake and enhances the efflux of cellular cholesterol to HDL. However, the effect of ApoM on cholesterol transport in macrophages remains unclear. Read More

View Article and Full-Text PDF

HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors.

Sci Rep 2021 Mar 19;11(1):6439. Epub 2021 Mar 19.

Université de La Réunion, INSERM, UMR 1188, Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France.

High density lipoproteins (HDLs) display pleiotropic functions such as anti-inflammatory, antioxidant, anti-protease, and anti-apoptotic properties. These effects are mediated by four main receptors: SCARB1 (SR-BI), ABCA1, ABCG1, and CD36. Recently, HDLs have emerged for their potential involvement in brain functions, considering their epidemiological links with cognition, depression, and brain plasticity. Read More

View Article and Full-Text PDF

Insulin Rescued MCP-1-Suppressed Cholesterol Efflux to Large HDL2 Particles via ABCA1, ABCG1, SR-BI and PI3K/Akt Activation in Adipocytes.

Cardiovasc Drugs Ther 2021 Mar 19. Epub 2021 Mar 19.

Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou, 510120, China.

Purpose: Intracellular cholesterol imbalance plays an important role in adipocyte dysfunction of obesity. However, it is unclear whether obesity induced monocyte chemoattractant protein-1 (MCP-1) causes the adipocyte cholesterol imbalance. In this study, we hypothesize that MCP-1 impairs cholesterol efflux of adipocytes to HDL2 and insulin rescues this process. Read More

View Article and Full-Text PDF

HDL mediates reverse cholesterol transport from ram spermatozoa and induces hyperactivated motility.

Biol Reprod 2021 Mar 1. Epub 2021 Mar 1.

Department of Biochemistry & Cell Biology, Utrecht University, The Netherlands.

Reverse Cholesterol Transport or cholesterol efflux is part of an extensive plasma membrane remodelling process in spermatozoa that is imperative for fertilisation. For ram spermatozoa, sheep serum is well known to support in vitro fertilisation (IVF), but knowledge of its explicit role is limited. Though, it is postulated to elicit cholesterol efflux owing to the presence of high density lipoproteins (HDLs) that interact with transmembrane cholesterol transporters, such as ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B, type I (SR-BI). Read More

View Article and Full-Text PDF

[Value of Elastography Strain Ratio Combined with Breast Ultrasound Imaging Reporting and Data System in the Diagnosis of Breast Nodules].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Feb;43(1):63-68

Department of Ultrasound, China-Japan Friendship Hospital,Beijing 100029,China.

Objective To explore the value of elastography strain ratio(SR)combined with breast ultrasound imaging reporting and data system(BI-RADS-US)in the differential diagnosis of breast nodules.Methods A total of 471 breast nodules(from 471 patients)were reclassified by SR combined with BI-RADS-US.With the pathology results as gold standard,the area under the receiver operating characteristic(ROC)curve(AUC)was employed to evaluate the diagnostic performance,and the sensitivity,specificity,and accuracy were compared between the combined method and BI-RADS-US. Read More

View Article and Full-Text PDF
February 2021

Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis.

J Clin Invest 2021 Apr;131(7)

Department of Medicine, Atherosclerosis Research Unit, Division of Cardiovascular Medicine.

Autophagy modulates lipid turnover, cell survival, inflammation, and atherogenesis. Scavenger receptor class B type I (SR-BI) plays a crucial role in lysosome function. Here, we demonstrate that SR-BI regulates autophagy in atherosclerosis. Read More

View Article and Full-Text PDF

Scavenger Receptor BI Attenuates IL-17A-dependent Neutrophilic Inflammation in Asthma.

Am J Respir Cell Mol Biol 2021 Mar 1. Epub 2021 Mar 1.

East Carolina University, 3627, Greenville, North Carolina, United States.

Asthma is a common respiratory disease currently affecting more than 300 million worldwide and is characterized by airway inflammation, hyperreactivity, and remodeling. It is a heterogeneous disease consisting of corticosteroid-sensitive Th2-driven eosinophilic and corticosteroid-resistant Th17-driven neutrophilic phenotypes. One pathway recently described to regulate asthma pathogenesis is cholesterol trafficking. Read More

View Article and Full-Text PDF

AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs.

J Mol Endocrinol 2021 Mar;66(3):223-231

Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, Japan.

Vascular complications are the main cause of morbidity and mortality in diabetic patients, and advanced glycation end products (AGEs) play a critical role in promoting diabetic vascular dysfunction. The human homolog of scavenger receptor class B type I (SR-BI), CD36, and LIMPII analog-1 (hSR-BI/CLA-1) facilitates the cellular uptake of cholesterol from HDL. In endothelial cells, HDL activates endothelial nitric oxide synthase (eNOS) via hSR-BI/CLA-1. Read More

View Article and Full-Text PDF

Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.

J Lipid Res 2021 Feb 9;62:100045. Epub 2021 Feb 9.

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high HDL-cholesterol levels, and at least one variant has been linked to cardiovascular disease. Therefore, while often regarded as beneficial, very high levels of HDL-cholesterol may result from impaired cholesterol clearance through SR-BI and contribute to cardiovascular risk. Read More

View Article and Full-Text PDF
February 2021

The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts.

Placenta 2021 Feb 26;105:50-60. Epub 2021 Jan 26.

Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; School of Medical Technology, Health Sciences Faculty, Universidad San Sebastian, Santiago, Chile. Electronic address:

Introduction: The uptake of low- and high-density lipoproteins (LDL and HDL) through the LDL receptor (LDLR) and the scavenger receptor class B type I (SR-BI) mediates maternal to fetal cholesterol transfer in syncytiotrophoblast (STB) cells. STB cells deliver cholesterol via cholesterol efflux through the ATP-binding cassette transporters A1 (ABCA1, to ApoA-I), G1 (ABCG1, to HDL), and SR-BI (to HDL). In the human placenta, these proteins are localized in the apical (LDLR, SR-BI, ABCA1) and basal (SR-BI, ABCA1, ABCG1) membrane of STB cells. Read More

View Article and Full-Text PDF
February 2021

Apolipoprotein M promotes the anti-inflammatory effect of high-density lipoprotein by binding to scavenger receptor BI.

Ann Transl Med 2020 Dec;8(24):1676

Clinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.

Background: Inflammation participates pivotally in the pathogenesis of atherosclerosis. Apolipoprotein M (apoM) is a high-density lipoprotein (HDL)-associated plasma protein that affects HDL metabolism and shows various anti-inflammatory functions in atherosclerosis. In this study, we aim to determine whether apoM is expressed in peripheral blood mononuclear cells (PBMCs) and promoted the anti-inflammatory effect of HDL by combing with scavenger receptor BI (SR-BI). Read More

View Article and Full-Text PDF
December 2020

Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism.

Nat Metab 2021 01 18;3(1):59-74. Epub 2021 Jan 18.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.

Activating transcription factor (ATF)3 is known to have an anti-inflammatory function, yet the role of hepatic ATF3 in lipoprotein metabolism or atherosclerosis remains unknown. Here we show that overexpression of human ATF3 in hepatocytes reduces the development of atherosclerosis in Western-diet-fed Ldlr or Apoe mice, whereas hepatocyte-specific ablation of Atf3 has the opposite effect. We further show that hepatic ATF3 expression is inhibited by hydrocortisone. Read More

View Article and Full-Text PDF
January 2021

Effect of apoA-I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins.

ACS Omega 2021 Jan 21;6(1):871-880. Epub 2020 Dec 21.

Department of Health Technology, Biotherapeutic Engineering and Drug Targeting, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

Biomimetic high-density lipoproteins (b-HDL) have in the past two decades been applied for various drug delivery applications. As b-HDL inherently have relatively long circulation half-life and high tumor accumulation, this has inspired researchers to use b-HDL to selectively deliver drugs to tumors. PEGylation of the b-HDL has been pursued to increase the circulation half-life and therapeutic efficacy even further. Read More

View Article and Full-Text PDF
January 2021

Novel Functions of Endothelial Scavenger Receptor Class B Type I.

Curr Atheroscler Rep 2021 Jan 9;23(2). Epub 2021 Jan 9.

Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Purpose Of Review: Scavenger receptor class B type I (SR-BI) serves a key role in the reverse cholesterol transport in the liver as the high-affinity receptor for HDL. SR-BI is abundantly expressed in endothelium, and earlier works indicate that the receptor mediates anti-atherogenic actions of HDL. However, more recent studies uncovered novel functions of endothelial SR-BI as a lipoprotein transporter, which regulates transcellular transport process of both LDL and HDL. Read More

View Article and Full-Text PDF
January 2021

High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects.

Int J Mol Sci 2020 Dec 24;22(1). Epub 2020 Dec 24.

Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1188, Diabète Athérothrombose Réunion Océan Indien (DéTROI), Reunion Island University, 97411 Saint-Denis de La Réunion, France.

High-density lipoproteins (HDLs) display endothelial protective effects. We tested the role of SR-BI, an HDL receptor expressed by endothelial cells, in the neuroprotective effects of HDLs using an experimental model of acute ischemic stroke. After transient intraluminal middle cerebral artery occlusion (tMCAO), control and endothelial SR-BI deficient mice were intravenously injected by HDLs or saline. Read More

View Article and Full-Text PDF
December 2020

SR-BI deficiency disassociates obesity from hepatic steatosis and glucose intolerance development in high fat diet-fed mice.

J Nutr Biochem 2021 03 13;89:108564. Epub 2020 Dec 13.

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands.

Scavenger receptor BI (SR-BI) has been suggested to modulate adipocyte function. To uncover the potential relevance of SR-BI for the development of obesity and associated metabolic complications, we compared the metabolic phenotype of wild-type and SR-BI deficient mice fed an obesogenic diet enriched in fat. Both male and female SR-BI knockout mice gained significantly more weight as compared to their wild-type counterparts in response to 12 weeks high fat diet feeding (1. Read More

View Article and Full-Text PDF

The turning away of serum amyloid A biological activities and receptor usage.

Immunology 2020 Dec 14. Epub 2020 Dec 14.

Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.

Serum amyloid A (SAA) is an acute-phase protein (APP) to which multiple immunological functions have been attributed. Regardless, the true biological role of SAA remains poorly understood. SAA is remarkably conserved in mammalian evolution, thereby suggesting an important biological function. Read More

View Article and Full-Text PDF
December 2020

Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520976761

Cavitation-Control Technology Inc, Farmington, CT, USA. D'Arrigo is now with Cav-Con, Inc, Bellevue, WA, USA.

By incorporating appropriate drug(s) into lipid (biobased) nanocarriers, one obtains a combination therapeutic for dementia treatment that targets certain cell-surface scavenger receptors (mainly class B type I, or "SR-BI") and thereby crosses the blood-brain barrier. The cardiovascular risk factors for dementia trigger widespread inflammation -- which lead to neurodegeneration, gradual cognitive/memory decline, and eventually (late-onset) dementia. Accordingly, one useful strategy to delay dementia could be based upon nanotargeting drug(s), using lipid nanocarriers, toward a major receptor class responsible for inflammation-associated (cytokine-mediated) cell signaling events. Read More

View Article and Full-Text PDF
December 2020

The Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing.

Adv Wound Care (New Rochelle) 2021 Jan 21. Epub 2021 Jan 21.

Vascular Research Centre, South Australian Health and Medical Research Institute, Adelaide, Australia.

Prolonged inflammation and impaired angiogenesis are the two principal factors that prevent successful wound healing, which is exacerbated in people with diabetes. There is a significant need for new wound healing treatments that target both these factors simultaneously. This review discusses the emerging evidence that high-density lipoproteins (HDL) have pleiotropic wound healing benefits. Read More

View Article and Full-Text PDF
January 2021

Plasma Metabolomic and Lipidomic Profiling of a Genetically Modified Mouse Model of Scavenger Receptor Class B Type I.

Proteomics 2020 Sep 23:e2000050. Epub 2020 Sep 23.

Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing, 100191, China.

Atherosclerosis is a chronic inflammatory disease of the arterial wall and is becoming the principal cause of death globally. The reverse cholesterol transport (RCT) mediated by scavenger receptor class B type I (SR-BI) is a major protection mechanism against atherosclerosis. To investigate the metabolome changes and to find potential biomarkers involved in RCT, nontargeted metabolomics and nontargeted lipidomics are applied to SR-BI knockout mice that are fed a high fat and high cholesterol diet. Read More

View Article and Full-Text PDF
September 2020

SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation.

PLoS One 2020 15;15(10):e0240659. Epub 2020 Oct 15.

Clinical Center, The National Institutes of Health, Bethesda, Maryland, United States of America.

SR-BI binds various lipoproteins, including HDL, LDL as well as VLDL, and mediates selective cholesteryl ester (CE) uptake. HDL derived CE accumulates in cellular lipid droplets (LDs), which also store triacylglycerol (TAG). We hypothesized that SR-BI could significantly facilitate LD formation, in part, by directly transporting LDL derived neutral lipids (NL) such as CE and TAG into LDs without lipolysis and de novo lipid synthesis. Read More

View Article and Full-Text PDF
December 2020

Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2-SR-BI Axis.

Arterioscler Thromb Vasc Biol 2021 01 15;41(1):200-216. Epub 2020 Oct 15.

Keenan Centre for Biomedical Research, St. Michael's Hospital, Toronto, Canada (S.G., F.N.N., R.S., N.K., C.W., W.L.L.).

Objective: LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and contributes to atherosclerosis. HMGB1 (high mobility group box 1) is a structural protein in the nucleus that is released by cells during inflammation; extracellular HMGB1 has been implicated in advanced disease. Whether intracellular HMGB1 regulates LDL transcytosis through its nuclear functions is unknown. Read More

View Article and Full-Text PDF
January 2021

Transendothelial transport of lipoproteins.

Atherosclerosis 2020 12 25;315:111-125. Epub 2020 Sep 25.

Keenan Centre for Biomedical Research, St. Michael's Hospital, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada; Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Canada; Department of Biochemistry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address:

The accumulation of low-density lipoproteins (LDL) in the arterial wall plays a pivotal role in the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol from the intima by cholesterol efflux to high density lipoproteins (HDL) and subsequent reverse cholesterol transport shall confer protection against atherosclerosis. To reach the subendothelial space, both LDL and HDL must cross the intact endothelium. Read More

View Article and Full-Text PDF
December 2020

Plasma Metabolomic and Lipidomic Profiling of a Genetically Modified Mouse Model of Scavenger Receptor Class B Type I (SR-BI).

Proteomics 2020 Sep 23:e2000050. Epub 2020 Sep 23.

Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing, 100191, China.

Atherosclerosis is a chronic inflammatory disease of the arterial wall and is becoming the principal cause of death globally. The reverse cholesterol transport (RCT) mediated by Scavenger receptor class B type I (SR-BI) is a major protection mechanism against atherosclerosis. To investigate the metabolome changes and to find potential biomarkers involved in RCT, we applied nontargeted metabolomics and nontargeted lipidomics to SR-BI knockout mice fed a high fat and high cholesterol (HFHC) diet. Read More

View Article and Full-Text PDF
September 2020

Apo AI Nanoparticles Delivered Post Myocardial Infarction Moderate Inflammation.

Circ Res 2020 Nov 21;127(11):1422-1436. Epub 2020 Sep 21.

Baker Heart and Diabetes Institute, Melbourne, Australia (A.L.R., M.R., M.K., A.L.N., S.E.H., G.L.L., A.J.M., B.G.D., B.A.K.).

Rationale: Decades of research have examined immune-modulatory strategies to protect the heart after an acute myocardial infarction and prevent progression to heart failure but have failed to translate to clinical benefit.

Objective: To determine anti-inflammatory actions of n-apo AI (Apo AI nanoparticles) that contribute to cardiac tissue recovery after myocardial infarction.

Methods And Results: Using a preclinical mouse model of myocardial infarction, we demonstrate that a single intravenous bolus of n-apo AI (CSL111, 80 mg/kg) delivered immediately after reperfusion reduced the systemic and cardiac inflammatory response. Read More

View Article and Full-Text PDF
November 2020

Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew.

Appl Microbiol Biotechnol 2020 Oct 3;104(20):8813-8823. Epub 2020 Sep 3.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.

Background: The Chinese tree shrew (Tupaia belangeri chinesis) is a rising experimental animal and has been used for studying a variety of human diseases, such as metabolic and viral infectious diseases.

Methods: In this study, we established an immortalized tree shrew hepatic cell line, ITH6.1, by introducing the simian virus 40 large T antigen gene into primary tree shrew hepatocytes (PTHs). Read More

View Article and Full-Text PDF
October 2020

Regulation effects of total flavonoids in Morus alba L. on hepatic cholesterol disorders in orotic acid induced NAFLD rats.

BMC Complement Med Ther 2020 Aug 17;20(1):257. Epub 2020 Aug 17.

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

Background: Mulberry leaves are the dried leaves of Morus alba L., flavonoids from mulberry leaves (MLF) has showed regulatory effect on abnormal lipid metabolism, but the regulatory mechanism of MLF on cholesterol metabolism is still missing. This study was designed to investigate the effect of MLF and its active metabolite quercetin on regulating cholesterol disorders. Read More

View Article and Full-Text PDF

Angiopoietin-like protein 8 accelerates atherosclerosis in ApoE mice.

Atherosclerosis 2020 08 7;307:63-71. Epub 2020 Jul 7.

Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China. Electronic address:

Background And Aims: Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in regulating lipid metabolism. Patients with coronary artery disease have markedly higher plasma levels of ANGPTL8 than controls; however, the role of ANGPTL8 in atherosclerosis has not been explored. Therefore, we explored the effects of ANGPTL8 on atherosclerosis development in a mouse model. Read More

View Article and Full-Text PDF

Expression of ABC transporter and scavenger receptor mRNAs in PBMCs in 100-km ultramarathon runners.

Eur J Clin Invest 2021 Feb 11;51(2):e13365. Epub 2020 Aug 11.

Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Cholesterol metabolism is tightly regulated at the cellular level. This study was to measure the expression levels of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1), scavenger receptor class B type I (SR-BI) and class A (SRA), and CD36 mRNAs in peripheral blood mononuclear cells (PBMCs) in response to 100-km ultramarathon event and determine any correlation between these ABC transporters/scavenger receptor expression levels and plasma cholesterol homeostasis.

Materials And Methods: Twenty-six participants were enrolled. Read More

View Article and Full-Text PDF
February 2021

The Janus-faced role of SR-BI in atherosclerosis.

Nat Metab 2019 06;1(6):586-587

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.

View Article and Full-Text PDF