G3 (Bethesda) 2012 Nov 1;2(11):1357-67. Epub 2012 Nov 1.
School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5006, Australia.
Alongside the well-established carbon catabolite repression by glucose and other sugars, acetate causes repression in Aspergillus nidulans. Mutations in creA, encoding the transcriptional repressor involved in glucose repression, also affect acetate repression, but mutations in creB or creC, encoding components of a deubiquitination system, do not. To understand the effects of acetate, we used a mutational screen that was similar to screens that uncovered mutations in creA, creB, and creC, except that glucose was replaced by acetate to identify mutations that were affected for repression by acetate but not by glucose. Read More