843 results match your criteria spreading bloodstream

In Situ Oxygen Generation Enhances the SCAP Survival in Hydrogel Constructs.

J Dent Res 2021 Jul 30:220345211027155. Epub 2021 Jul 30.

Restorative Dental Science, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong, China.

Prolonged and severe hypoxia is the main cause of death of transplanted cells prior to the establishment of functional circulation. In situ generation of oxygen by oxygen-producing scaffolds-a unique solution that could produce and deliver oxygen to the adjacent cells independently of blood perfusion-has attracted considerable attention to enhance the survivability of the transplanted cells. However, the application of oxygen-generating scaffolds for facilitating cell survival in pulp-like tissue regeneration is yet to be explored. Read More

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Interactions of platelets with circulating tumor cells contribute to cancer metastasis.

Sci Rep 2021 Jul 29;11(1):15477. Epub 2021 Jul 29.

Department of Systems Design Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.

Recent studies have suggested that platelets have a crucial role in enhancing the survival of circulating tumor cells in the bloodstream and aggravating cancer metastasis. The main function of platelets is to bind to the sites of the damaged vessels to stop bleeding. However, in cancer patients, activated platelets adhere to circulating tumor cells and exacerbate metastatic spreading. Read More

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spreads to the large intestine lumen via multiple pathways.

Infect Immun 2021 Jul 19:IAI0025421. Epub 2021 Jul 19.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, Texas 78229.

in the genital tract is known to spread via the blood circulation system to the large intestinal lumen to achieve long-lasting colonization. However, the precise pathways for genital to access to the large intestinal lumen remain unclear. The spleen was recently reported to be critical for the chlamydial spreading. Read More

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Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines.

Carcinogenesis 2021 Jul 5. Epub 2021 Jul 5.

The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, United Kingdom.

Peanut agglutinin (PNA) is a carbohydrate-binding protein in peanuts that accounts for ~0.15% peanut weight. PNA is highly resistant to cooking and digestion and is rapidly detectable in the blood after peanut consumption. Read More

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Clinical and Microbiological Characteristics of a Community-Acquired Carbapenem-Resistant ST410 Isolate Harbouring NDM-5-Encoding IncX3-Type Plasmid From Blood.

Front Med (Lausanne) 2021 11;8:658058. Epub 2021 Jun 11.

Department of Infectious Medicine, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

The aim of this research was to investigate the clinical and microbiological characteristics of a case of community-acquired carbapenem-resistant isolated from a patient with a bloodstream infection in China. Huamei202001 was recovered from the first blood culture from a patient hospitalised in China. An antimicrobial susceptibility test was performed, and the genome was sequenced on an Illumina HiSeq X 10 platform with a 150-bp paired-end approach. Read More

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Biophysical interactions between components of the tumor microenvironment promote metastasis.

Biophys Rev 2021 Jun 4;13(3):339-357. Epub 2021 Jun 4.

Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.

During metastasis, tumor cells need to adapt to their dynamic microenvironment and modify their mechanical properties in response to both chemical and mechanical stimulation. Physical interactions occur between cancer cells and the surrounding matrix including cell movements and cell shape alterations through the process of mechanotransduction. The latter describes the translation of external mechanical cues into intracellular biochemical signaling. Read More

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Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle.

Nat Microbiol 2021 Jun 24;6(6):757-768. Epub 2021 May 24.

Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.

Most clonal lineages of Staphylococcus epidermidis are commensals present on human skin and in the nose. However, some globally spreading healthcare-associated and methicillin-resistant S. epidermidis (HA-MRSE) clones are major causes of difficult-to-treat implant or bloodstream infections. Read More

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Emerging progress on diagnosis and treatment of female genital tuberculosis.

J Int Med Res 2021 May;49(5):3000605211014999

Department of Respiratory Medicine, Jingzhou Chest Hospital, Jingzhou, Hubei, China.

Female genital tuberculosis (FGTB) is an infection caused by and usually occurs secondary to pulmonary tuberculosis (TB) through the blood circulation, lymph circulation, or direct spreading from abdominal TB. FGTB is an uncommon type of TB that can destroy genital organs, and lead to menstrual disorders and infertility. The diagnosis of FGTB is often made by detection of acid-fast bacilli under microscopy, culture with endometrial biopsy, or histopathological examination of epithelioid granuloma on a biopsy. Read More

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Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis.

Ageing Res Rev 2021 08 9;69:101358. Epub 2021 May 9.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address:

Huntington disease (HD) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene, which leads to a toxic, aggregation-prone, mutant HTT-polyQ protein. Beyond the well-established mechanisms of HD progression in the central nervous system, growing evidence indicates that also peripheral tissues are affected in HD and that systemic signaling originating from peripheral tissues can influence the progression of HD in the brain. Herein, we review the systemic manifestation of HD in peripheral tissues, and the impact of systemic signaling on HD pathogenesis. Read More

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Interplay between inflammation and thrombosis in cardiovascular pathology.

Nat Rev Cardiol 2021 May 6. Epub 2021 May 6.

Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.

Thrombosis is the most feared complication of cardiovascular diseases and a main cause of death worldwide, making it a major health-care challenge. Platelets and the coagulation cascade are effectively targeted by antithrombotic approaches, which carry an inherent risk of bleeding. Moreover, antithrombotics cannot completely prevent thrombotic events, implicating a therapeutic gap due to a third, not yet adequately addressed mechanism, namely inflammation. Read More

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Seroprevalence of SARS-CoV-2 Antibodies in Adults and Healthcare Workers in Southern Italy.

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via L. Armanni, 5 80138 Naples, Italy.

Background: This study was carried out to estimate the seroprevalence of SARS-CoV-2 antibodies in a Southern Italian population.

Methods: The study was performed among students and workers of the University of Campania "Luigi Vanvitelli" and the relative Teaching Hospital. Participants were invited to undergo a blood sampling, an interview or to complete a self-administered questionnaire. Read More

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Unleashing the potential of cell membrane-based nanoparticles for COVID-19 treatment and vaccination.

Expert Opin Drug Deliv 2021 Jun 6:1-20. Epub 2021 Jun 6.

Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal.

: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a particular coronavirus strain responsible for the coronavirus disease 2019 (COVID-19), accounting for more than 3.1 million deaths worldwide. Several health-related strategies have been successfully developed to contain the rapidly-spreading virus across the globe, toward reduction of both disease burden and infection rates. Read More

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ETosis in tambaqui Colossoma macropomum: A programmed cell death pathway and approach of leukocytes immune response.

Microb Pathog 2021 Jun 27;155:104918. Epub 2021 Apr 27.

São Paulo State University (UNESP), Aquaculture Center of UNESP, Laboratory of Microbiology and Parasitology of Aquatic Organisms, São Paulo, 14884-900, Brazil. Electronic address:

Tambaqui Colossoma macropomum is the most cultivated native fish in South America and Aeromonas hydrophila is one of the main bacteria infecting tropical fish. Despite the economic importance of this round fish, to date, there has been a paucity of investigations into haematological changes in tambaqui. In this study, detailed blood analyses (0 h, 6 h, 24 h, 7 d and 14 d) following intraperitoneal challenge with A. Read More

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Clonal Dissemination of KPC-2, VIM-1, OXA-48-Producing ST147 in Katowice, Poland.

Pol J Microbiol 2021 Mar 19;70(1):107-116. Epub 2021 Mar 19.

Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.

Carbapenem-resistant (CRKP) is an important bacterium of nosocomial infections. In this study, CRKP strains, which were mainly isolated from fecal samples of 14 patients in three wards of the hospital in the Silesia Voivodship, rapidly increased from February to August 2018. Therefore, we conducted microbiological and molecular studies of the CRKP isolates analyzed. Read More

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Astrocyte Ca Waves and Subsequent Non-Synchronized Ca Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization.

Int J Mol Sci 2021 Mar 26;22(7). Epub 2021 Mar 26.

Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Korányi fasor 9, 6720 Szeged, Hungary.

Spreading depolarization (SD) is a wave of mass depolarization that causes profound perfusion changes in acute cerebrovascular diseases. Although the astrocyte response is secondary to the neuronal depolarization with SD, it remains to be explored how glial activity is altered after the passage of SD. Here, we describe post-SD high frequency astrocyte Ca oscillations in the mouse somatosensory cortex. Read More

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Oncolytic adenovirus with hyaluronidase activity that evades neutralizing antibodies: VCN-11.

J Control Release 2021 04 3;332:517-528. Epub 2021 Mar 3.

VCN Biosciences, Sant Cugat del Vallès, Barcelona, Spain. Electronic address:

Tumor targeting and intratumoral virus spreading are key features for successful oncolytic virotherapy. VCN-11 is a novel oncolytic adenovirus, genetically modified to express hyaluronidase (PH20) and display an albumin-binding domain (ABD) on the hexon. ABD allows the virus to self-coat with albumin when entering the bloodstream and evade neutralizing antibodies (NAbs). Read More

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The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences.

Front Immunol 2021 5;12:587146. Epub 2021 Feb 5.

Keizo Asami Immunopathology Laboratory, Universidade Federal de Pernambuco, Recife, Brazil.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast spreading virus leading to the development of Coronavirus Disease-2019 (COVID-19). Severe and critical cases are characterized by damage to the respiratory system, endothelial inflammation, and multiple organ failure triggered by an excessive production of proinflammatory cytokines, culminating in the high number of deaths all over the world. Sedentarism induces worse, continuous, and progressive consequences to health. Read More

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February 2021

Minimal Residual Disease, Metastasis and Immunity.

Biomolecules 2021 01 20;11(2). Epub 2021 Jan 20.

Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.

Progression from localized to metastatic disease requires cancer cells spreading to distant organs through the bloodstream. Only a small proportion of these circulating tumor cells (CTCs) survives dissemination due to anoikis, shear forces and elimination by the immune system. However, all metastases originate from CTCs capable of surviving and extravasating into distant tissue to re-initiate a tumor. Read More

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January 2021

Cortical spreading depression aggravates early brain injury in a mouse model of subarachnoid hemorrhage.

J Biophotonics 2021 04 3;14(4):e202000379. Epub 2021 Jan 3.

Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China.

Cortical spreading depression (CSD) has been observed during the early phase of subarachnoid hemorrhage (SAH). However, the effect of CSD on the cerebral blood flow (CBF) and cerebral oxyhemoglobin (CHbO) during the early phase of SAH has not yet been assessed directly. We, therefore, used laser speckle imaging and optical intrinsic sinal imaging to record CBF and CHbO during CSD and cerebral cortex perfusion (CCP) at 24 hours after CSD in a mouse model of SAH. Read More

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Social distancing measures and demands for the reorganization of hemotherapy services in the context of Covid-19.

Cien Saude Colet 2020 Dec 9;25(12):4969-4978. Epub 2020 Oct 9.

Instituto de Saúde Coletiva, Universidade Federal da Bahia. R. Basílio da Gama s/n, Canela. 40110-040 Salvador BA Brasil.

The article aims to discuss the consequences of social distancing measures on the availability of blood and organization of blood therapy services at the beginning of the Covid-19 pandemic in Brazil. News published in April 2020 on the websites of the country's state Blood Service Networks were consulted and organized in an Excel spreadsheet, presented in summary charts, and descriptions of results were prepared. A critical situation of blood supply, especially of some blood types, has been observed in many states. Read More

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December 2020

The effect of Tai Chi on the quality of life in the elderly patients recovering from coronavirus disease 2019: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(49):e23509

School of Acupuncture and Moxibustion and Tuina.

Background: coronavirus disease 2019 (COVID-19) is spreading fast starting late 2019. As their cardiopulmonary and immune functions gradually decline, elderly people are prone to COVID-19. Tai Chi has a positive impact on heart function, blood pressure, lung function, blood circulation, and so on, and it's suitable for the elderly. Read More

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December 2020

Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks.

Korean J Fam Med 2020 Nov 19;41(6):365-373. Epub 2020 Nov 19.

Department of Family Medicine, Jeju National University Hospital, Jeju, Korea.

One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8. Read More

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November 2020

Neurological Involvements of SARS-CoV2 Infection.

Mol Neurobiol 2021 Mar 16;58(3):944-949. Epub 2020 Oct 16.

Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.

COVID-19 is a pandemic viral infection caused by a novel coronavirus, SARS-CoV2, which is a global concern of the twenty-first century for its rapid spreading in a short period. Apart from its known acute respiratory involvements, the CNS manifestations of COVID-19 are common. These neurological symptoms are diverse and could range from mild nonspecific or specific symptoms such as the loss of various sensory perceptions, the worrying autoimmune Guillain-Barré syndrome, to the life-threatening acute disseminated encephalomyelitis, and the CNS-mediated respiratory distress. Read More

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Carbapenem-Resistant Enterobacteriaceae Bloodstream Infection Treated Successfully With High-Dose Meropenem in a Preterm Neonate.

Front Pharmacol 2020 11;11:566060. Epub 2020 Sep 11.

Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

Carbapenem-resistant enterobacteriaceae (CRE) bloodstream infections have been rapidly spreading worldwide with a high mortality and pose a challenge to therapeutic decision-making, especially in premature neonates because insufficient empirical antimicrobial therapy is independently associated with high mortality. This case reported that a premature infant with CRE bloodstream infection was treated successfully with high-dose meropenem treatment with model-based therapeutic drug monitoring (TDM). In clinical settings, treatment target attainment of meropenem can be improved by increasing the frequency of administration, prolonging the infusion time, and using a high dose. Read More

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September 2020

Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread.

J Immunol 2020 11 9;205(10):2726-2741. Epub 2020 Oct 9.

Department of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and

HIV has become a chronic disease despite the effective use of antiretroviral therapy (ART). However, the mechanisms of tissue colonization, viral evolution, generation of viral reservoirs, and compartmentalization are still a matter of debate due to the challenges involved in examining early events of infection at the cellular and molecular level. Thus, there is still an urgent need to explore these areas to develop effective HIV cure strategies. Read More

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November 2020

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.

Circulation 2021 Jan 29;143(1):45-61. Epub 2020 Sep 29.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China (Z.Q., W.Y., D.J., Z.Y., K.Y., A.S., J.Q., J.G.).

Background: PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein cholesterol by degrading low-density lipoprotein receptor. Pleiotropic effects of PCSK9 beyond lipid metabolism have been shown. However, the direct effects of PCSK9 on platelet activation and thrombosis, and the underlying mechanisms, as well, still remain unclear. Read More

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January 2021

[Neuroradiological Diagnosis of Progressive Multifocal Leukoencephalopathy (PML): Pathology of Extending/expanding Demyelinating Lesions Detected by MRI].

Brain Nerve 2020 Sep;72(9):973-986

Department of Pathology and applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

Although progressive multifocal leukoencephalopathy (PML) is known as a fatal disease, some recent cases have shown favorable prognosis with early diagnosis. Therefore, detection of early PML lesions using magnetic resonance imaging (MRI) is important. PML lesions are divided into 4 groups based on distinct developing patterns: A)cerebral lesion, B)central lesion including deep gray matter, C)infratentorial lesion of the brain stem and cerebellum, and D)punctate lesions in the deep white matter. Read More

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September 2020

Spreading of SARS-CoV-2 in West Africa and assessment of risk factors.

Epidemiol Infect 2020 09 14;148:e213. Epub 2020 Sep 14.

Pathogenesis and Control of Chronic Infections, Université de Montpellier, INSERM, EFS, Montpellier, France.

Although the African continent is, for the moment, less impacted than the rest of the world, it still faces the risk of a spread of COVID-19. In this study, we have conducted a systematic review of the information available in the literature in order to provide an overview of the epidemiological and clinical features of COVID-19 pandemic in West Africa and of the impact of risk factors such as comorbidities, climatic conditions and demography on the pandemic. Burkina Faso is used as a case study to better describe the situation in West Africa. Read More

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September 2020

Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.

PLoS Pathog 2020 08 10;16(8):e1008414. Epub 2020 Aug 10.

Department of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, United States of America.

The host innate immune system has developed elegant processes for the detection and clearance of invasive fungal pathogens. These strategies may also aid in the spread of pathogens in vivo, although technical limitations have previously hindered our ability to view the host innate immune and endothelial cells to probe their roles in spreading disease. Here, we have leveraged zebrafish larvae as a model to view the interactions of these host processes with the fungal pathogen Candida albicans in vivo. Read More

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Antibiotic multi-drug-resistance of Escherichia coli causing device- and procedure-related infections in the United States reported to the National Healthcare Safety Network (NHSN), 2013-2017.

Clin Infect Dis 2020 Jul 23. Epub 2020 Jul 23.

Division of Healthcare Quality Promotion, National Center for Zoonotic and Emerging Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Escherichia coli is one of the most common causes of healthcare-associated infections (HAI); multidrug resistance reduces available options for antibiotic treatment. We examined factors associated with the spread of multidrug-resistant E. coli phenotypes responsible for device- and procedure-related HAI from acute care hospitals, long term acute care hospitals and inpatient rehabilitation facilities, using isolate and antimicrobial susceptibility data reported to the National Healthcare Safety Network (NHSN) from 2013-2017. Read More

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