5,368 results match your criteria spray-drying

Oxidative degradation in pharmaceuticals: Mechanism and stabilization of a spray-dried amorphous drug - A case study.

J Pharm Biomed Anal 2022 Jul 25;220:114962. Epub 2022 Jul 25.

Department of Small Molecule Analytical Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address:

Drug formulations such as spray drying are often required to improve the physicochemical properties and bioavailability of hydrophobic drugs. However, excipients often carry contaminants/ impurities and may also increase moisture levels in solid formulations, which can have detrimental effects on the drugs, including drug degradation and stability. Hence, achieving adequate shelf life of drug products has been among the most challenging issues for pharmaceuticals. Read More

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Preparation and Evaluation of Low-Dose Calcitriol Dry Powder Inhalation as Host-Directed Adjunct Therapy for Tuberculosis.

Pharm Res 2022 Aug 12. Epub 2022 Aug 12.

CSIR-Central Drug Research Institute, Lucknow, 226031, India.

Background: It is unclear whether Vitamin D is efficacious as a host-directed therapy (HDT) for patients of tuberculosis (TB). We investigated pulmonary delivery of the active metabolite of Vitamin D, i.e. Read More

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Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles.

Polim Med 2022 Aug 12. Epub 2022 Aug 12.

Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Kraków, Poland.

In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in the food, chemical and pharmaceutical industries for converting liquids into solids, in order to form products of uniform appearance. The construction of spray dryer enables to atomize the liquid into small droplets, which ensures a large surface area for heat and mass transfer, and significantly shortens the processing. Read More

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Effect of Mixed Particulate Emulsifiers on Spray-Dried Avocado Oil-in-Water Pickering Emulsions.

Polymers (Basel) 2022 Jul 28;14(15). Epub 2022 Jul 28.

Sección de Estudios de Posgrado e Investigación, UPIITA, Avenida Instituto Politécnico Nacional No. 2580, Col. Barrio la Laguna Ticomán, Gustavo A. Madero, Mexico City 07340, Mexico.

Avocado oil is a very valuable agro-industrial product which can be perishable in a short time if it is not stored in the right conditions. The encapsulation of the oils through the spray drying technique protects them from oxidation and facilitates their incorporation into different pharmaceutical products and food matrices; however, the selection of environmentally friendly emulsifiers is a great challenge. Four formulations of the following solid particles: Gum Arabic, HI-CAP100 starch, and phosphorylated waxy maize starch, were selected to prepare avocado oil Pickering emulsions. Read More

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Incorporation of Ethylcellulose Microparticles Containing a Model Drug with a Bitter Taste into Nanofibrous Mats by the Electrospinning Technique-Preliminary Studies.

Materials (Basel) 2022 Jul 31;15(15). Epub 2022 Jul 31.

Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.

Electrospinning is considered a simple and comprehensive technique to formulate ultrafine fibres by using an electric field. Polymeric nanofibers constitute promising materials in biomedical applications as drug delivery systems. For their preparation, both natural and synthetic polymers are utilised. Read More

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Channeled PM, PM and PM Emission Factors Associated with the Ceramic Process and Abatement Technologies.

Int J Environ Res Public Health 2022 Aug 5;19(15). Epub 2022 Aug 5.

Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona 18, 08034 Barcelona, Spain.

A sampling methodology and a mathematical data treatment were developed that enable to determine not only total suspended particulates (TSP) emitted at channeled sources but also the PM, PM, and PM mass fractions (w, w, and w) and emission factors (E.F.), using a seven-stage cascade impactor. Read More

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Evaluation of Guava Pulp Microencapsulated in Mucilage of Aloe Vera and as a Natural Dye for Yogurt: Functional Characterization and Color Stability.

Foods 2022 Aug 8;11(15). Epub 2022 Aug 8.

Grupo Química-Física Molecular y Modelamiento Computacional (QUIMOL®), Escuela de Ciencias Químicas, Universidad Pedagógica y Tecnológica de Colombia, Sede Tunja, Avenida Central del Norte, Tunja 050030, Boyacá, Colombia.

The substitution of artificial colorants for pigments extracted from fruits is a highly desirable strategy in the food industry for the manufacture of natural, functional, and safe products. In this work, a 100% natural spray-dried (SD) microencapsulated colorant of pink guava pulp, using aloe vera (AV) or (OFI) mucilage as functional encapsulating material, was prepared and evaluated as an additive into a yogurt (Y) matrix. The characterization of yogurt samples supplemented with OFI (Y-SD-OFI) and AV (Y-SD-AV) mucilage-covered guava pulp microcapsules was carried out through carotenoid quantification using UV-vis and HPLC-MS techniques, dietary fiber content, antioxidant capacity, colorimetry, and textural analysis, as well as by an evaluation of color stability after 25 days of storage at 4 °C in the dark. Read More

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Current Trends in the Production of Probiotic Formulations.

Foods 2022 Aug 4;11(15). Epub 2022 Aug 4.

Department of Biotechnology and Food Microbiology, Poznań University of Life Sciences, Wojska Polskiego 48, 60-627 Poznań, Poland.

Preparations containing probiotic strains of bacteria have a beneficial effect on human and animal health. The benefits of probiotics translate into an increased interest in techniques for the preservation of microorganisms. This review compares different drying methods and their improvements, with specific reference to processing conditions, microorganisms, and protective substances. Read More

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Impact of Freeze- and Spray-Drying Microencapsulation Techniques on β-Glucan Powder Biological Activity: A Comparative Study.

Foods 2022 Jul 29;11(15). Epub 2022 Jul 29.

Institute of Horticulture, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, Slovakia.

The study compares the impact of freeze- and spray-drying (FD, SD) microencapsulation methods on the content of β-glucan, total polyphenols (TP), total flavonoids (TF), phenolic acids (PA), and antioxidant activity (AA) in commercially β-glucan powder () using maltodextrin as a carrier. Morphology (scanning electron microscopy- SEM), yield, moisture content (MC), and water activity (a) were also evaluated in the samples. Our examinations revealed significant structural differences between powders microencapsulated by the drying methods. Read More

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Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives.

Drug Deliv Transl Res 2022 Aug 11. Epub 2022 Aug 11.

Department of Chemical Engineering, Dr. B.R. Ambedkar National Institute of Technology, Jalandhar, India.

The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and bioavailability. The application of ultrasound and additives is discussed to prepare the particles with narrow size distribution. The use of ionic liquid as an alternative to conventional organic solvent is presented. Read More

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Spray-drying Microencapsulation of an Extract from Tilia tomentosa Moench Flowers: Physicochemical Characterization and in Vitro Intestinal Activity.

Plant Foods Hum Nutr 2022 Aug 10. Epub 2022 Aug 10.

Department of Biotechnology, University of Verona, Strada Le Grazie, 15 - CV1, 37134, Verona, Italy.

Silver linden (Tilia tomentosa Moench, TtM) flowers possess several health-promoting properties, especially at the neurological level, such as intestinal relaxation activity associated with specific flavonols, particularly quercetin and kaempferol derivatives. However, such molecules are susceptible to degradation upon different triggers like heat, light and extreme pH values. To overcome the scarce stability of TtM flowers bioactive molecules and make them suitable for developing functional food and supplements, we applied microencapsulation. Read More

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Effect of the crosslinking and drying method on the oxidative stability of lipid microcapsules obtained by complex coacervation.

Food Funct 2022 Aug 9. Epub 2022 Aug 9.

School of Food and Health, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology and Business University, Beijing 100048, China.

The crosslinking and drying method of microcapsules prepared by complex coacervation has been investigated in order to achieve a better control of the oxidative stability of the final powder product. Methyl oleate was microencapsulated with gelatin and gum arabic as wall materials. For improving the oxidative stability of microcapsules, the crosslinking and drying method was optimized in order to obtain a product with a stable and dense wall layer structure. Read More

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Ultrahigh Stable Methanol Oxidation Enabled by a High Hydroxyl Concentration on Pt Clusters/MXene Interfaces.

J Am Chem Soc 2022 Aug 9. Epub 2022 Aug 9.

School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.

Anchoring platinum catalysts on appropriate supports, e.g., MXenes, is a feasible pathway to achieve a desirable anode for direct methanol fuel cells. Read More

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Microencapsulating role of whey protein isolate and sucrose in protecting the cell membrane and enhancing survival of probiotic lactobacilli strains during spray drying, storage, and simulated gastrointestinal passage.

Food Res Int 2022 Sep 9;159:111651. Epub 2022 Jul 9.

Technological Innovation of Probiotics and Plant Extracts for Functional Food Special Research Unit, Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand. Electronic address:

Limosilactobacillus reuteriKUB-AC5 andLactobacillus johnsoniiKUNN19-2 were spray-dried using whey protein isolate, sucrose, and whey protein isolate combined with sucrose at 130 °C and 150 °C. Differences in membrane fatty acid compositions of probiotics led to differences in cell membrane fluidity, cell injury, and cell survival during spray drying. Combination of whey protein isolate and sucrose improved survival of L. Read More

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September 2022

Co-amorphous systems using epigallocatechin-3-gallate as a co-former: stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms.

Eur J Pharm Biopharm 2022 Aug 3. Epub 2022 Aug 3.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China; Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System (DDS), Nanjing 210023, PR China. Electronic address:

Co-amorphous strategy has been extensively investigated to improve the dissolution of hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former in co-amorphous systems based on its unique structure including phenyl rings, phenolic hydroxyl groups and the galloyl moiety. Two model BCS class II drugs, simvastatin (SIM) and nifedipine (NIF), were selected to be co-amorphized with EGCG. Read More

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Process Modelling, Scale-Up and Characterization of Acetaminophen Spray Dried Milk Powder as Novel Pediatric Dosage Form.

Pharm Res 2022 Aug 5. Epub 2022 Aug 5.

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, 382481, India.

Purpose: Successful drug therapy in children is contingent upon hassle-free administration of pediatric dosage forms. Pediatric patients suffer from difficulty in swallowing due to weak esophagus muscles in their early age. Considering this challenge liquid formulations are preferred over solid dosage form among pediatric patients to avoid the possibility of choking which can be a serious life-threatening condition in children. Read More

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Development and Characterization of Celecoxib Solid Self-nanoemulsifying Drug Delivery Systems (S-SNEDDS) Prepared Using Novel Cellulose-Based Microparticles as Adsorptive Carriers.

AAPS PharmSciTech 2022 Aug 3;23(6):213. Epub 2022 Aug 3.

University of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Straße 3, 17489, Greifswald, Germany.

Self-nanoemulsifying drug delivery systems (SNEDDS) represent an interesting platform for improving the oral bioavailability of poorly soluble lipophilic drugs. While Liquid-SNEDDS (L-SNEDDS) effectively solubilize the drug in vivo, they have several drawbacks, including poor storage stability. Solid-SNEDDS (S-SNEDDS) combine the advantages of L-SNEDDS with those of solid dosage forms, particularly stability. Read More

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Solid state of inhalable high dose powders.

Adv Drug Deliv Rev 2022 Jul 30;189:114468. Epub 2022 Jul 30.

School of Pharmacy, University of Otago, Dunedin 9054, New Zealand. Electronic address:

High dose inhaled powders have received increased attention for treating lung infections. These powders can be prepared using techniques such as spray drying, spray-freeze drying, crystallization, and milling. The selected preparation technique is known to influence the solid state of the powders, which in turn can potentially modulate aerosolization and aerosolization stability. Read More

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Hydroxypropyl methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes.

Eur J Pharm Biopharm 2022 Jul 30. Epub 2022 Jul 30.

Pharmaceutical Development, Genentech Inc., 1 DNA Way South San Francisco CA 94080.

The ability to deliver stable and active dried protein therapeutics from biopharmaceutical drug delivery systems is critical for solid dosage formulation development. Spray dried formulations with carefully selected excipients provide a unique opportunity in amorphous phase stabilization of the therapeutic proteins. Herein, we discuss the role of hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives as polymeric excipients for stabilizing a model fragment antibody (Fab2) during high temperature processing and in possible low pH environments of a drug delivery platform. Read More

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Understanding the factors affecting the surface chemical composition of dairy powders: a systematic review.

Crit Rev Food Sci Nutr 2022 Aug 2:1-15. Epub 2022 Aug 2.

College of Engineering, China Agricultural University, Beijing, China.

Dairy powder, with abundant chemical components such as protein, fat, and lactose possessing diverse physical and chemical structures, can exhibit a surface composition distinct from its bulk content during the conversion of liquid milk into dry powder. Surface chemical composition is a significant parameter in the dairy industry, as it is directly associated with the techno-functional properties of dairy powder products. The current work provides an overview of the factors influencing the surface composition of dairy powders such as the bulk composition of raw milk (animal source and formulation), liquid dairy processing (homogenization, thermal treatment, and evaporation), the drying process (drying methods as well as operating conditions during the most commonly used spray drying), and storage conditions (temperature, relative humidity, and duration). Read More

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Improved Aerosolization Stability of Inhalable Tobramycin Powder Formulation by Co-Spray Drying with Colistin.

Pharm Res 2022 Aug 2. Epub 2022 Aug 2.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA.

Purpose: Tobramycin shows synergistic antibacterial activity with colistin and can reduce the toxic effects of colistin. The purpose of this study is to prepare pulmonary powder formulations containing both colistin and tobramycin and to assess their in vitro aerosol performance and storage stability.

Methods: The dry powder formulations were manufactured using a lab-scale spray dryer. Read More

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Micro-fluidic Spray Freeze Dried Ciprofloxacin Hydrochloride-Embedded Dry Powder for Inhalation.

AAPS PharmSciTech 2022 Aug 2;23(6):211. Epub 2022 Aug 2.

Engineering Research Centre of Advanced Powder Technology (ERCAPT), School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province, 215123, People's Republic of China.

Active pharmaceutical ingredient (API)-embedded dry powder for inhalation (AeDPI) is highly desirable for pulmonary delivery of high-dose drug. Herein, a series of spray freeze-dried (SFD) ciprofloxacin hydrochloride (CH)-embedded dry powders were fabricated via a self-designed micro-fluidic spray freeze tower (MFSFT) capable of tuning freezing temperature of cooling air as the refrigerant medium. The effects of total solid content (TSC), mass ratio of CH to -leucine (Leu) as the aerosol dispersion enhancer, and the freezing temperature on particle morphology, size, density, moisture content, crystal properties, flowability, and aerodynamic performance were investigated. Read More

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Microencapsulation of Dandelion ( L.) Leaf Extract by Spray Drying.

Food Technol Biotechnol 2022 Jun;60(2):237-252

University of Zagreb, Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia.

Research Background: Due to numerous health-promoting properties, dandelion has been used in traditional medicine as a herbal remedy, but also as a food product. Dandelion health benefits are ascribed to the presence of different bioactive compounds in its tissues, among which polyphenols play a significant role. However, the low stability of polyphenols is a critical parameter for their successful implementation into products. Read More

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Inhalable microparticle platform based on a novel shell-forming lipid excipient and its feasibility for respirable delivery of biologics.

Eur J Pharm Biopharm 2022 Aug 26;177:308-322. Epub 2022 Jul 26.

Department of Mechanical Engineering, University of Alberta, Alberta, Canada. Electronic address:

Administration of biologics such as proteins, vaccines, and phages via the respiratory route is becoming increasingly popular. Inhalable powder formulations for the successful delivery of biologics must first ensure both powder dispersibility and physicochemical stability. A lipid-based inhalable microparticle platform combining the stability advantages offered by dry powder formulations and high dispersibility afforded by a rugose morphology was spray dried and tested. Read More

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Profiling the process development of Wurster coating for modified release capsule products in approved drug product applications.

Int J Pharm 2022 Jul 25;625:122053. Epub 2022 Jul 25.

Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States.

In this paper, we have studied Wurster Coating operation for the manufacture of modified release (MR) capsule products submitted to FDA as New Drug Applications (NDAs) and Abbreviated New Drug Applications (ANDAs) by using a data-driven approach. We have collected and classified information into Wurster coating associated process variables, quality attributes, and scale up strategies under Quality by Design (QbD) paradigm. We have quantified the importance and risk of the process variables and quality attributes by analyzing reported frequencies and risk factors, respectively. Read More

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Hierarchical Self-Assembly Strategy for Scalable Synthesis of LiVO/N Doped C Nanosheets for High-Rate Li-Ion Storage.

ACS Appl Mater Interfaces 2022 Aug 28;14(31):35854-35863. Epub 2022 Jul 28.

College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang 443002, China.

While the comprehensive merits of high safety and high capacity make LiVO (LVO) a potential anode material for lithium-ion batteries, the practical application of LVO was severely impeded by the unfavorable high-rate capability and unscalable preparation. Here, LVO/N doped C nanosheets ([email protected] NSs) assembled from primary [email protected] nanoparticles are prepared via a scalable and concise spray drying approach. The 2D morphology and the interconnected [email protected] constituents endow the [email protected] NSs with continuously excellent reaction activity, leading to prominent rate performance. Read More

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Inhalable Formulation Based on Lipid-Polymer Hybrid Nanoparticles for the Macrophage Targeted Delivery of Roflumilast.

Biomacromolecules 2022 08 28;23(8):3439-3451. Epub 2022 Jul 28.

Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo90123, Italy.

Here, novel lipid-polymer hybrid nanoparticles (LPHNPs), targeted to lung macrophages, were realized as potential carriers for Roflumilast administration in the management of chronic obstructive pulmonary disease (COPD). To achieve this, Roflumilast-loaded fluorescent polymeric nanoparticles, based on a polyaspartamide-polycaprolactone graft copolymer, and lipid vesicles, made from 1,2-dipalmitoyl--glycero-3-phosphocholine and 1,2-distearoyl--glycero-phosphoethanolamine--(polyethylene glycol)-mannose, were properly combined using a two-step method, successfully obtaining Roflumilast-loaded hybrid fluorescent nanoparticles ([email protected]). These exhibit colloidal size and a negative ζ potential, 50 wt % phospholipids, and a core-shell-type morphology; they slowly release the entrapped drug in a simulated physiological fluid. Read More

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Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO Process and Celecoxib Immediate Release Tablet Formulation by Quality by Design Approach.

Pharmaceutics 2022 Jul 26;14(8). Epub 2022 Jul 26.

College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

Significant improvements in the wettability and dissolution rate of celecoxib (CEL), a poorly soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al., 2019 by combining the binary pharmaceutical compositions including CEL and one of the two co-formers, adipic acid (ADI) and saccharin (SAC), into eutectic mixtures (EM). In this study, we developed a therapeutic eutectic system for CEL which is a promising approach for oral delivery to enhance bioavailability. Read More

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Design of Functional Powdered Beverages Containing Co-Microcapsules of Sacha Inchi Oil and Antioxidant Extracts of Camu Camu and Mango Skins.

Antioxidants (Basel) 2022 Jul 22;11(8). Epub 2022 Jul 22.

Instituto de la Grasa-Consejo Superior de Investigaciones Científicas, Campus Universidad Pablo de Olavide Ed. 46, Crtra. Sevilla-Utrera km 1, 41013 Sevilla, Spain.

Sacha inchi oil (SIPHO) was co-microencapsulated, by spray drying using gum arabic as a coating material, with antioxidant extracts of camu camu ( (HBK) McVaugh) (CCSE) and mango () (MSE) skins obtained by ultrasound-microwave-assisted extraction (UMAE). The physicochemical characteristics of the microcapsules, such as, particle size, morphology, and moisture, as well as the encapsulation efficiency, the fatty acid composition, and oxidative stability, were determined in order to select the best formulation for the design of functional powdered beverages. The formulation with the highest amounts of ω3 acids and polyphenols was used to prepare a functional powdered beverage that contained ω3 (52. Read More

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Microencapsulation by Spray Drying and Antioxidant Activity of Phenolic Compounds from Tucuma Coproduct ( Mart.) Almonds.

Polymers (Basel) 2022 Jul 18;14(14). Epub 2022 Jul 18.

Laboratory of Pharmaceutical and Cosmetic R&D, Federal University of Pará, Belém 66075-110, Brazil.

The industrial processing of fruits in the Amazon region, such as tucuma, generates a large amount of coproducts with great nutritional potential. In this work, phenolic compounds from tucuma coproduct almonds were extracted and microencapsulated by spray drying using maltodextrin as the encapsulating agent and verified its antioxidant activity. Phenolic compounds were determined by UV spectroscopy and identified by Ultraefficiency Liquid Chromatography. Read More

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