129 results match your criteria spontaneously infarcted

Chimerism as the basis for organ repair.

Ann N Y Acad Sci 2021 03 29;1487(1):12-20. Epub 2020 Sep 29.

Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Organ and tissue repair are complex processes involving signaling molecules, growth factors, and cell cycle regulators that act in concert to promote cell division and differentiation at sites of injury. In embryonic development, progenitor fetal cells are actively involved in reparative mechanisms and display a biphasic interaction with the mother; and there is constant trafficking of fetal cells into maternal circulation and vice versa. This phenomenon of fetal microchimerism may have significant impact considering the primitive, multilineage nature of these cells. Read More

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Efficient Cardiac Differentiation of Human Amniotic Fluid-Derived Stem Cells into Induced Pluripotent Stem Cells and Their Potential Immune Privilege.

Int J Mol Sci 2020 Mar 29;21(7). Epub 2020 Mar 29.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70457, Taiwan.

Mature mammalian hearts possess very limited regenerative potential. The irreversible cardiomyocyte loss after heart injury can lead to heart failure and death. Pluripotent stem cells (PSCs) can differentiate into cardiomyocytes for cardiac repair, but there are obstacles to their clinical application. Read More

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Physical training prior to myocardial infarction potentializes stem cell therapy, SDF-1/CXCR4 axis activation and inhibits the vasoconstrictor response in hypertensive rats.

Cytokine 2020 02 6;126:154912. Epub 2019 Nov 6.

Departamento de Ciências Básicas da Saúde, Programa de Pós-Doutorado em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Av. Sarmento Leite, 245, Prédio III, Room 507 - Centro Histórico, Porto Alegre, RS 90050-170, Brazil. Electronic address:

Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical training on cell homing activation and associated mechanisms after acute myocardial infarction and therapy with adipose-derived stem cells in spontaneously hypertensive rats (SHR). Read More

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February 2020

Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.

Proc Natl Acad Sci U S A 2019 06 20;116(24):11786-11795. Epub 2019 May 20.

Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

The extremely limited regenerative potential of adult mammalian hearts has prompted the need for novel cell-based therapies that can restore contractile function in heart disease. We have previously shown the regenerative potential of mixed fetal cells that were naturally found migrating to the injured maternal heart. Exploiting this intrinsic mechanism led to the current hypothesis that Caudal-type homeobox-2 (Cdx2) cells in placenta may represent a novel cell type for cardiac regeneration. Read More

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Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats.

Clin Sci (Lond) 2019 04 29;133(8):939-951. Epub 2019 Apr 29.

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, U.S.A.

Epoxyeicosatrienoic acids (EETs) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p. Read More

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Spontaneously infarcted parotid tumours: MRI findings.

Dentomaxillofac Radiol 2019 Jul 12;48(5):20180382. Epub 2019 Feb 12.

4 Department of Radiology, Osaka University Graduate School of Medicine , Osaka-sayama, Osaka , Japan.

Objectives: To report MRI findings of spontaneous infarction in parotid tumours.

Methods: 14 patients (13 male, 1 female; mean age 73 years) with spontaneously infarcted parotid tumours were reviewed retrospectively. MR images were assessed for the location, the presence of synchronous parotid masses, margin characteristics, signal intensity on and weighted images, and internal architecture according to the distribution of signal hyperintensity. Read More

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Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction.

Nano Lett 2018 09 29;18(9):5885-5891. Epub 2018 Aug 29.

MicroRNA-based therapy that targets cardiac macrophages holds great potential for treatment of myocardial infarction (MI). Here, we explored whether boosting the miRNA-21 transcript level in macrophage-enriched areas of the infarcted heart could switch their phenotype from pro-inflammatory to reparative, thus promoting resolution of inflammation and improving cardiac healing. We employed laser capture microdissection (LCM) to spatially monitor the response to this treatment in the macrophage-enriched zones. Read More

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September 2018

Strategic design of cardiac mimetic core-shell nanofibrous scaffold impregnated with Salvianolic acid B and Magnesium l-ascorbic acid 2 phosphate for myoblast differentiation.

Mater Sci Eng C Mater Biol Appl 2018 Sep 21;90:131-147. Epub 2018 Apr 21.

Biological Materials Laboratory, CSIR - Central Leather Research Institute, Adyar, Chennai, 600020, Tamil Nadu, India. Electronic address:

The major loss of myocardial tissue extracellular matrix after infarction is a serious complication that leads to heart failure. Regeneration and integration of damaged cardiac tissue is challenging since the functional restoration of the injured myocardium is an incredible task. The injured micro environment of myocardium fails to regenerate spontaneously. Read More

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September 2018

Homing of endogenous bone marrow mesenchymal stem cells to rat infarcted myocardium via ultrasound-mediated recombinant SDF-1α adenovirus in microbubbles.

Oncotarget 2018 Jan 8;9(1):477-487. Epub 2017 Dec 8.

Department of Echocardiography, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Stem cells can promote myocardial regeneration and accelerate the formation of new blood vessels. As such, transplanted stem cells represent a promising treatment modality for acute myocardial infarction (AMI). Stem cells spontaneously home to the infarcted myocardium using chemotaxis, in which the stromal cell-derived factor (SDF-1α) has been shown to be one of the most important chemokines. Read More

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January 2018

Spontaneous rectus sheath hematoma in pregnancy and a systematic anatomical workup of rectus sheath hematoma: a case report.

J Med Case Rep 2016 Oct 19;10(1):292. Epub 2016 Oct 19.

Department of Gynecology and Obstetrics, Kiel School of Gynaecological Endoscopy, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, House 24, 24105, Kiel, Germany.

Background: Rectus sheath hematoma is a rare clinical diagnosis, particularly in pregnancy. Due to unspecific symptoms, misdiagnosis is likely and could potentially endanger a patient as well as her fetus.

Case Presentation: A 26-year-old white woman presented with mild right-sided abdominal pain, which increased during palpation and movement, at 26 + 3 weeks' gestational age. Read More

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October 2016

Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts.

Stem Cell Res Ther 2015 May 27;6:108. Epub 2015 May 27.

ICREC Research Program, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Camí de les Escoles s/n, Badalona, Barcelona, 08916, Spain.

Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovascularization in an acellular pericardial-derived scaffold used as a myocardial bioimplant. To this end, 17 swine were submitted to a myocardial infarction followed by implantation of a decellularized human pericardial-derived scaffold. Read More

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Novel xeno-free human heart matrix-derived three-dimensional scaffolds.

J Transl Med 2015 Jun 18;13:194. Epub 2015 Jun 18.

Division of Cardiothoracic Surgery, Department of Surgery, University of Utah, Salt Lake City, UT, 84112, USA.

Rationale: Myocardial infarction (MI) results in damaged heart tissue which can progress to severely reduce cardiac function, leading to death. Recent studies have injected dissociated, suspended cardiac cells into coronary arteries to restore function with limited results attributed to poor cell retention and cell death. Extracellular matrix (ECM) injected into damaged cardiac tissue sites show some promising effects. Read More

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Nonenzymatic lipid mediators, neuroprostanes, exert the antiarrhythmic properties of docosahexaenoic acid.

Free Radic Biol Med 2015 Sep 21;86:269-78. Epub 2015 Apr 21.

INSERM U1046-UMR 9214, Centre National de la Recherche Scientifique, Physiologie et Médecine Expérimentale du Coeur et des Muscles, Université de Montpellier, 34295 Montpellier Cedex 5, France. Electronic address:

Neuroprostanes are lipid mediators produced by nonenzymatic free radical peroxidation of docosahexaenoic acid (DHA). DHA is associated with a lower atherosclerosis risk, suggesting a beneficial role in cardiovascular diseases. The aim of this study was to investigate the influence of DHA peroxidation on its potentially antiarrhythmic properties (AAP) in isolated ventricular cardiomyocytes and in vivo in post-myocardial infarcted mice. Read More

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September 2015

Dynamics of propagation of premature impulses in structurally remodeled infarcted myocardium: a computational analysis.

Candido Cabo

Front Physiol 2014 16;5:483. Epub 2014 Dec 16.

Department of Computer Systems, New York City College of Technology, City University of New York New York, NY, USA ; Doctoral Program in Computer Science, Graduate Center, City University of New York New York, NY, USA.

Unlabelled: Initiation of cardiac arrhythmias typically follows one or more premature impulses either occurring spontaneously or applied externally. In this study, we characterize the dynamics of propagation of single (S2) and double premature impulses (S3), and the mechanisms of block of premature impulses at structural heterogeneities caused by remodeling of gap junctional conductance (Gj) in infarcted myocardium. Using a sub-cellular computer model of infarcted tissue, we found that |INa,max|, prematurity (coupling interval with the previous impulse), and conduction velocity (CV) of premature impulses change dynamically as they propagate away from the site of initiation. Read More

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January 2015

High matrix metalloproteinase-9 expression induces angiogenesis and basement membrane degradation in stroke-prone spontaneously hypertensive rats after cerebral infarction.

Neural Regen Res 2014 Jun;9(11):1154-62

Department of Pathology, the First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

Basement membrane degradation and blood-brain barrier damage appear after cerebral infarction, severely impacting neuronal and brain functioning; however, the underlying pathogenetic mechanisms remain poorly understood. In this study, we induced cerebral infarction in stroke-prone spontaneously hypertensive rats by intragastric administration of high-sodium water (1.3% NaCl) for 7 consecutive weeks. Read More

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Spontaneously infarcted fibroadenoma of the breast in an adolescent girl: sonographic findings.

Suk Jung Kim

J Med Ultrason (2001) 2014 Jan 29;41(1):83-5. Epub 2013 Jun 29.

Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 1435 Jwa-dong, Haeundae-gu, Busan, 612-030, South Korea.

Spontaneous infarction in fibroadenoma unrelated to any known risk factors is extremely rare. Here, I present a case of a spontaneously infarcted fibroadenoma in an adolescent girl in whom no plausible predisposing factors were identified. High-resolution sonographic imaging showed a unique circumscribed, complex echoic mass containing a frondular solid portion. Read More

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January 2014

MRI blood-brain barrier permeability measurements to predict hemorrhagic transformation in a rat model of ischemic stroke.

Transl Stroke Res 2012 Dec 16;3(4):508-16. Epub 2012 Sep 16.

Department of Radiology, Neuroradiology Division, University of Virginia, Box 800170, Charlottesville, VA, 22908, USA.

Permeability imaging might add valuable information in the risk assessment of hemorrhagic transformation. This study evaluates the predictive value of blood-brain barrier permeability (BBBP) measurements extracted from dynamic contrast-enhanced MRI for hemorrhagic transformation in ischemic stroke. Spontaneously hypertensive and Wistar rats with 2 h filament occlusion of the right MCA underwent MRI during occlusion, at 4 and 24 h post reperfusion. Read More

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December 2012

Regulation of PTEN/Akt pathway enhances cardiomyogenesis and attenuates adverse left ventricular remodeling following thymosin β4 Overexpressing embryonic stem cell transplantation in the infarcted heart.

PLoS One 2013 24;8(9):e75580. Epub 2013 Sep 24.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America.

Thymosin β4 (Tβ4), a small G-actin sequestering peptide, mediates cell proliferation, migration, and angiogenesis. Whether embryonic stem (ES) cells, overexpressing Tβ4, readily differentiate into cardiac myocytes in vitro and in vivo and enhance cardioprotection following transplantation post myocardial infarction (MI) remains unknown. Accordingly, we established stable mouse ES cell lines, RFP-ESCs and Tβ4-ESCs, expressing RFP and an RFP-Tβ4 fusion protein, respectively. Read More

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Fine-needle aspiration cytology of breast lesions with spontaneous infarction: a five-year study.

Acta Cytol 2013 12;57(4):413-7. Epub 2013 Jul 12.

Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, India.

Objective: To put forth the cytological features and diagnostic pitfalls of spontaneously infarcted breast lesions on fine-needle aspiration cytology (FNAC).

Study Design: We present 19 cases of spontaneously infarcted breast lesions encountered on FNAC over a 5-year period. Histological follow-up was correlated wherever available. Read More

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October 2013

Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats.

Exp Transl Stroke Med 2013 25;5. Epub 2013 Jun 25.

Department of Neurology, Otto-von-Guericke-University, Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.

Background: Human cerebral small vessel disease (CSVD) has distinct histopathologic and imaging findings in its advanced stages. In spontaneously hypertensive stroke-prone rats (SHRSP), a well-established animal model of CSVD, we recently demonstrated that cerebral microangiopathy is initiated by early microvascular dysfunction leading to the breakdown of the blood-brain barrier and an activated coagulatory state resulting in capillary and arteriolar erythrocyte accumulations (stases). In the present study, we investigated whether initial microvascular dysfunction and other stages of the pathologic CSVD cascade can be detected by serial magnetic resonance imaging (MRI). Read More

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Fine needle aspiration diagnosis of a spontaneously infarcted fibroadenoma mimicking carcinoma: a case report.

Anal Quant Cytopathol Histpathol 2013 Feb;35(1):57-60

Department of Pathology, Farwaniya Hospital, P.O. Box 18373, Farwaniya 81004, Kuwait.

Background: Spontaneous infarction of fibroadenoma is an extremely rare complication in a nonpregnant/nonlactating female undergoing first-time aspiration. It can be misdiagnosed as carcinoma in all aspects of triple approach used for evaluation of patients with breast lesions.

Case: A 37-year-old woman presented to the outpatient surgical clinic with a 6-month history of a breast lump that was slowly increasing in size and had become painful during the past month. Read More

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February 2013

Intramyocardial dissecting hematoma and postinfarction cardiac rupture.

Echocardiography 2013 Jan 20;30(1):106-13. Epub 2012 Nov 20.

Echocardiography Department, National Institute of Cardiology Ignacio Chávez, México City, DF, México.

Potentially fatal cardiac rupture is a complication of myocardial infarction (MI), which can appear in the first hours of the acute event and during the course of the first week. The intramyocardial dissecting hematoma might appear as a component of the rupture during the evolution process. The description of the myocardium as a helical muscular band facilitates the explanation of the fiber dissection. Read More

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January 2013

Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart.

Basic Res Cardiol 2012 Nov 18;107(6):301. Epub 2012 Oct 18.

Department of Pathology and Laboratory Medicine, University of Cincinnati, OH, 45267-0529, USA.

The strategy to reprogram somatic stem cells to pluripotency status has provided an alternative source of surrogate ES cells (ESC). We report efficient reprogramming of multipotent bone marrow (BM) mesenchymal stem cells (MSC) to pluripotent status and the resultant MSC derived iPS cells (MiPS) and their derived progenitors effectively repaired the infarcted heart. MSC from young, male, Oct4-GFP transgenic mice were reprogrammed by retroviral transduction with Oct4, Sox2, Klf4, and c-Myc stemness factors. Read More

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November 2012

Endothelial differentiation in multipotent cells derived from mouse and human white mature adipocytes.

J Mol Cell Cardiol 2012 Dec 18;53(6):790-800. Epub 2012 Sep 18.

Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.

White mature adipocytes give rise to multipotent cells, so-called de-differentiated fat (DFAT) cells, when losing their fat in culture. The objective of this study was to examine the ability of DFAT cells to give rise to endothelial cells (ECs) in vitro and vivo. We demonstrate that mouse and human DFAT cells, derived from adipose tissue and lipospirate, respectively, initially lack expression of CD34, CD31, CD146, CD45 and pericyte markers, distinguishing them from progenitor cells previously identified in adipose stroma. Read More

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December 2012

c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart.

Proc Natl Acad Sci U S A 2012 Aug 30;109(33):13380-5. Epub 2012 Jul 30.

Department of Biomedical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

We examined the myogenic response to infarction in neonatal and adult mice to determine the role of c-kit(+) cardiovascular precursor cells (CPC) that are known to be present in early heart development. Infarction of postnatal day 1-3 c-kit(BAC)-EGFP mouse hearts induced the localized expansion of (c-kit)EGFP(+) cells within the infarct, expression of the c-kit and Nkx2.5 mRNA, myogenesis, and partial regeneration of the infarction, with (c-kit)EGFP(+) cells adopting myogenic and vascular fates. Read More

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Cytohistological correlation of early changes in spontaneously infarcted fibroadenoma-a rare case report.

Ecancermedicalscience 2012 12;6:257. Epub 2012 Jun 12.

Department of Pathology, Government Medical College, Latur-413512, Maharashtra, India.

Fibroadenoma is the most commonly diagnosed benign tumour in adolescents and young women but spontaneous infarction in fibroadenoma is rarely seen. We report here a case of spontaneously infracted fibroadenoma in a 20 year old unmarried female without history of trauma or previous fine needle aspiration. It is important to recognize this entity because microscopic findings in an infarct are influenced by the duration of the infarct and on cytology it mimics mastitis, duct ectasia and even carcinoma. Read More

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Short-term low intensity PMF does not improve functional or histological outcomes in a rat model of transient focal cerebral ischemia.

Brain Res 2012 Jun 13;1458:76-85. Epub 2012 Apr 13.

Experimental and Regenerative Neurosciences, School of Animal Biology, University of Western Australia, Crawley Western Australia, 6009, Australia.

Stimulation with pulsed magnetic fields (PMF) is a non-invasive technique that can modulate neural activity and has the potential to facilitate functional recovery and tissue preservation/repair following brain injury. The effect of low intensity (8 mT) PMF on functional recovery and infarct tissue volume was assessed in a middle cerebral artery occlusion model of transient focal ischemia in Spontaneously Hypertensive rats. Rats received a combination of PMF protocols, including high and low frequencies and recovery was monitored over eight days. Read More

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Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells.

PLoS One 2011 17;6(8):e23667. Epub 2011 Aug 17.

Department of Pathology, University of Cincinnati, Cincinnati, Ohio, United States of America.

Unlabelled: The current protocols for generation of induced pluripotent stem (iPS) cells involve genome integrating viral vectors which may induce tumorgenesis. The aim of this study was to develop and optimize a non-viral method without genetic manipulation for reprogramming of skeletal myoblasts (SMs) using small molecules.

Methods And Results: SMs from young male Oct3/4-GFP(+) transgenic mouse were treated with DNA methyltransferase (DNMT) inhibitor, RG108. Read More

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January 2012

miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.

J Cell Biol 2011 Jun;193(7):1197-212

Translational Cardiomyology Laboratory, Interdepartmental Stem Cell Institute, Catholic University of Leuven, 3000 Leuven, Belgium.

Postnatal heart stem and progenitor cells are a potential therapeutic tool for cardiomyopathies, but little is known about the mechanisms that control cardiac differentiation. Recent work has highlighted an important role for microribonucleic acids (miRNAs) as regulators of cardiac and skeletal myogenesis. In this paper, we isolated cardiac progenitors from neonatal β-sarcoglycan (Sgcb)-null mouse hearts affected by dilated cardiomyopathy. Read More

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Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats.

Am J Physiol Heart Circ Physiol 2011 Jul 6;301(1):H87-97. Epub 2011 May 6.

Dept. of Pharmacology and Toxicology, B346 Life Sciences Bldg., Michigan State Univ., East Lansing, MI 48824, USA.

Matrix metalloproteases (MMPs) are a family of zinc peptidases involved in extracellular matrix turnover. There is evidence that increased MMP activity is involved in remodeling of resistance vessels in chronic hypertension. Thus we hypothesized that inhibition of MMP activity with doxycycline (DOX) would attenuate vascular remodeling. Read More

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