J Hypertens 2021 Jun 16. Epub 2021 Jun 16.
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy Internal Medicine Department, ICMID, Hospital Clínic, University of Barcelona, Barcelona, Spain Cardiology, Geneva University Hospitals, Geneva, Switzerland King's College London British Heart Foundation Centre, London, UK Université de Lorraine, Centre d'Investigations Cliniques Plurithématique Inserm 1433 CHRU de Nancy, Inserm U1116 FCRIN INI-CRCT, Nancy, France University Medical Centre Ljubljana, Hypertension Department, Medical University Ljubljana, Ljubljana, Slovenia Department of Hypertension, National Institute of Cardiology, Warsaw, Poland Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden Cardiology Department, Asklepeion General Hospital, Athens, Greece Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria Økern Heart Centre Institute for Surgical Research and Department of Cardiology, Oslo University Hospital, Rikshospitalet, and University of Oslo Department of Cardiology, Oslo University Hospital Institute of Clinical Medicine, Medical Faculty, University of Oslo, and Departments of Cardiology and Nephrology, Oslo University Hospital, Ullevaal, Oslo, Norway Università Milano-Bicocca, Milan; Policlinico di Monza, Monza, Italy Charité - Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Klinische Pharmakologie und Toxikologie, Berlin, Germany.
Hypertension constitutes a major risk factor for heart failure with preserved ejection fraction (HFpEF). HFpEF is a prevalent clinical syndrome with increased cardiovascular morbidity and mortality. Specific guideline-directed medical therapy (GDMT) for HFpEF is not established due to lack of positive outcome data from randomized controlled trials (RCTs) and limitations of available studies. Read More