414,761 results match your criteria spinal

Water-Based Interventions for People With Neurological Disability, Autism, and Intellectual Disability: A Scoping Review.

Adapt Phys Activ Q 2021 Apr 19:1-20. Epub 2021 Apr 19.

University of South Australia.

The purpose of this study was to produce a descriptive overview of the types of water-based interventions for people with neurological disability, autism, and intellectual disability and to determine how outcomes have been evaluated. Literature was searched through MEDLINE, EMBASE, Ovid Emcare, SPORTDiscus, Google Scholar, and Google. One hundred fifty-three papers met the inclusion criteria, 115 hydrotherapy, 62 swimming, 18 SCUBA (self-contained underwater breathing apparatus), and 18 other water-based interventions. Read More

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On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review.

Biomed Pharmacother 2021 Apr 16;139:111563. Epub 2021 Apr 16.

Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders, which interferes with daily activities and life of the affected patients. Despite many developments in related recognizing and treating procedures, post-SCI neuropathic pain (NP) is still a clinical challenge for clinicians with no distinct treatments. Accordingly, a comprehensive search was conducted in PubMed, Medline, Scopus, Web of Science, and national database (SID and Irandoc). Read More

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A comprehensive approach for the validation of lumbar spine finite element models investigating post-fusion adjacent segment effects.

A Azadi N Arjmand

J Biomech 2021 Apr 15;121:110430. Epub 2021 Apr 15.

Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. Electronic address:

Spinal fusion surgery is usually followed by accelerated degenerative changes in the unfused segments above and below the treated segment(s), i.e., adjacent segment disease (ASD). Read More

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Development of an in vitro test method to simulate intra-operative impaction loading on lumbar intervertebral body fusion devices.

J Biomech 2021 Apr 5;121:110412. Epub 2021 Apr 5.

U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, MD 20993, USA.

Intervertebral body fusion devices (IBFDs) are commonly used in the treatment of various spinal pathologies. Intra-operative fractures of polyether-ether-ketone (PEEK) implants have been reported in the literature and to the FDA as device-related adverse events. The device and/or implant inserter failures typically occur during device impaction into the disc space and require implant removal and replacement. Read More

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Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE).

Mol Immunol 2021 Apr 16;135:84-94. Epub 2021 Apr 16.

Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST-School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea. Electronic address:

The immune system plays a critical role not only in homeostasis of the body but also in pathogenesis. Autoimmunity and dysregulation of the immune balance are closely related to age. To examine the influence of age on autoimmunity, the pathophysiological features of experimental autoimmune encephalomyelitis (EAE) induced at different ages were elucidated on the basis of plasma-level metabolic changes. Read More

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Rupture, reconstruction, and rehabilitation: A multi-disciplinary review of mechanisms for central nervous system adaptations following anterior cruciate ligament injury.

Knee 2021 Apr 15;30:78-89. Epub 2021 Apr 15.

Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH, USA; Division of Athletic Training, School of Applied Health Sciences and Wellness, College of Health Sciences and Professions, Ohio University, Athens, OH, USA; Division of Physical Therapy, School of Rehabilitation and Communication Sciences, College of Health Sciences and Professions, Ohio University, Athens, OH, USA.

Background: Despite surgical reconstruction and extensive rehabilitation, persistent quadriceps inhibition, gait asymmetry, and functional impairment remain prevalent in patients after anterior cruciate ligament (ACL) injury. A combination of reports have suggested underlying central nervous system adaptations in those after injury govern long-term neuromuscular impairments. The classic assumption has been to attribute neurophysiologic deficits to components of injury, but other factors across the continuum of care (e. Read More

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Burden of Pre-operative Opioid Use and Its Impact on Healthcare Utilization After Primary Single Level Lumbar Discectomy.

Spine J 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, University of Louisville, 200 Abraham Flexner Hwy, Louisville, KY, U.S.A. 40202. Electronic address:

Background Context: The complication profile and higher cost of care associated with pre-operative opioid use and spinal fusion is well described. However, the burden of opioid use and its impact in patients undergoing lumbar discectomy is not known. Knowledge of this, especially for a relatively benign and predictable procedure will be important in bundled and value-based payment models. Read More

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Comparison of the effects of corticosteroid and hyaluronic acid-carboxylmethylcellulose (HA-CMC) solution on selective nerve root block (SNRB) for lumbar radiculopathy: A prospective, double-blind, randomized controlled clinical trial.

Pain Pract 2021 Apr 19. Epub 2021 Apr 19.

Department of Orthopaedic Surgery, College of Medicine, Daegu Catholic University, Daegu city, Korea.

Background: SNRB was shown to effectively control radiating pain and reduce the need for surgical intervention. However, repetitive injections may trigger corticosteroid-induced side effects (hypercorticism, hyperglycemia, or fluid retention). This study aims to compare the potency of hyaluronic acid-carboxymethylcellulose (HA-CMC) solution versus that of corticosteroids regarding lower leg radiating pain (LLRP) improvement and functional outcome. Read More

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Identification of Deep Brain Stimulation Targets for Neuropathic Pain After Spinal Cord Injury Using Localized Increases in White Matter Fiber Cross-Section.

Neuromodulation 2021 Apr 19. Epub 2021 Apr 19.

Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.

Objectives: The spinal cord injury (SCI) patient population is overwhelmingly affected by neuropathic pain (NP), a secondary condition for which therapeutic options are limited and have a low degree of efficacy. The objective of this study was to identify novel deep brain stimulation (DBS) targets that may theoretically benefit those with NP in the SCI patient population. We hypothesize that localized changes in white matter identified in SCI subjects with NP compared to those without NP could be used to develop an evidence-based approach to DBS target identification. Read More

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Examining the utility of the Violence Prevention Climate scale: In a metropolitan Australian general hospital.

J Clin Nurs 2021 Apr 19. Epub 2021 Apr 19.

Department of Nursing, Midwifery and Health, Northumbria University, Newcastle-Upon-Tyne, UK.

Aim And Objectives: To evaluate and examine the utility of the Violence Prevention Climate scale by generalist healthcare professionals.

Background: Workplace violence in general hospital settings remains a challenge for healthcare organisations. High rates of violence are still being reported towards healthcare workers, despite organisational violence prevention strategies being implemented. Read More

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Spinal cord stimulation for the management of painful diabetic neuropathy: a systematic review and meta-analysis of individual patient and aggregate data.

Pain 2021 Mar 9. Epub 2021 Mar 9.

Liverpool Reviews and Implementation Group, Department of Health Data Science, University of Liverpool, Liverpool, United Kingdom Departments of Neurosurgery and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark Institute of Health and Well Being, University of Glasgow, Glasgow, United Kingdom College of Medicine and Health, University of Exeter, Exeter, United Kingdom Department of Pain Medicine, The James Cook University Hospital, Middlesbrough, United Kingdom Department of Neurology and Neurosurgery, Medisch Spectrum Twente, Enschede, the Netherlands Centre for Pain Medicine, Department of Anesthesiology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.

Abstract: Spinal cord stimulation (SCS) has been suggested as a treatment option for patients with painful diabetic neuropathy (PDN). We conducted a systematic review and undertook a meta-analysis on individual patient data from randomised controlled trials (RCTs) to assess the effectiveness of SCS for the management of PDN. Electronic databases were searched from inception to May 2020 for RCTs of SCS for PDN. Read More

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A Systematic Review of Cognitive Function in Adults with Spina Bifida.

Dev Neurorehabil 2021 Apr 19:1-14. Epub 2021 Apr 19.

Division of Pediatric Neurology, Duke University Health System, Durham, United States.

: Though much research has been done on the cognitive profiles of children, the abilities of patients with SBM as they age into adulthood are not well understood.: Determine if adults with SBM have impairments in overall cognition, attention, executive function, and memory compared to typically developing adults or a standardized population mean.: A medical librarian composed a search of spina bifida, adults, and cognitive function. Read More

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The T-type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity.

Br J Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.

Background And Purpose: T-type voltage-gated calcium channels are an emerging potential therapeutic target for neurological disorders including epilepsy and pain. Inhibition of T-type channels reduces the excitability of peripheral nociceptive sensory neurons and reverses pain hypersensitivity in male rodent pain models. However, administration of peripherally restricted T-type antagonists has failed to show efficacy in multiple clinical and preclinical pain trials, suggesting that inhibition of peripheral T-type channels alone may be insufficient for pain relief. Read More

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Postoperative pelvic incidence (PI) change may impact sagittal spinopelvic alignment (SSA) after instrumented surgical correction of adult spine deformity (ASD).

Spine Deform 2021 Apr 19. Epub 2021 Apr 19.

Department of Orthopedics, University of Colorado Anschutz Medical Campus, 12631 E. 17th Ave., Mail Stop B202, Aurora, CO, 80045, USA.

Objectives: To study factors causing postoperative change of PI after surgical correction of ASD and to assess the effect of this variability on postoperative PI-LL mismatch.

Background: PI is used as an individual constant to define lumbar lordosis (LL) correction goal (PI-LL < 10). Postoperative changes of PI were shown but with opposite vectors. Read More

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Spinal muscular atrophy: state of the art and new therapeutic strategies.

Neurol Sci 2021 Apr 19. Epub 2021 Apr 19.

Department of Child Neurology, University Policlinico Gemelli, Rome, Italy.

Spinal muscular atrophy (SMA) is a severe disorder of motor neurons and the most frequent cause of genetic mortality, due to respiratory complications. We are facing an exciting era with three available therapeutic options in a disease considered incurable for more than a century. However, the availability of effective approaches has raised up ethical, medical, and financial issues that are routinely faced by the SMA community. Read More

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Hip arthoplasty in a forester after numerous tick bites.

Int J Occup Med Environ Health 2021 Apr 13. Epub 2021 Apr 13.

Mazovian Center of Rehabilitation STOCER, Konstancin-Jeziorna, Poland (Department of Neurorthopedics).

Arthritis is one of the most important symptoms of late-stage borreliosis, observed in approximately 60% of untreated patients with Lyme disease. In several percent of them, this manifestation is of interest to orthopedic surgeons. The authors present a case of a patient, working as a forester, who underwent left hip replacement arthroplasty having contracted a Borrelia burgdorferi infection in the past, and who was hospitalized 12 years before in the infectious ward due to suspected neuroborreliosis for which he was treated with Ceftriaxone 2 × 2. Read More

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Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system.

EMBO Rep 2021 Apr 19:e51777. Epub 2021 Apr 19.

Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Enterovirus-A71 (EV-A71) has been associated with severe neurological forms of hand, foot, and mouth disease (HFMD). EV-A71 infects motor neurons at neuromuscular junctions (NMJs) to invade the central nervous system (CNS). Here, we investigate the role of peripherin (PRPH) during EV-A71 infection, a type III intermediate neurofilament involved in neurodegenerative conditions. Read More

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A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis.

Brain 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurology, Ulm University, Ulm, Germany.

Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in most ALS cases. Previously, we identified serum microRNAs downregulated in familial ALS, the majority of sporadic ALS patients, but also in presymptomatic mutation carriers. A 5-nucleotide sequence motif (GDCGG; D = G, A or U) was strongly enriched in these ALS-related microRNAs. Read More

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Myelopathy associated with SARS-COV-2 infection. A systematic review.

Neurol Res 2021 Apr 17:1-9. Epub 2021 Apr 17.

Medical School, University of Cyprus, Nicosia, Cyprus.

COVID-19 (CoranaVirus disease 2019) is an ongoing infectious disease caused by the RNA SARS-CoV-2 virus (Severe Acute Respiratory Syndrome CoronaVirus-2). More than one-third of COVID-19 patients report neurological symptoms and cases of neurological diseases are increasingly accumulating. The aim of this systematic review was to characterize all - to date - reported cases with COVID-19 related myelopathy. Read More

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Central vein sign and other radiographic features distinguishing myelin oligodendrocyte glycoprotein antibody disease from multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica.

Mult Scler 2021 Apr 19:13524585211007086. Epub 2021 Apr 19.

Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.

Background: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Central vein sign (CVS) prevalence has not yet been well-established in MOGAD.

Objective: Characterize the magnetic resonance imaging (MRI) appearance and CVS prevalence of MOGAD patients in comparison to matched cohorts of MS and AQP4+ NMOSD. Read More

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Nerve transfers in tetraplegia: a review and practical guide.

J Neurosurg Sci 2021 Apr 16. Epub 2021 Apr 16.

Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.

Introduction: Spinal cord injury (SCI) may lead to tetraplegia. Several nerve transfers have been successfully used for the restoration of the upper limb in tetraplegia. Reconstruction of an upper limb is individualized based on the functional level. Read More

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MRI of Nitrous Oxide-Related Subacute Cervical Myelopathy.

J Belg Soc Radiol 2021 Apr 8;105(1):22. Epub 2021 Apr 8.

AZ Monica, BE.

Myelopathy may occur following nitrous oxide (NO) misuse, even if vitamin B12-levels are normal. The typical appearance on magnetic resonance imaging (MRI), is an inverted V-shaped T2-weighted hypersignal in the dorsal columns of the cervicothoracic spinal cord. Read More

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Hypophosphatasia: A Case of Two Patients With Spinal Cord Compression From Increase in Ligamentous Ossifications During Treatment.

JBMR Plus 2021 Apr 5;5(4):e10449. Epub 2021 Mar 5.

Centre de Rhumatologie du Centre Hospitalo-Universitaire de Toulouse [Rheumatology Center of Toulouse University Hospital] Toulouse France.

Treatment with asfotase alfa has transformed the prognosis of hypophosphatasia in children and improves the bone and muscle signs in adults. The doses used in adults are the same as in children, whereas bone remodeling is different between them. We report on the cases of two patients treated with 1 mg/kg/day of asfotase alfa who developed spinal cord compression from spinal ossifications during treatment. Read More

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Impact of appendicular and trunk skeletal muscle mass and back extensor strength on sagittal spinal alignment in Japanese women without vertebral fracture.

Osteoporos Sarcopenia 2021 Mar 4;7(1):36-41. Epub 2021 Mar 4.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Objectives: Progressive and generalized loss of skeletal muscle mass (SMM) and strength are characteristics of sarcopenia. However, the impact of appendicular and trunk SMM and back extensor strength (BES) on spinal sagittal alignment remains unclear. Herein, we investigate the relationship between these factors and spinal sagittal alignment. Read More

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Coexistence of osteoporosis, sarcopenia and obesity in community-dwelling adults - The Yishun Study.

Osteoporos Sarcopenia 2021 Mar 7;7(1):17-23. Epub 2021 Jan 7.

Geriatric Education and Research Institute, Singapore.

Objectives: To 1) report prevalence of 'osteosarcopenia' (OS) and osteosarcopenic obesity (OSO) entities using evidence-based diagnostic techniques and definitions, 2) examine if OSO offers additional predictive value of functional decline over its components, and 3) identify associated factors in a multi-racial Southeast Asian population.

Methods: We performed a cross-sectional study of a representative sample of 542 community-dwelling adults (21-90 years old), and assessed anthropometry, cognition, functional performance, and self-report sociodemographic, health and lifestyle questionnaires. Low muscle mass, and the Asian Working Group for Sarcopenia (AWGS) 2019 criteria, were used to assess sarcopenia. Read More

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Bone morphogenic protein signaling in spinal cord injury.

Neuroimmunol Neuroinflamm 2021 21;8:53-63. Epub 2021 Mar 21.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Spinal cord injury (SCI) is a debilitating injury that results from traumatic or non-traumatic insults to the spinal cord, causing significant impairment of the patient's activity and quality of life. Bone morphogenic proteins (BMPs) are a group of polyfunctional cytokines belonging to the transforming growth factor beta superfamily that regulates a wide variety of cellular functions in healthy and disease states. Recent studies suggest that dysregulation of BMP signaling is involved in neuronal demyelination and death after traumatic SCI. Read More

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Roles of miRNAs in spinal cord injury and potential therapeutic interventions.

Neuroimmunol Neuroinflamm 2019 17;6. Epub 2019 Oct 17.

Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.

Spinal cord injury (SCI) affects approximately 200,000 individuals per year worldwide. There are more than 27 million people worldwide living with long-term disability due to SCI. Historically, it was thought that the central nervous system (CNS) had little ability for regeneration; however, more recent studies have demonstrated potential for repair within the CNS. Read More

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October 2019

Economic impact of traumatic spinal cord injuries in the United States.

Neuroimmunol Neuroinflamm 2019 20;6. Epub 2019 Jul 20.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Individuals having sustained traumatic spinal cord injury (TSCI) in the United States are living longer as compared to historical trends, thanks to an ever-evolving understanding of the nature of this injury. Despite this, multiple barriers to care for TSCI patients remain including variations in government-issued veteran insurance, privatized insurance, and among uninsured individuals. The United States alone experiences 12,000 new TSCI cases every year, many of these are found to occur in a growing proportion of elderly individuals. Read More

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Primary intramedullary melanoma of lumbar spinal cord: A case report.

World J Clin Cases 2021 Apr;9(10):2352-2356

Department of Medical Laboratory, Southern Medical University, Guangzhou 510515, Guangdong Province, China.

Background: Primary intramedullary melanoma is a very rare tumor, most frequently occurring in the cervical and thoracic spinal cord.

Case Summary: We present a rare case in which the primary intramedullary melanoma was located in the lumbar spine. A 56-year-old man complained of progressive intermittent pain in the lumbar area. Read More

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