19,853 results match your criteria spectrum neurologic

T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm 2021 Nov 17;8(6). Epub 2021 Sep 17.

From the Neuroimmunology and MS Research (NIMS) (C.C., M.P., P.T.O., I.J., M.J.D., R.P., P.M., C.W., I.J., A.L., R.M., M.S.), Department of Neurology, University Hospital and University Zurich, Switzerland; Department of Neuroscience DNS (M.P.), University-Hospital of Padova, Italy; Jung Diagnostics GmbH (R.O.), HIP - Health Innovation Port, Germany; Department of Health Sciences and Technology (C.W.), ETH Zurich, Switzerland; and Clinical Department of Neurology (M.R.), Medical University of Innsbruck, Austria.

Background And Objectives: Encouraged by the enormous progress that the identification of specific autoantigens added to the understanding of neurologic autoimmune diseases, we undertook here an in-depth study of T-cell specificities in the autoimmune disease multiple sclerosis (MS), for which the spectrum of responsible autoantigens is not fully defined yet. The identification of target antigens in MS is crucial for therapeutic strategies aimed to induce antigen-specific tolerance. In addition, knowledge of relevant T-cell targets can improve our understanding of disease heterogeneity, a hallmark of MS that complicates clinical management. Read More

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November 2021

Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies.

J Neuroinflammation 2021 Sep 16;18(1):208. Epub 2021 Sep 16.

Department of Neurology, Fleni, Buenos Aires, Argentina.

Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) characterized by acute optic neuritis (ON) and transverse myelitis (TM). NMO is caused by a pathogenic serum IgG antibody against the water channel aquoporin 4 (AQP4) in the majority of patients. AQP4-antibody (AQP4-ab) presence is highly specific, and differentiates NMO from multiple sclerosis. Read More

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September 2021

Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder.

J Neurodev Disord 2021 Sep 16;13(1):40. Epub 2021 Sep 16.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Mailstop 3063, Boston, MA, 02115, USA.

Background: CDKL5 deficiency disorder (CDD) is associated with refractory infantile onset epilepsy, global developmental delay, and variable features that include sleep, behavioral disturbances, and movement disorders. Current treatment is primarily symptom-based and informed by experience in caring for this population.

Methods: We describe medication and non-medication approaches to treatment of epilepsy and additional key neurologic symptoms (sleep disturbances, behavioral issues, movement disorders, and swallowing dysfunction) in a cohort of 177 individuals meeting criteria for CDD, 154 evaluated at 4 CDKL5 Centers of Excellence in the USA and 40 identified through the NIH Natural History Study of Rett and Related Disorders. Read More

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September 2021

A de novo CSDE1 variant causing neurodevelopmental delay, intellectual disability, neurologic and psychiatric symptoms in a child of consanguineous parents.

Am J Med Genet A 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatric Neurology, Centre for Neuromuscular Disorders, Centre for Translational Neuro- and Behavioral Sciences, University Duisburg-Essen, Essen, Germany.

CSDE1 encodes the cytoplasmic cold shock domain-containing protein E1 (CSDE1), which is highly conserved across species and functions as an RNA-binding protein involved in translationally coupled mRNA turnover. CSDE1 displays a bidirectional role: promoting and repressing the translation of RNAs but also increasing and decreasing the abundance of RNAs. Preclinical studies highlighted an involvement of CSDE1 in different forms of cancer. Read More

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September 2021

Acquisition of Developmental Milestones in Hypomyelination With Atrophy of the Basal Ganglia and Cerebellum and Other TUBB4A-Related Leukoencephalopathy.

J Child Neurol 2021 Sep;36(10):805-811

Division of Neurology, 6567Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Mutations in are associated with a spectrum of neurologic disorders categorized as -related leukoencephalopathy. Affected children can present with global developmental delay or normal early development, followed by a variable loss of skills over time. Further research is needed to characterize the factors associated with the divergent developmental trajectories in this rare monogenic disorder because this phenotypic spectrum is not fully explained by genotype alone. Read More

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September 2021

Allogeneic Hematopoietic Stem Cell Transplantation for PEX1-Related Zellweger Spectrum Disorder: A Case Report and Literature Review.

Front Pediatr 2021 25;9:672187. Epub 2021 Aug 25.

Department of Hematology and Oncology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.

Zellweger spectrum disorder (ZSD) is a heterogeneous group of autosomal recessive disorders characterized by a defect in peroxisome formation and attributable to mutations in the gene family. Patients with ZSD have profound neurologic impairments, including seizures, severe retardation, and dysmorphic features, and poor prognosis. Currently, there is no specific, effective treatment. Read More

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Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia.

Neurol Genet 2021 Oct 2;7(5):e624. Epub 2021 Sep 2.

Molecular Mechanisms of Cancer Program (P.M.-G., P.A.L.), Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Salamanca; Instituto de Investigación Biomédica de Salamanca (IBSAL) (P.M.-G., P.A.L.), Hospital Universitario de Salamanca, Spain; Genetics Department (B.K.), La Pitié-Salpêtrière Hospital, APHP. Sorbonne Université, Paris, France; Molecular Modelling Group (I.M.-A.), Centro de Biología Molecular "Severo Ochoa". CSIC - Universidad Autónoma de Madrid, Spain; Biosciences Research Institute (I.M.-A., P.G.-P.), School of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain; and Sorbonne Université - Université Pierre et Marie Curie (F.M.), Institut du Cerveau et de la Moelle épinière, INSERM U-1127, CNRS-UMR 7225, Paris, France.

Background And Objectives: To conduct a genetic and molecular functional study of a family with members affected of hereditary spastic paraplegia (HSP) of unknown origin and carrying a novel pathogenic vaccinia-related kinase 1 (1) variant.

Methods: Whole-exome sequencing was performed in 2 patients, and their parents diagnosed with HSP. The novel 1 variant was detected by whole-exome sequencing, molecularly modeled and biochemically characterized in kinase assays. Read More

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October 2021

Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study.

J Headache Pain 2021 Sep 9;22(1):107. Epub 2021 Sep 9.

Department of Neurology, Chinese PLA General Hospital, 28 Fuxing Road, 100853, Beijing, China.

Background: Medication-overuse headache (MOH) is a relatively frequently occurring secondary headache caused by overuse of analgesics and/or acute migraine medications. It is believed that MOH is associated with dependence behaviors and substance addiction, in which the salience network (SN) and the habenula may play an important role. This study aims to investigate the resting-state (RS) functional connectivity between the habenula and the SN in patients with MOH complicating chronic migraine (CM) compared with those with episodic migraine (EM) and healthy controls (HC). Read More

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September 2021

Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.

BMJ 2021 09 8;374:n1034. Epub 2021 Sep 8.

Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.

Objective: To determine the benefits and harms of medical cannabis and cannabinoids for chronic pain.

Design: Systematic review and meta-analysis.

Data Sources: MEDLINE, EMBASE, AMED, PsycInfo, CENTRAL, CINAHL, PubMed, Web of Science, Cannabis-Med, Epistemonikos, and trial registries up to January 2021. Read More

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September 2021

Management of Neurogenic Orthostatic Hypotension in Neurodegenerative Disorders: A Collaboration Between Cardiology and Neurology.

Neurol Ther 2021 Sep 7. Epub 2021 Sep 7.

Center for Cardiac and Vascular Research, Adventist Healthcare White Oak Medical Center, Silver Spring, MD, USA.

Treatment of patients with α-synucleinopathies (e.g., Parkinson disease, multiple system atrophy, diffuse Lewy body disease) may require clinicians to manage both neurologic and cardiovascular issues due to autonomic dysfunction. Read More

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September 2021

[Spectrum and indications of acupuncture and moxibustion therapy based on bibliometric analysis].

Zhongguo Zhen Jiu 2021 Sep;41(9):1055-9

Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.

Objective: To analyze the literature of acupuncture and moxibustion for diseases in the recent 5 years, and discuss the spectrum and indications of acupuncture and moxibustion.

Methods: The literature on acupuncture and moxibustion for diseases in CNKI, Wanfang and VIP databases from January 1, 2015 to December 31, 2019 was searched, summarized and analyzed, and the disease spectrum was summarized. At the same time, the literature from 2015 to 2019 (group A), 1978 to 2005 (group B), and 1949 to 2005 (group C) was compared, and the indications of acupuncture and moxibustion therapy were summarized. Read More

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September 2021

Psychotic symptoms prior or concomitant to diagnosis of multiple sclerosis: a systematic review of case reports and case series.

Int J Psychiatry Clin Pract 2021 Sep 6:1-7. Epub 2021 Sep 6.

Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Thonex, Switzerland.

Objective: We aimed to examine the clinical features of psychotic symptoms preceding or concomitant to multiple sclerosis (MS) diagnosis.

Method: From the 1st to 10th of January 2020 a systematic review was conducted through an electronic search of different databases. Results were limited to English, French, German, Italian and Spanish language articles. Read More

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September 2021

Inebilizumab for treatment of neuromyelitis optica spectrum disorder.

Neurodegener Dis Manag 2021 Sep 6. Epub 2021 Sep 6.

Horizon Therapeutics plc, Deerfield, IL 60015, USA.

Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease characterized by recurrent optic neuritis and transverse myelitis often resulting in severe disability. Anti-aquaporin-4-immunoglobulin (Ig) G is a pathogenic product of CD19-positive plasma cells found in most, but not all, individuals with NMOSD and is associated with immune-mediated neurologic injury. Inebilizumab, an afucosylated humanized IgG1 κ, anti-CD19 monoclonal antibody, may target pathogenic CD19-expressing B cells. Read More

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September 2021

CASPR2-Related Morvan Syndrome: Autonomic, Polysomnographic, and Neuropsychological Observations.

Neurol Clin Pract 2021 Jun;11(3):e267-e276

Departments of Neurology (PSS, AN, VP-K, KU, RY, SV, SSR, KP, SN, MN), Neurophysiology (TNS), Psychiatric Social Work (PTT), Neuroimaging & Interventional Neuroradiology (NIIR) (BM), Neuropsychology (RJ), and Neuropathology (AM), National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.

Objective: Morvan syndrome is characterized by central, autonomic, and peripheral hyperexcitability due to contactin-associated protein 2 (CASPR2) antibody. Our objective was to study the clinical spectrum, electrophysiologic, autonomic, polysomnographic, and neuropsychological profile in patients with CASPR2-related Morvan syndrome.

Methods: Serum and CSF samples that were CASPR2 antibody positive from 2016 to 2019 were assessed. Read More

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Novel CLCN4 variant associated with syndromic X-linked intellectual disability in a Chinese girl: a case report.

BMC Pediatr 2021 09 3;21(1):384. Epub 2021 Sep 3.

Department of Rehabilitation, Children's Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing, 210008, Jiangsu Province, China.

Background: The Raynaud-Claes type of X-linked syndromic mental retardation (MRXSRC) is a very rare condition, by intellectual disability ranged from borderline to profound, impaired language development, brain abnormalities, facial dysmorphisms and seizures. MRXSRC is caused by variants in CLCN4 which encodes the 2Cl/H exchanger ClC-4 prominently expressed in brain.

Case Presentation: We present a 3-year-old Chinese girl with intellectual disability, dysmorphic features, brain abnormalities, significant language impairment and autistic features. Read More

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September 2021

[Neurology and COVID-19: Case Series of Neurological Complications in 96 patients Admitted at a University Hospital].

Rev Med Chil 2021 Apr;149(4):527-532

Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: There are multisystemic consequences secondary to SARS- CoV-2 infection.

Aim: To characterize neurological complications in patients admitted due to SARS-CoV-2 infection.

Methods: Review of medical records of patients aged over 15 years with COVID-19 evaluated by the neurology team between April and August 2020 at a university hospital. Read More

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Variably Protease-sensitive Prionopathy in a Middle-aged Man With Rapidly Progressive Dementia.

Cogn Behav Neurol 2021 Sep 2;34(3):220-225. Epub 2021 Sep 2.

Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi.

Variably protease-sensitive prionopathy (VPSPr) is a recently described sporadic prion disease with distinctive clinical and histopathological features. We report the clinical, imaging, and neuropathological features of VPSPr in a 46-year-old right-handed man who presented with progressive cognitive decline, behavior disturbances, and a 50-pound weight loss over 6 months. The initial evaluation revealed severe cognitive impairment with no focal neurologic deficits. Read More

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September 2021

[Neurological manifestations in pediatric patients with COVID-19: case report].

Rev Peru Med Exp Salud Publica 2021 Apr-Jun;38(2):352-357. Epub 2021 Aug 30.

Instituto Nacional de Salud del Niño Breña, Lima, Perú.

The COVID-19 pandemic currently affects millions of people including the pediatric population. The clinical manifestations in children are diverse: respiratory, gastrointestinal, hematological, neurological and systemic. In order to describe the various clinical and neurological manifestations during the evolution of the disease, we documented a series of cases of pediatric patients with COVID-19. Read More

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September 2021

[Glossalgia as a psychodermatological syndrome].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(7):7-13

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Objective: To study clinical characteristics of burning mouth syndrome or glossalgia is a functional disorder with painful sensations in the oral cavity with verification of the psychopathological structure, typology and nosology of the syndrome within the continuum of neurotic/psychotic disorders and dermatological pathology, i.e. lichen planus (LP). Read More

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September 2021

Acute motor axonal neuropathy after ipilimumab and nivolumab treatment in melanoma brain metastases: A case report and review of the literature.

SAGE Open Med Case Rep 2021 25;9:2050313X211042215. Epub 2021 Aug 25.

Department of Neuro-Oncology, H. Lee Moffitt Cancer Center (MCC) & Research Institute, Tampa, FL, USA.

The use of immune checkpoint inhibitors including ipilimumab and nivolumab has expanded for several tumors including melanoma brain metastasis. These have resulted in a growing spectrum of neurologic immune-related adverse events, including ones that are rare and difficult to diagnose and treat. Here, we present a patient with melanoma brain metastasis who was treated with immune checkpoint inhibitors and developed an Acute Motor Axonal Neuropathy. Read More

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Natural history of Tay-Sachs disease in sheep.

Mol Genet Metab 2021 Aug 21. Epub 2021 Aug 21.

Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America; Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, United States of America; Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America; Department of Radiology, University of Massachusetts Medical School, Worcester, MA, United States of America. Electronic address:

Tay-Sachs disease (TSD) is a fatal neurodegenerative disease caused by a deficiency of the enzyme β-N-acetylhexosaminidase A (HexA). TSD naturally occurs in Jacob sheep is the only experimental model of TSD. TSD in sheep recapitulates neurologic features similar to juvenile onset and late onset TSD patients. Read More

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Atypical bacterial infections of the central nervous system transmitted by ticks: an unknown threat.

Radiologia 2021 Aug 25. Epub 2021 Aug 25.

Servicio de Radiodiagnóstico, Hospital Universitario Marqués de Valdecilla, Santander, España.

Infections of the central nervous system caused by atypical bacteria are becoming more common. Borrelia burgdorferi and Rickettsia conorii are microorganisms transmitted by ticks; infection with these bacteria result in a wide spectrum of manifestations on imaging. In areas where these tick-borne microorganisms are endemic, including Spain, these infections must be included in the differential diagnosis of patients with a variety of systemic and neurologic symptoms. Read More

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A wide spectrum of neurological manifestations in pediatrics patients with the COVID-19 infection: a case series.

J Neurovirol 2021 Aug 26. Epub 2021 Aug 26.

Division of Neurology, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceará, Brazil.

Neurological symptoms in COVID-19 patients can also be found in the pediatric population, but they are usually described as mild symptoms. Herein, we described a case series of four pediatric patients with severe and highly heterogeneous central and peripheral nervous system manifestations. The objective was to report neurological manifestations of COVID-19 in children and adolescents. Read More

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Muscular abnormalities in liver cirrhosis.

Andrej Hari

World J Gastroenterol 2021 Aug;27(29):4862-4878

Department of Gastroenterology and Hepatology, General Hospital Celje, Celje 3000, Savinjska, Slovenia.

Sarcopenia is becoming a well-established player in evaluating patients with chronic liver disease. Data regarding its clinical significance and consequences in the course of liver disease have been growing; many of the data support the idea that it impacts decompensation event frequency, prolonged hospitalization, and mortality, as well as providing the possibility to better prioritize patients on lists awaiting liver transplantation. When assessing the whole clinical scope of the field, which includes malnutrition and frailty, as well as the complete spectrum of muscle mass, strength, and function, it becomes clear that a well-founded approach in everyday clinical practice is essential. Read More

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Outreach physiatry clinics in remote Manitoba communities: an economic cost analysis.

CMAJ Open 2021 Jul-Sep;9(3):E818-E825. Epub 2021 Aug 26.

Section of Physical Medicine and Rehabilitation (Reid, Ethans), Department of Internal Medicine, University of Manitoba, Winnipeg, Man.; KITE - Toronto Rehabilitation Institute (Chan), University Health Network; Institute of Health Policy, Management and Evaluation (Chan), University of Toronto, Toronto, Ont.

Background: One in 5 people in Canada have a disability affecting daily activities, and, for rural patients, accessing lifelong physiatry care to improve function and manage symptoms requires complex and expensive travel. We compared the costs of new outreach physiatry clinics with those of conventional urban clinics in Manitoba.

Methods: Six outreach clinics were held from January 2018 to September 2019 in the remote communities of St. Read More

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Clinical Features of COVID-19 on Patients With Neuromyelitis Optica Spectrum Disorders.

Neurol Neuroimmunol Neuroinflamm 2021 11 26;8(6). Epub 2021 Aug 26.

From the Hospital das Clínicas (S.L.A., M.B., G.D.S., L.B., C.C.D.D., D.C.), FM-USP, São Paulo; Universidade Federal de Sergipe and Univ. Tiradentes (L.C.F.), Aracaju; Hospital Univ. Getúlio Vargas (N.A.d.C.S.), Manaus; Hospital Geral de Fortaleza (G.J.M., J.A.d.A., M.S.P., L.S.M.); Universidade Federal da Bahia/Ebserh (T.F.), Salvador; Hospital Ophir Loyola (H.L.S., L.C.R.), Belém; FUNAD (B.E.S.), João Pessoa; UNICAMP (C.R.A.), Campinas; Universidade Federal de São Paulo (E.M.L., L.d.S.A.), UNIFESP; Universidade Metropolitana de Santos (A.A.F.d.C., Y.D.F.); Santa Casa (A.P.G.), Belo Horizonte; Hospital da Restauração (M.I.d.M., A.J.P.), Recife; Santa Casa (R.P.C., M.F.M.), São Paulo; Hospital de Base do Distrito Federal (R.M.D.), Brasília; Hospital Santa Marcelina (A.C.P.), São Paulo; Private Service (A.K.), Cuiabá; Clínica AMO (A.M.), Salvador; Hospital Universitário Gaffree e Guinle (C.C.F.V.), Rio de Janeiro; Santa Casa (D.R.K.M.), Londrina; Universidade Federal de Goiás (D.S.D.), Goiânia; Private Service (E.R.C.-F.), Belo Horizonte; Faculdade de Medicina de Botucatu (F.C.G.D.R, D.G.B.), UNESP; Santa Casa and ABEM-Assoc. Brasileira de Esclerose Múltipla (G.S.d.O.), São Paulo; Universidade Estácio de Sá and Universidade Federal Fluminenses (G.A.C.), Rio de Janeiro; Universidade Federal Fluminense (H.H.R.), Campinas; Universidade Federal do Mato Grosso (H.H.S., J.A.F., L.S.), Cuiabá; Private Service (H.K.S.), Curitiba; IAMSPE (H.R.S.N.), São Paulo; Private Service (L.C.C.), São Paulo; Faculdade de Medicina de Marília (L.D.M.); Univ. da Região de Joinville (Univille) (M.V.M.G.); Santa Casa (M.L.V.P.), Rio de Janeiro; Univ. Federal R G Norte (M.E.T.D.), Natal; Univ. Federal Ciências da Saúde de Porto Alegre (M.d.C.R.); PUC (P.D.d.G.), Sorocaba; Hospital Israelita Albert Einstein (R.B.T.), São Paulo; Univ. Federal de Uberlândia (R.d.R.M.); Hospital Beneficência Portuguesa (S.G.), São Paulo; Hospital Memorial São José (S.S.), rede D'OR, Recife; Univ. Federal do Rio de Janeiro (S.N.M., V.C.S.R.P.); Private Service (S.N.M.), Florianópolis; Univ. Federal de Goiás (T.A.G.J.R.), Goiânia; Hospital Neurológico de Goiânia (V.M.C.); Pontifícia Universidade Católica de Campinas (M.M.d.M.P.); Hospital Universitário da Universidade Federal de Santa Catarina (A.W.d.N.J.), Florianópolis; Faculdade de Medicina de Ribeirão Preto (E.A.D.), USP; Hospital Sírio-Libanês (T.A.), São Paulo; and Faculty of Medicine (F.v.G.), University of Brasilia, Brazil.

Background And Objectives: To describe the clinical features and disease outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD).

Methods: The Neuroimmunology Brazilian Study Group has set up the report of severe acute respiratory syndrome (SARS-CoV2) cases in patients with NMOSD (pwNMOSD) using a designed web-based case report form. All neuroimmunology outpatient centers and individual neurologists were invited to register their patients across the country. Read More

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November 2021

Parental Reports on Early Autism Behaviors in Their Children with Fragile X Syndrome as a Function of Infant Feeding.

Cara J Westmark

Nutrients 2021 Aug 22;13(8). Epub 2021 Aug 22.

Department of Neurology, Molecular & Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA.

This study evaluates the prevalence of autistic behaviors in fragile X syndrome as a function of infant diet. Retrospective survey data from the , which included data on infant feeding and caregiver-reported developmental milestones for 190 children with fragile X syndrome enrolled in the Fragile X Online Registry with Accessible Database (FORWARD), were analyzed. Exploratory, sex-specific associations were found linking the use of soy-based infant formula with worse autistic behaviors related to language in females and self-injurious behavior in males. Read More

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Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum.

Int J Environ Res Public Health 2021 08 18;18(16). Epub 2021 Aug 18.

Louis Stokes Cleveland VA Medical Center, University Hospitals Cleveland Medical Center, Cleveland, OH 44022, USA.

Ethanol consumption remains a major concern at a world scale in terms of transient or irreversible neurological consequences, with motor, cognitive, or social consequences. Cerebellum is particularly vulnerable to ethanol, both during development and at the adult stage. In adults, chronic alcoholism elicits, in particular, cerebellar vermis atrophy, the anterior lobe of the cerebellum being highly vulnerable. Read More

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Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.

Cells 2021 Aug 3;10(8). Epub 2021 Aug 3.

Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University "Our Lady of Good Counsel", Rruga Dritan Hoxha, 1000 Tirana, Albania.

Folic acid has been identified to be integral in rapid tissue growth and cell division during fetal development. Different studies indicate folic acid's importance in improving childhood behavioral outcomes and underline its role as a modifiable risk factor for autism spectrum disorders. The aim of this systematic review is to both elucidate the potential role of folic acid in autism spectrum disorders and to investigate the mechanisms involved. Read More

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