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Serum phosphate is associated with mortality among patients admitted to ICU for acute pancreatitis.

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Service de Réanimation Médicale, CHRU Jean Minjoz, Besançon, France.

Background And Aims: Routine laboratory tests can be useful predictors in the early assessment of the severity and mortality of acute pancreatitis (AP). The aim of this study was to evaluate the accuracy of clinical and laboratory parameters for the prediction of mortality among patients admitted to the intensive care unit (ICU) for AP.

Methods: We conducted a retrospective analysis of prospectively collected data from Beth Israel Deaconess Hospital made publicly available to examine the relationship between routine clinical and laboratory parameters with respect to mortality for AP. Read More

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The utility of c-Met as a diagnostic tissue biomarker in primary colorectal cancer.

Int J Exp Pathol 2021 May 5. Epub 2021 May 5.

Leeds Institute of Medical Research, St. James's University Hospital, University of Leeds, Leeds, UK.

The transmembrane protein, c-Met, is thought to be overexpressed and activated in colorectal cancer (CRC). This study explored its potential as a diagnostic tissue biomarker for CRC in a large human CRC tissue collection obtained from a randomized clinical trial. Tissue microarrays of matched normal colorectal epithelium and primary cancer were prepared from specimens obtained from 280 patients recruited to the MRC CLASICC trial (ISRCTN 74883561) and interrogated using immunohistochemistry for c-Met expression. Read More

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Relationship between blood neutrophil-lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients.

J Clin Lab Anal 2021 May 5:e23774. Epub 2021 May 5.

Department of Nephrology, Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

Background: The study aimed to explore the relationship between neutrophil-lymphocyte ratio(NLR) in peripheral blood and renal tubular atrophy/interstitial fibrosis and to evaluate the clinical significance of NLR in IgA nephropathy (IgAN) patients.

Methods: A Total of 263 IgAN patients were included. The participants were categorized into four groups based on quartile of NLR. Read More

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A novel diagnostic and prognostic approach for unresponsive patients with anthroponotic cutaneous leishmaniasis using artificial neural networks.

PLoS One 2021 5;16(5):e0250904. Epub 2021 May 5.

Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Cutaneous leishmaniasis (CL) imposes a major health burden throughout the tropical and subtropical regions of the globe. Unresponsive cases are common phenomena occurred upon exposure to the standard drugs. Therefore, rapid detection, prognosis and classification of the disease are crucial for selecting the proper treatment modality. Read More

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Musculoskeletal ultrasound for ankylosing spondylitis: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25822

Department of Rheumatology, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou, China.

Objective: To clarify if musculoskeletal ultrasound (US) would give additional information for the clinical examination to diagnose and evaluate the activity of ankylosing spondylitis (AS).

Methods: A literature search was performed in PubMed, Embase, Web of Science, the Cochrane Library, Sinomed, Chinese National Knowledge Infrastructure (CINK), and Wanfang databases from their inceptions to May 15, 2020. Studies that examined the musculoskeletal US, which detected sacroiliac joints in people with AS were included. Read More

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Automated Explainable Multidimensional Deep Learning Platform of Retinal Images for Retinopathy of Prematurity Screening.

JAMA Netw Open 2021 May 3;4(5):e218758. Epub 2021 May 3.

Joint Shantou International Eye Center of Shantou University, the Chinese University of Hong Kong, Shantou, Guangdong, China.

Importance: A retinopathy of prematurity (ROP) diagnosis currently relies on indirect ophthalmoscopy assessed by experienced ophthalmologists. A deep learning algorithm based on retinal images may facilitate early detection and timely treatment of ROP to improve visual outcomes.

Objective: To develop a retinal image-based, multidimensional, automated, deep learning platform for ROP screening and validate its performance accuracy. Read More

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Analysis of risk factors for thrombosis of the left atrium/left atrial appendage in patients with non-valvular atrial fibrillation.

Cardiovasc J Afr 2021 Apr 16;32:1-7. Epub 2021 Apr 16.

Department of Ultrasound, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China. Email:

Objectives: Left atrial appendage (LAA) morphology is a powerful predictor of thrombogenesis of the left atrium (LA) in patients with non-valvular atrial fibrillation (NVAF). However, it remains unknown whether LAA morphology is useful for stroke risk stratification in patients with NVAF.

Methods: A total of 555 atrial fibrillation patients were divided into thrombus and non-thrombus groups according to transoesophageal echocardiography. Read More

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Aiding clinical assessment of neonatal sepsis using hematological analyzer data with machine learning techniques.

Int J Lab Hematol 2021 May 4. Epub 2021 May 4.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Introduction: Early diagnosis and antibiotic administration are essential for reducing sepsis morbidity and mortality; however, diagnosis remains difficult due to complex pathogenesis and presentation. We created a machine learning model for bacterial sepsis identification in the neonatal intensive care unit (NICU) using hematological analyzer data.

Methods: Hematological analyzer data were gathered from NICU patients up to 48 hours prior to clinical evaluation for bacterial sepsis. Read More

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Diagnostic accuracy of myocardial perfusion imaging in patients evaluated for kidney transplantation: A systematic review and meta-analysis.

J Nucl Cardiol 2021 May 4. Epub 2021 May 4.

University of Groningen, Medical Imaging Centre, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands.

Background: Cardiovascular disease is the most common cause of death after kidney transplantation. Coronary artery disease (CAD) assessment is therefore mandatory in patients evaluated for transplantation. We aimed to assess the diagnostic accuracy for CAD of single-photon emission computed tomography (SPECT) compared to the standards invasive coronary angiography (ICA) and coronary computed tomography angiography (CCTA) in patients evaluated for kidney transplantation. Read More

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A modern deep learning framework in robot vision for automated bean leaves diseases detection.

Int J Intell Robot Appl 2021 Apr 30:1-17. Epub 2021 Apr 30.

Computer Science Department, Al-Ma'aref University College, Ramadi, Anbar Iraq.

The bean leaves can be affected by several diseases, such as angular leaf spots and bean rust, which can cause big damage to bean crops and decrease their productivity. Thus, treating these diseases in their early stages can improve the quality and quantity of the product. Recently, several robotic frameworks based on image processing and artificial intelligence have been used to treat these diseases in an automated way. Read More

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Serum Levels of ITGBL1 as an Early Diagnostic Biomarker for Hepatocellular Carcinoma with Hepatitis B Virus Infection.

J Hepatocell Carcinoma 2021 27;8:285-300. Epub 2021 Apr 27.

Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200025, People's Republic of China.

Purpose: Early diagnostic biomarkers of hepatocellular carcinoma (HCC) are needed to distinguish hepatitis B virus (HBV) associated HCC (HBV-HCC) patients from at-risk patients. We assessed the diagnostic values of serum Integrin beta-like 1 (ITGBL1) for early-stage HBV-HCC.

Patients And Methods: We recruited 716 participators including 299 in the training and 417 in the validation stage, (HBV-HCC, chronic hepatitis B (CHB), HBV-related liver cirrhosis (HBV-LC), and healthy controls) between 2017 and 2020 from three centers. Read More

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Establishment of a suitable combination of serological markers to diagnose surgical site infection following spine surgery: A novel surgical site infection scoring system.

J Orthop Sci 2021 May 1. Epub 2021 May 1.

Orthopedic Department, National Defense College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: The accuracy rates of several effective serological markers of surgical site infection following spine surgery are unclear. We aimed to verify the accuracy of each significant marker and identify the most suitable and effective combination of these markers for the diagnosis of surgical site infection following spine surgery.

Methods: This retrospective study enrolled 329 patients who underwent spine surgery for causes other than infectious spondylitis, including 9 patients with surgical site infection. Read More

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Reciprocal assessment of urinary beta-2-microglobulin and BUN levels in renal dysfunction of neonates with birth asphyxia.

J Matern Fetal Neonatal Med 2021 May 4:1-7. Epub 2021 May 4.

Faculty of Medicine, Department of Immunology, Guilan University of Medical Sciences, Rasht, Iran.

Objective: Asphyxia at birth is one of the major causes of morbidity and mortality in all neonates due to various organ dysfunctions, for example, kidneys. Recent advances in this area have suggested new urinary proteins for the assessment of renal damage, including beta-2 microglobulin (β2-MG). The aim of this study was to investigate the changes of urinary β2-MG in asphyxiated neonates and to evaluate the value of combined detection of multiple biomarkers in the early diagnosis of acute kidney injury (AKI) in asphyxiated neonates. Read More

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Predicting intraventricular hemorrhage growth with a machine learning-based, radiomics-clinical model.

Aging (Albany NY) 2021 May 4;13. Epub 2021 May 4.

Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

We constructed a radiomics-clinical model to predict intraventricular hemorrhage (IVH) growth after spontaneous intracerebral hematoma. The model was developed using a training cohort (N=626) and validated with an independent testing cohort (N=270). Radiomics features and clinical predictors were selected using the least absolute shrinkage and selection operator (LASSO) method and multivariate analysis. Read More

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Machine learning in diagnosis and disability prediction of multiple sclerosis using optical coherence tomography.

Comput Biol Med 2021 Apr 26;133:104416. Epub 2021 Apr 26.

Group of Biomaterials, Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain; Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain. Electronic address:

Background: Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system, especially the brain, spinal cord, and optic nerve. Diagnosis of this disease is a very complex process and generally requires a lot of time. In addition, treatments are applied without any information on the disability course in each MS patient. Read More

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Detection of anti-mitochondrial 2-oxoacid dehydrogenase complex subunit's antibodies for the diagnosis of primary biliary cholangitis.

Clin Immunol 2021 May 1:108749. Epub 2021 May 1.

Department of Immunology, Hospital Universitari de Bellvitge, Catalonia, Spain.

Anti-mitochondrial antibodies (AMA), directed against the E2 subunits of the 2-oxo acid dehydrogenase complexes, are markers of Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease. However, the clinical significance of subunits-specific AMA type PDC-E2 -E2 subunit of the pyruvate dehydrogenase complex-, BCOADC-E2 -E2 subunit of the branched-chain 2-oxo acid dehydrogenase complex-, OGDC-E2 -E2 subunit of the 2-oxo-glutarate dehydrogenase complex- and nPDC -native pyruvate dehydrogenase complex (M2-AMA) . Is not well known, and not all AMA specificities are associated with PBC. Read More

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Clinical value of thoracic ultrasonography in the diagnosis of pulmonary embolism: a systematic review and meta-analysis.

Med Ultrason 2021 Apr 22. Epub 2021 Apr 22.

The First Hospital of Shanxi Medical University.

Aims: The present study investigated and evaluated the accuracy of thoracic ultrasonography (TUS) in the diagnosis of pulmonary embolism (PE) by conducting a systematic review and meta-analysis.

Material And Methods: The PubMed, Em-base and the Cochrane library databases were searched till March 2019 to retrieve relevant articles and the overall diagnostic accuracy of TUS in PE diagnosis was evaluated by meta-analysis.

Results: Overall, 16 studies including 1,916 patients were enrolled in this meta-analysis. Read More

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The Cutoff Value of Low Sex Hormone-Binding Globulin and Its Predictive Role in Impaired Glucose Metabolism Among Chinese Women with Polycystic Ovarian Syndrome.

Metab Syndr Relat Disord 2021 May 4. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Low levels of sex hormone-binding globulin (SHBG) is a potential predictor of type 2 diabetes mellitus (T2DM), and when combined with insulin resistance (IR), lead to impaired glucose metabolism. Few studies involve women with polycystic ovarian syndrome (PCOS). Studies on cutoff values of SHBG among Asian women were scanty. Read More

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Diagnostic value of serum human Galactomannan aspergillus antigen and 1,3-beta-D-glucan in immunocompromised patient suspected fungal infection.

J Clin Lab Anal 2021 May 4:e23806. Epub 2021 May 4.

Pulmonology and Respiratory Department of Faculty Medicine Brawijaya University, Dr. Saiful Anwar General Hospital, Malang, Indonesia.

Background: The prevalence of fungal infection (FI) in developing countries is high, but the diagnosis of FI is still challenging to determine, so it is needed evaluation of biomarkers other than microbiological culture, because the culture has low sensitivity, high cost, not available in every laboratory and needs a long time. The detection of human galactomannan Aspergillus antigen (GAL) and 1,3-beta-D-glucan (BDG) on the fungal cell wall could be the promising biomarkers for fungal infection. Neutropenia, lymphopenia and CD4T cells in the immunocompromised patients are essential factors, but these cell associations with BDG and GAL levels have not been evaluated yet. Read More

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Left ventricular systolic dyssynchrony index and endothelial dysfunction parameters as subclinical predictors of cardiovascular involvement in patients with beta-thalassemia major.

Echocardiography 2021 May 4. Epub 2021 May 4.

Department of Cardiology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Objective: Cardiovascular iron load is the leading cause of morbidity and mortality in beta-thalassemia major (β-TM). However, many patients remain asymptomatic until the late stage. In this cross-sectional study, we investigated the role of three-dimensional (3D) echocardiography and endothelial dysfunction parameters in asymptomatic β-TM patients, and the relationship between these parameters and cardiac magnetic resonance imaging (MRI) T2* value. Read More

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Urine metabolomic biomarkers for prediction of isolated fetal congenital heart defect.

J Matern Fetal Neonatal Med 2021 May 4:1-8. Epub 2021 May 4.

Division of Maternal Fetal Medicine, William Beaumont Health, Royal Oak, MI, USA.

Objective: To identify maternal second and third trimester urine metabolomic biomarkers for the detection of fetal congenital heart defects (CHDs).

Study Design: This was a prospective study. Metabolomic analysis of randomly collected maternal urine was performed, comparing pregnancies with isolated, non-syndromic CHDs versus unaffected controls. Read More

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Red cell index: A novel biomarker for 3-month mortality in acute ischemic stroke patients treated with intravenous thrombolysis.

Brain Behav 2021 May 4:e02170. Epub 2021 May 4.

Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: The red cell index (RCI) was described as a biomarker for evaluating respiratory function in previous studies, but the relationship between RCI and stroke, remained a mystery. The present study aimed to probe the association between RCI at 24-hr and 3-month mortality and functional outcomes among acute ischemic stroke (AIS) patients treated with recombinant tissue plasminogen activator (r-tPA).

Methods: A total of 217 AIS patients between January 2016 and January 2019 were recruited in this retrospective study. Read More

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Monocyte-to-lymphocyte ratio as a predictor of stroke-associated pneumonia: A retrospective study-based investigation.

Brain Behav 2021 May 4:e02141. Epub 2021 May 4.

Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Background And Purpose: Early prediction of stroke-associated pneumonia (SAP) is significant in clinical practice, as it is frequently challenging due to delays in typical clinical manifestations and radiological changes. The monocyte-to-lymphocyte ratio (MLR) has been proposed as an indicator of systemic inflammation and infection. However, none of these studies have focused on the predictive value of the MLR for SAP. Read More

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One-Minute Multi-contrast Echo Planar Brain MRI in Ischemic Stroke: A Retrospective Observational Study of Diagnostic Performance.

J Magn Reson Imaging 2021 May 4. Epub 2021 May 4.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Fast multi-contrast echo planar MRI (EPIMix) has comparable diagnostic performance to standard MRI for detecting brain pathology but its performance in detecting acute cerebral infarctions has not been determined.

Purpose: To assess the diagnostic performance of EPIMix for the detection of acute cerebral infarctions.

Study Type: Retrospective observational cohort. Read More

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Super-enhancer-associated long noncoding RNA RP11-569A11.1 inhibited cell progression and metastasis by regulating IFIT2 in colorectal cancer.

J Clin Lab Anal 2021 May 4:e23780. Epub 2021 May 4.

Department of Clinical Laboratory, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China.

Background: Recent studies have revealed that super-enhancer-associated long noncoding RNAs (SE-LncRNAs) act pivotal roles in carcinogenesis. This study aimed to report the identification of a novel SE-LncRNA, RP11-569A11.1, and its functional role in colorectal cancer (CRC) progression. Read More

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Machine learning-based radiomic evaluation of treatment response prediction in glioblastoma.

Clin Radiol 2021 Apr 30. Epub 2021 Apr 30.

University of Birmingham, Birmingham, UK; Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Electronic address:

Aim: To investigate machine learning based models combining clinical, radiomic, and molecular information to distinguish between early true progression (tPD) and pseudoprogression (psPD) in patients with glioblastoma.

Materials And Methods: A retrospective analysis was undertaken of 76 patients (46 tPD, 30 psPD) with early enhancing disease following chemoradiotherapy for glioblastoma. Outcome was determined on follow-up until 6 months post-chemoradiotherapy. Read More

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Artificial intelligence improves the accuracy of residents in the diagnosis of hip fractures: a multicenter study.

BMC Musculoskelet Disord 2021 May 3;22(1):407. Epub 2021 May 3.

Nonprofit Organization (NPO) Nagoya Orthopedic Regional Healthcare Support Center, AI Research Division, Meitohonmachi 2-22-1, Meito-ward, Nagoya, Japan.

Background: Less experienced clinicians sometimes make misdiagnosis of hip fractures. We developed computer-aided diagnosis (CAD) system for hip fractures on plain X-rays using a deep learning model trained on a large dataset. In this study, we examined whether the accuracy of the diagnosis of hip fracture of the residents could be improved by using this system. Read More

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Magnetic resonance imaging characteristics of chronic prostatitis in patients under the age of 50: is it more than the eye can see?

Acta Radiol 2021 May 3:2841851211010397. Epub 2021 May 3.

Radiology, Surgical Specialties Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: The magnetic resonance (MRI) diagnosis of chronic prostatitis (CP) is insufficiently evaluated.

Purpose: To evaluate the MRI appearance of CP in young patients by comparing it to individuals with non-prostatic related pathology.

Material And Methods: The study included 47 patients with prostatitis-like symptoms evaluated by urologists and referred to pelvic MRI examination (mean age=40. Read More

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Radiomics analysis on CT images for prediction of radiation-induced kidney damage by machine learning models.

Comput Biol Med 2021 Apr 19;133:104409. Epub 2021 Apr 19.

Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Radiation Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: We aimed to assess the power of radiomic features based on computed tomography to predict risk of chronic kidney disease in patients undergoing radiation therapy of abdominal cancers.

Methods: 50 patients were evaluated for chronic kidney disease 12 months after completion of abdominal radiation therapy. At the first step, the region of interest was automatically extracted using deep learning models in computed tomography images. Read More

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Third trimester HbA1c and the association with large-for-gestational-age neonates in women with gestational diabetes.

Arch Endocrinol Metab 2021 Apr 29. Epub 2021 Apr 29.

Departamento de Endocrinologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal.

Objective: To evaluate the association between HbA1c levels measured in the third trimester and the risk for large for gestational age (LGA) in neonates of mothers affected by gestational diabetes mellitus (GDM). Secondarily, we aimed to identify an ideal cut-off for increased risk of LGA amongst pregnant women with GDM.

Methods: Observational retrospective review of singleton pregnant women with GDM evaluated in a diabetes and pregnancy clinic of a tertiary and academic hospital. Read More

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