7,419 results match your criteria specific il-12

Cytokine Receptor Diversity in the Lamprey Predicts the Minimal Essential Cytokine Networks of Vertebrates.

J Immunol 2022 Aug 1. Epub 2022 Aug 1.

Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University, Atlanta, GA.

The vertebrate adaptive immune systems (Agnatha and Gnathostomata) use sets of T and B lymphocyte lineages that somatically generate highly diverse repertoires of Ag-specific receptors and Abs. In Gnathostomata, cytokine networks regulate the activation of lymphoid and myeloid cells, whereas little is known about these components in Agnathans. Most gnathostome cytokines are four-helix bundle cytokines with poorly conserved primary sequences. Read More

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Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice.

Front Immunol 2022 14;13:818015. Epub 2022 Jul 14.

Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.

Natural killer (NK) cells are important effectors of the innate immune system and participate in the first line of defense against infections and tumors. Prior to being functional, these lymphocytes must be educated or licensed through interactions of their major histocompatibility complex class I molecules with self-specific inhibitory receptors that recognize them. In the absence of such contacts, caused by either the lack of expression of the inhibitory receptors or a very low level of major histocompatibility complex class I (MHC class I) proteins, NK cells are hypo-reactive at baseline (). Read More

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SteE Enhances the Virulence of Pullorum in Chickens by Regulating the Inflammation Response.

Front Vet Sci 2022 14;9:926505. Epub 2022 Jul 14.

College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.

serovar Pullorum (. Pullorum) is a host-specific pathogen, which causes acute gastroenteritis with high mortality in poultry. However, the association between , encoded by type III secretion system 2, and virulence is not well-understood. Read More

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Emerging Therapies in Cutaneous Lupus Erythematosus.

Front Med (Lausanne) 2022 11;9:968323. Epub 2022 Jul 11.

Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Cutaneous lupus erythematosus (CLE) is an autoimmune disease that can occur with or without underlying systemic lupus erythematosus (SLE) and often has a profoundly negative impact on patient quality of life. There is substantial need for new and more effective therapies to treat CLE. CLE has a multifactorial pathogenesis that involves several key immune cells and pathways, including abnormalities in innate (e. Read More

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The Mechanisms of Effector Th Cell Responses Contribute to Treg Cell Function: New Insights into Pathogenesis and Therapy of Asthma.

Front Immunol 2022 11;13:862866. Epub 2022 Jul 11.

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.

CD4 helper T (Th) cell subsets are critically involved in the pathogenesis of asthma. Naive Th cells differentiate into different subsets under the stimulation of different sets of cytokines, and the differentiation process is dominantly driven by lineage specific transcription factors, such as T-bet (Th1), GATA3 (Th2), RORγt (Th17) and Foxp3 (Treg). The differentiation mechanisms driven by these transcription factors are mutually exclusive, resulting in functional inhibition of these Th subsets to each other, particularly prominent between effector Th cells and Treg cells, such as Th2 versus Treg cells and Th17 versus Treg cells. Read More

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Immunization with Virus-Like Particle Vaccine Protects Rabbits against Hepatitis E-3 Virus Infection.

Viruses 2022 06 29;14(7). Epub 2022 Jun 29.

Department of Infectious Disease, College of Veterinary Medicine, Konkuk University, 120 Neundong-ro, Gwangjin-gu, Seoul 05029, Korea.

Here, rabbits were immunized with a virus-like particle (VLP) vaccine prepared by expressing 239 amino acids of the swine hepatitis E virus (HEV)-3 capsid protein using a baculovirus system. Thirty specific-pathogen-free rabbits were divided into five groups (negative and positive control and 10, 50, and 100 μg VLP-vaccinated). Positive control group rabbits showed viremia and fecal viral shedding, whereas rabbits vaccinated with 10 μg VLP showed transient fecal viral shedding, and rabbits vaccinated with 50 and 100 μg VLP did not show viremia or fecal viral shedding. Read More

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Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice.

Vaccines (Basel) 2022 Jul 19;10(7). Epub 2022 Jul 19.

National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Interleukin-12 receptor β1 (IL12RB1)-deficient individuals show increased susceptibilities to local or disseminated BCG infection and environmental mycobacteria infection. However, the low clinical penetrance of IL12RB1 deficiency and low recurrence rate of mycobacteria infection suggest that protective immunity still exists in this population. In this study, we investigated the mechanism of tuberculosis suppression using the IL12RB1-deficient mouse model. Read More

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A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against Infection.

Vaccines (Basel) 2022 Jul 19;10(7). Epub 2022 Jul 19.

Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte 30130-100, MG, Brazil.

Currently, there is no licensed vaccine to protect against human visceral leishmaniasis (VL), a potentially fatal disease caused by infection with parasites. In the current study, a recombinant chimeric protein ChimT was developed based on T-cell epitopes identified from the immunogenic amastigote proteins LiHyp1, LiHyV, LiHyC and LiHyG. ChimT was associated with the adjuvants saponin (Sap) or monophosphoryl lipid A (MPLA) and used to immunize mice, and their immunogenicity and protective efficacy were evaluated. Read More

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Safety and Prophylactic Efficacy of Liposome-Based Vaccine against the Drug-Resistant in Mice.

Pharmaceutics 2022 Jun 27;14(7). Epub 2022 Jun 27.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.

In recent years, the emergence of multidrug-resistant has greatly threatened public health and depleted our currently available antibacterial armory. Due to limited therapeutic options, the development of an effective vaccine formulation becomes critical in order to fight this drug-resistant pathogen. The objective of the present study was to develop a safe vaccine formulation that can be effective against infection and its associated complications. Read More

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Pathogenesis of Paradoxical Reactions Associated with Targeted Biologic Agents for Inflammatory Skin Diseases.

Fumi Miyagawa

Biomedicines 2022 Jun 23;10(7). Epub 2022 Jun 23.

Department of Dermatology, Nara Medical University School of Medicine, Nara 634-8522, Japan.

Targeted biologic agents have dramatically changed the therapeutic landscape for immune-mediated inflammatory diseases, particularly in rheumatology and dermatology. Their introduction has resulted in a paradigm shift, i.e. Read More

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Vitamin D3 Priming of Dendritic Cells Shifts Human Neutrophil-Dependent Th17 Cell Development to Regulatory T Cells.

Front Immunol 2022 7;13:872665. Epub 2022 Jul 7.

Department of Experimental Immunology, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Vitamin D3 (VD3) is a potential adjuvant for use in tolerogenic vaccine formulations that target dendritic cells (DCs) for the treatment of chronic inflammatory disorders, e.g., autoimmune diseases. Read More

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Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype.

Front Immunol 2022 4;13:912583. Epub 2022 Jul 4.

Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.

GM-CSF-producing T helper (Th) cells play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Recent studies have identified a distinct population of GM-CSF-producing Th cells, named ThGM cells, that also express cytokines TNF, IL-2, and IL-3, but lack expression of master transcription factors (TF) and signature cytokines of commonly recognized Th cell lineages. ThGM cells are highly encephalitogenic in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Read More

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Drug Survival, Safety, and Effectiveness of Biologics in Older Patients with Psoriasis: A Comparison with Younger Patients-A BioCAPTURE Registry Study.

Drugs Aging 2022 Jul 21. Epub 2022 Jul 21.

Department of Dermatology, Radboud University Medical Centre (Radboudumc), PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Background: Psoriasis is a common inflammatory disease in any age group, but also in older patients (≥ 65 years of age). Since older patients are often excluded from clinical trials, limited data specifically on this growing population are available, e.g. Read More

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Transient and durable T cell reactivity after COVID-19.

Proc Natl Acad Sci U S A 2022 Jul 12;119(30):e2203659119. Epub 2022 Jul 12.

Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

This study analyzed whole blood samples ( = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2-derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until ∼70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-γ remained stable and highly correlated at 3 to 21 mo after infection. Read More

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Toxocara canis extract fractions promote mainly the production of Th1 and regulatory cytokines by human leukocytes in vitro.

Acta Trop 2022 Jul 16;234:106579. Epub 2022 Jul 16.

Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

Helminths possibly down-modulate immune responses to airborne allergens through the induction of a regulatory network. The identification of helminths bioactive molecules is highly desirable, given their immunomodulatory potential which could be used in immunotherapies for allergy and autoimmune diseases. To investigate the immunoregulatory potential of the adult Toxocara canis crude extract and ten protein fractions of its extract, human peripheral blood mononuclear cells (PBMC) from 10 allergic and 9 non-allergic individuals were cultivated, in vitro, in the presence or absence of these antigens, and their supernatants were evaluated for cytokine production (TGF-β, IL-10, IL-12, TNF-α, IL-6, IL-5, IL13, and IL-17). Read More

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Suppression of Allergic Asthma by Loss of Function of Miz1-Mediated Th1 Skewing.

Am J Respir Cell Mol Biol 2022 Jul 14. Epub 2022 Jul 14.

University of Illinois at Chicago College of Medicine, 12247, Chicago, Illinois, United States;

Asthma is the most prevalent chronic respiratory disease worldwide. There is currently no cure, and it remains an important cause of morbidity and mortality. Here we report that lung-specific loss of function of the transcription factor c-Myc-interacting zinc finger protein-1 (Miz1) upregulates the pro-T helper 1 (Th1) cytokine interleukin 12 (IL-12). Read More

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Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1).

Front Microbiol 2022 27;13:884374. Epub 2022 Jun 27.

Prof. M. Viswanathan Diabetes Research Centre, Chennai, India.

Aim: The prevalence of latent tuberculosis infection (LTBI) among diabetes patients is poorly studied. In the present study, the prevalence of LTBI among pre-diabetes and diabetes patients was studied, along with immunoendocrine biomarkers ( = 804).

Methods: LTBI was screened by Quantiferon TB gold in Normal glucose tolerance [(NGT); = 170, [Pre-diabetes (PDM; = 209), Newly diagnosed diabetes (NDM; = 165) and Known diabetes (KDM; = 260) subjects. Read More

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and Its Major Compound Tricin Regulate Immune Responses in OVA-Treated Mice.

Molecules 2022 Jun 21;27(13). Epub 2022 Jun 21.

Department of Food Science and Technology, Keimyung University, Daegu 42601, Korea.

Tricin, a flavone belonging to the family, has been confirmed to be the primary compound in a extract (ZLE) that prevents allergies. Various allergic reactions occur because of the unbalanced differentiation of T help cells (Th) and the consequent overproduction of IgE. Therefore, the regulation of Th1 and Th2 responses by T helper cell differentiation is essential for suppressing allergic responses. Read More

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Cytokine Profile in Patients with Multiple Sclerosis Following Exercise: A Systematic Review of Randomized Clinical Trials.

Int J Environ Res Public Health 2022 Jul 2;19(13). Epub 2022 Jul 2.

Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

Multiple sclerosis (MS) is one of the most prevalent causes of nontraumatic neurological impairment in young adults. This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. We used specific keywords in PubMed, Web of Science, The Cochrane Library, and Scopus to find randomized clinical trials addressing the effects of physical activity and exercise training on inflammatory markers levels in MS patients. Read More

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TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and .

J Immunol 2022 Aug 8;209(3):435-445. Epub 2022 Jul 8.

University of Washington, Seattle, WA;

TOLLIP is a central regulator of multiple innate immune signaling pathways, including TLR2, TLR4, IL-1R, and STING. Human TOLLIP deficiency, regulated by single-nucleotide polymorphism rs5743854, is associated with increased tuberculosis risk and diminished frequency of bacillus Calmette-Guérin vaccine-specific CD4 T cells in infants. How TOLLIP influences adaptive immune responses remains poorly understood. Read More

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Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs.

Matter 2022 Jun 21;5(6):1816-1838. Epub 2022 Mar 21.

Department of Materials Science & Engineering, Stanford University, Stanford, CA 94305, USA.

Directing biological functions is at the heart of next-generation biomedical initiatives in tissue and immuno-engineering. However, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb specific signaling pathways at distinct times and places. Using lipid nanotechnology and the principles of supramolecular self-assembly, we developed an injectable liposomal nanocomposite hydrogel platform to precisely control the release of multiple protein drugs. Read More

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Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease.

Brain Behav Immun Health 2022 Aug 23;23:100482. Epub 2022 Jun 23.

Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.

Background: Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by a triad of cognitive, psychiatric and motor symptoms. One of the main mechanisms of the disease, besides the aggregation of mutant proteins, is the chronic inflammation that occurs in patients long before the onset of motor dysfunction. Currently, no effective therapy is available for HD. Read More

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mTORC1 signaling in antigen-presenting cells of the skin restrains CD8 T cell priming.

Cell Rep 2022 Jul;40(1):111032

Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

How mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism, affects dendritic cell (DC) metabolism and T cell-priming capacity has primarily been investigated in vitro, but how mTORC1 regulates this in vivo remains poorly defined. Here, using mice deficient for mTORC1 component raptor in DCs, we find that loss of mTORC1 negatively affects glycolytic and fatty acid metabolism and maturation of conventional DCs, particularly cDC1s. Nonetheless, antigen-specific CD8 T cell responses to infection are not compromised and are even enhanced following skin immunization. Read More

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Tuscany consensus for the treatment of moderate-severe psoriasis: update and focus on practical guidelines for place in therapy of anti-IL-17 and anti-IL-23 biologics.

Ital J Dermatol Venerol 2022 Jul 5. Epub 2022 Jul 5.

Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

Psoriasis is a common chronic skin disease characterized by a worldwide distribution and a natural tendency towards progression. According to the many clinical forms, the extension of the disease and the many comorbidities, almost the 20% of the patients require a systemic treatment. Biologics have greatly changed the ongoing of psoriasis and the quality of life of psoriasis patients. Read More

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Peptidoglycan-Like Components in Z-100, Extracted from Strain Aoyama B, Increase IL-12p40 via NOD2.

J Immunol Res 2022 22;2022:3530937. Epub 2022 Jun 22.

Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., 2512-1, Numagami, Oshikiri, Kumagaya City, 360-0111 Saitama, Japan.

Background: Z-100 is a hot-water extract of the human-type strain Aoyama B. While Z-100's macrophage-mediated immunomodulatory effects have been reported, the mechanistic details have not been fully clarified. Here, we studied the immunomodulatory effects of Z-100 on mouse bone marrow-derived cells, human CD14 cells, and skin. Read More

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Parasitemia and Associated Immune Response in Pregnant and Non-Pregnant Beef Cows Naturally Infected With .

Front Vet Sci 2022 14;9:905271. Epub 2022 Jun 14.

Facultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Balcarce, Argentina.

The aim of this longitudinal study was to characterize the parasitemia of and the associated immunological parameters in naturally infected beef cows for 10 months. The following groups were established: seropositive pregnant cows (+Preg, = 7), seropositive non-pregnant cows (+Npreg, = 7), seronegative pregnant cows (-Preg, = 4), and seronegative non-pregnant cows (-Npreg, = 4). Several samples were obtained for absolute and relative leukocyte counting, cytokines IL-10, IL-12, α-TNF, and γ-IFN quantification, specific IgG, IgG1, and IgG2 and avidity and DNA molecular detection and quantification. Read More

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Lactic Acid Bacterial Supplementation Ameliorated the Lipopolysaccharide-Induced Gut Inflammation and Dysbiosis in Mice.

Front Microbiol 2022 13;13:930928. Epub 2022 Jun 13.

Healthy Gut Research Group, Centre for Excellence in Functional Foods, Food and Nutrition Biotechnology Division, National Agri-Food Biotechnology Institute, Sahibzada Ajit Singh Nagar, India.

Lipopolysaccharide (LPS), a gut-transmitted endotoxin from Gram-negative bacteria, causes inflammatory diseases leading to the loss of gut barrier integrity and has been identified as a major pathogenic stimulator in many dysfunctions. Hence, supplementation with probiotics is believed to be one of the most effective strategies for treating many inflammatory gut disorders. Although probiotics are known to have a variety of therapeutic characteristics and to play a beneficial role in host defense responses, the molecular mechanisms by which they achieve these beneficial effects are unknown due to species- and strain-specific behaviors. Read More

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Interleukin-35 ameliorates cardiovascular disease by suppressing inflammatory responses and regulating immune homeostasis.

Jie Feng Yanqing Wu

Int Immunopharmacol 2022 Jun 24;110:108938. Epub 2022 Jun 24.

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address:

The immune response is of great significance in the initiation and progression of a diversity of cardiovascular diseases involving pro-and anti-inflammatory cytokines. Interleukin-35 (IL-35), a cytokine of the interleukin-12 family, is a novel anti-inflammation and immunosuppressive cytokine, maintaining inflammatory suppression and regulating immune homeostasis. The role of IL-35 in cardiovascular diseases (CVDs) has aroused enthusiastic attention, a diversity of experimental or clinical evidence has indicated that IL-35 potentially has a pivot role in protecting against cardiovascular diseases, especially atherosclerosis and myocarditis. Read More

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Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion.

J Exp Med 2022 Aug 27;219(8). Epub 2022 Jun 27.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.

IL-12 is an essential cytokine involved in the generation of memory or memory-like NK cells. Mouse cytomegalovirus infection triggers NK receptor-induced, ligand-specific IL-12-dependent NK cell expansion, yet specific IL-12 stimulation ex vivo leading to NK cell proliferation and expansion is not established. Here, we show that IL-12 alone can sustain human primary NK cell survival without providing IL-2 or IL-15 but was insufficient to promote human NK cell proliferation. Read More

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Extracellular vesicles from Trichinella spiralis: Proteomic analysis and protective immunity.

PLoS Negl Trop Dis 2022 06 23;16(6):e0010528. Epub 2022 Jun 23.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Trichinella spiralis (T. spiralis) derived extracellular vesicles (EVs) have been proposed to play a key role in regulating the host immune responses. In this study, we provided the first investigation of EVs proteomics released by T. Read More

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