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Early initiation of ambroxol treatment diminishes neurological manifestations of type 3 Gaucher disease: A long-term outcome of two siblings.

Eur J Paediatr Neurol 2021 Mar 31;32:66-72. Epub 2021 Mar 31.

Department of Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia. Electronic address:

Gaucher disease type 3 (GD3) is a severely debilitating disorder characterized by multisystemic manifestations and neurodegeneration. Enzyme replacement therapy alleviates visceral signs and symptoms but has no effect on neurological features. Ambroxol has been suggested as an enzyme enhancement agent. Read More

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Motivational Interviewing: An Evidence-Based Approach for Use in Medical Practice.

Dtsch Arztebl Int 2021 Feb;118(7):109-115

Lübeck University, Department of Psychiatry and Psychotherapy, Lübeck.

Background: Motivational factors in health-relevant modes of behavior are an important matter in medical practice. Motivational interviewing (MI) is a technique that has been specifically developed to help motivate ambivalent patients to change their behav - ior.

Methods: This review is based on pertinent publications retrieved by a selective search in the PubMed, Cochrane, and Web of Science databases. Read More

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February 2021

[Cobalamin in the complex treatment and prevention of cognitive impairment].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):132-137

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Cognitive impairment (CI) develops not only in structural damage to the central nervous system, but also in encephalopathies of dysmetabolic and deficiency etiology. Recently, special attention is focused on the appearance of CI due to the deficiency of cobalamin (vitamin B) and folic acid (FA), the change in the level of homocysteine (HC). To detect vitamin B deficiency is possible by examining key biomarkers in serum based on a decrease in the levels of vitamin B and holotranscobalamin, and levels of methylmalonic acid (MMA) and HC. Read More

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January 2021

Hepatic Dendritic Cells in the Development and Progression of Metabolic Steatohepatitis.

Front Immunol 2021 23;12:641240. Epub 2021 Mar 23.

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia.

Metabolic Associated Fatty liver disease (MAFLD) is a global health problem and represents the most common cause of chronic liver disease in the world. MAFLD spectrum goes from simple steatosis to cirrhosis, in between metabolic steatohepatitis with progressive fibrosis, which pathogenesis is not completely understood. Hence, the role of the immune system has become an important fact in the trigger of inflammatory cascades in metabolic steatohepatitis and in the activation of hepatic stellate cells (HSCs). Read More

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Evidence-Based Approach to Timing of Nerve Surgery: A Review.

Ann Plast Surg 2021 Mar 24. Epub 2021 Mar 24.

From the Texas Tech University Health Sciences Center University Medical Center, Lubbock, TX Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA Indiana Hand Center, Indianapolis, IN The Buncke Clinic, San Francisco, CA Orthopaedic Surgery, Cleveland Clinic of Florida, Weston, FL Department of Orthopaedics and Rehabilitation, The University of New Mexico, Albuquerque, NM Washington Nerve Institute, McLean, VA.

Abstract: Events causing acute stress to the health care system, such as the COVID-19 pandemic, place clinical decisions under increased scrutiny. The priority and timing of surgical procedures are critically evaluated under these conditions, yet the optimal timing of procedures is a key consideration in any clinical setting. There is currently no single article consolidating a large body of current evidence on timing of nerve surgery. Read More

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Bayesian spatial survival modelling for dengue fever in Makassar, Indonesia.

Gac Sanit 2021 ;35 Suppl 1:S59-S63

School of Mathematical Science, Queensland University of Technology, Brisbane 4000, Australia.

Objective: To understand the spatial pattern of dengue fever (DF) patients' survival and investigated factors influencing DF patients' survival.

Method: A Bayesian spatial survival method via a conditional autoregressive approach was used to analyze the factors that influence DF patients' survival in 14 sub-districts from January 2015 to May 2017 in Makassar city, Indonesia. Bayesian spatial and a non-spatial model were compared by using deviance information criterion. Read More

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January 2021

Global Perspectives on Improving Chronic Disease Prevention and Management in Diverse Settings.

Prev Chronic Dis 2021 Apr 8;18:E33. Epub 2021 Apr 8.

Office of Research Training and Special Programs, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

The Centers for Disease Control and Prevention (CDC) define chronic diseases as conditions that last 1 year or more and that require ongoing medical attention or limit activities of daily living, or both (1). Chronic diseases may be influenced by a combination of genetics, lifestyle and social behaviors, health care system factors, community influences, and environmental determinants of health (2). These risk factors often coexist and interact with each other. Read More

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Application of 2D Materials to Potassium-Ion Hybrid Capacitors.

ChemSusChem 2021 Apr 7. Epub 2021 Apr 7.

College of Medicine, Yan'an University, Yan'an, 716000, P. R. China.

Metal-ion hybrid supercapacitors (MICs) are a new type of electrochemical energy storage (EES) device, consisting of a battery-type electrode and a supercapacitor (SC)-type electrode. Exhibiting the advantages of both batteries and SCs (e. g. Read More

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Printable Off-On Thermoswitchable Fluorescent Materials for Programmable Thermally Controlled Full-Color Displays and Multiple Encryption.

Adv Mater 2021 Apr 7:e2008055. Epub 2021 Apr 7.

State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

Thermoswitchable fluorescent materials (TFMs) have received special attention due to their unique fluorescent colorimetric responses to temperature. Conventional TFMs generally display unicolor with switching from one color to another, showing unprintable and unsatisfied performances. These limitations greatly hinder their development and expansion toward advanced applications. Read More

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Sudden Cardiac Death-A New Insight Into Potentially Fatal Genetic Markers.

Front Med (Lausanne) 2021 22;8:647412. Epub 2021 Mar 22.

Medical School, University of Split, Split, Croatia.

Sudden cardiac death (SCD) is an unexpected and dramatic event. It draws special attention especially in young, seemingly healthy athletes. Our scientific paper is based on the death of a young, 23-year-old professional footballer, who died on the football field after a two-year history of cardiac symptoms. Read More

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Microsaccades: Empirical Research and Methodological Advances - Introduction to Part 1 of the Thematic Special Issue.

J Eye Mov Res 2020 Jun 19;12(6). Epub 2020 Jun 19.

University of Bern and SciAns GmbH, Iffwil, Switzerland.

Recent technical developments and increased affordability of high-speed eye tracking devices have brought microsaccades to the forefront of research in many areas of sensory, perceptual, and cognitive processes. The present thematic issue on "Microsaccades: Empirical Research and Methodological Advances" invited authors to submit original research and reviews encompassing measurements and data analyses in fundamental, translational, and applied studies. We present the first volume of this special issue, comprising 14 articles by research teams around the world. Read More

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A perspective on adverse health outcomes after breast cancer treatment in women with spinal cord injury.

Spinal Cord 2021 Apr 7. Epub 2021 Apr 7.

Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.

Aging women face increased risks of both breast cancer and spinal cord injury (SCI). Unique treatment challenges for this population warrant consideration. Despite advances in breast cancer treatments, significant adverse health outcomes continue to occur. Read More

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Magnetic Resonance Imaging of the Oral Cavity and Oropharynx.

Top Magn Reson Imaging 2021 Apr;30(2):79-83

Neuroradiology Division, Northwell Health, Glen Oaks, NY.

Abstract: Understanding oral cavity and oropharyngeal anatomy is important to identify various pathologies that may afflict them. This article reviews normal magnetic resonance imaging anatomy of these vital spaces and structures, with special attention to the complex musculature, mucosal surfaces, relevant osseous structures, salivary glands, and nerves. Anatomic awareness of these spaces and critical potential pathways for perineural tumoral spread are important to recognize to improve diagnostic evaluation and treatment. Read More

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Direct visualization of anionic electrons in an electride reveals inhomogeneities.

Sci Adv 2021 Apr 7;7(15). Epub 2021 Apr 7.

Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.

Electrides are an unusual family of materials that feature loosely bonded electrons that occupy special interstitial sites and serve as anions. They are attracting increasing attention because of their wide range of exotic physical and chemical properties. Despite the critical role of the anionic electrons in inducing these properties, their presence has not been directly observed experimentally. Read More

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TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential.

Biochemistry (Mosc) 2021 Jan;86(Suppl 1):S50-S70

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.

Although TRPV1 ion channel has been attracting researchers' attention for many years, its functions in animal organisms, the principles of regulation, and the involvement in pathological processes have not yet been fully clarified. Mutagenesis experiments and structural studies have identified the structural features of the channel and binding sites for its numerous ligands; however, these studies are far from conclusion. This review summarizes recent achievements in the TRPV1 research with special focus on structural and functional studies of the channel and on its ligands, which are extremely diverse in their nature and interaction specificity to TRPV1. Read More

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January 2021

Engineering Z-scheme silver oxide/bismuth tungstate heterostructure incorporated reduced graphene oxide with superior visible-light photocatalytic activity.

J Colloid Interface Sci 2021 Mar 24;596:22-33. Epub 2021 Mar 24.

Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530005, China. Electronic address:

Photocatalytic degradation of multiple organic contaminants has received extensive research attention and rational design of visible-light driven photocatalyst has been considered as an efficient approach. In this study, a visible-light AgO/BiWO heterostructure incorporated reduced graphene oxide (ABW-RGO) composite photocatalyst was prepared through a facile hydrothermal method for the first time and exhibited synergetic degradation behavior for contaminants in aqueous solutions. Under visible light, Tetracycline antibiotics has degraded 95. Read More

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Aggressive Behavior and Psychiatric Inpatients: a Narrative Review of the Literature with a Focus on the European Experience.

Curr Psychiatry Rep 2021 Apr 7;23(5):29. Epub 2021 Apr 7.

Institute of Psychiatry, Department of Neurosciences and Rehabilitation, University of Ferrara, Ferrara, Italy.

Purpose Of Review: We summarized peer-reviewed literature on aggressive episodes perpetrated by adult patients admitted to general hospital units, especially psychiatry or emergency services. We examined the main factors associated with aggressive behaviors in the hospital setting, with a special focus on the European experience.

Recent Findings: A number of variables, including individual, historical, and contextual variables, are significant risk factors for aggression among hospitalized people. Read More

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Imaging for Staging of Pediatric Abdominal Tumors: An Update, From the Special Series on Cancer Staging.

AJR Am J Roentgenol 2021 Apr 7. Epub 2021 Apr 7.

Department of Radiology, Emory University, Children's Healthcare of Atlanta, Atlanta GA 30307.

The three most common pediatric solid tumors of the abdomen are neuroblastoma, Wilms tumor, and hepatoblastoma. These embryonal tumors most commonly present in the first decade of life. Each tumor exhibits unique imaging findings, including locoregional presentation and patterns of distant spread. Read More

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[Development and Clinical Application of Portable Electronic Endoscope].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Apr;45(2):153-158

Zhejiang Center for Medical Device Evaluation, Hangzhou, 311121.

Electronic endoscope is one of the crucial tools for minimally invasive diagnosis and treatment. Along with the continuous development of clinical applications, conventional electronic endoscope has not been able to meet all the clinical requirements. In recent years, with the rapid development of the material, sensor and electronic technologies, electronic endoscope has attracted many researchers and companies' attention. Read More

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A Cost-Effective Task Trainer for Complex Lip Laceration Repair.

Cureus 2021 Mar 2;13(3):e13659. Epub 2021 Mar 2.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, USA.

Facial laceration repair is a common emergency department procedure with important cosmetic implications for patients. In instances where the vermillion border is violated special attention must be paid to accurate opposition, as little as 1 mm of misalignment can result in poor cosmetic results. We sought to construct and evaluate an affordable, effective, and easily reproduced simulation trainer of full-thickness lip laceration requiring vermillion border repair primarily for Emergency Medicine resident education. Read More

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Observation on China's efficient mobilization and external dependencies in COVID-19 detection reagents, vaccines and drugs development.

Xiang Yu Na Li

Pak J Pharm Sci 2020 Sep;33(5):2193-2198

Law at Ningbo University, 818st Fenghua Road, Ningbo Zhejiang, China.

Respiratory infectious diseases had happened in China in recent years, and the outbreak of Corona Virus Disease 2019(COVID-19) had drawn worldwide attention. In order to control such high-mortality infectious diseases, the work of the Chinese government and the medical community in detection reagents, drugs, and vaccines had been speeded up. This research extensively searched the medical data of drugs, vaccines and kits development, the company's business report and the government's policy documents and conducted case analysis. Read More

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September 2020

Combination of aqueous extracts of Curcuma longa (turmeric) and some calcium channel blockers synergistically improves CCl4-induced nephrotoxicity in albino rats.

Pak J Pharm Sci 2020 Sep;33(5):2059-2065

Department of Medical Laboratory Science, University of Nigeria, Enugu Campus, Nigeria.

In the present study, special attention was drawn to CCl4-induced acute kidney injury (AKI) and how the nephrotoxicity could be treated or prevented by administration of aqueous extracts of Curcuma longa (AECL) alone or in combination with some calcium channel blockers. Thirty (30) male albino wister rats were grouped according to their weight into 6 groups (A-F) of 5 rats per group. Rats in groups A-D received CCl4 (0. Read More

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September 2020

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study.

Ital J Pediatr 2021 Apr 6;47(1):84. Epub 2021 Apr 6.

College of Health Science, Debre Markos University, Debre Markos, Ethiopia.

Background: Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and develop public health interventions in children receiving antiretroviral therapy. Thus, this study aims to assess the magnitude and associated factors of virological failure among children on antiretroviral therapy. Read More

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Multiscale Computational Screening of Metal-Organic Frameworks for Kr/Xe Adsorption Separation: A Structure-Property Relationship-Based Screening Strategy.

ACS Appl Mater Interfaces 2021 Apr 6. Epub 2021 Apr 6.

Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong 515063, China.

The separation of radioactive noble gases, such as Xe and Kr, has attracted special attention in the context of used nuclear fuel (UNF). In this study, 180 metal-organic frameworks (MOFs) formally used for selective adsorptions of ethane and ethylene, with a similar kinetic diameter to Kr and Xe, were initially screened for the Kr/Xe separation using the grand canonical Monte Carlo (GCMC) method. Then, the structure-adsorption property relationships were generalized, that is, the MOFs of higher Kr/Xe selectivity are with the porosity at 0. Read More

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[Parents' subjective burden of home schooling their children at times of the Corona-related lockdown in spring 2020].

Z Erziehwiss 2021 Apr 1:1-27. Epub 2021 Apr 1.

Leibniz-Institut für Bildungsverläufe e. V. (LIfBi), Bamberg, Wilhelmsplatz 3, 96047 Bamberg, Deutschland.

The Corona-related school closures and the closure of childcare facilities in April and May 2020 meant an immense challenge for many parents. Suddenly, children had to be looked after and educated at home all day. In this paper, we address the question of the subjective burden that parents faced when schooling their children at home. Read More

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Operation analysis of the wideband high-power microwave sources based on the gyromagnetic nonlinear transmission lines.

Rev Sci Instrum 2021 Mar;92(3):034702

National Key Laboratory of Science and Technology on Vessel Integrated Power System, Naval University of Engineering, Wuhan 430033, China.

The wideband High-Power Microwave (HPM) sources, which combine the advantages of narrowband and ultrawideband sources, have drawn much attention. As a kind of wideband source, the gyromagnetic nonlinear transmission lines (GNLTLs) can directly modulate the incident pulses into radio frequency pulses without relying on the interaction between e-beam and microwaves. Due to the special working mechanism of gyromagnetic precession, the center frequency of the GNLTL can also be adjusted in a certain range. Read More

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Risk estimation of SUDEP during COVID-19 pandemic era in a tertiary referral center.

Epilepsy Res 2021 Mar 24;173:106625. Epub 2021 Mar 24.

Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Objective: No data exist regarding the impact of the lockdown due to the COVID-19 pandemic on the risk factors of sudden unexpected death in epilepsy (SUDEP). This study aimed to stratify risk factors of SUDEP in relation to COVID-19 lockdown, among patients with epilepsy (PWE) in Cairo University epilepsy unit (CUEU). Therefore, we can detect risk factors and mitigate such factors in the second wave of the virus. Read More

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Large residual pilocytic astrocytoma after failed ultrasound-guided resection: intraoperative ultrasound limitations require special attention.

World Neurosurg 2021 Apr 2. Epub 2021 Apr 2.

Department of Neurosurgery, Comenius University, Faculty of Medicine, University Hospital Bratislava, Limbová 5, 833 05 Bratislava, Slovakia.

While benefits of neurosurgical intraoperative ultrasound (IOUS) are reported frequently, this method still has some significant pitfalls, which are described less often. However, sufficient knowledge on dealing with IOUS drawbacks, particularly various image artifacts, is important for successful surgery course. Read More

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