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High-speed stretch-shortening cycle exercises as a strategy to provide eccentric overload during resistance training.

Scand J Med Sci Sports 2021 Sep 18. Epub 2021 Sep 18.

Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027 WA, Australia.

Resistance exercises eliciting eccentric overload (EO) are considered to strongly promote muscular hypertrophy and broad neuromuscular adaptations, but typically require specialized equipment. The aims of these experiments were to assess whether EO is achieved during common high-speed stretch-shortening cycle (SSC) exercises (rebound bench press throw [RBPT] and squat jump [SJ]), and to test the effect of the external load on the EO achieved. Twenty-nine under-18 handball players and fifteen physically active males (24. Read More

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September 2021

Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2).

Bioorg Chem 2021 Sep 6;116:105326. Epub 2021 Sep 6.

Laboratoire de Chimie Organique et Thérapeutique, Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France. Electronic address:

Multidrug resistance constitutes a serious obstacle of the treatment success of cancer by chemotherapy. Mostly it is driven by expression of ABC transport proteins that actively efflux the anticancer agents out of the cell. This work describes the design and synthesis of 12 new pyrimidopyrimidines, as well as their inhibition of ABCG2 a transporter referred also to as breast cancer resistance protein, the selectivity versus ABCB1 (P-glycoprotein/P-gp) and ABCC1 as well as the investigation of their accumulation in single cells. Read More

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September 2021

Functional correlates of response inhibition in impulse control disorders in Parkinson's disease.

Neuroimage Clin 2021 Sep 11;32:102822. Epub 2021 Sep 11.

Neuroscience Area, CIMA, University of Navarra, Av. de Pío XII 55, 31008 Pamplona, Spain; Department of Neurology, Clínica Universidad de Navarra, Universidad de Navarra, Av. de Pío XII 36, 31008 Pamplona, Spain. Electronic address:

Impulse control disorder is a prevalent side-effect of Parkinson's disease (PD) medication, with a strong negative impact on the quality of life of those affected. Although impulsivity has classically been associated with response inhibition deficits, previous evidence from PD patients with impulse control disorder (ICD) has not revealed behavioral dysfunction in response inhibition. In this study, 18 PD patients with ICD, 17 PD patients without this complication, and 15 healthy controls performed a version of the conditional Stop Signal Task during functional magnetic resonance imaging. Read More

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September 2021

The multimodality of infant's rhythmic movements as a modulator of the interaction with their caregivers.

Infant Behav Dev 2021 Sep 15;65:101645. Epub 2021 Sep 15.

CES Cardenal Cisneros, Universidad Complutense de Madrid, Spain.

Children's rhythmic movements during the first year of life possess a meaningful predictive validity for later communicative development. However, their role within adult-child interactions is still underexplored. In this study, we examined whether children's rhythmic movements were significantly responded by adults and the role of multimodality and object use in this process. Read More

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September 2021

Using a station within an objective structured clinical examination to assess interprofessional competence performance among undergraduate nursing students.

Nurse Educ Pract 2021 Sep 4;56:103190. Epub 2021 Sep 4.

Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Department of Nursing, Spain.

Aim/objective: To describe and analyse the use of a station within an OSCE to assess interprofessional competence performance in undergraduate nursing students. The specific objectives were: - To measure the students' level of competence performance in relation to the interprofessional competences Roles and Responsibilities, Communication and Teamwork. - To determine inter-observer concordance in the assessment of the interprofessional competences. Read More

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September 2021

Exploring the effect of two different teaching strategies on first-year nursing students' understanding of nutritional concepts: A mixed-method approach.

Nurse Educ Pract 2021 Sep 4;56:103193. Epub 2021 Sep 4.

Basque Nurse Education Research Group, Department of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bº Sarriena s/n, 48940 Leioa, Spain; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903 Barakaldo, Spain. Electronic address:

Aim: The aim of the study was twofold. First, to explore understanding difficulties in nutritional concepts among nursing students and second, to analyse the effect of two teaching strategies on the level of understanding.

Background: Previous studies have pointed out the need to improve the nutritional care education offered to undergraduates in health sciences. Read More

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September 2021

Optimisation of the methodology for obtaining enzymatic protein hydrolysates from an industrial grape seed meal residue.

Food Chem 2021 Sep 8;370:131078. Epub 2021 Sep 8.

Food Colour and Quality Laboratory, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain. Electronic address:

The grape pomace industry produces large quantities of protein-rich seeds, which can be a sustainable non-animal protein source; their techno-functional properties could be exploited to improve the colour stabilisation and modulating the astringency of red wines in warm climates. This study aims to optimise the methodology of obtaining protein hydrolysates from defatted grape seed meal residue. Five assays using different quantities of enzyme and raw materials were considered. Read More

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September 2021

Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.

Biomed Pharmacother 2021 Sep 15;143:112171. Epub 2021 Sep 15.

NGN Healthcare - New Generation Nutraceuticals s.r.l., Torrette Via Nazionale 207, 83013 Mercogliano, Avellino, Italy. Electronic address:

Several studies reported an increase in cardiovascular risk (CVR) in women with polycystic ovary syndrome (PCOS), considered primarily as the result of the combination of all the clinical features that characterize the syndrome, including hyperandrogenism, insulin resistance, diabetes, obesity chronic low-grade inflammation. Interestingly, in 2012 it has been proposed the so-called DOGMA theory, suggesting the pivotal role played by microbiota alteration in the development of PCOS. Subsequently, several authors evidenced the existence in PCOS women of a marked dysbiosis, which is related to the development of metabolic diseases and cardiovascular complications, mainly due to the production of bacteria-derived metabolites that interfere with various pathways. Read More

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September 2021

Regression of corpus luteum in cetaceans: A systematic review.

Zoology (Jena) 2021 Aug 25;149:125960. Epub 2021 Aug 25.

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China. Electronic address:

Functional and structural change of corpus luteum through the cascade of several genes in the ovary leads to ovulation and pregnancy. In most mammals, the absence of pregnancy leads to the disintegration of the corpus luteum. In the ovary of cetaceans, the regression of the corpus luteum gets delayed and persists on the surface as scars (corpus albicans). Read More

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Persistent organic pollutants: The trade-off between potential risks and sustainable remediation methods.

J Environ Manage 2021 Sep 15;300:113737. Epub 2021 Sep 15.

Department of Materials, Escuela Politécnica Nacional, Ladrón de Guevara E11-253, Quito, 170525, Ecuador. Electronic address:

Persistent Organic Pollutants (POPs) have become a very serious issue for the environment because of their toxicity, resistance to conventional degradation mechanisms, and capacity to bioconcentrate, bioaccumulate and biomagnify. In this review article, the safety, regulatory, and remediation aspects of POPs including aromatic, chlorinated, pesticides, brominated, and fluorinated compounds, are discussed. Industrial and agricultural activities are identified as the main sources of these harmful chemicals, which are released to air, soil and water, impacting on social and economic development of society at a global scale. Read More

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September 2021

Biomarkers of response to rapid-acting antidepressants.

Eur Neuropsychopharmacol 2021 Sep 15;53:101-103. Epub 2021 Sep 15.

Mental Health Department, Unitat de Neurociència Traslacional, Parc Tauli University Hospital, Institut d'Investigació i Innovació Sanitària Parc Taulí (I3PT), Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Madrid, Spain; Department of Psychiatry and Forensic Medicine, School of Medicine Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

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September 2021

Benefits and risks of agricultural reuse of digestates from plastic tubular digesters in Colombia.

Waste Manag 2021 Sep 15;135:220-228. Epub 2021 Sep 15.

GEMMA - Group of Environmental Engineering and Microbiology, Department of Civil and Environmental Engineering, Universitat Politècnica de Catalunya·BarcelonaTech (UPC), c/ Jordi Girona, 1-3, Building D1, E-08034 Barcelona, Spain.

The aim of this study is to characterize the digestates from three plastic tubular digesters implemented in Colombia fed with: i) cattle manure; ii) cattle manure mixed with cheese whey; iii) pig manure. All the digesters worked under psychrophilic conditions. Physico-chemical characteristics, heavy metals, pathogens, and agronomic quality were investigated. Read More

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September 2021

The role of hydrodynamic fluctuations and wind intensity on the distribution of plastic debris on the sandy beaches of Paraná River, Argentina.

Environ Pollut 2021 Sep 14;291:118168. Epub 2021 Sep 14.

UMR 7324 CNRS CITERES and Graduate School of Engineering Polytech Tours, University of Tours, France. Electronic address:

Plastic in the environment is considered an emerging pollutant of global concern. In spite of intensive research, many questions remain open, such as the processes that drive the deposition and remobilization of plastic debris on river beaches. The objectives of this study were: i) to analyze the influence of the natural hydrological fluctuations and wind intensity on the distribution of mesoplastic (0. Read More

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September 2021

Diurnal variations of cold-induced thermogenesis in young, healthy adults: A randomized crossover trial.

Clin Nutr 2021 Aug 24;40(10):5311-5321. Epub 2021 Aug 24.

PROFITH "PRO-moting FITness and Health Through Physical Activity" Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain. Electronic address:

Background: Harnessing cold-induced thermogenesis (CIT) and brown adipose tissue (BAT) activity has been proposed as a means of counteracting a positive energy balance, and thus of combating obesity and its related comorbidities. However, it has remained unclear whether CIT and BAT activity show diurnal variation in humans - knowledge that might allow treatments based on these factors to be time-optimized.

Methods: A randomized crossover experiment was designed to examine whether CIT shows morning/evening variation in young, healthy adults (n = 14, 5 women). Read More

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Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial.

Clin Nutr 2021 Aug 10;40(10):5269-5277. Epub 2021 Aug 10.

Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Lipid Clinic, Endocrinology & Nutrition Dept., Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain. Electronic address:

Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mortality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010.

Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Read More

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Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain.

Int J Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

UNIR Health Sciences School & Medical Center, Madrid, Spain. Electronic address:

Background: The advent of SARS-CoV-2 vaccines has been associated with a significant decline in COVID-19 hospitalizations and deaths. However, little is known about the benefits experienced by different population groups and/or using distinct vaccines.

Methods: We analyzed the Spanish public registry for associations between calendar vaccination scale up and incidence of COVID-19 hospitalizations by age, gender and vaccine modality. Read More

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September 2021

Direct anterior approach vs. SuperPATH vs. conventional approaches in total hip replacement: a network meta-analysis of randomized controlled trials.

Orthop Traumatol Surg Res 2021 Sep 15:103058. Epub 2021 Sep 15.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747 Jena, Germany.

Background: Two minimally invasive approaches showed some advantages in outcomes compared to conventional approaches (CAs) - the direct anterior approach (DAA) and the supercapsular percutaneously assisted approach in THA (SuperPATH). To the best of our knowledge, DAA and SuperPATH have never been compared in clinical studies before. Therefore, we conducted a systematic review and network meta-analysis of randomized controlled trials comparing short-term outcomes of DAA, SuperPATH and CAs in total hip joint arthroplasty (THA), using CAs as common comparator. Read More

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September 2021

Postoperative Pain after Clitoral Reconstruction in Women with Female Genital Mutilation: an evaluation of practices.

J Gynecol Obstet Hum Reprod 2021 Sep 15:102230. Epub 2021 Sep 15.

Service de Gynécologie-Obstétrique, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75010 Paris.

Introduction: More than 200 million women and girls have undergone genital mutilation. Clitoral reconstruction (CR) can improve the quality of life of some of them, but is accompanied by significant postoperative pain.

Objective: Assess and describe the management of postoperative pain after CR, and the practices among specialists in different countries. Read More

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September 2021

Permeable spaces between glenohumeral ligaments as potential gateways for rapid regional anesthesia of the shoulder.

Ann Anat 2021 Sep 15:151814. Epub 2021 Sep 15.

MoMaRC Morphological Madrid Research Center, Madrid (Spain). Calle Arzobispo Morcillo, 4, 28029.Madrid (Spain); Department of Anesthesia and Chronic Pain, Móstoles University Hospital. C. Gladiolo, s/n, 28933. Móstoles (Spain). Electronic address:

Shoulder pain is a highly prevalent condition, often resulting in major life limitations, and requiring effective treatments. In this work, we explore the anatomical basis of a proposed approach to the regional anesthesia of the shoulder through a single injection under the subscapularis muscle. Bilateral experimental injections in shoulders from body donors (Radiolar ® and Methylene-Blue) under the subscapular muscle (n = 11) and cadaveric systematic dissections of other 35 shoulders from body donors were performed. Read More

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September 2021

The Attitudes of European Medical Students towards the Clinical Importance of Neuroanatomy.

Ann Anat 2021 Sep 15:151832. Epub 2021 Sep 15.

Department of Morphological Sciences, Division of Anatomy, Faculty of Medicine, C. Davila University, Bucharest, Romania.

The attitudes of medical students towards the clinical importance of neuroanatomy have been little studied. Because it has been reported that medical students find neuroanatomy difficult and can have 'neurophobia', here we test the hypothesis that early-stage medical students across Europe have a low regard for neuroanatomy's clinical relevance. The work was conducted under the auspices of the Trans-European Pedagogic Research Group (TEPARG), with just over 1,500 students from 12 European medical schools providing responses to a survey (52% response rate) that assessed their attitudes using Thurstone and Chave methodologies. Read More

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September 2021

Revisiting the T Spectrum Imaging Inverse Problem: Bayesian Regularized Non-Negative Least Squares.

Neuroimage 2021 Sep 15:118582. Epub 2021 Sep 15.

Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), EPFL-STI-IEL-LTS5, Station 11, CH-1015, Lausanne, Switzerland; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Multi-echo T magnetic resonance images contain information about the distribution of T relaxation times of compartmentalized water, from which we can estimate relevant brain tissue properties such as the myelin water fraction (MWF). Regularized non-negative least squares (NNLS) is the tool of choice for estimating non-parametric T spectra. However, the estimation is ill-conditioned, sensitive to noise, and highly affected by the employed regularization weight. Read More

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September 2021

Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Sep 15:110440. Epub 2021 Sep 15.

Biomedical Research Networking Centre in Mental Health (CIBERSAM), Spain; Department of Psychiatry, Hospital Clínico Universitario de Valencia, INCLIVA, School of Medicine, Universidad de Valencia, Valencia, Spain.

Background: Social cognition impairments, such as facial emotion recognition (FER), have been acknowledged since the earliest description of schizophrenia. Here, we tested FER as an intermediate phenotype for psychosis using two approaches that are indicators of genetic risk for schizophrenia: the proxy-genetic risk approach (family design) and the polygenic risk score for schizophrenia (PRS-SCZ).

Methods: The sample comprised 2039 individuals with schizophrenia, 2141 siblings, and 2049 healthy controls (HC). Read More

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September 2021

Baculovirus infection affects caterpillar chemoperception.

Insect Biochem Mol Biol 2021 Sep 15:103648. Epub 2021 Sep 15.

Department of Genetics, Instituto de Biotecnología i Biomedicina (ERI-BIOTECMED), Universitat de València, 46100, Burjassot (Valencia), Spain. Electronic address:

Baculoviruses are double-stranded DNA entomopathogenic viruses that infect predominantly insects of the order Lepidoptera. Research in the last decade has started to disentangle the mechanisms underlying the insect-virus interaction, particularly focusing on the effects of the baculovirus infection in the host's physiology. Among crucial physiological functions, olfaction has a key role in reproductive tasks, food source detection and enemy avoidance. Read More

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September 2021

Ageing: Not only an age-related issue.

Mech Ageing Dev 2021 Sep 15;199:111568. Epub 2021 Sep 15.

School of Applied Psychology, University College Cork, North Mall Campus, Cork, Ireland. Electronic address:

Developments in the last century have led to an unprecedented increase in life expectancy. These changes open opportunities for humans to grow and develop in healthy and adaptive ways, adding life to years as well as years to life. There are also challenges, however - as we live longer, a greater number of people will experience chronic illness and disability, often linked to lifestyle factors. Read More

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September 2021

Differential effects of ergometer-cycling and Whole-Body-Vibration training on serological BDNF and IGF-1 in the treatment of adolescent depression - is there an impact of BDNF-p.Val66Met variants?

Physiol Behav 2021 Sep 15:113596. Epub 2021 Sep 15.

Department of Child and Adolescent Psychiatry, Psychotherapy and Paediatric Neurology, Gemeinschaftskrankenhaus Herdecke & Chair of Child and Adolescent Psychiatry, Witten/Herdecke University, Witten, Germany.

Background: Pathogenesis and treatment of adolescent depression may be influenced by growth-factors, including brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). We investigated, if treatment response to two different add-on exercise-therapies in juvenile depression, differ in the changes of BDNF and IGF-1 serology. A subgroup analysis for genetic variations in BDNF p. Read More

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September 2021

Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitisation.

Clin Exp Allergy 2021 Sep 18. Epub 2021 Sep 18.

Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.

Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant.

Objective: We aimed to see if there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitisation, in a multi-centre population-based study. Read More

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September 2021

The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy 2021 Sep 18. Epub 2021 Sep 18.

Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Service d'allergie, Québec, QC, Canada.

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. Read More

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September 2021

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts.

CNS Drugs 2021 Sep 18. Epub 2021 Sep 18.

Neurology Unit, Garibaldi Hospital, Catania, Italy.

Introduction: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined.

Objective: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. Read More

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September 2021