20 results match your criteria sox-2 neurod1

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Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke.

Can J Physiol Pharmacol 2020 Sep 23;98(9):659-666. Epub 2020 Jun 23.

Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA.

Stimulation of endothelin B receptors by its agonist IRL-1620 (INN, sovateltide) provides neuroprotection and neurological and motor function improvement following cerebral ischemia. We investigated the effect of sovateltide on stem and progenitor cells mediated neural regeneration and its effect on the cerebral tissue repair and restoration of neurological and motor function. Sovateltide (5 μg/kg) was injected intravenously in permanent middle cerebral artery occluded (MCAO) rats at 4, 6, and 8 h at days 0, 3, and 6. Read More

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September 2020

Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2.

Dev Biol 2020 01 14;457(1):43-56. Epub 2019 Sep 14.

Institute of Biotechnology CAS, Vestec, Czechia. Electronic address:

SOX2 is essential for maintaining neurosensory stem cell properties, although its involvement in the early neurosensory development of cranial placodes remains unclear. To address this, we used Foxg1-Cre to conditionally delete Sox2 during eye, ear, and olfactory placode development. Foxg1-Cre mediated early deletion of Sox2 eradicates all olfactory placode development, and disrupts retinal development and invagination of the lens placode. Read More

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January 2020

Sox2 and Pax6 Play Counteracting Roles in Regulating Neurogenesis within the Murine Olfactory Epithelium.

PLoS One 2016 12;11(5):e0155167. Epub 2016 May 12.

Graduate Program in Cellular, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America.

In the adult olfactory epithelium, the transcription factors Pax6 and Sox2 are co-expressed in sustentacular cells, horizontal basal cells (HBCs), and less-differentiated globose basal cells (GBCs)-both multipotent and transit amplifying categories-but are absent from immediate neuronal precursor GBCs and olfactory sensory neurons (OSNs). We used retroviral-vector transduction to over-express Pax6 and Sox2 individually and together during post-lesion recovery to determine how they regulate neuronal differentiation. Both Pax6 and Sox2, separately and together, can suppress the production of OSNs, as fewer clones contain neurons than with empty vector (EV), although this effect is not absolute. Read More

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The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation.

Acta Otolaryngol 2016 4;136(3):277-82. Epub 2015 Dec 4.

a Department of Otolaryngology Head and Neck Surgery , Institute of Otology, the Second Xiangya Hospital, Central South University , Changsha , PR China ;

Conclusions: Previous studies have stated the roles and correlation of the four TFs (Sox2, Atoh1, Neurog1, and Neurod1) in the development of neurosensory cells. but whether they are inherited pathogenic factors to cause non-syndromic sensorineural hearing loss is unknown so far. This is the first time for screening the Sox2, Atoh1, Neurog1, and Neurod1 genes in children with NSHL. Read More

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December 2016

SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.

Proc Natl Acad Sci U S A 2015 Apr 30;112(15):E1936-45. Epub 2015 Mar 30.

Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; and

Newborn granule neurons generated from neural progenitor cells (NPCs) in the adult hippocampus play a key role in spatial learning and pattern separation. However, the molecular mechanisms that control activation of their neurogenic program remain poorly understood. Here, we report a novel function for the pluripotency factor sex-determining region Y (SRY)-related HMG box 2 (SOX2) in regulating the epigenetic landscape of poised genes activated at the onset of neuronal differentiation. Read More

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Glial-like differentiation potential of human mature adipocytes.

J Mol Neurosci 2015 Jan 10;55(1):91-98. Epub 2014 Jul 10.

Clinica di Ematologia, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Via Tronto, 60020, Ancona, Italy.

The potential ability to differentiate dedifferentiated adipocytes into a neural lineage is attracting strong interest as an emerging method of producing model cells for the treatment of a variety of neurological diseases. Here, we describe the efficient conversion of dedifferentiated adipocytes into a neural-like cell population. These cells grew in neurosphere-like structures and expressed a high level of the early neuroectodermal marker Nestin. Read More

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January 2015

The neurogenic factor NeuroD1 is expressed in post-mitotic cells during juvenile and adult Xenopus neurogenesis and not in progenitor or radial glial cells.

PLoS One 2013 14;8(6):e66487. Epub 2013 Jun 14.

Centre de Ressources Biologiques Xénope UMS U3387, CNRS, and Rennes 1 University, Rennes, France.

In contrast to mammals that have limited proliferation and neurogenesis capacities, the Xenopus frog exhibit a great potential regarding proliferation and production of new cells in the adult brain. This ability makes Xenopus a useful model for understanding the molecular programs required for adult neurogenesis. Transcriptional factors that control adult neurogenesis in vertebrate species undergoing widespread neurogenesis are unknown. Read More

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January 2014

Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1.

J Neurosci 2013 Feb;33(9):3879-90

National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA.

Sox2 is required for proper neuronal formation in the CNS, but the molecular mechanisms involved are not well characterized. Here, we addressed the role of Sox2 in neurogenesis of the developing chicken inner ear. Overexpressing Sox2 from a constitutive (β-actin) promoter induces the expression of the proneural gene, Neurogenin1 (Ngn1); however, the expression of a downstream target of Ngn1, Neurod1, is unchanged. Read More

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February 2013

Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors.

Glia 2013 Feb 9;61(2):225-39. Epub 2012 Oct 9.

INSERM U1051, Institut des Neurosciences de Montpellier, Hôpital St Eloi, 80 av Augustin, Fliche 34091, Montpellier, Cedex 05, France.

Glioblastoma multiform (GBM) are devastating brain tumors containing a fraction of multipotent stem-like cells which are highly tumorigenic. These cells are resistant to treatments and are likely to be responsible for tumor recurrence. One approach to eliminate GBM stem-like cells would be to force their terminal differentiation. Read More

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February 2013

Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones.

Genet Mol Res 2012 May 15;11(2):1385-400. Epub 2012 May 15.

Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.

SOX2, a universal marker of pluripotent stem cells, is a transcription factor that helps control embryonic development in vertebrates; its expression persists in neural stem/progenitor cells into adulthood. Considering the critical role of the SOX2 transcription factor in the regulation of genes required for self-renewal and pluripotency of stem cells, we developed and characterized SOX2-overexpressing NT2/D1 cell clones. Using Southern blot and semi-quantitative RT-PCR, we confirmed integration and expression of exogenous SOX2 in three NT2/D1 cell clones. Read More

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The neuroprotective and neurogenic effects of neuropeptide Y administration in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy induced by trimethyltin.

J Neurochem 2012 Jul 21;122(2):415-26. Epub 2012 May 21.

Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Rome, Italy.

The effects of intracerebroventricular administration of neuropeptide Y (NPY), which is believed to play an important role in neuroprotection against excitotoxicity and in the modulation of adult neurogenesis, were evaluated in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy represented by trimethyltin (TMT) intoxication. A single TMT injection (8 mg/kg) causes, in the rat brain, massive neuronal death, selectively involving pyramidal neurons, accompanied by glial activation and enhanced hippocampal neurogenesis. Our data indicate that intracerebroventricular administration of exogenous NPY (at the dose of 2 μg/2 μL, 4 days after TMT-administration), in adult rats, exerts a protective role in regard to TMT-induced hippocampal damage and a proliferative effect on the hippocampal neurogenic niche through the up-regulation of Bcl-2, Bcl2l1, Bdnf, Sox-2, NeuroD1, Noggin and Doublecortin genes, contributing to delineate more clearly the role of NPY in in vivo neurodegenerative processes. Read More

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EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.

Development 2012 Jun 18;139(11):1965-77. Epub 2012 Apr 18.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA.

Inner ear neurogenesis depends upon the function of the proneural basic helix-loop-helix (bHLH) transcription factors NEUROG1 and NEUROD1. However, the transcriptional regulation of these factors is unknown. Here, using loss- and gain-of-function models, we show that EYA1 and SIX1 are crucial otic neuronal determination factors upstream of NEUROG1 and NEUROD1. Read More

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Prenatal carbofuran exposure inhibits hippocampal neurogenesis and causes learning and memory deficits in offspring.

Toxicol Sci 2012 May 12;127(1):84-100. Epub 2012 Jan 12.

Developmental Toxicology Division, Systems Toxicology Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow-226001, India.

Neurogenesis is a process of generation of new neurons in the hippocampus and associated with learning and memory. Carbofuran, a carbamate pesticide, elicits several neurochemical, neurophysiological, and neurobehavioral deficits. We evaluated whether chronic prenatal oral exposure of carbofuran during gestational days 7-21 alters postnatal hippocampal neurogenesis at postnatal day 21. Read More

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Expression of pax6 and sox2 in adult olfactory epithelium.

J Comp Neurol 2010 Nov;518(21):4395-418

Cell, Molecular, and Developmental Biology Graduate Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA.

The olfactory epithelium maintains stem and progenitor cells that support the neuroepithelium's life-long capacity to reconstitute after injury. However, the identity of the stem cells--and their regulation--remain poorly defined. The transcription factors Pax6 and Sox2 are characteristic of stem cells in many tissues, including the brain. Read More

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November 2010

Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas.

J Neurosurg Pediatr 2010 Jun;5(6):608-14

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Republic of Korea.

Object: Supratentorial primitive neuroectodermal tumor (PNET) and medulloblastoma are highly malignant embryonal brain tumors. They share morphological similarities, but differ in their differentiation patterns and global gene expression. The authors compared the expression of specific genes involved in neuroglial differentiation in supratentorial PNETs and medulloblastomas to define the distinct characters of these tumors. Read More

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Sox2 induces neuronal formation in the developing mammalian cochlea.

J Neurosci 2010 Jan;30(2):714-22

Section on Developmental Neuroscience and Section on Synaptic Transmission, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA.

In the cochlea, spiral ganglion neurons play a critical role in hearing as they form the relay between mechanosensory hair cells in the inner ear and cochlear nuclei in the brainstem. The proneural basic helix-loop-helix transcription factors Neurogenin1 (Neurog1) and NeuroD1 have been shown to be essential for the development of otocyst-derived inner ear sensory neurons. Here, we show neural competence of nonsensory epithelial cells in the cochlea, as ectopic expression of either Neurog1 or NeuroD1 results in the formation of neuronal cells. Read More

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January 2010

Wnts blow on NeuroD1 to promote adult neuron production and diversity.

Nat Neurosci 2009 Sep;12(9):1079-81

The author is at the Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Brussels, Belgium.

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September 2009

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis.

Nat Neurosci 2009 Sep 23;12(9):1097-105. Epub 2009 Aug 23.

National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Science City, Japan.

In adult hippocampus, new neurons are continuously generated from neural stem cells (NSCs), but the molecular mechanisms regulating adult neurogenesis remain elusive. We found that Wnt signaling, together with the removal of Sox2, triggered the expression of NeuroD1 in mice. This transcriptional regulatory mechanism was dependent on a DNA element containing overlapping Sox2 and T-cell factor/lymphoid enhancer factor (TCF/LEF)-binding sites (Sox/LEF) in the promoter. Read More

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September 2009

Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis.

Glia 2006 Dec;54(8):805-14

Max-Delbrück-Center for Molecular Medicine Berlin-Buch, 13125 Berlin-Buch, Germany.

In the course of adult hippocampal neurogenesis, new cells go through a series of stages associated with proliferative activity. The most highly proliferative cell type is an intermediate precursor cell, called type-2 cell. We here report that on the level of type-2 cells a transition takes place between features associated with the glial and the neuronal lineage. Read More

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December 2006

Neurogenic potential of human umbilical cord blood: neural-like stem cells depend on previous long-term culture conditions.

J Neurosci Res 2006 Mar;83(4):627-37

Department of NeuroRepair, Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.

In vitro studies conducted by our research group documented that neural progenitor cells can be selected from human umbilical cord blood (HUCB-NPs). Due to further expansion of these cells we have established the first human umbilical cord blood-derived neural-like stem cell line (HUCB-NSC) growing in serum-free (SF) or low-serum (LS) medium for over 3 years. The purpose of the study was to evaluate the neurogenic potential of HUCB-NSCs cultured in SF and LS condition in different in vitro settings before transplantation. Read More

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