52,125 results match your criteria southern china


Hypomagnesemia Is a Risk Factor for Cardiovascular Disease- and Noncardiovascular Disease-Related Mortality in Peritoneal Dialysis Patients.

Blood Purif 2021 Apr 21:1-8. Epub 2021 Apr 21.

Department of Nephrology, Jiujiang No. 1 People's Hospital, Jiujiang, China.

Purpose: Recent research has shown that hypomagnesemia is associated with increased all-cause mortality in hemodialysis patients. However, the relationship between the long-term prognosis of peritoneal dialysis (PD) and the study is not yet clear. This study will analyze the effects of hypomagnesemia on all-cause, cardiovascular diseases (CVD), and non-CVD mortality in PD patients. Read More

View Article and Full-Text PDF

A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair.

Biomaterials 2021 Apr 9;273:120811. Epub 2021 Apr 9.

Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address:

Conductive hydrogel is a potential therapeutic tool to treat damaged heart muscles in myocardial infarction (MI). However, it is still a quite challenge to optimize the fabrication of a therapeutic hydrogel patch that sustains favorable biocompatibility, electronic and mechanical stability under a complicated MI microenvironment. Herein, a tunable self-healing ionic hydrogel (POG) was developed through the introduction of a biocompatible polyacrylic acid (PAA, FDA-approved) into the hydrogel matrix. Read More

View Article and Full-Text PDF

Macromolecular fraction (MMF) from 3D ultrashort echo time Cones magnetization transfer (3D UTE-Cones-MT) imaging predicts meniscal degeneration and knee osteoarthritis.

Osteoarthritis Cartilage 2021 Apr 18. Epub 2021 Apr 18.

University of California San Diego, San Diego, CA, United States. Electronic address:

Objective: Meniscal degeneration is strongly associated with osteoarthritis (OA). We aimed to evaluate a 3D ultrashort-echo-time Cones magnetization transfer (UTE-Cones-MT) sequence for quantification of macromolecular fraction (MMF) and MT ratio (MTR) in menisci of healthy volunteers and patients with different degrees of OA.

Methods: Patients with mild OA (n=19;37-86 years;10 males) or advanced OA (n=12;52-88 years;4 males) and healthy volunteers (n=17;20-49 years;7 males) were scanned with T2-FSE and UTE-Cones-MT sequences at 3T. Read More

View Article and Full-Text PDF

Phasic Off responses of auditory cortex underlie perception of sound duration.

Cell Rep 2021 Apr;35(3):109003

School of Biomedical Engineering, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Key Laboratory of Mental Health of the Ministry of Education, Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou 510515, China; Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510220, China. Electronic address:

It has been proposed that sound information is separately streamed into onset and offset pathways for parallel processing. However, how offset responses contribute to auditory perception remains unclear. Here, loose-patch and whole-cell recordings in awake mouse primary auditory cortex (A1) reveal that a subset of pyramidal neurons exhibit a transient "Off" response, with its onset tightly time-locked to the sound termination and its frequency tuning similar to that of the transient "On" response. Read More

View Article and Full-Text PDF

MiR-30a-5p Regulates GLT-1 Function via a PKCα-Mediated Ubiquitin Degradation Pathway in a Mouse Model of Parkinson's Disease.

ACS Chem Neurosci 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

Glutamate excitotoxicity is caused by dysfunctional glutamate transporters and plays an important role in the pathogenesis of Parkinson's disease (PD); however, the mechanisms that underlie the regulation of glutamate transporters in PD are still not fully elucidated. MicroRNAs(miRNA), which are abundant in astrocytes and neurons, have been reported to play key roles in regulating the translation of glutamate-transporter mRNA. In this study, we hypothesized that the miR-30a-5p contributes to the pathogenesis of PD by regulating the ubiquitin-mediated degradation of glutamate transporter 1 (GLT-1). Read More

View Article and Full-Text PDF

Bufadienolides from the Eggs of the Toad and Their Antimelanoma Activities.

J Nat Prod 2021 Apr 21. Epub 2021 Apr 21.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.

Toads produce potent toxins, named bufadienolides, to defend against their predators. Pharmacological research has revealed that bufadienolides are potential anticancer drugs. In this research, we reported nine bufadienolides from the eggs of the toad , including two new compounds ( and ). Read More

View Article and Full-Text PDF

Interferon-α activates interleukin-1 receptor-associated kinase 1 to induce regulatory T-cell apoptosis in patients with systemic lupus erythematosus.

J Dermatol 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.

Impaired regulatory T-cell (Treg) responses and upregulated interleukin-1 receptor-associated kinase 1 (IRAK1) expression are associated with the development of human systemic lupus erythematosus (SLE). Here, we show that the levels of upregulated IRAK1 expression in circulating Tregs are correlated with the percentages of apoptotic Tregs, Systemic Lupus Erythematosus Disease Activity Index scores, and serum complement C3 levels in SLE patients. High levels of plasma interferon (IFN)-α in SLE patients induced IRAK1 phosphorylation to trigger Treg apoptosis, which was mitigated by IRAK1 inhibitor (IRAK-Inh) treatment. Read More

View Article and Full-Text PDF

The proportion and effect of corticosteroid therapy in patients with COVID-19 infection: A systematic review and meta-analysis.

PLoS One 2021 21;16(4):e0249481. Epub 2021 Apr 21.

Department of Orthopedics, Honghui Hospital, Xi'anJiaotong University, Xi'an, PR China.

Objectives: Coronavirus disease 2019 (COVID-19) remains a global challenge. Corticosteroids constitute a group of anti-inflammatory and immunosuppressive drugs that are widely used in the treatment of COVID-19. Comprehensive reviews investigating the comparative proportion and efficacy of corticosteroid use are scarce. Read More

View Article and Full-Text PDF

A Peer-to-Peer Live Streaming Intervention for Children during COVID-19 Home Schooling to Promote Physical Activity and Reduce Anxiety and Eye Strain: Cluster Randomized Controlled Trial.

J Med Internet Res 2021 Apr 14. Epub 2021 Apr 14.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Room 509, No.7 Jinsui Rd, Zhujiang New Town, Guangzhou, CN.

Background: The COVID-19 pandemic has led to global school closures, and millions of children are confined to online learning at home. As a result, children may be susceptible to anxiety and digital eye strain, highlighting a need for population interventions.

Objective: The objective of our study was to investigate whether a digital behavior change intervention could reduce children's anxiety and digital eye strain while undergoing prolonged home schooling during the COVID-19 pandemic. Read More

View Article and Full-Text PDF

Risk Factors for Intravesical Recurrence After Minimally Invasive Nephroureterctomy for Upper Tract Urothelial Cancer (Robuust Collaboration).

J Urol 2021 Apr 21:101097JU0000000000001786. Epub 2021 Apr 21.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.

Purpose: Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) has an incidence of approximately 20-50%. Studies to date have been composed of mixed treatment cohorts - open, laparoscopic, and robotic. The objective of this study is to assess clinicopathologic risk factors for intravesical recurrence after RNU for UTUC in a completely minimally invasive cohort. Read More

View Article and Full-Text PDF

The distribution of Fusarium graminearum and F. asiaticum causing Fusarium head blight of wheat in relation to climate and cropping system.

Plant Dis 2021 Apr 21. Epub 2021 Apr 21.

Henan Academy of Agricultural SciencesZhengzhou , China, 450002;

In the main wheat production area of China (The Huang Huai Plain, HHP), both Fusarium graminearum and F. asiaticum, the causal agents of Fusarium head blight (FHB), are present. We investigated whether the relative prevalence of F. Read More

View Article and Full-Text PDF

Litchi anthracnose caused by Colletotrichum karstii in Guangxi, China.

Plant Dis 2021 Apr 21. Epub 2021 Apr 21.

University of Guelph, Environmental Sciences, 50 Stone Road East, Guelph, Ontario, Canada, N1G2W1;

Litchi (Litchi chinensis Sonn.), a native fruit tree from southern China, has been planted in many subtropical and tropical countries for its fruit which are considered delicious and of medicinal value (Anderson et al. 2013). Read More

View Article and Full-Text PDF

Self-Powered Rewritable Electrochromic Display based on WO Film with Mechanochemically Synthesized MoO Nanosheets.

ACS Appl Mater Interfaces 2021 Apr 21. Epub 2021 Apr 21.

School of Electronic and Information Engineering and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, P. R. China.

Electrochromic displays with bistable color states provide a promising means toward transparent human-machine interfaces. However, the need for external power and the weak optical modulation in the visible light region of most electrochromic devices hinder their practical applications in displays. Here we prepare the MoO/WO films based on MoO nanosheets, which show a dark blue color that matches the response of the eye and meets visual comfort standards compared to pure WO film. Read More

View Article and Full-Text PDF

Tissue metabolic profiling reveals major metabolic alteration in colorectal cancer.

Mol Omics 2021 Apr 20. Epub 2021 Apr 20.

The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.

Metabolic reprogramming is a hallmark of cancer, which is still far from being fully understood in colorectal cancer. In order to characterize the metabolic changes in colorectal cancer, we performed metabolomics analysis of paired colon tissues from colorectal cancer patients by using a liquid chromatography-mass spectrometry (LC-MS)-based method. Bioinformation analysis was used to define important metabolites and metabolic pathways, as well as the prognosis significance and expression levels of the key molecules. Read More

View Article and Full-Text PDF

Hierarchically porous FeNi@FeNi layered double hydroxide nanostructures: one-step fast electrodeposition and highly efficient electrocatalytic performances for overall water splitting.

Dalton Trans 2021 Apr 21. Epub 2021 Apr 21.

College of Chemistry and Materials Science, Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Provincial Engineering Laboratory for New-Energy Vehicle Battery Energy-Storage Materials, Anhui Normal University, 189 Jiuhua Southern Road, Wuhu, 241002, PR China.

FeNi-layered double hydroxide (LDH) is thought to be an excellent electrocatalyst for oxygen evolution reaction (OER) but it always shows extremely poor electrocatalytic activity toward hydrogen evolution reaction (HER) in alkaline media. Hence, it is significant to improve its HER activity to make it a bifunctional electrocatalyst for the decomposition of water. Here, a simple galvanostatic electrodeposition method was designed for the successful construction of the bifunctional FeNi3@FeNi LDH electrocatalyst. Read More

View Article and Full-Text PDF

Nanomechanics of Lignin-Cellulase Interactions in Aqueous Solutions.

Biomacromolecules 2021 Apr 21. Epub 2021 Apr 21.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada.

Efficient enzymatic hydrolysis of cellulose in lignocellulose to glucose is one of the most critical steps for the production of biofuels. The nonproductive adsorption of lignin to expensive cellulase highly impedes the development of biorefinery. Understanding the lignin-cellulase interaction mechanism serves as a vital basis for reducing such nonproductive adsorption in their practical applications. Read More

View Article and Full-Text PDF

Prey decline leads to diet shift in the largest population of Indo-Pacific humpback dolphins?

Integr Zool 2021 Apr 21. Epub 2021 Apr 21.

Southern Marine Science and Engineering Guangdong Laboratory, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai Key Laboratory of Marine Bioresource and Environment, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China.

The Pearl River Delta (PRD) region on the southeast coast of China has long been known as a highly productive fishing ground. Since the late 1980s, fishing pressure in the PRD has been intense, which warrants concerns of potential fishery-related impacts on the food resources and foraging ecology of apex marine predators in this region, such as the Indo-Pacific humpback dolphin (Sousa chinensis). In this study, we examined 54 stomachs with food remains, collected from beached carcasses of humpback dolphins recovered during fifteen years between 2003 and 2017. Read More

View Article and Full-Text PDF

Coupling stable isotopes to evaluate sources and transformations of nitrate in groundwater and inflowing rivers around the Caohai karst wetland, Southwest China.

Environ Sci Pollut Res Int 2021 Apr 21. Epub 2021 Apr 21.

College of Resource and Environmental Engineering, Guizhou University, Guiyang, 550025, Guizhou, China.

Nitrate is one of the most common pollutants in aquatic ecosystems, particularly in highly vulnerable karst aquifers. In Caohai Lake, an important karst wetland in southwestern China, karst surface water and groundwater are important recharge water sources, and nitrates flow into the wetland along with the surface water and groundwater, degrading the wetland water quality. Therefore, identifying the sources of nitrate in the surface water and groundwater in the Caohai catchment is of great significance to the protection of the wetland water environment. Read More

View Article and Full-Text PDF

Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway.

J Diabetes Res 2021 5;2021:8873956. Epub 2021 Apr 5.

Department of Endocrinology, People's Hospital of Shenzhen Baoan District, The Second School of Clinical Medicine, Southern Medical University, The Second Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.

Purpose: To explore the regulatory effects of liraglutide on the kidney and liver through the miR-34a/SIRT1 pathway with related factors in diabetic nephropathy (DN) rats.

Methods: DN rats were randomly divided into two groups ( = 10) and were injected with liraglutide or normal saline twice a day. The 24-hour urine microalbumin content and biochemical index levels were measured. Read More

View Article and Full-Text PDF

Prevalence, Risk Factors, and Causes of Visual Impairment in an Elderly Chinese Uygur Population in Southern Xinjiang.

J Ophthalmol 2021 5;2021:8843032. Epub 2021 Apr 5.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Purpose: To investigate the prevalence, risk factors, and major causes of visual impairment (VI) in an elderly Chinese Uygur population in southern Xinjiang.

Methods: This was a population-based cross-sectional study. Participants aged 50 years and older from Haohan Country, Xinjiang Uygur Autonomous Region, were enrolled from August 2018 to December 2018 using cluster sampling. Read More

View Article and Full-Text PDF

Development of a Joint Prediction Model Based on Both the Radiomics and Clinical Factors for Predicting the Tumor Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer.

Cancer Manag Res 2021 13;13:3235-3246. Epub 2021 Apr 13.

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.

Purpose: Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for locally advanced rectal cancer (LARC). However, the accuracy of traditional clinical indicators in predicting tumor response is poor. Recently, radiomics based on magnetic resonance imaging (MRI) has been regarded as a promising noninvasive assessment method. Read More

View Article and Full-Text PDF

Whole-Exome Sequencing for Identifying Genetic Causes of Intellectual Developmental Disorders.

Int J Gen Med 2021 13;14:1275-1282. Epub 2021 Apr 13.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510280, People's Republic of China.

Background: Intellectual developmental disorders (IDD) generally refers to the persistent impairment of cognitive activities and mental retardation caused by physical damage to the brain or incomplete brain development. We aimed to explore its genetic causes.

Methods: In this study, 21 IDD patients were recruited. Read More

View Article and Full-Text PDF

Expanding of ST11 Carbapenemase-Producing Subclones in a Chinese Hospital, Shenzhen, China.

Infect Drug Resist 2021 13;14:1415-1422. Epub 2021 Apr 13.

Shenzhen People's Hospital, Shenzhen Institute of Respiratory Diseases, Shenzhen, Guangdong, People's Republic of China.

Background: ST11 is the most prevalent sequence type of clinical in China.

Methods: We investigated the characteristics of the ST11 subclones using core genome multi-locus sequence typing (cgMLST). Ninety-three carbapenemase-producing isolates were collected at Shenzhen People's Hospital. Read More

View Article and Full-Text PDF

Dual-Functional PLGA Nanoparticles Co-Loaded with Indocyanine Green and Resiquimod for Prostate Cancer Treatment.

Int J Nanomedicine 2021 12;16:2775-2787. Epub 2021 Apr 12.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Purpose: With the advance of screening techniques, there is a growing number of low-risk or intermediate-risk prostate cancer (PCa) cases, remaining a serious threat to men's health. To obtain better efficacy, a growing interest has been attracted to develop such emerging treatments as immunotherapy and focal therapy. However, few studies offer guidance on whether and how to combine these modalities against PCa. Read More

View Article and Full-Text PDF

Correction to: Correspondence on "AminoacyltRNA synthetase deficiencies in search of common themes" by Fuchs et al.

Genet Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, The First Medical Center of PLA General Hospital, China Medical School of Chinese PLA, Beijing, China.

View Article and Full-Text PDF

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination.

Cell Death Differ 2021 Apr 20. Epub 2021 Apr 20.

Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms are poorly understood. We demonstrate here that heterotypic cell-in-cell structures with lymphocytes inside multinucleate syncytia are prevalent in the lung tissues of coronavirus disease 2019 (COVID-19) patients. These unique cellular structures are a direct result of SARS-CoV-2 infection, as the expression of the SARS-CoV-2 spike glycoprotein is sufficient to induce a rapid (~45. Read More

View Article and Full-Text PDF

β-arrestin-dependent PI(4,5)P synthesis boosts GPCR endocytosis.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195.

β-arrestins regulate many cellular functions including intracellular signaling and desensitization of G protein-coupled receptors (GPCRs). Previous studies show that β-arrestin signaling and receptor endocytosis are modulated by the plasma membrane phosphoinositide lipid phosphatidylinositol-(4, 5)-bisphosphate (PI(4,5)P). We found that β-arrestin also helped promote synthesis of PI(4,5)P and up-regulated GPCR endocytosis. Read More

View Article and Full-Text PDF

Do all gliflozins reduce stroke in patients with type 2 diabetes mellitus and impaired renal function?

J Stroke Cerebrovasc Dis 2021 Apr 17:105799. Epub 2021 Apr 17.

Department of General Medicine, Shenzhen Longhua District Central Hospital, Shenzhen 518110, China. Electronic address:

View Article and Full-Text PDF

Long-term prognosis analysis of PARACHUTE device implantation in patients with ischemic heart failure: a single-center experience of Chinese patients.

J Cardiothorac Surg 2021 Apr 20;16(1):98. Epub 2021 Apr 20.

Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People's Hospital, Shenzhen, 518020, Guangdong, China.

Background: Heart failure (HF) is one of the leading causes of mortality and morbidity. The PARACHUTE device is designed to partition for left ventricular (LV) apical aneurysm post extensive anterior myocardial infarction (MI). However, the long-term prognosis of the PARACHUTE device post-implantation is unclear. Read More

View Article and Full-Text PDF

Effects of plant growth regulator and chelating agent on the phytoextraction of heavy metals by Pfaffia glomerata and on the soil microbial community.

Environ Pollut 2021 Apr 15;283:117159. Epub 2021 Apr 15.

Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. Electronic address:

Pfaffia glomerata is a candidate for the remediation of heavy metal-contaminated soil, but phytoremediation efficiency requires enhancement. In this study, we evaluated how application of DA-6, EDTA, or CA affected the growth and heavy metal accumulation of P. glomerata and soil microorganisms. Read More

View Article and Full-Text PDF