Anal Chem 2021 Sep 19. Epub 2021 Sep 19.
Institute of Particle Technology, Friedrich Alexander University Erlangen Nuremberg, Interdisciplinary Center for Functional Particle Systems (FPS), Haberstr. 9a, 91058 Erlangen, Germany.
One of the outcomes of electrospray ionization is the size distribution of the droplets, which determines, together with the solvent composition and the source gas temperature, the minimum distance from the sprayer tip to the mass spectrometer inlet and therefore the ion transfer efficiency. Even more importantly, the average number of analyte molecules and, if present, contaminant species per droplet depend on the drop size. Consequently, the drop size distribution is a key parameter in nonspecific ion clustering in solution and ion suppression. Read More