2,027 results match your criteria sole respiratory


Long-term amikacin liposome inhalation suspension in cystic fibrosis patients with chronic P. aeruginosa infection.

J Cyst Fibros 2021 Jun 15. Epub 2021 Jun 15.

Case Western Reserve University and Rainbow Babies and Children's Hospital, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address:

Background: . In CLEAR-108-a phase 3, randomised, open-label study-once-daily amikacin liposome inhalation suspension (ALIS) was noninferior to twice-daily tobramycin inhalation solution (TIS) in improving lung function in patients with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa infection after 3 treatment cycles (28 days on/28 days off). The CLEAR-110 extension study (ClinicalTrials. Read More

View Article and Full-Text PDF

Evaluation of Dexmedetomidine Dosing in Obese Critically Ill Patients.

J Pharm Pract 2021 Jun 10:8971900211021578. Epub 2021 Jun 10.

Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Dexmedetomidine is a highly selective α-adrenoreceptor agonist that produces dose-dependent sedation, anxiolysis, and analgesia without respiratory depression. Due to these ideal sedative properties, there has been increased interest in utilizing dexmedetomidine as a first-line sedative for critically ill patients requiring light sedation.

Objective: To evaluate the ability to achieve goal intensive care unit (ICU) sedation before and after an institutional change of dosing from actual (ABW) to adjusted (AdjBW) body weight in obese patients on dexmedetomidine. Read More

View Article and Full-Text PDF

Schistosoma mansoni infection is associated with decreased risk of respiratory allergy symptoms and low production of CCL2.

Trop Med Int Health 2021 Jun 9. Epub 2021 Jun 9.

Setor de Imunologia, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brasil.

Objectives: We measured the production of cytokines, chemokines, and antibodies involved in allergic responses and sCD23 levels during Schistosoma mansoni infection.

Methods: Individuals (n = 164) were selected using the ISAAC questionnaire and parasitological exams. The subjects were divided as follows: those infected individuals with allergy-related symptoms (A-I), those with allergy-related symptoms only (A-NI); those only infected (NA-I); and those non-infected individuals without allergy-related symptoms (NA-NI). Read More

View Article and Full-Text PDF

Associations between feeding behaviors collected from an automated milk feeder and disease in group-housed dairy calves in Ontario: A cross-sectional study.

J Dairy Sci 2021 Jun 4. Epub 2021 Jun 4.

Department of Population Medicine, University of Guelph, Guelph, ON, Canada, N1G 2W1. Electronic address:

The adoption of automated milk feeders and group housing of preweaning dairy calves has become more common in Canada; however, disease detection in group-housed calves remains a challenge. The aim of this cross-sectional study was to assess whether feeding behavior data collected from a single point in time could be used to aid in the detection of neonatal calf diarrhea (NCD), bovine respiratory disease (BRD), and general disease, in preweaning group-housed calves being fed via an automated milk feeder. The data used was collected in an earlier study. Read More

View Article and Full-Text PDF

The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination.

Pulm Pharmacol Ther 2021 Jun 1;69:102047. Epub 2021 Jun 1.

Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, SE1 9NH, London, United Kingdom. Electronic address:

Introduction/background And Purpose: Studies with Cannabis Sativa plant extracts and endogenous agonists of cannabinoid receptors have demonstrated anti-inflammatory, bronchodilator, and antitussive properties in the airways of allergic and non-allergic animals. However, the potential therapeutic use of cannabis and cannabinoids for the treatment of respiratory diseases has not been widely investigated, in part because of local irritation of airways by needing to smoke the cannabis, poor bioavailability when administered orally due to the lipophilic nature of cannabinoids, and the psychoactive effects of Δ9-Tetrahydrocannabinol (Δ9-THC) found in cannabis. The primary purpose of this study was to investigate the anti-inflammatory effects of two of the non-psychotropic cannabinoids, cannabidiol (CBD) and cannabigerol (CBG) alone and in combination, in a model of pulmonary inflammation induced by bacterial lipopolysaccharide (LPS). Read More

View Article and Full-Text PDF

Point of care diagnostic of hypercoagulability and platelet function in COVID-19 induced acute respiratory distress syndrome: a retrospective observational study.

Thromb J 2021 Jun 2;19(1):39. Epub 2021 Jun 2.

Department of Anesthesiology and Critical Care, University Hospital Wuerzburg, Oberdürrbacherstr. 6, 97080, Wuerzburg, Germany.

Background: Coronavirus disease 2019 (COVID-19) associated coagulopathy (CAC) leads to thromboembolic events in a high number of critically ill COVID-19 patients. However, specific diagnostic or therapeutic algorithms for CAC have not been established. In the current study, we analyzed coagulation abnormalities with point-of-care testing (POCT) and their relation to hemostatic complications in patients suffering from COVID-19 induced Acute Respiratory Distress Syndrome (ARDS). Read More

View Article and Full-Text PDF

Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat.

Antioxidants (Basel) 2021 May 25;10(6). Epub 2021 May 25.

Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)-A specialised peripheral chemoreceptor. Central to CB O-sensing is their unique mitochondria but the link between mitochondrial inhibition and cellular stimulation is unresolved. The objective of this study was to evaluate if ex vivo intact CB nerve activity and in vivo whole body ventilatory responses to hypoxia were modified by alterations in succinate metabolism and mitochondrial ROS (mitoROS) generation in the rat. Read More

View Article and Full-Text PDF

Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication.

PLoS One 2021 28;16(5):e0252399. Epub 2021 May 28.

Scaled Microbiomics, LLC, Hagerstown, MD, United States of America.

Background: The global pandemic of Coronavirus infectious disease 2019 (COVID-19), caused by SARS-CoV-2, has plunged the world into both social and economic disarray, with vaccines still emerging and a continued paucity of personal protective equipment; the pandemic has also highlighted the potential for rapid emergence of aggressive respiratory pathogens and the need for preparedness. Avian immunoglobulins (IgY) have been previously shown in animal models to protect against new infection and mitigate established infection when applied intranasally. We carried out a proof-of-concept study to address the feasibility of using such antibodies as mucosally-applied prophylaxis against SARS-CoV-2. Read More

View Article and Full-Text PDF

Qipengyuania soli sp. nov., Isolated from Mangrove Soil.

Curr Microbiol 2021 Jul 28;78(7):2806-2814. Epub 2021 May 28.

Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Open Laboratory of Applied Microbiology, Guangdong Microbial Culture Collection Center (GDMCC), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, People's Republic of China.

A novel Gram-stain-negative, non-motile, and rod-shaped bacterial strain, designated as 6D36, was isolated from mangrove soil and characterized by using a polyphasic taxonomic approach. Strain 6D36 was found to grow at 10-37 °C (optimum, 28 °C), at pH 6.0-9. Read More

View Article and Full-Text PDF

Unexplained worsening of parkinsonian symptoms in a patient with advanced Parkinson's disease as the sole initial presentation of COVID-19 infection: a case report.

Egypt J Neurol Psychiatr Neurosurg 2021 17;57(1):60. Epub 2021 May 17.

Department of Neurology, Ibn Sina Hospital, Gamal Abdel Nasser Street, Sabah Medical Area, Sabah, Kuwait.

Background: Parkinson's disease (PD) is a neurodegenerative condition that has been reported following viral infections in rare occasions. Several neurological complications have emerged in association with coronavirus disease 2019 (COVID-19), since its declaration as a pandemic. Herein, we present a novel case of unexplained worsening of PD as the sole initial presentation of COVID-19, in the absence of fever or respiratory symptoms. Read More

View Article and Full-Text PDF

Saving time in the radiotherapy procedures for COVID-19 pneumonia treatment. A single-institution experience.

Clin Transl Oncol 2021 May 19. Epub 2021 May 19.

Radiation Oncology Department, Hospital Universitari Arnau de Vilanova, Av. Alcalde Rovira Roure, 80, 25198, Lleida, Spain.

Background: The use of low dose radiotherapy (LD-RT) for the treatment of COVID-19 pneumonia is supported by biological rationale for its immunomodulatory effect. Some institutions have started to treat these patients showing encouraging results. To shorten procedure times is crucial for the comfort of symptomatic patients receiving respiratory support and to optimize institutional facilities. Read More

View Article and Full-Text PDF

sp. nov., isolated from marine sediment.

Int J Syst Evol Microbiol 2021 May;71(5)

State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, PR China.

A Gram-stain negative, rod-shaped, facultatively aerobic, pale-beige-coloured bacterial strain, designated F7233, was isolated from coastal sediment sampled at Jingzi Bay, Weihai, PR China. Cells of strain F7233 were 0.3-0. Read More

View Article and Full-Text PDF

A novel and recurrent KLHL40 pathogenic variants in a Chinese family of multiple affected neonates with nemaline myopathy 8.

Mol Genet Genomic Med 2021 May 12:e1683. Epub 2021 May 12.

Genetic and Metabolic Central Laboratory, Birth Defect Prevention Research Institute, Maternal and Child Health Hospital, Children's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Background: Nemaline myopathy 8 is a severe autosomal recessive muscle disorder characterized by fetal akinesia or hypokinesia, contractures, fractures, respiratory failure and swallowing difficulties apparent at birth.

Methods: An affected dizygotic twin pair from a non-consanguineous Chinese family presented with severe asphyxia, lethargy and no response to stimuli. The dysmorphic features included prominent nasal bridge, telecanthus, excessive hip abduction, limb edema, absent palmar and sole creases, acromelia, bilateral clubfoot, appendicular hypertonia and cryptorchidism. Read More

View Article and Full-Text PDF

Diversity and genomic determinants of the microbiomes associated with COVID-19 and non-COVID respiratory diseases.

Gene Rep 2021 Jun 7;23:101200. Epub 2021 May 7.

Department of Pathology and Parasitology, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram 4202, Bangladesh.

The novel coronavirus disease 2019 (COVID-19) is a rapidly emerging and highly transmissible disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Understanding the microbiomes associated with the upper respiratory tract infection (URTI), chronic obstructive pulmonary disease (COPD) and COVID-19 diseases has clinical interest. We hypothesize that microbiome diversity and composition, and their genomic features are associated with different pathological conditions of these human respiratory tract diseases. Read More

View Article and Full-Text PDF

Asthma is associated with lower respiratory tract involvement and worse clinical score in children with COVID-19.

Pediatr Allergy Immunol 2021 May 9. Epub 2021 May 9.

Division of Allergy, Clinical Immunology and Rheumatology, Federal University of São Paulo, São Paulo, Brazil.

View Article and Full-Text PDF

Devosia aurantiaca sp. nov., Isolated from Mountain Soil and Proposal of Albitalea gen. nov. to Replace the Illegitimate Prokaryotic Genus Name Geomonas Khan et al. 2020.

Curr Microbiol 2021 Jul 7;78(7):2548-2555. Epub 2021 May 7.

Department of Life Science, Chung-Ang University, 84, HeukSeok-Ro, Dongjak-Gu, Seoul, 06974, Republic of Korea.

Strain H239, a gram-negative, strictly aerobic, and oxidase-positive, and catalase-negative bacterium, was isolated from mountain soil in Gangwon-do of South Korea. Colonies were orange colored, and cells were motile rods with a single polar flagellum. Growth was observed between 25 and 30 °C (optimum, 30 °C), between pH 7. Read More

View Article and Full-Text PDF

Condensation: A Retrospective Cohort Study to Investigate the Association Between Maternal Pre-pregnancy Obesity and Childhood Respiratory Disease.

Matern Child Health J 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, 84101, Beer-Sheva, Israel.

Objective: We sought to explore whether maternal pre-pregnancy obesity is an independent risk factor for offspring respiratory morbidity during childhood.

Methods: A population-based retrospective cohort analysis comparing childhood respiratory morbidity incidence in offspring to mothers with pre-pregnancy obesity (BMI ≥ 30 kg/m) and those who had lower BMI was conducted. Respiratory diagnoses were pre-defined based on ICD-9 codes. Read More

View Article and Full-Text PDF

Over-expression of an electron transport protein OmcS provides sufficient NADH for D-lactate production in cyanobacterium.

Biotechnol Biofuels 2021 Apr 29;14(1):109. Epub 2021 Apr 29.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No. 1 West Beichen Road, Chaoyang District, Beijing, 100101, China.

Background: An efficient supply of reducing equivalent is essential for chemicals production by engineered microbes. In phototrophic microbes, the NADPH generated from photosynthesis is the dominant form of reducing equivalent. However, most dehydrogenases prefer to utilize NADH as a cofactor. Read More

View Article and Full-Text PDF

Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity.

Bull Natl Res Cent 2021 23;45(1):79. Epub 2021 Apr 23.

Drug Discovery and Multi-Omics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE), Kelambakkam, Tamilnadu 603103 India.

Background: The ongoing pandemic of COVID-19 viruses takes its sole origin from the Wuhan Huanan seafood market, China. The first case was recorded as viral pneumonia and later became a worldwide pandemic (officially declared by WHO on March 11, 2020).

Main Body: SARS-CoV-2 is an extremely infectious and transferrable virus that develops severe conditions like respiratory syndrome, high blood pressure and weakens the immune system. Read More

View Article and Full-Text PDF

Draconibacterium halophilum sp. nov., A Halophilic Bacterium Isolated from Marine Sediment.

Curr Microbiol 2021 Jun 27;78(6):2440-2446. Epub 2021 Apr 27.

Department of Biology, Jeju National University, 102 Jejudaehak-ro, Jeju, 63243, South Korea.

A Gram-stain-negative, long-rod shaped, and facultatively anaerobic bacterium, designated as strain M1, was isolated from the marine sediment of Jeju Island, South Korea. Strain M1 was found to be catalase- and oxidase-positive, light yellow-pigmented, non-motile, and non-flagellated, growing optimally at 30 °C, pH 7.0, and in the presence of 3% (w/v) NaCl. Read More

View Article and Full-Text PDF

sp. nov., isolated from the intestine of the dark diving beetle , and sp. nov., isolated from the intestine of the diving beetle .

Int J Syst Evol Microbiol 2021 Apr;71(4)

Department of Biology and Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.

A polyphasic taxonomic approach was used to characterize two novel bacterial strains, designated as HDW11 and HDW19, isolated from intestine samples of the dark diving beetle and the diving beetle , respectively. Both isolates were Gram-stain-positive, facultatively anaerobic and non-motile. Strain HDW11 grew optimally at 30 °C, pH 8 and in the presence of 1% (w/v) NaCl. Read More

View Article and Full-Text PDF

No Difference in Morbidity or Mortality Between Octogenarians and Other Geriatric Burn Trauma Patients.

Am Surg 2021 Apr 16:31348211011122. Epub 2021 Apr 16.

Department of Surgery, Division of Trauma, Burns and Surgical Critical Care, 8788University of California Irvine, Orange, CA, USA.

Background: Geriatric burn trauma patients (age ≥65 years) have a 5-fold higher mortality rate than younger adults. With the population of the US aging, the number of elderly burn and trauma patients is expected to increase. A past study using the National Burn Repository revealed a linear increase in mortality for those >65 years old. Read More

View Article and Full-Text PDF

Quasilobar minimalist lung volume reduction surgery.

Eur J Cardiothorac Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Biostatistics, Tor Vergata University of Rome, Rome, Italy.

Objectives: Our goal was to assess the results and the costs of the quasilobar minimalist (QLM) thoracoscopic lung volume reduction (LVR) surgical method developed to minimize the trauma from the operation and the anaesthesia and to maximize the effect of the lobar volume reduction.

Methods: Forty patients with severe emphysema underwent QLM-LVR that entailed adoption of sole intercostal block analgesia and lobar plication through a single thoracoscopic incision. Results were compared after propensity matching with 2 control groups undergoing non-awake resectional LVR with double-lumen tracheal intubation or awake non-resectional LVR by plication with thoracic epidural anaesthesia. Read More

View Article and Full-Text PDF

sp. nov., isolated from blood of an immunocompromised patient.

Int J Syst Evol Microbiol 2021 Apr;71(4)

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

A novel Gram-stain-negative, facultative aerobic and rod-shaped bacterium, designated as MKL-01 and isolated from the blood of immunocompromised patient, was genotypically and phenotypically characterized. The colonies were found to be creamy yellow and convex. Phylogenetic analysis based on 16S rRNA gene and whole-genome sequences revealed that strain MKL-01 was most closely related to LMG 5886, present within a large cluster in the genus . Read More

View Article and Full-Text PDF

The Impact of COVID-19 on Primary Care General Practice Consultations in a Teaching Hospital in Shanghai, China.

Front Med (Lausanne) 2021 26;8:642496. Epub 2021 Mar 26.

Department of General Practice, Tongren Hospital, Shanghai, China.

The COVID-19 (2019 novel coronavirus disease) pandemic is deeply concerning because of its massive mortality and morbidity, creating adverse perceptions among patients likely to impact on their overall medical care. Thus, we evaluated the impact of the COVID-19 pandemic on the pattern of primary care consultations within a Shanghai health district. A retrospective observational cohort study was performed, with data analyzed concerning the pattern of patient visits to general practitioners within the Tongren Hospital network (the sole provider of general practice to the population of 700,000). Read More

View Article and Full-Text PDF

Aquabacterium terrae sp. nov., isolated from soil.

Arch Microbiol 2021 Apr 7. Epub 2021 Apr 7.

Department of Biological Science, College of Science and Engineering, Sangji University, Wonju, 26339, Republic of Korea.

A yellow-colored bacterial strain, designated S2 was isolated from soil in South Korea. Cells of strain S2 were strictly aerobic, Gram-stain-negative, motile with single polar flagellum, rod-shaped, oxidase and catalase-negative. Growth occurs at 10-37 °C (optimum, 28 °C), pH 5. Read More

View Article and Full-Text PDF

A Call for the World Health Organization to Create International Classification of Disease Diagnostic Codes for Post-Intensive Care Syndrome in the Age of COVID-19.

World Med Health Policy 2021 Feb 22. Epub 2021 Feb 22.

Post-intensive care syndrome (PICS), a condition found in survivors of critical illness, is characterized by persistent physical, cognitive, and psychological sequelae that impact the quality of life after discharge from an intensive care unit (ICU). At present, there are no International Classification of Disease (ICD) billing codes for this condition. Without financial alignment, clinicians cannot diagnose PICS, hindering tracking of its prevalence and impeding policy development for this condition. Read More

View Article and Full-Text PDF
February 2021

Aquiflexum lacus sp. nov., isolated from a lake sediment sample.

Arch Microbiol 2021 Mar 24. Epub 2021 Mar 24.

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China.

A novel Gram-staining negative, crescent-like or rod-shaped, non-motile bacterium, designated strain CUG 91378, was isolated from a sediment sample of Qinghai Lake, Qinghai Province, China. The strain was red-colored, and catalase- and oxidase-positive. Strain CUG 91378 was able to grow at 15-37 °C (optimum, 28 °C), pH 7-9 (pH 7. Read More

View Article and Full-Text PDF

Genome insight and description of antibiotic producing Massilia antibiotica sp. nov., isolated from oil-contaminated soil.

Sci Rep 2021 Mar 23;11(1):6695. Epub 2021 Mar 23.

Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea.

An ivory-coloured, motile, Gram-stain-negative bacterium, designated TW-1 was isolated from oil-contaminated experimental soil in Kyonggi University. The phylogenetic analysis based on 16S rRNA gene sequence revealed, strain TW-1 formed a lineage within the family Oxalobacteraceae and clustered as members of the genus Massilia. The closest members were M. Read More

View Article and Full-Text PDF