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A Platform and Multisided Market for Translational, Software-Defined Medical Procedures in the Operating Room (OP 4.1): Proof-of-Concept Study.

JMIR Med Inform 2022 Jan 20;10(1):e27743. Epub 2022 Jan 20.

Department of Urology, Heidelberg University Hospital, Heidelberg, Germany.

Background: Although digital and data-based technologies are widespread in various industries in the context of Industry 4.0, the use of smart connected devices in health care is still in its infancy. Innovative solutions for the medical environment are affected by difficult access to medical device data and high barriers to market entry because of proprietary systems. Read More

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January 2022

Comprehensive assessment of multimorbidity burden in a population-based cohort of patients with rheumatoid arthritis.

RMD Open 2022 Jan;8(1)

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Objective: To comprehensively assess multimorbidity burden in patients with rheumatoid arthritis (RA) in order to unify the multimorbidity definition for RA research and clinical practice.

Methods: In this population-based study, residents of eight Minnesota counties with prevalent RA on 1 January 2015 were identified. Age, sex and county-matched non-RA comparators were selected from the same population. Read More

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January 2022

Evaluating Pointwise Reliability of Machine Learning prediction.

J Biomed Inform 2022 Jan 15:103996. Epub 2022 Jan 15.

Department of Electrical, Computer and Biomedical Engineering, University of Pavia (Italy).

Interest in Machine Learning applications to tackle clinical and biological problems is increasing. This is driven by promising results reported in many research papers, the increasing number of AI-based software products, and by the general interest in Artificial Intelligence to solve complex problems. It is therefore of importance to improve the quality of machine learning output and add safeguards to support their adoption. Read More

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January 2022

An automated and mobile magnetoresistive biosensor system for early hepatocellular carcinoma diagnosis.

Biosens Bioelectron 2022 Jan 10;202:113982. Epub 2022 Jan 10.

Department of Electrical Engineering, Stanford University, Stanford, CA, United States.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Most patients, however, are not diagnosed until advanced stage because early HCC lesions generally cause no overt symptoms, and the presence of cirrhosis adds another layer of complexity. While early diagnosis enables more therapeutic options and greatly improves survival rates, it is difficult to achieve. Read More

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January 2022

Host T cell dedifferentiation effects drive HIV-1 latency stability.

J Virol 2022 Jan 12:jvi0197421. Epub 2022 Jan 12.

Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

The development of therapies to eliminate the latent HIV-1 reservoir is hampered by our incomplete understanding of the biomolecular mechanism governing HIV-1 latency. To further complicate matters, recent single cell RNA-seq studies reported extensive heterogeneity between latently HIV-1-infected primary T cells, implying that latent HIV-1 infection can persist in greatly differing host cell environments. We here show that transcriptomic heterogeneity is also found between latently infected T cell lines, which allowed us to study the underlying mechanisms of intercell heterogeneity at high signal resolution. Read More

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January 2022

What is the deviation in 3D preoperative planning software? A systematic review of concordance between plan and actual implant in reverse total shoulder arthroplasty.

J Shoulder Elbow Surg 2022 Jan 8. Epub 2022 Jan 8.

The Steadman Philippon Research Institute, Vail, CO, USA; The Steadman Clinic, Vail, CO, USA. Electronic address:

Background: 3D preoperative planning software for reverse total shoulder arthroplasty (rTSA) has been implemented in recent years in order to increase accuracy, improve efficiency, and add value to the outcome. A comprehensive literature review is required to determine utility of preoperative 3D planning software in guiding orthopedic surgeons for implant placement in rTSA.

Hypothesis: Implementation of 3D preoperative planning software in the setting of rTSA leads to high concordance with minimal deviation from the preoperative plan. Read More

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January 2022

Efficacy and Safety of Mucopolysaccharide Polysulfate Cream for Non-Exudative Eczema: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2021 24;8:788324. Epub 2021 Dec 24.

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Mucopolysaccharide polysulfate (MPS) cream as a moisturizer is widely applied to treat eczema, and a lot of clinical trials have demonstrated its efficacy and safety. However, there is no further research to collect and analyze these studies. This meta-analysis aimed to assess the efficacy and safety of MPS cream as monotherapy or add-on therapy for non-exudative eczema. Read More

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December 2021

Predictors of pearl vitamin D3 consumption in pregnant women: application of the theory of planned behaviour.

J Obstet Gynaecol 2022 Jan 7:1-6. Epub 2022 Jan 7.

Department of Health Education and Health Promotion, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

This study aimed at determining the applicability planned-behaviour theory to predict the consumption of pearl vitamin D3 (1000 IU) among pregnant women in Iran in 2020. The participants of the present study were 200 pregnant women who were selected through random cluster sampling. In addition, data collection was done through the use of questionnaire and the proceeding analyses including correlation and linear regression were conducted using SPSS (version 20) (SPSS Inc. Read More

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January 2022

LaRA 2: parallel and vectorized program for sequence-structure alignment of RNA sequences.

BMC Bioinformatics 2022 Jan 6;23(1):18. Epub 2022 Jan 6.

Department of Mathematics and Computer Science, Free University Berlin, Takustraße 9, 14195, Berlin, Germany.

Background: The function of non-coding RNA sequences is largely determined by their spatial conformation, namely the secondary structure of the molecule, formed by Watson-Crick interactions between nucleotides. Hence, modern RNA alignment algorithms routinely take structural information into account. In order to discover yet unknown RNA families and infer their possible functions, the structural alignment of RNAs is an essential task. Read More

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January 2022

Feasibility, usability and acceptance of weekly electronic patient-reported outcomes among patients receiving pelvic CT- or online MR-guided radiotherapy - A prospective pilot study.

Tech Innov Patient Support Radiat Oncol 2022 Mar 15;21:8-15. Epub 2021 Dec 15.

Department of Oncology, AgeCare, Academy of Geriatric Cancer Research, Odense University Hospital, Denmark.

Introduction: The potential of patient symptoms being monitored longitudinally in radiotherapy (RT) is still unexploited. When novel technologies like online adaptive MR-guided radiotherapy (MRgRT) are evaluated, weekly electronic patient-reported outcomes (ePROs) may add knowledge about the symptom trajectory. This study aimed at evaluating feasibility, usability and acceptance of weekly ePRO among patients receiving pelvic radiotherapy. Read More

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Perspectives on modes of labour and delivery after different modalities of surgery for bowel endometriosis.

J Obstet Gynaecol 2021 Dec 29:1-5. Epub 2021 Dec 29.

Brighton and Sussex University Hospitals NHS Foundation Trust, Princess Royal Hospital, Haywards Heath, UK.

Bowel or intestinal endometriosis is estimated to affect 5-37% of women with deep infiltrative endometriosis (DIE), especially in the rectum and recto-sigmoid junction. However, there are no current guidelines or consensus regarding safest mode of delivery in pregnant women after different surgical interventions for bowel/intestinal endometriosis. From October 2019 to February 2020, we conducted an online survey of members of the British Society for Gynaecological Endoscopy (BSGE). Read More

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December 2021

The solutions to increase the participation of men in sexual and reproductive health of women in Iran: an analytic hierarchy process (AHP) analysis.

J Obstet Gynaecol 2021 Dec 16:1-5. Epub 2021 Dec 16.

Department of Midwifery, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.

Ever since the Cairo Declaration in 1994, women's Sexual and Reproductive Health (SRH) has become a priority and substantial efforts have been made to improve it. Men's contribution to promote the SRH of women is essential. Therefore, this study aimed to identify the best solutions to increase the men's participation in the SRH of women in Iran, using an analytic hierarchy process (AHP) approach. Read More

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December 2021

Reference intervals for reticulocyte parameters (reticulocyte haemoglobin equivalent and immature reticulocyte fraction) in first-trimester pregnancy.

J Obstet Gynaecol 2021 Dec 16:1-3. Epub 2021 Dec 16.

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, India.

Reticulocyte parameters including reticulocyte haemoglobin equivalent (Ret-He) and immature reticulocyte fraction (IRF) are newly recognised hematological parameters that are being used for diagnosis and follow-up of anaemic patients. Reference intervals of these parameters have been established in different populations, however, the data relating to pregnancy are still lacking. One hundred and fifty-five first-trimester pregnant females were screened and the reference interval was calculated after selecting the patient with fixed criteria. Read More

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December 2021

Fourier Transform Infrared Spectroscopy for Typing Burkholderia cenocepacia ET12 Isolates.

Microbiol Spectr 2021 12 8;9(3):e0183121. Epub 2021 Dec 8.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

The IR Biotyper and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) using ClinProTools software (MALDI-TOF MS-ClinProTools) are two novel typing methods that rely on the analysis of carbohydrate and peptide residues in intact bacterial cells. These two methods have shown promising results in the rapid and accurate typing of bacteria. In this study, we evaluated these novel typing methods in comparison with genotypic typing for cluster analysis of Burkholderia cenocepacia epidemic strain ET12, isolated from adult cystic fibrosis patients. Read More

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December 2021

Cortical bone structure of the proximal femur and incident fractures.

Bone 2022 Feb 4;155:116284. Epub 2021 Dec 4.

Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Department of Orthopedic Surgery, University Hospital of North Norway, Tromsø, Norway.

Purpose: Fracture risk is most frequently assessed using Dual X-ray absorptiometry to measure areal bone mineral density (aBMD) and using the Fracture Risk Assessment Tool (FRAX). However, these approaches have limitations and additional bone measurements may enhance the predictive ability of these existing tools. Increased cortical porosity has been associated with incident fracture in some studies, but not in others. Read More

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February 2022

eQuilibrator 3.0: a database solution for thermodynamic constant estimation.

Nucleic Acids Res 2022 Jan;50(D1):D603-D609

Department of Plant and Environmental Sciences, Weizmann Institute of Science, Herzl 234, Rehovot 7610001, Israel.

eQuilibrator (equilibrator.weizmann.ac. Read More

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January 2022

Variability of redundant scan coverages along the Z-axis and dose implications for common computed tomography examinations.

J Med Imaging Radiat Sci 2021 Nov 23. Epub 2021 Nov 23.

Radiation Protection Institute (RPI), Ghana Atomic Energy Commission, Accra, Ghana.; Radiological and Non-ionizing Radiation Directorate, Nuclear Regulatory Authority, Accra, Ghana.

Background: Scan length optimization is a method of optimization which ensures that, imaging is performed to cover just the area of interest without unnecessarily exposing structures that would not add value to answer a given clinical question.

Purpose: This study assessed the variability and degree of redundant scan coverages along the z-axis of CT examinations of common indications and the associated radiation dose implications in CT facilities in Ghana for optimization measures to be recommended.

Methods: On reconstructed acquired CT images, the study measured extra distances covered above and below anatomical targets for common indications with calibrated calipers across 25 CT facilities. Read More

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November 2021

Running App "Zombies, Run!" Users' Engagement with Physical Activity: A Qualitative Study.

Games Health J 2021 Dec 23;10(6):420-429. Epub 2021 Nov 23.

Department of Behavioural Science and Health, University College London, London, United Kingdom.

Sufficient physical activity (PA) is important for all aspects of health. Smartphone apps and the use of gamification, such as narrative-based augmented reality (AR), have a great potential to engage a variety of people in more PA. Zombies, Run! (ZR) is the world's most popular running exergame app and therefore a suitable model to understand what users find engaging. Read More

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December 2021

Parametric Imaging With Dynamic PET for Oncological Applications: Protocols, Interpretation, Current Applications and Limitations for Clinical Use.

Semin Nucl Med 2021 Nov 19. Epub 2021 Nov 19.

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany.

Nuclear medicine imaging modalities, and in particular positron emission tomography (PET), provide functional images that demonstrate the mean radioactivity distribution at a defined point in time. With the help of mathematical model's, it is possible to depict isolated parameters of the radiotracers' pharmacokinetics and to visualize them. These so called parametric images add a new dimension to the existing conventional PET images and provide more detailed information about the tracer distribution over time and space. Read More

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November 2021

Framework for automated sorting of neural spikes from Neuralynx-acquired tetrode recordings in freely-moving mice.

Bioelectron Med 2021 Nov 23;7(1):17. Epub 2021 Nov 23.

Laboratory of Immune & Neural Networks, Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA, 350 Community Drive, Manhasset, NY, 11030, USA.

Background: Extracellular recording represents a crucial electrophysiological technique in neuroscience for studying the activity of single neurons and neuronal populations. The electrodes capture voltage traces that, with the help of analytical tools, reveal action potentials ('spikes') as well as local field potentials. The process of spike sorting is used for the extraction of action potentials generated by individual neurons. Read More

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November 2021

Simplifying the OpenFlexure microscope software with the web of things.

R Soc Open Sci 2021 Nov 17;8(11):211158. Epub 2021 Nov 17.

Centre for Photonics and Photonic Materials, Department of Physics, University of Bath, Bath, UK.

We present the OpenFlexure Microscope software stack which provides computer control of our open source motorised microscope. Our diverse community of users needs both graphical and script-based interfaces. We split the control code into client and server applications interfaced via a web API conforming to the W3C Web of Things standard. Read More

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November 2021

A Smart Capacitive Sensor Skin with Embedded Data Quality Indication for Enhanced Safety in Human-Robot Interaction.

Sensors (Basel) 2021 Oct 29;21(21). Epub 2021 Oct 29.

Machine Learning and Data Analytics Lab, Department Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Carl-Thiersch-Straße 2b, 91052 Erlangen, Germany.

Smart sensors are an integral part of the Fourth Industrial Revolution and are widely used to add safety measures to human-robot interaction applications. With the advancement of machine learning methods in resource-constrained environments, smart sensor systems have become increasingly powerful. As more data-driven approaches are deployed on the sensors, it is of growing importance to monitor data quality at all times of system operation. Read More

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October 2021

Ten simple rules on writing clean and reliable open-source scientific software.

PLoS Comput Biol 2021 11 11;17(11):e1009481. Epub 2021 Nov 11.

Berkeley Institute for Data Science, University of California, Berkeley, Berkeley, California, United States of America.

Functional, usable, and maintainable open-source software is increasingly essential to scientific research, but there is a large variation in formal training for software development and maintainability. Here, we propose 10 "rules" centered on 2 best practice components: clean code and testing. These 2 areas are relatively straightforward and provide substantial utility relative to the learning investment. Read More

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November 2021

New insights into toxicity of microcystins produced by cyanobacteria using in silico ADMET prediction.

Toxicon 2021 Dec 4;204:64-71. Epub 2021 Nov 4.

Departamento de Microbiologia, Imunologia e Parasitologia [Department of Microbiology, Immunology and Parasitology], Universidade Federal de São Paulo [Federal University of São Paulo], Rua Botucatu, 862, São Paulo, SP, Zip Code: 04023-901, Brazil.

In silico methodologies can be used in the discovery of new drugs for measuring toxicity, predicting effects of substances not yet analyzed by in vivo methodologies. The ADMET Predictor® software (absorption, distribution, metabolism, elimination, and toxicity [ADMET]) was used in this work to predict toxic effects of microcystin variants MC-LR, MC-YR, MC-RR, and MC-HarHar. In the case of rodents, predictive results for all analyzed variants indicated carcinogenic potential. Read More

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December 2021

Replication of chromosomal loci involved in Parkinson's disease: A quantitative synthesis of GWAS.

Toxicol Rep 2021 12;8:1762-1768. Epub 2021 Oct 12.

Department of Biomathematics, Faculty of Medicine, University of Thessaly Larissa, Greece.

Introduction: Parkinson's disease is a neurodegenerative disorder with a complex etiology coming from interactions between genetic and environmental factors. Research on Parkinson's disease genetics has been an effortful struggle, while new technologies and novel study designs served as indispensable boosters. Until now, 90 loci and 20 disease-causing gene mutations have been identified. Read More

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October 2021

Development of Inflammatory Bowel Diseases Registry Software.

Middle East J Dig Dis 2021 Apr 29;13(2):145-152. Epub 2021 May 29.

MSc in Medical Informatics, Department of Health Information Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

BACKGROUND With an increase in the prevalence and incidence of inflammatory bowel diseases (IBDs), they have become a global challenge. The IBD registry provides complete and timely data, thereby greatly contributing to the estimation of the burden of these diseases and development of control and prevention programs. We aimed to develop an IBD registry software. Read More

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Evaluating the role of endometrial colour Doppler dynamic tissue perfusion measurements in fertilisation success.

J Obstet Gynaecol 2021 Oct 28:1-7. Epub 2021 Oct 28.

Family Planning and Infertility Research and Treatment Center, Ege University, Izmir, Turkey.

The role of uterine receptivity and endometrial perfusion in fertilisation (IVF) remains unclear. In our prospective pilot study, we used a new dynamic tissue perfusion measurement method to evaluate this relationship in humans. A standard ovulation induction and embryo transfer method were applied to all the volunteers. Read More

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October 2021

Open data products-A framework for creating valuable analysis ready data.

J Geogr Syst 2021 Oct 20:1-18. Epub 2021 Oct 20.

Geographic Data Science Lab, Department of Geography and Planning, University of Liverpool, Roxby Building, 74, Bedford St S., Liverpool, L69 7ZT UK.

This paper develops the notion of "open data product". We define an open data product as the open result of the processes through which a variety of data (open and not) are turned into accessible information through a service, infrastructure, analytics or a combination of all of them, where each step of development is designed to promote open principles. Open data products are born out of a (data) need and add value beyond simply publishing existing datasets. Read More

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October 2021

Testing potential disclosures for e-cigarette sponsorship on social media.

Addict Behav 2022 Feb 11;125:107146. Epub 2021 Oct 11.

Truth Initiative, 900 G Street NW, Washington, DC 20001, USA.

Objectives: Few e-cigarette social media posts are authentic posts to friends; most come from commercially sponsored influencers. Potential disclosure strategies need to be tested to confirm whether users recognize such posts as commercially sponsored.

Methods: Between July - August 2019, young adult (ages 16-24; n = 200) participants were recruited to view their native Instagram feed on a laboratory mobile device. Read More

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February 2022

From Spreadsheets to Script: Experiences From Converting a Scottish Cardiovascular Disease Policy Model into R.

Appl Health Econ Health Policy 2021 Oct 21. Epub 2021 Oct 21.

Health Economics and Health Technology Assessment (HEHTA), Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Given the advantages in transparency, reproducibility, adaptability and computational efficiency in R, there is a growing interest in converting existing spreadsheet-based models into an R script for model re-use and upskilling training among health economic modellers. The objective of this exercise was to convert the Scottish Cardiovascular Disease (CVD) Policy Model from Excel to R and discuss the lessons learnt throughout this process. The CVD model is a competing risk state transition cohort model. Read More

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October 2021