51,589 results match your criteria sodium channel

Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.

Aging Cell 2021 Jun 12:e13407. Epub 2021 Jun 12.

Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.

The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging-related kidney injury, we performed RNA-Seq on kidney extracts of young and aged mice. Expression of chloride (Cl) channel accessory 1 (CLCA1) mRNA and protein was increased in the kidneys of aged mice. Read More

View Article and Full-Text PDF

P2X3 receptors participate in purinergic inhibition of gastrointestinal smooth muscle.

Brian F King

Auton Neurosci 2021 Jun 5;234:102830. Epub 2021 Jun 5.

University College London (UCL), Research Department of Neuroscience, Pharmacology & Physiology (NPP), Gower Street, London WC1E 6BT, United Kingdom. Electronic address:

The ATP analogue α,β-meATP is a potent relaxant of gastrointestinal smooth muscle, but its molecular target is uncertain inside the gut. α,β-meATP relaxed the carbachol-precontracted guinea-pig taenia coli in a concentration-dependent manner (EC, 2.0 ± 0. Read More

View Article and Full-Text PDF

Effectiveness and Effect on Renal Parameters of Amlodipine vs. Other Dihydropyridine Calcium Channel Blockers in Patients with Essential Hypertension: Retrospective Observational Study Based on Real-World Evidence from Electronic Medical Records.

Cardiol Ther 2021 Jun 11. Epub 2021 Jun 11.

Heart and General Hospital, Jaipur, Rajasthan, India.

Introduction: The renoprotective effects of dihydropyridine calcium channel blockers (CCBs) have been established as non-inferior to other classes of antihypertensive drugs. Studying their effect on renal outcome parameters, specifically for amlodipine as monotherapy, in real-world settings can further help in expanding its usage among Indian patients. This study was performed to assess the effects of amlodipine and other dihydropyridine CCBs (cilnidipine, benidipine and azelnidipine) on renal parameters and effectiveness in blood pressure reduction in Indian patients. Read More

View Article and Full-Text PDF

KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum.

Brain 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Neurology Department, Lyon University Hospital, 69500 Bron, France.

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1), have been associated with a spectrum of epilepsies and neurodevelopmental disorders. These range from familial autosomal dominant or sporadic sleep-related hypermotor epilepsy ((AD)SHE) to epilepsy of infancy with migrating focal seizures (EIMFS) and include developmental and epileptic encephalopathies (DEE). This study aims to provide a comprehensive overview of the phenotypic and genotypic spectrum of KCNT1 mutation-related epileptic disorders in 248 individuals, including 66 unpreviously published and 182 published cases, the largest cohort reported so far. Read More

View Article and Full-Text PDF

Long QT syndrome - Bench to bedside.

Heart Rhythm O2 2021 Feb 22;2(1):89-106. Epub 2021 Jan 22.

Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio.

Long QT syndrome (LQTS) is a cardiovascular disorder characterized by an abnormality in cardiac repolarization leading to a prolonged QT interval and T-wave irregularities on the surface electrocardiogram. It is commonly associated with syncope, seizures, susceptibility to torsades de pointes, and risk for sudden death. LQTS is a rare genetic disorder and a major preventable cause of sudden cardiac death in the young. Read More

View Article and Full-Text PDF
February 2021

Overexpressed Na 1.7 Channels Confer Hyperexcitability to Trigeminal Sensory Neurons of Ca 2.1 Mutant Hemiplegic Migraine Mice.

Front Cell Neurosci 2021 25;15:640709. Epub 2021 May 25.

Department of Neuroscience, International School for Advanced Studies (SISSA), Trieste, Italy.

Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated Ca 2.1 Ca channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. Here, we show that the expression of Na 1. Read More

View Article and Full-Text PDF

An 80-Year-Old Woman with Alzheimer Disease and Accidental Poisoning with Pyrethroid Pesticide Successfully Treated with Intravenous Lipid Emulsion.

Am J Case Rep 2021 Jun 10;22:e928420. Epub 2021 Jun 10.

Department of Toxicology, Universidad del Valle (University del Valle), Cali, Colombia.

BACKGROUND Pesticides are commonly used in the agricultural industry. Overdose can be lethal due to its effects generating closure of the voltage-gated sodium channels in the axonal membranes. Most case reports of toxicity refer to skin exposure and there are very few that refer to effects due to its oral intake. Read More

View Article and Full-Text PDF

Reduction of the Structure Parameter of Forward Osmosis Membranes by Using Sodium Bicarbonate as Pore-Forming Agent.

Langmuir 2021 Jun 9. Epub 2021 Jun 9.

School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6619, Tehran 25529, Iran.

The forward osmosis (FO) process suffers from unfavorable internal concentration polarization (ICP) of the solute within the support layer of thin-film composite forward osmosis (TFC-FO) membranes. To lower the ICP effect, a support layer with low tortuosity, high porosity, and interconnected pores is necessary. In the present investigation, sodium bicarbonate has been presented as a simple pore-forming agent to decline the ICP within a poly(ethersulfone) substrate. Read More

View Article and Full-Text PDF

Molecular Monitoring of Knockdown Resistance in Head Louse (Phthiraptera: Pediculidae) Populations in Iran.

J Med Entomol 2021 Jun 9. Epub 2021 Jun 9.

Cellular and Molecular Research Center, Research Institute on Cellular and Molecular Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Knockdown resistance (kdr) is a common mechanism of insecticide resistance in head lice to the conventionally used pyrethroid pediculosis and can be the result of various amino acid substitutions within the voltage-sensitive sodium channel (VSSC). In this study, 54 sequences from varied specimens were investigated to monitor well-known resistance mutations and probable new mutations. The Pediculus humanus capitis de Geer specimens were collected from 13 provinces in Iran. Read More

View Article and Full-Text PDF

A Case Report of Recurrent Hypokalemia During Pregnancies Associated With Nonaldosterone-Mediated Renal Potassium Loss.

Can J Kidney Health Dis 2021 28;8:20543581211017424. Epub 2021 May 28.

Medical University of South Carolina, College of Medicine, Charleston, SC, USA.

Rationale: Geller et al reported a rare mutation in the mineralocorticoid receptor (MR) resulting in constitutive MR activity. Progesterone, normally an MR antagonist, acts as a potent agonist with this mutation. Progesterone levels can increase 100-fold during pregnancy and thus lead to increased MR activity in this setting, resulting in hypertension (HTN) and hypokalemia during pregnancy and resolution of hypokalemia after delivery. Read More

View Article and Full-Text PDF

Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain.

Acta Pharmacol Sin 2021 Jun 8. Epub 2021 Jun 8.

Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266073, China.

Voltage-gated sodium channel Nav1.7 robustly expressed in peripheral nociceptive neurons has been considered as a therapeutic target for chronic pain, but there is no selective Nav1.7 inhibitor available for therapy of chronic pain. Read More

View Article and Full-Text PDF

Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart.

Sci Rep 2021 Jun 8;11(1):12014. Epub 2021 Jun 8.

AnaBios Corporation, 3030 Bunker Hill St., Suite 312, San Diego, CA, 92109, USA.

Late sodium current (late INa) inhibition has been proposed to suppress the incidence of arrhythmias generated by pathological states or induced by drugs. However, the role of late INa in the human heart is still poorly understood. We therefore investigated the role of this conductance in arrhythmias using adult primary cardiomyocytes and tissues from donor hearts. Read More

View Article and Full-Text PDF


Georgian Med News 2021 Apr(313):173-176

2Tbilisi State Medical University, Georgia.

In this review, we discuss the role of adrenoceptors in the regulation of the rheological functions of erythrocytes. β-adrenoceptors play an important role in the regulation of erythrocytes functions and metabolism. They participate in the modification of transport membrane proteins (Na+/K+-ATPase, Ca+2-ATPase, Na+/K+/2Cl-cotransporter, Na+/H+-antiporter, CAT-1, Ca2+-dependent K+ channels (Gard channels), the activity of adenylate cyclase and cAMP, AMP-dependent activation of the L-arginine/NOS system and erythrocyte NOS) and by this way modulate the cells volume, rheological properties (deformability, aggregability), intensity of NO synthesis and ATP reliase. Read More

View Article and Full-Text PDF

Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis.

BMC Neurol 2021 Jun 8;21(1):217. Epub 2021 Jun 8.

Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Gunma, Japan.

Background: Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels. Read More

View Article and Full-Text PDF

Molecular survey of pyrethroid and fipronil resistance in isolates of Rhipicephalus microplus in the north of Uruguay.

Ticks Tick Borne Dis 2021 May 19;12(5):101747. Epub 2021 May 19.

Departamento de Patobiología, Unidad de Enfermedades Parasitarias, Facultad de Veterinaria, UDELAR. Av. Lasplaces 1620, CP 11600 Montevideo, Uruguay.

The resistance of Rhipicephalus microplus to acaricides is a serious control problem, so its early diagnosis by a molecular technique is important. This study aims to develop a multiplex allele-specific polymerase chain reaction (PCR) for single-nucleotide polymorphisms (SNPs) in the para-sodium channel gene and in the GABA-Cl gene, associated with pyrethroids (cypermethrin and flumethrin) and fipronil resistance, respectively. We used 22 tick field isolates from farms with tick control problems (sampling convenience). Read More

View Article and Full-Text PDF

Identification of a novel variant p.Ser606Gly in SCN3A associated with childhood absence epilepsy.

Epilepsy Res 2021 Jun 2;175:106682. Epub 2021 Jun 2.

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China. Electronic address:

Sodium (Na) channels are the basis for action potential generation and propagation, which play a key role in the regulation of neuronal excitability. SCN3A is a gene encoding for sodium channel protein type 3 subunit alpha (or known as Nav1.3). Read More

View Article and Full-Text PDF

The Na (SCN7A) channel: an atypical regulator of tissue homeostasis and disease.

Cell Mol Life Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Surgery, Northwestern University-Feinberg School of Medicine, Chicago, USA.

Within an articulately characterized family of ion channels, the voltage-gated sodium channels, exists a black sheep, SCN7A (Na). Na, in contrast to members of its molecular family, has lost its voltage-gated character and instead rapidly evolved a new function as a concentration-dependent sensor of extracellular sodium ions and subsequent signal transducer. As it deviates fundamentally in function from the rest of its family, and since the bulk of the impressive body of literature elucidating the pathology and biochemistry of voltage-gated sodium channels has been performed in nervous tissue, reports of Na expression and function have been sparse. Read More

View Article and Full-Text PDF

Ropivacaine induced systemic toxicity in a patient with phacomatosis pigmentokeratotica.

Indian J Pharmacol 2021 Mar-Apr;53(2):153-156

Department of Anesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Calculation of the maximum recommended dose of local anesthetic minimizes the risk of Local Anesthetic Systemic Toxicity (LAST) when administrating multiple blocks for lower limb surgeries. Ropivacaine is the preferred local anesthetic as it is less lipophilic than bupivacaine and thus results in less central nervous system (CNS) and cardiovascular toxicity. The presence of developmental, congenital, and metabolic disorders mandates an extracautious approach in the administration of large volume of Local anaesthesia (LA) as the vascularity of the limb, levels of alpha-1-acid glycoprotein, and sensitivity of the sodium channels may be altered. Read More

View Article and Full-Text PDF

Subcellular distribution of persistent sodium conductance in cortical pyramidal neurons.

J Neurosci 2021 Jun 4. Epub 2021 Jun 4.

Dept. of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel

Cortical pyramidal neurons possess a persistent Na current (I) which, in contrast to the larger transient current, does not undergo rapid inactivation. Although relatively quite small, I is active at subthreshold voltages and therefore plays an important role in neuronal input-output processing. The subcellular distribution of channels responsible for I and the mechanisms which render them persistent are not known. Read More

View Article and Full-Text PDF

Expression and purification of the cardiac sodium channel Na1.5 for cryo-EM structure determination.

Methods Enzymol 2021 12;653:89-101. Epub 2021 Mar 12.

Department of Pharmacology, University of Washington, Seattle, WA, United States. Electronic address:

Voltage-gated sodium channel Na1.5 is responsible for initiating and propagating cardiac action potentials by selectively conducting Na into cardiomyocytes. Class-I antiarrhythmic drugs target Na1. Read More

View Article and Full-Text PDF

Structural determination of human Na1.4 and Na1.7 using single particle cryo-electron microscopy.

Methods Enzymol 2021 27;653:103-120. Epub 2021 Apr 27.

State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:

Voltage-gated sodium (Na) channels are responsible for the initiation and propagation of action potentials. Their abnormal functions are associated with numerous diseases, such as epilepsy, cardiac arrhythmia, and pain syndromes. Therefore, these channels represent important drug targets. Read More

View Article and Full-Text PDF

Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult.

J Med Chem 2021 Jun 7. Epub 2021 Jun 7.

Chemistry Department, University of Milan, Via Golgi 19, 20133 Milan, Italy.

Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca ions, listed among putative targets in central nervous system (CNS) diseases in which a pH modification occurs. We targeted novel compounds able to modulate ASIC1 and to reduce the progression of ischemic brain injury. We rationally designed and synthesized several diminazene-inspired diaryl mono- and bis-guanyl hydrazones. Read More

View Article and Full-Text PDF

Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Na) channels properties.

Neurobiol Stress 2021 Nov 14;15:100338. Epub 2021 May 14.

Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. Read More

View Article and Full-Text PDF
November 2021

Regulatory control of the Na-Cl co-transporter NCC and its therapeutic potential for hypertension.

Acta Pharm Sin B 2021 May 22;11(5):1117-1128. Epub 2020 Sep 22.

Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.

Hypertension is the largest risk factor for cardiovascular disease, the leading cause of mortality worldwide. As blood pressure regulation is influenced by multiple physiological systems, hypertension cannot be attributed to a single identifiable etiology. Three decades of research into Mendelian forms of hypertension implicated alterations in the renal tubular sodium handling, particularly the distal convoluted tubule (DCT)-native, thiazide-sensitive Na-Cl cotransporter (NCC). Read More

View Article and Full-Text PDF

Differential Functional Changes of Nav1.2 Channel Causing -Related Epilepsy and Status Epilepticus During Slow Sleep.

Front Neurol 2021 19;12:653517. Epub 2021 May 19.

Pediatric Department, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Nav1.2 encoded by the gene is a brain-expressed voltage-gated sodium channel known to be associated with neurodevelopment disorders ranging from benign familial neonatal infantile seizures (BFIS) to developmental and epileptic encephalopathy (DEE) and autism spectrum disorder. Interestingly, status epilepticus during slow sleep (ESES), which aggravates cognitive impairment, has been found in -related epilepsy. Read More

View Article and Full-Text PDF

Ion Channels and Electrophysiological Properties of Astrocytes: Implications for Emergent Stimulation Technologies.

Front Cell Neurosci 2021 20;15:644126. Epub 2021 May 20.

Department of Neuroscience, Carleton University, Ottawa, ON, Canada.

Astrocytes comprise a heterogeneous cell population characterized by distinct morphologies, protein expression and function. Unlike neurons, astrocytes do not generate action potentials, however, they are electrically dynamic cells with extensive electrophysiological heterogeneity and diversity. Astrocytes are hyperpolarized cells with low membrane resistance. Read More

View Article and Full-Text PDF

Lamotrigine and Stevens-Johnson Syndrome Prevention.

Psychopharmacol Bull 2021 Mar;51(2):96-114

Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.

Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The condition centers around a delayed-type hypersensitivity reaction with a complex etiology stemming from a variety of causes. The number one cause is medication-related-common ones including sulfonamides, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. Read More

View Article and Full-Text PDF

Corrigendum to "Voltage-gated sodium channel Nav1.5 promotes tumor progression and enhances chemosensitivity to 5-fluorouracil in colorectal cancer" [Canc. Lett. 500 (2021) 119-131].

Cancer Lett 2021 Jun 3;516:57-60. Epub 2021 Jun 3.

Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China; State Key Laboratory of Oncology in South China, Guangzhou, 510060, PR China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, PR China. Electronic address:

View Article and Full-Text PDF