23,583 results match your criteria smell

Olfaction, cholinergic basal forebrain degeneration, and cognition in early Parkinson disease.

Parkinsonism Relat Disord 2021 Jul 27;90:27-32. Epub 2021 Jul 27.

Department of Radiology and Medical Imaging, Division of Neuroradiology, University of Virginia Health System, Charlottesville, VA, USA.

Introduction: Impaired olfaction and reduced cholinergic nucleus 4 (Ch4) volume both predict greater cognitive decline in Parkinson's disease (PD). We examined the relationship between olfaction, longitudinal change in cholinergic basal forebrain nuclei and their target regions, and cognition in early PD.

Methods: We analyzed a cohort of 97 PD participants from the Parkinson's Progression Markers Initiative with brain MRIs at baseline, 1 year, 2 years, and 4 years. Read More

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Transmission of SARS-CoV-2 in the household setting: a prospective cohort study in children and adults in England.

J Infect 2021 Aug 1. Epub 2021 Aug 1.

Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ, London, United Kingdom. Electronic address:

Objectives: To measure secondary attack rates (SARs) in prospectively followed household contacts of paediatric and adult cases of SARS-CoV-2 infection in England.

Methods: Self-taken nasal swabs from household contacts of PCR confirmed cases of COVID-19 and blood samples on day 35 were tested for evidence of infection with SARS-CoV-2 virus.

Results: The secondary attack rate (SAR) among 431 contacts of 172 symptomatic index cases was 33% (95% confidence intervals [CI] 25-40) and was lower from primary cases without respiratory symptoms, 6% (CI 0-14) vs 37% (CI 29-45), p=0. Read More

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Levels of SERPIN family proteins in peri-implant crevicular fluid in patients with peri-implantitis.

J Clin Lab Anal 2021 Aug 4:e23926. Epub 2021 Aug 4.

Department of Stomatology, Fujian Medical University Union Hospital, Fuzhou, China.

Purpose: Serine protease inhibitors (SERPINs) family has been discovered in many disorders with proteolysis mechanisms. Our study determined the SERPINBs protein expression via public-based GEO databases and further validated by peri-implant crevicular fluid (PICF) of peri-implantitis patients and healthy recruiters.

Methods: This study is a retrospective analysis. Read More

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Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries.

Autism Res 2021 Aug 4. Epub 2021 Aug 4.

Department of Women's and Children's Health, Skaraborgs Hospital, Skövde, Sweden.

The Childhood Autism Rating Scale (CARS) is a simple and inexpensive tool for Autism spectrum disorder (ASD) assessments, with evidenced psychometric data from different countries. However, it is still unclear whether ASD symptoms are measured the same way across different societies and world regions with this tool, since data on its cross-cultural validity are lacking. This study evaluated the cross-cultural measurement invariance of the CARS among children with ASD from six countries, for whom data were aggregated from previous studies in India (n = 101), Jamaica (n = 139), Mexico (n = 72), Spain (n = 99), Turkey (n = 150), and the United States of America (n = 186). Read More

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No evidence for association between human body odor quality and immune system functioning.

Psychoneuroendocrinology 2021 Jul 20;132:105363. Epub 2021 Jul 20.

Department of Zoology, Faculty of Science, Charles University, Viničná 7, 128 44 Prague, Czech Republic; National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic.

Previous studies have shown that women perceive male faces with a more reactive immune system as more attractive, but whether body odor might likewise provide cues to immune function has not been investigated yet. These two studies tested a possible relationship between body odor quality and immunoreactivity (Study 1) and immune system function (Study 2). In Study 1, we collected body odor samples from 21 men just before and two weeks after vaccination against hepatitis A/B and meningococcus. Read More

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Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infection.

Clin Immunol 2021 Jul 31:108814. Epub 2021 Jul 31.

Laboratory of Nuclear Lipid BioPathology, Centro Ricerche Analisi Biochimico Specialistiche, Perugia, Italy. Electronic address:

Better understanding of antibody responses against SARS-CoV-2 after natural infection might provide valuable insights into the future implementation of vaccination policies.Longitudinal analysis of IgG antibody titers was carried out in 32 recovered COVID-19 patients based in the Umbria region of Italy for 14 months after Mild and Moderately-Severe infection.Two FDA-approved immunoassays against SARS-CoV-2 Nucleocapsid protein(NCP) and anti-spike-receptor binding domain(S-RBD) were used for sequential serological tests at different time points. Read More

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Effects of Fluticasone Exhalation Delivery System in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review.

Am J Rhinol Allergy 2021 Aug 3:19458924211033214. Epub 2021 Aug 3.

Department of Otolaryngology, Capital Institute of Pediatrics, Beijing, China.

Background: Nasal sprays with corticosteroids deliver medication to the restricted areas including anterior and inferior parts of the nasal cavity. The fluticasone exhalation delivery system (EDS-FLU) has recently been proved to improve care by increasing superior/posterior intranasal corticosteroid deposition.

Objective: This study aims to evaluate the efficacy of EDS-FLU in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Read More

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The study of recovery rates of COVID-19 olfactory and gustatory dysfunctions requires psychophysical evaluations.

Am J Otolaryngol 2021 Jul 29;42(6):103168. Epub 2021 Jul 29.

COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy; Biomedical Science PhD School, Biomedical Science Department, University of Sassari, Italy.

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The mechanisms of smell loss after SARS-CoV-2 infection.

Richard L Doty

Lancet Neurol 2021 Jul 30. Epub 2021 Jul 30.

Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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Post-viral effects of COVID-19 in the olfactory system and their implications.

Lancet Neurol 2021 Jul 30. Epub 2021 Jul 30.

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

Background: The mechanisms by which any upper respiratory virus, including SARS-CoV-2, impairs chemosensory function are not known. COVID-19 is frequently associated with olfactory dysfunction after viral infection, which provides a research opportunity to evaluate the natural course of this neurological finding. Clinical trials and prospective and histological studies of new-onset post-viral olfactory dysfunction have been limited by small sample sizes and a paucity of advanced neuroimaging data and neuropathological samples. Read More

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Playing Tetris Lets You Rate Odors as Less Intense.

Front Psychol 2021 14;12:657188. Epub 2021 Jul 14.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Overweight and obesity are considered a huge problem in modern societies. Previous studies have shown that people who are regularly distracted by playing videogames or watching TV while eating are more likely to be overweight and that the number of people that are gaming worldwide is rising. Further, it has been established that both, watching TV or playing video games lead to an increased snack intake and a lower rating of perceived taste intensity. Read More

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Turk J Med Sci 2021 Aug 2. Epub 2021 Aug 2.

Background/aim: This study aims evaluation of olfactory and gustatory function of COVID-19 patients and possible risk factors for olfactory and gustatory disfunction.

Materials And Methods: The study included adult patients who diagnosed with COVID-19 in XXXX University Hospital between April 2020 and June 2020. Volunteered patients participated to a survey in which olfactory and gustatory function and various clinical information were questioned. Read More

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The prevalence of olfactory and gustatory dysfunction in covid-19 - A systematic review.

Auris Nasus Larynx 2021 Jul 15. Epub 2021 Jul 15.

Department of Medical Research, Cathay General Hospital, Taipei, Taiwan; Department of Otolaryngology Head & Neck Surgery, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Objectives: Loss of smell or taste are early symptoms of COVID-19. Given the high asymptomatic rate of COVID-19, as well as unreliable temperature checking and contact history taking, it is important to understand the role of olfactory and gustatory dysfunction (OGD) in the diagnosis of COVID-19. The aim of this study is to determine how initial symptoms of OGD can be used to screen patients for COVID-19 laboratory testing. Read More

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Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A).

Am J Med Genet A 2021 Jul 30. Epub 2021 Jul 30.

National Eye Institute, Bethesda, Maryland, USA.

Sensorineural hearing loss (SNHL) is characteristic of Usher syndrome type 2 (USH2), but less is known about SNHL in nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) and olfaction in USH2A-associated retinal degeneration. The Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) is a natural history study that enrolled 127 participants, 80 with USH2 and 47 with ARRP. Hearing was measured by pure-tone thresholds and word recognition scores, and olfaction by the University of Pennsylvania Smell Identification Test (UPSIT). Read More

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The attractive effects of amino acids and some classical substances on grass carp (Ctenopharyngodon idellus).

Fish Physiol Biochem 2021 Jul 31. Epub 2021 Jul 31.

Hubei Provincial Engineering Laboratory for Pond Aquaculture, College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.

Grass carp (Ctenopharyngodon idellus) is one of the most essential fishing species in China. The bait for this fish is rapidly developing. However, the study on the attractants in the bait for this fish lacks. Read More

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Dietary supplements and herbal medicine for COVID-19: A systematic review of randomized control trials.

Clin Nutr ESPEN 2021 08 1;44:50-60. Epub 2021 Jun 1.

Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Department of Rehabilitation, Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen, Guangdong, China. Electronic address:

Background: The world is currently struggling with the Coronavirus disease 2019 (COVID-19) pandemic. Dietary supplements (DSs) and herbal medicine provide a potentially convenient and accessible method for its recovery, but direct evidence is limited.

Objective: This study aims to investigate the effectiveness of DSs and herbs in patients with COVID-19. Read More

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Visits for Possible COVID-19 in a Pediatric Primary Care Practice Early in the Pandemic.

R I Med J (2013) 2021 Aug 2;104(6):43-48. Epub 2021 Aug 2.

Division of General Pediatrics, Department of Pediatrics, Alpert Medical School of Brown University/Hasbro Children's Hospital, Providence, RI.

Background: Children with COVID-19 usually present with mild symptoms. We characterize visits with respect to symptoms and testing in the outpatient setting.

Methods: A retrospective chart review of sick visits in a pediatric academic primary care clinic April-August 2020. Read More

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Be here now: Perceptions of uncertainty enhance savoring.

Emotion 2021 Jul 29. Epub 2021 Jul 29.

School of Social Ecology.

Savoring-an emotion-regulation strategy that involves deliberately upregulating positive affect-has many benefits, but what enhances savoring in the present moment? Drawing from life-history theory, affective and developmental science, and social-psychological frameworks, we examined the idea that perceptions of uncertainty--perceiving the world as random and unpredictable-enhance subsequent savoring. In a large experience-sampling study (Study 1, = 6,680), we found that individuals who perceived more uncertainty showed increases in subsequent savoring in their daily lives. In a preregistered experiment (Study 2, = 397), individuals who watched a film that induced uncertainty (vs. Read More

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COVID-19 In Lung transplant recipients: A single-center experience.

Transpl Infect Dis 2021 Jul 29. Epub 2021 Jul 29.

University of Health Sciences, Ankara City Hospital, Department of Thoracic Surgery and Lung Transplantation, Ankara, Turkey.

Background: Coronavirus disease 2019 (COVID-19) is a global health problem. However, the course of this disease in immunosuppressed patients remains unknown. This study aimed to describe the course of COVID-19 infection and its effects on lung transplant recipients. Read More

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Blindness, But Not HMHA Anosmia, Predicts Loneliness: A Psychophysical Study.

Pers Soc Psychol Bull 2021 Jul 29:1461672211034376. Epub 2021 Jul 29.

Institute of Psychology, University of Wroclaw, Poland.

Olfactory deficits can play a detrimental role in everyday social functioning. Perception of 3-hydroxy-3-methylhexanoic acid (HMHA)-a body odor component-could also be linked to this research area. However, no study so far has addressed the problem of HMHA perception in the context of the previously reported relationship between olfactory abilities and social difficulties. Read More

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Impairment of olfactory and gustatory sensations in severe acute respiratory syndrome corona virus 2 (SARS-CoV-2 virus) disease.

J Family Med Prim Care 2021 Jun 2;10(6):2153-2158. Epub 2021 Jul 2.

Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-graduate Research Institute, Parbhani, Maharashtra, India.

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2 virus) disease had first appeared in December 2019 in Wuhan, China, and since then, it has emerged as a global threat to humanity. An early diagnosis and isolation are the most significant measures required to prevent its spread. Recent anecdotal evidence has suggested impairment of olfactory and gustatory sensations associated with corona virus disease (COVID-19). Read More

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Development and Validation of a Prognostic Model for Cognitive Impairment in Parkinson's Disease With REM Sleep Behavior Disorder.

Front Aging Neurosci 2021 12;13:703158. Epub 2021 Jul 12.

Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The presentation and progression of Parkinson's disease (PD) are not uniform, but the presence of rapid eye movement sleep behavior disorder (RBD) in PD patients may indicate a worse prognosis than isolated PD. Increasing evidence suggests that patients with comorbid PD and RBD (PD-RBD) are more likely to develop cognitive impairment (CI) than those with isolated PD; however, the predictors of CI in PD-RBD patients are not well understood. This study aimed to develop a prognostic model for predicting mild cognitive impairment (MCI) in PD-RBD patients. Read More

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Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland.

Infect Prev Pract 2020 Sep 15;2(3):100076. Epub 2020 Jul 15.

Department of Infectious Diseases, St. James's Hospital Dublin, Ireland.

Background: Coronaviruses are known to precipitate disorders of smell and taste function. With the emerging global coronavirus disease (CoVID19) pandemic due to the severe acute respiratory syndrome coronavirus 2, early reports suggested that smell and taste dysfunction were clinical features of CoVID19. Our study aimed to investigate the prevalence of smell and taste disturbances in a cohort of CoVID19 positive patients who were isolated at home and being medically managed through telephone consultation. Read More

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September 2020

Seeing Beyond Your Nose? The Effects of Lifelong Olfactory Sensory Deprivation on Cerebral Audio-visual Integration.

Neuroscience 2021 Jul 24. Epub 2021 Jul 24.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Monell Chemical Senses Center, Philadelphia, PA, United States; Department of Psychology, University of Pennsylvania, Philadelphia, United States; Stockholm University Brain Imaging Centre, Stockholm University, Stockholm, Sweden.

Lifelong auditory and visual sensory deprivation have been demonstrated to alter both perceptual acuity and the neural processing of remaining senses. Recently, it was demonstrated that individuals with anosmia, i.e. Read More

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Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

EClinicalMedicine 2021 Jul 15:101019. Epub 2021 Jul 15.

Patient-Led Research Collaborative.

Background: A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. Few systematic studies have investigated this population, particularly in outpatient settings. Hence, relatively little is known about symptom makeup and severity, expected clinical course, impact on daily functioning, and return to baseline health. Read More

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Assessing Knowledge and Practices of the Community towards Corona Virus Disease 2019 in Mbale Municipality, Uganda: Across Section Study.

East Afr Health Res J 2021 11;5(1):20-25. Epub 2021 Jun 11.

Islamic University in Uganda.

Background: The Corona virus disease, first identified in Wuhan city, Hubei province of China, is a respiratory illness caused by Novel Corona Virus also known as Severe Acute Respiratory Syndrome Corona Virus 2 (SARS Cov.2). The disease is characterised by; dry cough and shortness of breath with difficulty in breathing and at least 2 of the following; fever, chills, muscle pain, headache, sore throat and loss of test and smell. Read More

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Olfactory and Gustatory Dysfunctions in Patients With Laboratory-Confirmed COVID-19 Infection: A Change in the Trend.

Indian J Otolaryngol Head Neck Surg 2021 Jul 18:1-7. Epub 2021 Jul 18.

Department of Otorhinolaryngology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029 India.

To study the presence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection in our set up. Longitudinal study, 1st March 2020-15th August 2020, at a tertiary care hospital. RT PCR positive for SARSCoV-2 patients, above 18 years age included. Read More

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Quantitative analysis of taste disorder in COVID-19 patients, the hypersensitivity to salty quality.

New Microbes New Infect 2021 Jul 17:100919. Epub 2021 Jul 17.

Otorhinolaryngology, head & neck surgery department of Baqiyatallah University of Medical Sciences, Tehran, Iran.

Recently, many of studies have illustrated that the new pandemic SARS-CoV-2 can affect Central Nervous System through olfactory bulb. In addition to investigating anosmia or hyposmia induced by this virus, the quantitative analysis was needed to clarify the taste and smell disorder of the new corona virus The four basic taste quality with five concentrations for sweet, sour, bitter and salty were administered in to 75 subject divided in to three groups: COVID-19 patients with taste disorder, COVID-19 patients without taste disorder and control group. The results indicated the increment of sweet (2. Read More

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High Prevalence of Early Parkinson's Disease in Patients With Subtle Parkinsonian Signs.

Shoichi Sasaki

Front Neurol 2021 9;12:656679. Epub 2021 Jul 9.

Department of Neurology, Agano City Hospital, Niigata, Japan.

Little is known about how frequently patients with a Unified Parkinson Disease Rating Scale part III (UPDRS-III) score of 3 or 4, including postural and action tremor, could be classified into early Parkinson's disease (PD). To examine the prevalence of early PD in patients with subtle parkinsonian signs (rest tremor, postural tremor, and rigidity) without bradykinesia, having a UPDRS-III score of 3 or 4. Parkinsonism was assessed using UPDRS-III based on both the United Kingdom PD Society Brain Bank criteria and the Movement Disorder Society PD criteria. Read More

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Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits.

Front Neural Circuits 2021 7;15:662349. Epub 2021 Jul 7.

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States.

Our sensory systems such as the olfactory and visual systems are the target of neuromodulatory regulation. This neuromodulation starts at the level of sensory receptors and extends into cortical processing. A relatively new group of neuromodulators includes cannabinoids. Read More

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