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Examining concurrent validity between COMLEX-USA Level 2-Cognitive Evaluation and COMLEX-USA Level 2-Performance Evaluation.

J Osteopath Med 2021 May 13. Epub 2021 May 13.

Midwestern University, Glendale, AZ, USA.

Context: The Comprehensive Osteopathic Medical Licensing Examination of the United States of America (COMLEX-USA) is a three level examination used as a pathway to licensure for students in osteopathic medical education programs. COMLEX-USA Level 2 includes a written assessment of Fundamental Clinical Sciences for Osteopathic Medical Practice (Level 2-Cognitive Evaluation [L2-CE]) delivered in a computer based format and separate performance evaluation (Level 2-Performance Evaluation [L2-PE]) administered through live encounters with standardized patients. L2-PE was designed to augment L2-CE. Read More

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Influence of the Head Neck Position on Imaging Measurements Used to Assess the Craniovertebral Junction in Small Breed Dogs: A Cadaveric Study.

Vet Comp Orthop Traumatol 2021 May 12. Epub 2021 May 12.

Department of Clinical Veterinary Medicine, Clinical Radiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Objective:  The study aimed to determine the influence of head neck position on imaging measurements used to assess the craniovertebral junction (CVJ) and to recommend the most appropriate position for the evaluation of the CVJ.

Study Design:  A cross-sectional sample of adult dogs' cadavers was subjected to a computed tomography scan of the cranium and the cranial cervical region in three standardized head positions. Imaging measurements often used to assess the CVJ were measured. Read More

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Structural neuroimaging phenotypes of a novel multi-gene risk score in youth bipolar disorder.

J Affect Disord 2021 Apr 28;289:135-143. Epub 2021 Apr 28.

University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Bipolar disorder (BD) is among the most heritable psychiatric disorders, particularly in early-onset cases, owing to multiple genes of small effect. Here we examine a multi-gene risk score (MGRS), to address the gap in multi-gene research in early-onset BD.

Methods: MGRS was derived from 34 genetic variants relevant to neuropsychiatric diseases and related systemic processes. Read More

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The duration of antibiotic treatment is associated with carriage of toxigenic and non-toxigenic strains of Clostridioides difficile in dogs.

PLoS One 2021 12;16(5):e0245949. Epub 2021 May 12.

Veterinary Pathology, Public Health and Disease Investigation, School of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.

Clostridioides difficile is a leading cause of human antibiotic-associated diarrhoeal disease globally. Zoonotic reservoirs of infection are increasingly suspected to play a role in the emergence of this disease in the community and dogs are considered as one potential source. Here we use a canine case-control study at a referral veterinary hospital in Scotland to assess: i) the risk factors associated with carriage of C. Read More

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Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents With Social Anxiety Disorder: A Randomized Clinical Trial.

JAMA Psychiatry 2021 May 12. Epub 2021 May 12.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Importance: Social anxiety disorder (SAD) is a prevalent childhood-onset disorder associated with lifelong adversity and high costs for the individual and society at large. Cognitive behavioral therapy (CBT) is an established evidence-based treatment for SAD, but its availability is limited.

Objective: To assess the efficacy and cost-effectiveness of therapist-guided internet-delivered cognitive behavioral therapy (ICBT) for SAD in youths vs an active comparator, internet-delivered supportive therapy (ISUPPORT). Read More

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An evaluation of assumptions underlying respondent-driven sampling and the social contexts of sexual and gender minority youth participating in HIV clinical trials in the United States.

J Int AIDS Soc 2021 May;24(5):e25694

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Introduction: Respondent-driven sampling (RDS) has been an effective sampling strategy for HIV research in many settings, but has had limited success among some youth in the United States. We evaluated a modified RDS approach for sampling Black and Latinx sexual and gender minority youth (BLSGMY) and explored how lived experiences and social contexts of BLSGMY youth may impact traditional RDS assumptions.

Methods: RDS was implemented in three US cities, Baltimore, Philadelphia and Washington DC, to engage BLSGMY aged 15 to 24 years in HIV prevention or care intervention trials. Read More

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Efficient and gentle delivery of molecules into cells with different elasticity Progressive Mechanoporation.

Lab Chip 2021 May 12. Epub 2021 May 12.

Max Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, 91058 Erlangen, Germany.

Intracellular delivery of cargo molecules such as membrane-impermeable proteins or drugs is crucial for cell treatment in biological and medical applications. Recently, microfluidic mechanoporation techniques have enabled transfection of previously inaccessible cells. These techniques create transient pores in the cell membrane by shear-induced or constriction contact-based rapid cell deformation. Read More

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Higher Cerebral Small Vessel Disease Burden is Associated with Smaller Hematoma Volume in Mixed-Location Intracerebral Hemorrhage.

Microcirculation 2021 May 12:e12705. Epub 2021 May 12.

Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, China.

Objective: To study the relationship between cerebral small vessel disease (CSVD) and hematoma volume in mixed-location intracerebral hemorrhage (ICH), and non-mixed ICH (hypertensive arteriopathy/cerebral amyloid angiopathy-related ICH).

Methods: We consecutively collected patients with primary ICH with MRI. Mixed-location ICH was defined as having ICH or cerebral microbleeds (CMBs) in both lobar and deep regions. Read More

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Which particles to select, and if yes, how many? : Subsampling methods for Raman microspectroscopic analysis of very small microplastic.

Anal Bioanal Chem 2021 May 12. Epub 2021 May 12.

Institute of Hydrochemistry, Chair of Analytical Chemistry and Water Chemistry, Technical University of Munich, Elisabeth-Winterhalter-Weg 6, 81377, Munich, Germany.

Micro- and nanoplastic contamination is becoming a growing concern for environmental protection and food safety. Therefore, analytical techniques need to produce reliable quantification to ensure proper risk assessment. Raman microspectroscopy (RM) offers identification of single particles, but to ensure that the results are reliable, a certain number of particles has to be analyzed. Read More

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Automated location invariant animal detection in camera trap images using publicly available data sources.

Ecol Evol 2021 May 10;11(9):4494-4506. Epub 2021 Mar 10.

School of IT and Engineering Melbourne Institute of Technology Melbourne Vic. Australia.

A time-consuming challenge faced by camera trap practitioners is the extraction of meaningful data from images to inform ecological management. An increasingly popular solution is automated image classification software. However, most solutions are not sufficiently robust to be deployed on a large scale due to lack of location invariance when transferring models between sites. Read More

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Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):227-231. Epub 2021 Apr 12.

Department of Cornea and Refractive Surgery, Instituto de Oftalmología, Conde de Valenciana, Mexico City, Mexico.

A 28-year-old male presented unilateral visual loss, intense ocular pain, redness and intraocular hypertension in his right eye 2 days after undergoing small-incision lenticule extraction (SMILE) in both eyes. Initial examination of the affected eye revealed the presence of white infiltrates within the corneal interface, as well as a central epithelial defect. The patient was diagnosed with infectious keratitis, posteriorly the eye was irrigated with balanced saline solution and treatment was initiated with hourly moxifloxacin 0. Read More

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Effectiveness of Tongue Crib Combination Treating Severe Skeletal Angle Class III Malocclusion in Mixed Dentition.

Int J Clin Pediatr Dent 2020 Nov-Dec;13(6):668-676

Oral Department, General Hospital of Datong Coal Mine, Datong, Shanxi, China.

Objective: To evaluate the treatment effects of tongue crib combination for treating severe skeletal Angle class III malocclusion in mixed dentition by X-ray cephalometric analysis.

Materials And Methods: A sample of 22 patients with severe skeletal Angle class III malocclusion of deficiency maxilla and overgrown mandible in mixed dentition was prospectively collected and equally divided into two groups. The patients (males 6 and females 5; mean age 8. Read More

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The RNA landscape of the human placenta in health and disease.

Nat Commun 2021 May 11;12(1):2639. Epub 2021 May 11.

Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long and small RNAs (~101 and 20 million reads per sample respectively) from 302 human placentas, including 94 cases of preeclampsia (PE) and 56 cases of fetal growth restriction (FGR). Read More

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County-level Predictors of Growth in Community-based Primary Care Use Among Veterans.

Med Care 2021 Jun;59(Suppl 3):S301-S306

Informatics, Decision-Enhancement and Analytic Sciences Center, VA Salt Lake City Health Care System.

Background: The 2014 Choice Act expanded the Veterans Health Administration's (VA) capacity to purchase services for VA enrollees from community providers, yet little is known regarding the growth of Veterans' primary care use in community settings.

Objectives: The aim was to measure county-level growth in VA community-based primary care (CBPC) penetration following the Choice Act and to assess whether CBPC penetration increased in rural counties with limited access to VA facilities.

Data And Sample: A total of 3132 counties from VA administrative data from 2015 to 2018, Area Health Resources Files, and County Health Rankings. Read More

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Determination of ultra-trace levels of titanium in human serum using inductively coupled plasma tandem mass spectrometry based on O/H reaction gas.

Anal Chim Acta 2021 Jun 24;1165:338564. Epub 2021 Apr 24.

Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410013, PR China.

This study proposes a new strategy to determine ultra-trace Ti in human serum using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). The human serum samples were diluted with 1% (v/v) HNO, followed by the determination of ultra-trace Ti using ICP-MS/MS. In the MS/MS mode, a small amount of H was mixed with O (the reaction gas) in a collision reaction cell (CRC) to form an O/H reaction mixture, and then, the conversion of Ti to TiO was determined by the O mass shift method. Read More

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Impacts of group stunning on the behavioral and physiological parameters of pigs and sheep in a small abattoir.

Meat Sci 2021 May 5;179:108538. Epub 2021 May 5.

Department of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:

This study investigated reactions of pigs (N = 148) and sheep (N = 77) to group stunning where animals were present for the slaughter of others. Mock stunning with an isolated animal was used as the control. In both species, there was little evidence to suggest a difference in blood glucose and cortisol with stun order (P ≥ 0. Read More

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Exploration of shear wave elastography measures of the iliotibial band during different tasks in pain-free runners.

Phys Ther Sport 2021 Apr 30;50:121-129. Epub 2021 Apr 30.

The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Qld, 4072, Australia. Electronic address:

Objectives: To determine whether shear wave velocity (SWV) of the iliotibial band (ITB): i) increases with active and passive static tasks, and a dynamic task, ii) differs between ITB regions, iii) changes after exposure to running. Additionally, it aimed to determine the between-day reliability.

Design: Case series & test-retest. Read More

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Intestinal amyloidosis: Clinical manifestations and diagnostic challenge.

Adv Clin Exp Med 2021 May 11. Epub 2021 May 11.

Department of Hematology, Transplantation and Internal Medicine, University Clinical Center of the Medical University of Warsaw, Poland.

Amyloidosis is a heterogeneous group of diseases in which the extracellular deposition of abnormal fibrillar proteins disrupts tissue structure and function. Intestinal involvement is a very rare manifestation of amyloidosis compared to the most affected organs, the heart and kidneys. Damage of the gastrointestinal tract may be the only manifestation of amyloidosis, or - more often - is a component of the involvement of several organs in systemic amyloidosis. Read More

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Non-invasive preimplantation genetic testing for putative mosaic blastocysts: a pilot study.

Hum Reprod 2021 May 11. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Anhui, China.

Study Question: What is the potential of applying non-invasive preimplantation genetic testing (niPGT) for chromosome abnormalities in blastocysts reported with a mosaic trophectoderm (TE) biopsy?

Summary Answer: niPGT of cell-free DNA in blastocyst culture medium exhibited a good diagnostic performance in putative mosaic blastocysts.

What Is Known Already: Advances in niPGT have demonstrated the potential reliability of cell-free DNA as a resource for genetic assessment, but information on mosaic embryos is scarce because the mosaicism may interfere with niPGT. In addition, the high incidence of mosaicism reported in the context of PGT and the viability of mosaic blastocysts raise questions about whether mosaicism really exists. Read More

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Rethinking Farkas: Updating Cephalic Index Norms in a Large, Diverse Population.

Plast Reconstr Surg 2021 May 10. Epub 2021 May 10.

From the Division of Plastic Surgery, Department of Surgery, and the Department of Quantitative Health Sciences, Division of Biostatistics, University of Massachusetts Medical School.

Background: Cephalic index, the ratio of head width to length, is frequently used in decision-making in craniofacial surgery. Insurers derive criteria for helmet authorization for plagiocephaly based on deviations from norms, with one indicator being cephalic index. Current cephalic index norms were established by the Farkas and Munro data set, a small sample of Caucasian children published in 1987. Read More

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Autocatalytic photodegradation of [Ru(II)(2,2'-bipyridine)DAD] (DADH = 1,2-dihydroxyanthracene-9,10-dione) by hydrogen peroxide under acidic aqueous conditions.

Dalton Trans 2021 May 11. Epub 2021 May 11.

Molecular Photonics Laboratory, Chemistry-School of Natural & Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.

As part of a continuing effort to identify ruthenium agents capable of the photorelease of anthraquinone-based ligands the complexes Δ/Λ-[Ru(bpy)2DAD]+ (bpy = 2,2'-bipyridine) were produced by the reaction of 1,2-dihydroxyanthracene-9,10-dione (DADH) with chirally pure Δ/Λ-[Ru(bpy)2(py)2][(+)-O,O'-dibenzoyl-d-tartrate]·12H2O (py = pyridine). A very subtle difference in the chemical shift of the hydroxyl proton in their high-field 1H NMR spectra was observed, supporting that the OH proton is susceptible to a small change in environment at the metal centre. The excited state lifetime of the complexes, as measured by femtosecond pump-probe spectroscopy, was 7. Read More

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Immune subgroup analysis for non-small cell lung cancer may be a good choice for evaluating therapeutic efficacy and prognosis.

Aging (Albany NY) 2021 May 11;13. Epub 2021 May 11.

Department of Oncology, Jinan Central Hospital, Shandong University, Jinan 250013, Shandong, P.R. China.

Due to its effectiveness, cancer immunotherapy has attracted widespread attention from clinicians and scientific researchers. Numerous studies have proven that effective stratification of cancer patients would promote the personalized application of immunotherapy. Therefore, we used the transcriptome data of nearly 1,000 patients with non-small cell lung cancer (NSCLC) to construct a new immune subgroup. Read More

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Investigating Barriers to Vaccination Among Durham County's Vulnerable Populations.

N C Med J 2021 May-Jun;82(3):164-170

Assistant research professor, Sanford School of Public Policy, Duke University, Durham, North Carolina.

Background: As antivaccination movements increase in the United States, underlying structural barriers to vaccination are often ignored. This study examines barriers to vaccination in an adult population to uncover factors leading to vaccination rates in underserved populations.

Methods: This study was approved by the Duke University Campus Institutional Review Board. Read More

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Pediatric Refugee Health and Patterns of Health Care Utilization in Durham, North Carolina.

N C Med J 2021 May-Jun;82(3):157-163

Professor, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: This study explored the health needs, trends of health care utilization, and barriers to care of a diverse population of refugee children resettled in Durham County, North Carolina.

Methods: Researchers conducted a retrospective chart review of 327 pediatric (aged 0-21 years) refugee patients who received care at Lincoln Community Health Center from 2016 to 2018.

Results: Results describe a low prevalence of infectious diseases, such as human immunodeficiency virus (0%), hepatitis B (2%), and tuberculosis (5%), but a high prevalence of nutritional problems, such as growth stunting (17%), overweight (21%), Vitamin D insufficiency (79% of the 39 tested), and anemia (13%). Read More

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Conducting national burden of disease studies in small countries in Europe- a feasible challenge?

Arch Public Health 2021 May 11;79(1):73. Epub 2021 May 11.

Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.

Background: Burden of Disease (BoD) studies use disability-adjusted life years (DALYs) as a population health metric to quantify the years of life lost due to morbidity and premature mortality for diseases, injuries and risk factors occurring in a region or a country. Small countries usually face a number of challenges to conduct epidemiological studies, such as national BoD studies, due to the lack of specific expertise and resources or absence of adequate data. Considering Europe's small countries of Cyprus, Iceland, Luxembourg, Malta and Montenegro, the aim was to assess whether the various national data sources identified are appropriate to perform national BoD studies. Read More

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Social functioning in schizophrenia: Comparing laboratory-based assessment with real-world measures.

J Psychiatr Res 2021 Apr 30;138:500-506. Epub 2021 Apr 30.

Department of Psychology, Indiana University - Purdue University Indianapolis, LD 124, 402 N Blackford St, Indianapolis, IN 46202, USA.

Researchers have measured social functioning in schizophrenia using many different strategies. Recent technological advances have made it possible to passively measure behaviors in real-world social situations-allowing for more objective, ecologically valid assessments. Yet, research testing the convergent validity among real-world and laboratory-based social functioning assessment is sparse. Read More

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Innovative use of σ and π electron acceptors in the development of three high throughput 96-microwell spectrophotometric assays for crizotinib.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 30;259:119884. Epub 2021 Apr 30.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Crizotinib (CZT) is a potent and selective tyrosine kinase inhibitor used for treatment of non-small cell lung cancer (NSCLC). The development of high-throughput assays for its quality control (QC) is very essential to assure its therapeutic benefits. CZT molecule has multiple electron-donating atoms that can contribute to the formation of colored charge-transfer (CT) complex with iodine as σ-electron acceptor and with 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (CHBQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-electron acceptors. Read More

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MR-compatible optical microscope for in-situ dual-mode MR-optical microscopy.

PLoS One 2021 10;16(5):e0250903. Epub 2021 May 10.

Department of Microsystemes Engineering (IMTEK), Laborarory for Microactuators, University of Freiburg, Freiburg, Germany.

We present the development of a dual-mode imaging platform that combines optical microscopy with magnetic resonance microscopy. Our microscope is designed to operate inside a 9.4T small animal scanner with the option to use a 72mm bore animal RF coil or different integrated linear micro coils. Read More

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A study on ship collision conflict prediction in the Taiwan Strait using the EMD-based LSSVM method.

Tian Chai Han Xue

PLoS One 2021 10;16(5):e0250948. Epub 2021 May 10.

Navigation Institute, Jimei University, Xiamen, China.

Ship collision accidents are the primary threat to traffic safety in the sea. Collision accidents can cause casualties and environmental pollution. The collision risk is a major indicator for navigators and surveillance operators to judge the collision danger between meeting ships. Read More

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Evidence of Orbital Ferromagnetism in Twisted Bilayer Graphene Aligned to Hexagonal Boron Nitride.

Nano Lett 2021 May 10. Epub 2021 May 10.

Stanford Institute for Materials and Energy Science, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, United States.

We have previously reported ferromagnetism evinced by a large hysteretic anomalous Hall effect in twisted bilayer graphene (tBLG). Subsequent measurements of a quantized Hall resistance and small longitudinal resistance confirmed that this magnetic state is a Chern insulator. Here, we report that when tilting the sample in an external magnetic field, the ferromagnetism is highly anisotropic. Read More

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