223,327 results match your criteria small intestinal


Cancer-related Emergency Department Visits: Comparing Characteristics and Outcomes.

West J Emerg Med 2021 Aug 21;22(5):1117-1123. Epub 2021 Aug 21.

University of California, San Diego, Department of Emergency Medicine, San Diego, California.

Introduction: There is increasing appreciation of the challenges of providing safe and appropriate care to cancer patients in the emergency department (ED). Our goal here was to assess which patient characteristics are associated with more frequent ED revisits.

Methods: This was a retrospective cohort study of all ED visits in California during the 2016 calendar year using data from the California Office of Statewide Health Planning and Development. Read More

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Altered gut microbial metabolites could mediate the effects of risk factors in Covid-19.

Rev Med Virol 2021 Sep 13;31(5):1-13. Epub 2021 Jan 13.

Research Department, Medlab Clinical, Sydney, Australia.

Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is now pandemic. While most Covid-19 patients will experience mild symptoms, a small proportion will develop severe disease, which could be fatal. Clinically, Covid-19 patients manifest fever with dry cough, fatigue and dyspnoea, and in severe cases develop into acute respiratory distress syndrome (ARDS), sepsis and multi-organ failure. Read More

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September 2021

Expression and biological functions of Ancylostoma ceylanicum saposin-like protein.

Parasitol Res 2021 Sep 21. Epub 2021 Sep 21.

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510542, China.

Ancylostoma ceylanicum is a common zoonotic nematode that inhabits the small intestine of humans, dogs, and cats. Saposin-like proteins (SLPs) have hemolytic and antibacterial activities and could be used as diagnostic or vaccine candidates. To explore the biological functions of Ancylostoma ceylanicum SLP (Ace-SLP-1), cDNA-encoding Ace-SLP-1 mature peptide was cloned into prokaryotic expression vector pET-28a and transformed into Escherichia coli BL21 (DE3) to induce expression. Read More

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September 2021

Left paraduodenal hernia treated by single-incision laparoscopic surgery: a case report.

Surg Case Rep 2021 Sep 21;7(1):213. Epub 2021 Sep 21.

Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara-cho, Toyonaka, Osaka, 560-8565, Japan.

Background: Paraduodenal hernia is a rare internal hernia which accounts for only 1% of all intestinal hernias. There have been limited reported cases of paraduodenal hernia treated by laparoscopic surgery. We report a case of left paraduodenal hernia that was successfully treated by single-incision laparoscopic surgery (SILS). Read More

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September 2021

Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.

J Exp Med 2021 Nov 21;218(11). Epub 2021 Sep 21.

Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru, India.

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause early-onset diarrhea and chronic inflammatory bowel disease (IBD). GC-C regulates ion and fluid secretion in the gut via cGMP production and activation of cGMP-dependent protein kinase II. We characterize a novel mouse model harboring an activating mutation in Gucy2c equivalent to that seen in an affected Norwegian family. Read More

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November 2021

Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials.

mSystems 2021 Sep 21:e0072521. Epub 2021 Sep 21.

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.

The neonatal period is a crucial time during development of the mammalian small intestine. Moreover, neonatal development and maturation of the small intestine are exceptionally important for early growth, successful weaning, and postweaning growth and development, in order to achieve species-specific milestones. Although several publications recently characterized intestinal epithelial cell diversity at the single-cell level, it remains unclear how differentiation and molecular interactions take place between types and subtypes of epithelial cells during the neonatal period. Read More

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September 2021

A systematic review of symptomatic hamartomas of the jejunum and ileum.

Ann R Coll Surg Engl 2021 Sep 21. Epub 2021 Sep 21.

Western Sussex Hospitals NHS Foundation Trust, UK.

Introduction: Gastrointestinal hamartomas are rarely encountered benign growths made of an abnormal mixture of tissues normally found in the body where the growth occurs. Most hamartomas are asymptomatic and diagnosed incidentally. Evidence regarding symptomatic hamartomas of the jejunum and ileum is limited and restricted to anecdotal case reports. Read More

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September 2021

Gut region induces gastrointestinal microbiota community shift in Ujimqin sheep (Ovis aries): from a multi-domain perspective.

Environ Microbiol 2021 Sep 20. Epub 2021 Sep 20.

College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, P.R. China.

Gastrointestinal (GI) microbiota is one of the most complicated microbial ecosystems and is vital in regulating biological processes associated with nutrient absorption and homeostatic maintenance. Although several efforts have been achieved in characterizing bacterial communities across gut regions, the variation of non-bacterial communities across GI tracts is still largely unexplored. To address this, we investigated microbial biogeography throughout the whole GI tracts of Ujimqin sheep (Ovis aries) by amplicon sequencing which targeted bacteria, fungi, and archaea. Read More

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September 2021

Multiple Primary Angiosarcomas of the Colon.

Case Rep Pathol 2021 9;2021:7237379. Epub 2021 Sep 9.

Ljudevit Jurak Department of Pathology and Cytology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.

Introduction: Gastrointestinal angiosarcomas are rare and represent less than 1% of all gastrointestinal tract malignancies, with most occurring in the stomach and small intestine. Occurrence in the colorectal segments is considered extremely rare. . Read More

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September 2021

Peptide based therapy for neurological disorders.

Curr Protein Pept Sci 2021 Sep 20. Epub 2021 Sep 20.

Jaypee Institute of Information Technology, Department of Biotechnology, JIIT Noida, Sector 62, Noida-201309, UP. India.

Peptides are small molecules composed of amino acids linked together by peptide bonds. The targeted action of these peptides along with their magnificent ability to reach locations in body that are complicated to access, is being considered of tremendous potential in disease modifying therapies. Synthetic as well as natural peptides like Carnosine are currently under research for treatment of neurodegenerative disorders (NDDs). Read More

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September 2021

Anaplasma phagocytophilum Hijacks Flotillin and NPC1 Complex To Acquire Intracellular Cholesterol for Proliferation, Which Can Be Inhibited with Ezetimibe.

mBio 2021 Sep 21:e0229921. Epub 2021 Sep 21.

Department of Veterinary Biosciences, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.

The intracellular cholesterol transport protein Niemann-Pick type C1 (NPC1) and lipid-raft protein flotillin (FLOT) are required for cholesterol uptake by the obligatory intracellular bacterium Anaplasma phagocytophilum and for infection, and each protein localizes to membrane-bound inclusions containing replicating bacteria. Here, we found striking localization of FLOT2 in NPC1-lined vesicles and a physical interaction between FLOT2 and NPC1. This interaction was cholesterol dependent, as a CRAC (cholesterol recognition/interaction amino acid cholesterol-binding) domain mutant of FLOT2 did not interact with NPC1, and the cholesterol-sequestering agent methyl-β-cyclodextrin reduced the interaction. Read More

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September 2021

Intestinal upregulation and specific dynamic action in snakes - Implications for the 'pay before pumping' hypothesis.

Authors:
Stanisław Bury

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 17:111080. Epub 2021 Sep 17.

Department of Comparative Anatomy, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland. Electronic address:

Animals which feed infrequently and on large prey, like many snake species, are characterized by a high magnitude of gut upregulation upon ingesting a meal. The intensity of intestinal upregulation was hypothesized to be proportional to the time and energy required for food processing (Specific-Dynamic-Action; SDA); hence, a positive correlation between the scope of intestinal growth and SDA response can be deduced. Such a correlation would support the so far not well established link between the intestinal and metabolic consequences of digestion. Read More

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September 2021

The clinical course of Crohn's disease in a Danish population-based inception cohort with more than 50 years of follow-up, 1962-2017.

Aliment Pharmacol Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology, North Zealand Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Few population-based studies have investigated the long-term prognosis of Crohn's disease (CD).

Aim: To determine the long-term natural disease course of CD with regard to surgery, cancer and mortality in a population-based cohort followed for more than 50 years.

Methods: All patients diagnosed with CD from 1962 to 1987 in Copenhagen County, Denmark were included in a population-based cohort. Read More

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September 2021

Assessment of small-intestine permeability in healthy Nigerian children is altered by urinary volume and voiding status.

PLoS One 2021 20;16(9):e0253436. Epub 2021 Sep 20.

Department of Human Nutrition, Wageningen University & Research, Wageningen, the Netherlands.

Objective: This study aimed to uncover the effect of voided urinary volume on small intestine permeability ratios in healthy children.

Methods: We assessed small intestine permeability in 155 apparently healthy children, aged 3-5 years old, without any visible symptoms of disease, in a rural, malaria-endemic setting in Nigeria, using a multi-sugar test solution, comprising lactulose, sucrose, mannitol, and rhamnose. Children were categorized into low urinary volume (LV) and high urinary volume (HV), based on the volume of urine voided per kg body weight per hour. Read More

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September 2021

Identification of translocation inhibitors targeting the type III secretion system of enteropathogenic .

Antimicrob Agents Chemother 2021 Sep 20:AAC0095821. Epub 2021 Sep 20.

Institute for Infectiology, University of Münster, Münster, Germany.

Infections with enteropathogenic (EPEC) cause severe diarrhea in children. The non-invasive bacteria adhere to enterocytes of the small intestine and use a type III secretion system (T3SS) to inject effector proteins into host cells to modify and exploit cellular processes in favor of bacterial survival and replication. Several studies have shown that the T3SSs of bacterial pathogens are essential for virulence. Read More

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September 2021

Evisceration of the small intestine through the vagina as a rare complication after laparoscopic pectopexy.

Ginekol Pol 2021 Sep 20. Epub 2021 Sep 20.

Department of Gynecology, Gynecologic Oncology and Gynecologic Endocrinology Medical University of Gdansk, Poland, Poland.

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September 2021

Fecal Sampling.

Bio Protoc 2017 Sep 20;7(18):e2547. Epub 2017 Sep 20.

Molecular Physiology, Zoological Institute, CAU Kiel, Kiel, Germany.

Fecal sampling is a non-invasive method which raises the possibility to study the development and the changes in the microbial community throughout different time points of a fly population or throughout different treatments. This method allows precise manipulation to trigger the fly's physiology by nutritional interventions, bacterial infections or other stressors. As in most other animals, the intestinal microbiota is essential for a healthy fly-life. Read More

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September 2017

Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter.

Front Nutr 2021 3;8:688715. Epub 2021 Sep 3.

Research Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Glucagon-like peptide-2 (GLP-2) has protective effects on gastrointestinal functions. Our previous study found that GLP-2 could significantly reduce intestinal permeability and bacterial translocation in total parenteral nutrition (TPN) animal model. However, the effects of GLP-2 on the impairment of the intestinal Paneth cells immune function and gut inflammation during intravenous fluid infusion mainly consisted of nutritional materials is currently scattered. Read More

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September 2021

Emerging of Fatal Colitis with Multidrug-Resistant after Small Bowel Transplantation.

Case Rep Transplant 2021 9;2021:9995583. Epub 2021 Sep 9.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Small bowel transplantation is a potential option for patients with intestinal-failure, and the incidences of infections caused by species that are more resistant to antifungal drugs are increasing in these patients. In this manuscript, we reported a case of fatal colitis after small bowel transplantation induces by multidrug-resistant (MDR) . A 52-year-old man has undergone an extensive small bowel resection with the length of the remaining bowel which was less than 40 cm who became a candidate for transplantation. Read More

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September 2021

Non-Coding RNAs in Human Breast Milk: A Systematic Review.

Front Immunol 2021 1;12:725323. Epub 2021 Sep 1.

Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway.

Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child's first immune defense. Additionally, several breast milk factors have been implicated in immune-related health outcomes later in life, including immunoglobulins, cytokines, chemokines, growth factors and, more recently, non-coding RNA (ncRNA) species. In this systematic review, we provide a comprehensive summary of the current literature on endogenous ncRNAs found in human breast milk. Read More

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September 2021

Intestinal ischemic manifestations of SARS-CoV-2: Results from the ABDOCOVID multicentre study.

World J Gastroenterol 2021 Aug;27(32):5448-5459

Department of Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.

Background: Intestinal ischemia has been described in case reports of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (coronavirus disease 19, COVID-19).

Aim: To define the clinical and histological, characteristics, as well as the outcome of ischemic gastrointestinal manifestations of SARS-CoV-2 infection.

Methods: A structured retrospective collection was promoted among three tertiary referral centres during the first wave of the pandemic in northern Italy. Read More

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Abdominal Pain: A Silent and Unlikely Cause.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211045254

Nassau University Medical Center, East Meadow, NY, USA.

While diverticulosis is a common phenomenon in the large intestine, it is a rare disease found in the small intestine accounting for only 0.06% to 1.3% of cases. Read More

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September 2021

Evolution of milk oligosaccharides: Origin and selectivity of the ratio of milk oligosaccharides to lactose among mammals.

Biochim Biophys Acta Gen Subj 2021 Sep 15:130012. Epub 2021 Sep 15.

School of Molecular Bioscience, The University of Sydney, Sydney, NSW 2006, Australia.

Background: The carbohydrate fraction of mammalian milk is constituted of lactose and oligosaccharides, most of which contain a lactose unit at their reducing ends. Although lactose is the predominant saccharide in the milk of most eutherians, oligosaccharides significantly predominate over lactose in the milk of monotremes and marsupials.

Scope Of Review: This review describes the most likely process by which lactose and milk oligosaccharides were acquired during the evolution of mammals and the mechanisms by which these saccharides are digested and absorbed by the suckling neonates. Read More

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September 2021

Letter to the Editor on "CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile".

Mucosal Immunol 2021 Sep 17. Epub 2021 Sep 17.

Ospedale Civile "A. Costa" - Porretta Terme, Bologna, Italy.

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September 2021

A new method for investigating microbiota-produced small molecules in adenomatous polyps.

Anal Chim Acta 2021 Sep 7;1179:338841. Epub 2021 Jul 7.

Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy. Electronic address:

The intestinal microbiota is composed of a large number of different bacteria that produce a variety of metabolites. Colorectal cancer, which typically develops from adenomatous polyps, is highly influenced by microbiota. Since a variety of molecular changes may occur as these polyps transform from benign tumor to malignant carcinoma, the ability to study the microbiota-produced metabolites can lead to new discoveries about the development and progression of this cancer. Read More

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September 2021

Case report of metastatic breast cancer mimicking ileal Crohn's disease.

Int J Surg Case Rep 2021 Sep 15;87:106408. Epub 2021 Sep 15.

Department of Clinical Surgical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Introduction: Lobular breast cancer (LBC) has an increased risk of gastrointestinal (GI) spread compared with ductal breast carcinoma. Breast cancer commonly metastasises to bone, lung, liver, central nervous system and rarely to the gastrointestinal tract. As the prognosis for breast cancer continues to improve with modern medical practice it is important to be aware of the various clinical presentations and the appropriate management of breast cancer metastases. Read More

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September 2021

Abdominal cocoon syndrome, a case report of a rare disease entity causing intestinal obstruction.

Int J Surg Case Rep 2021 Sep 13;87:106401. Epub 2021 Sep 13.

Alzaiem Alazhari University - Department of Surgery, Sudan.

Introduction And Importance: Abdominal cocoon syndrome is a rare condition characterized by small bowel encapsulation by a fibrous membrane or a cocoon-like sac. It is an uncommon cause of intestinal obstruction. Less than 300 cases have been reported from all over the world. Read More

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September 2021

2-Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC-1 cells via cannabinoid receptor CB1.

Lipids 2021 Sep 17. Epub 2021 Sep 17.

Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.

Cholecystokinin (CCK) is a peptide hormone secreted from enteroendocrine cells and regulates the exocrine pancreas, gastric motility, and appetite. Dietary triacylglycerols are hydrolyzed to fatty acids (FA) and 2-monoacylglycerols (2-MAG) in the small intestine. Although it is well known that FA stimulate CCK secretion, whether 2-MAG have the CCK-releasing activity remains unclear. Read More

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September 2021

Enhancing the utility of antroduodenal manometry in pediatric intestinal pseudo-obstruction.

Neurogastroenterol Motil 2021 Sep 16:e14259. Epub 2021 Sep 16.

Neurogastroenterology & Motility Unit, Gastroenterology Department, Great Ormond Street Hospital for Children, London, UK.

Background: Antroduodenal manometry (ADM) and histopathology are currently employed to aid the diagnosis of pediatric intestinal pseudo-obstruction (PIPO). Limited data are available on the reliability of ADM analysis and its correlation with histopathology. We aimed to develop a protocol for enhanced analysis of ADM contractile patterns, including a scoring system, and explore whether this provided better correlation with histopathology. Read More

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September 2021

Magneto-Responsive Microneedle Robots for Intestinal Macromolecule Delivery.

Adv Mater 2021 Sep 17:e2104932. Epub 2021 Sep 17.

Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210002, China.

Oral administration is the most convenient and commonly used approach for drug delivery, while it is still a challenge to overcome the complicated gastrointestinal barriers and realize efficient macromolecular drug absorption. Here, novel magneto-responsive microneedle robots are presented for efficient oral delivery of versatile macromolecules. These microneedle robots with three components of the magnetic substrate, the separable connection, and tips are generated by a Lego-brick-stacking-inspired multistage 3D fabrication strategy. Read More

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September 2021