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Correlation Between Pulmonary Sclerosing Pneumocytoma Features and MSCT Imaging Manifestations in 34 Patients: Implications for Precision Medicine.

Front Med (Lausanne) 2021 18;8:650996. Epub 2021 Mar 18.

Department of Radiology, First People's Hospital of Pingjiang County, Yueyang, China.

To identify and analyze the multi-slice computed tomography (MSCT) imaging manifestations and clinicopathological features of PSP to improve the preoperative and intraoperative diagnosis of the disease. This was a retrospective study conducted on the imaging and clinicopathological data of the PSP patients treated in two major hospitals in China from October 2001 to December 2019. The locations of lung lesions, clinical symptoms, surgical complications, MSCT imaging features, and the corresponding relationship with clinicopathological features were assessed. Read More

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Differences Between CT-Perfusion and Biphasic Contrast-enhanced CT for Detection and Characterization of Hepatocellular Carcinoma: Potential Explanations for Discrepant Cases.

Anticancer Res 2021 Mar;41(3):1451-1458

Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.

Aim: To compare the diagnostic value of liver perfusion computed tomography (PCT) and biphasic contrast-enhanced CT (bpCECT) for detection and characterization of hepatocellular carcinoma (HCC), and to identify potential causes for inter-modal discrepancies.

Patients And Methods: In this retrospective study, 162 cases with a total of 325 HCC-typical lesions were evaluated using both PCT and bpCECT (mean time between examinations=15 days, range=0-13 days). HCC diagnosis was performed by multi-modality imaging including lesion growth at follow-up. Read More

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Topographical Organization of M-Current on Dorsal and Median Raphe Serotonergic Neurons.

Front Cell Neurosci 2021 25;15:614947. Epub 2021 Feb 25.

Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Dorsal and median raphe nuclei (DR and MR, respectively) are members of the reticular activating system and play important role in the regulation of the sleep-wakefulness cycle, movement, and affective states. M-current is a voltage-gated potassium current under the control of neuromodulatory mechanisms setting neuronal excitability. Our goal was to determine the proportion of DR and MR serotonergic neurons possessing M-current and whether they are organized topographically. Read More

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February 2021

Anatomical location of the spinothalamic tract in the subcortical white matter in the human brain: A diffusion tensor imaging study.

Clin Anat 2021 Jan 16. Epub 2021 Jan 16.

Department of Physical Therapy, College of Health Sciences, Dankook University, Cheonan, Chungnam, Republic of Korea.

Introduction: We investigated the anatomical location of the spinothalamic tract and its thalamocortical pathway (STT) in the subcortical white matter in normal subjects, using diffusion tensor tractography (DTT).

Materials And Methods: The STT was reconstructed using FMRIB software in 40 normal subjects. The most probable locations of the STT were defined as the location on an axial slice of the centrum semiovale (CS), corona radiata (CR), and posterior limb of the internal capsule (PL). Read More

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January 2021

HeaDax: A simple pre-surgical procedure for localizing superficial brain lesions in resource-limited environments.

Ali Akhaddar

Surg Neurol Int 2020 22;11:461. Epub 2020 Dec 22.

Department of Neurosurgery, Avicenne Military Hospital of Marrakech and Mohammed V University in Rabat, Marrakech, Morocco.

Background: Intracranial convexity lesions are poorly defined by recognizable anatomical landmarks. Even in expert hands, exact localization of small subcortical lesion and its projection to the skull is sometimes unreliable and can cause potential surgical complications. In this report, a simple and handy technique for localizing superficial intracranial lesions on the scalp under computed tomography (CT)-scan guidance is described. Read More

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December 2020

The Diagnostic Value of FDG PET/CT and Thin-Slice High-Resolution Chest CT in Pulmonary Intravascular Metastasis.

AJR Am J Roentgenol 2021 03 6;216(3):769-775. Epub 2021 Jan 6.

Department of PET/CT, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Rd, Jinan, Shandong 250117, China.

Pulmonary intravascular metastasis is a special type of pulmonary metastasis of malignancies; however, few relevant studies have been performed. This study aimed to determine the characteristics of pulmonary intravascular metastasis and improve understanding of the disease by retrospective analysis of FDG PET/CT and thin-layer high-resolution CT (HRCT) imaging of the chest in patients with tumors. We identified all patients who underwent FDG PET/CT at two hospitals between January 2016 and February 2019 and conducted a comparative analysis of HRCT and PET/CT images. Read More

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The Entorhinal Cortical Alvear Pathway Differentially Excites Pyramidal Cells and Interneuron Subtypes in Hippocampal CA1.

Cereb Cortex 2021 Mar;31(5):2382-2401

Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

The entorhinal cortex alvear pathway is a major excitatory input to hippocampal CA1, yet nothing is known about its physiological impact. We investigated the alvear pathway projection and innervation of neurons in CA1 using optogenetics and whole cell patch clamp methods in transgenic mouse brain slices. Using this approach, we show that the medial entorhinal cortical alvear inputs onto CA1 pyramidal cells (PCs) and interneurons with cell bodies located in stratum oriens were monosynaptic, had low release probability, and were mediated by glutamate receptors. Read More

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A new approach to interspecific synchrony in population ecology using tail association.

Ecol Evol 2020 Dec 10;10(23):12764-12776. Epub 2020 Nov 10.

Department of Ecology and Evolutionary Biology and Kansas Biological Survey University of Kansas Lawrence KS USA.

Standard methods for studying the association between two ecologically important variables provide only a small slice of the information content of the association, but statistical approaches are available that provide comprehensive information. In particular, available approaches can reveal , that is, accentuated or reduced associations between the more extreme values of variables. We here study the nature and causes of tail associations between phenological or population-density variables of co-located species, and their ecological importance. Read More

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December 2020

Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro.

Neurochem Int 2021 01 13;142:104902. Epub 2020 Nov 13.

Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8521, Japan. Electronic address:

The primary cilium is a solitary organelle that organizes a sensitive signaling hub in a highly ordered microenvironment. Cilia are plastic structures, changing their length in response to bioactive substances, and ciliary length may be regulated to ensure efficient signaling capacity. Mammalian brain neurons possess primary cilia that are enriched in a set of G protein-coupled receptors (GPCRs), including the feeding-related melanin-concentrating hormone (MCH) receptor 1 (MCHR1). Read More

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January 2021

Hepatic vascular variations and visual three-dimensional reconstruction technique in pediatric patients with choledochal cyst.

Surg Radiol Anat 2020 Dec 11;42(12):1489-1499. Epub 2020 Oct 11.

Department of Radiology, Children's Hospital of Soochow University, Suzhou, 215025, China.

Purpose: The aim of the present study was to identify the hepatic vascular variations with visual three-dimensional (3D) reconstruction of vessels in pediatric patients with choledochal cyst (CDC).

Methods: We retrospectively analyzed the data of 84 children with pathologically confirmed CDCs treated in the Children's Hospital of Soochow University. 180 patients without CDCs as a control to analysis the hepatic artery and portal vein anatomy. Read More

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December 2020

Anterior supra-acetabular external fixation for tile C1 pelvic fractures: a digital anatomical study and a finite element analysis.

Eur J Trauma Emerg Surg 2020 Oct 8. Epub 2020 Oct 8.

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: Investigating the anatomical characteristics of supra-acetabular screw corridor as well as comparing the biomechanical stability between semi- and full-length screw external fixations for Tile C1 pelvic fractures.

Methods: 50 male and 50 female uninjured pelvic CT data were converted into three-dimensional models and the supra-acetabular corridors were reconstructed by the Mimics software. The horizontal slice was redefined passing through the bilateral anterior inferior iliac spine and bilateral posterior superior iliac spine at the same time. Read More

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October 2020

Retrosigmoid approach assisted by high-resolution computed tomography: a cost-effective technique to identify the transverse and sigmoid sinus transition.

Chin Neurosurg J 2020 1;6:12. Epub 2020 Jul 1.

Tangdu Hospital, Air Force Military Medical University, No. 1, Xisi Road, Baqiao District, Xi'an City, China.

Background: When utilizing the retrosigmoid approach (RA), accurately identifying the transverse and sigmoid sinus transition (TSST) is a key procedure for neurosurgeons, especially in developing countries restricted by the lack of expensive devices, such as the neural navigation system and the three-dimensional volumetric image-rendered system. Before operations, a computed tomography scan is a common and cost-effective method of checking patients who suffer lesions located at the cerebellopontine angle. Therefore, we present a technique using only high-resolution computed tomography to identify the transverse and sigmoid sinus transition. Read More

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Multi-slice spiral CT evaluation of chronic radiation colitis and rectitis.

Exp Ther Med 2020 Oct 29;20(4):3033-3040. Epub 2020 Jul 29.

Key Laboratory for Biorheological Science and Technology of the Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing 400044, P.R. China.

The aim of the present study was to retrospectively analyse the multi-slice spiral CT (MSCT) findings of radiation colitis and rectitis (RC&R). A total of 23 cases of RC&R detected by helical CT were included. The CT findings and clinical and endoscopy data of the patients were reviewed. Read More

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October 2020

Clinical evaluation of right recurrent laryngeal nerve nodes in thoracic esophageal squamous cell carcinoma.

J Thorac Dis 2020 Jul;12(7):3622-3630

Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Background: The accuracy of clinical N staging of esophageal squamous cell carcinoma is suboptimal. As an important station of lymph node metastasis, station C201 (right recurrent laryngeal nerve nodes) has rarely been evaluated alone. We aimed to explore an effective way to evaluate the right recurrent laryngeal nerve nodes in thoracic esophageal squamous cell carcinoma. Read More

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Chimney Detection Based on Faster R-CNN and Spatial Analysis Methods in High Resolution Remote Sensing Images.

Sensors (Basel) 2020 Aug 5;20(16). Epub 2020 Aug 5.

Key Laboratory of Digital Earth Science, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China.

Spatially location and working status of pollution sources are very important pieces of information for environment protection. Waste gas produced by fossil fuel consumption in the industry is mainly discharged to the atmosphere through a chimney. Therefore, detecting the distribution of chimneys and their working status is of great significance to urban environment monitoring and environmental governance. Read More

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Nonliposuction Endoscopic Sentinel Lymph Node Biopsy Through the Periareolar Incision.

Surg Innov 2020 Dec 20;27(6):570-579. Epub 2020 Jul 20.

117889Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

. Sentinel lymph node biopsy (SLNB) has been an alternative to axillary lymph node dissection as a standard procedure for breast cancer patients with clinically negative lymph nodes. Endoscopic technique has been developed for over 20 years but remains to be mastered by a slice of surgeons. Read More

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December 2020

Injury of the Tibial Nutrient Artery Canal during External Fixation for Lower Extremity Fractures: A Computed Tomography Study.

J Clin Med 2020 Jul 14;9(7). Epub 2020 Jul 14.

Department of Diagnostic and Interventional Radiology, Tuebingen University Hospital, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.

The tibial nutrient artery (TNA) is the major diaphyseal artery of the tibia supplying two thirds of the inner osseous cortex. Hence, iatrogenic injury of the TNA endangers the integrity of the tibial blood supply and may compromise fracture healing. The incidence of its injury in the setting of external fixation for lower limb fractures has not been previously investigated. Read More

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Semilunar Granule Cells Are the Primary Source of the Perisomatic Excitatory Innervation onto Parvalbumin-Expressing Interneurons in the Dentate Gyrus.

eNeuro 2020 Jul/Aug;7(4). Epub 2020 Jul 7.

Department of Cell Biology, Neurobiology Unit, Interdisciplinary Research Structure for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, E-46100 Burjasot (Valencia), Calle Dr Moliner 50 Valencia, Spain

We analyzed the origin and relevance of the perisomatic excitatory inputs on the parvalbumin interneurons of the granule cell layer in mouse. Confocal analysis of the glutamatergic innervation showed that it represents ∼50% of the perisomatic synapses that parvalbumin cells receive. This excitatory input may originate from granule cell collaterals, the mossy cells, or even supramammillary nucleus. Read More

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Gadolinium-doped Au@prussian blue nanoparticles as MR/SERS bimodal agents for dendritic cell activating and tracking.

Theranostics 2020 15;10(13):6061-6071. Epub 2020 May 15.

College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, 94 Weijin Road, Tianjin 300071, China.

tracking of dendritic cell (DC) migration to the lymphatic system is essential for evaluating the outcome of DC-based immunotherapies. Novel multimodal imaging strategies with high analytical performance are urgently needed to supply complementary information about the migration and colonization of DCs. In this study, we designed a bimodal imaging agent, namely Au@Prussian blue-Gd@ovalbumin nanoparticles (APG@OVA NPs), for activating DCs and real-time tracking of DC migration process by magnetic resonance imaging (MRI). Read More

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Early Detection of Alzheimer's Disease Using Magnetic Resonance Imaging: A Novel Approach Combining Convolutional Neural Networks and Ensemble Learning.

Front Neurosci 2020 13;14:259. Epub 2020 May 13.

SFU ImageTech Lab, Surrey Memorial Hospital, Fraser Health, Surrey, BC, Canada.

Early detection is critical for effective management of Alzheimer's disease (AD) and screening for mild cognitive impairment (MCI) is common practice. Among several deep-learning techniques that have been applied to assessing structural brain changes on magnetic resonance imaging (MRI), convolutional neural network (CNN) has gained popularity due to its superb efficiency in automated feature learning with the use of a variety of multilayer perceptrons. Meanwhile, ensemble learning (EL) has shown to be beneficial in the robustness of learning-system performance via integrating multiple models. Read More

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Three-Dimensional Pressure Profile of the Lower Esophageal Sphincter and Crural Diaphragm in Patients with Achalasia Esophagus.

Gastroenterology 2020 09 8;159(3):864-872.e1. Epub 2020 May 8.

Department of Medicine, Division of Gastroenterology, and Department of Radiology, University of California, San Diego, California.

Background & Aims: Smooth muscles of the lower esophageal sphincter (LES) and skeletal muscle of the crural diaphragm (esophagus hiatus) provide the sphincter mechanisms at the esophagogastric junction (EGJ). We investigated differences in the 3-dimensional (3D) pressure profile of the LES and hiatal contraction between healthy subjects and patients with achalasia esophagus.

Methods: We performed a prospective study of 10 healthy subjects (controls; 7 male; mean age, 60 ± 15 years; mean body mass index, 25 ± 2) and 12 patients with a diagnosis of achalasia (7 male; mean age, 63 ± 13 years; mean body mass index, 26 ± 1), enrolled at a gastroenterology clinic. Read More

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September 2020

Neuropeptide Y Expression Defines a Novel Class of GABAergic Projection Neuron in the Inferior Colliculus.

J Neurosci 2020 06 6;40(24):4685-4699. Epub 2020 May 6.

Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109

Located in the midbrain, the inferior colliculus (IC) integrates information from numerous auditory nuclei and is an important hub for sound processing. Despite its importance, little is known about the molecular identity and functional roles of defined neuron types in the IC. Using a multifaceted approach in mice of both sexes, we found that neuropeptide Y (NPY) expression identifies a major class of inhibitory neurons, accounting for approximately one-third of GABAergic neurons in the IC. Read More

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Prevalence of mitral annular disjunction in patients with mitral valve prolapse and severe regurgitation.

Int J Cardiovasc Imaging 2020 Jul 27;36(7):1363-1370. Epub 2020 Mar 27.

Biological Sciences Division, University of Chicago Medicine, Chicago, IL, USA.

Mitral annular disjunction (MAD) is routinely diagnosed by cardiac imaging, mostly by echocardiography, and shown to be a risk factor for ventricular arrhythmias. While MAD is associated with mitral valve (MV) prolapse (MVP), it is unknown which patients with MAD are at higher risk and which additional imaging features may help identify them. The value of cardiac computed tomography (CCT) for the diagnosis of MAD is unknown. Read More

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Huge intrameniscal cyst successfully treated by open debridement and combined arthroscopic and open repair: a case report.

BMC Musculoskelet Disord 2020 Mar 27;21(1):190. Epub 2020 Mar 27.

Department of Orthopedic Surgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Munhwa-dong, Jung-gu, Daejeon, 301-721, South Korea.

Background: Meniscal cysts are not uncommon in clinical practice, with reported incidence rates varying from 1 to 22%. Most meniscal cysts are parameniscal cysts, which are created by extravasation of synovial fluid through the meniscal tear into the adjacent soft tissue. In contrast, intrameniscal cysts in which the fluid collects in the meniscus are very rare. Read More

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Perforator Mapping of the Superficial and Deep Inferior Epigastric Artery in the Abdominal Region of the Vietnamese.

Open Access Maced J Med Sci 2019 Dec 15;7(24):4209-4213. Epub 2019 Oct 15.

Institute for Research and Development, Duy Tan University, 03 Quang Trung, Danang, Vietnam.

Background: Previous studies worldwide have investigated the anatomy of the perforators of the deep inferior epigastric arteries to figure out the navigation patterns of the perforators on the abdominal wall. This has been inconsistent amongst the researchers about how to select the perforator to increase the blood supply area for the flap.

Aim: To explore the blood supply area of the perforators of the superficial and deep inferior epigastric artery in the abdominal region of the Vietnamese by dissection and 64-slice multislice computed tomography (64-slice MSCT). Read More

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December 2019

[Application of multi-slice spiral CT in the diagnosis of children's parotid cleft deformity].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):146-149

Department of Radiology and Medicine Imaging,Shanghai Children's Hospital,Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai,200040,China.

The aim of this study is to evaluate the value of multi-slice spiral CT (CT) and multi-planar reconstruction (MPR) in the diagnosis of children with parotid cleft deformity. The CT images of 55 cases of branchial cleft deformity confirmed by surgery and pathology were retrospectively analyzed. CT examination showed that 37 cases had strip-like, tubular fistula or cystic mass located in the anterior cervical triangle, anterior margin of sternocleidomastoid muscle, and 2 of them had bilateral fistula structure. Read More

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February 2020

Anatomical Evaluation of Lumbar Arteries for Lateral Lumbar Interbody Fusion with Magnetic Resonance Imaging.

Spine Surg Relat Res 2020 20;4(1):69-73. Epub 2019 Sep 20.

Department of Orthopaedic Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.

Introduction: Lateral lumbar interbody fusion (LLIF) is becoming a more common surgical treatment option for adult degenerative lumbar conditions. LLIF is a mini-open access technique with wound retractors, and postoperative hematoma due to segmental vessels injury is reported. Thus, it is considered that there is a need to conduct detailed preoperative examinations to identify where the lumbar vessels are. Read More

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September 2019

Proteomic characterization of the normal human medial meniscus body using data-independent acquisition mass spectrometry.

J Orthop Res 2020 08 31;38(8):1735-1745. Epub 2020 Jan 31.

Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.

Recent research suggests an important role of the meniscus in the development of knee osteoarthritis. We, therefore, aimed to analyze the proteome of the normal human meniscus body, and specifically to gain new knowledge on global protein expression in the different radial zones. Medial menisci were retrieved from the right knees of 10 human cadaveric donors, from which we cut a 2 mm radial slice from the mid-portion of the meniscal body. Read More

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WBCaps: A Capsule Architecture-based Classification Model Designed for White Blood Cells Identification.

Annu Int Conf IEEE Eng Med Biol Soc 2019 Jul;2019:7027-7030

This pilot study presented a capsule architecture-based classification model named WBCaps to automatically recognize the five types of white blood cells (WBC) from normal peripheral blood smears. The entire WBCs identification workflow including two sections were also reported here. The first section automatically located the WBCs from the whole slice of blood smears through a three-step image segmentation method including color normalization, color deconvolution and cell extraction. Read More

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Evaluation of clinical application of multi-slice computerized tomography in primary retroperitoneal tumors.

J Clin Lab Anal 2020 May 27;34(5):e23169. Epub 2019 Dec 27.

Retroperitoneal Tumor Center, Peking University International Hospital, Beijing, China.

Background: To accurately identify primary retroperitoneal tumors by multi-slice spiral CT (MSCT) for better treatment.

Materials And Methods: The common types of 380 cases of primary retroperitoneal tumor, lesion sites, and MSCT features were compared with pathological results. Fisher's or chi-square test approaches have been applied in this study. Read More

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