1,251 results match your criteria sleep paralysis

Comparison of fixed dose versus train-of-four titration of cisatracurium in acute respiratory distress syndrome.

J Crit Care 2021 May 25;65:86-90. Epub 2021 May 25.

University of Kentucky HealthCare, Department of Pharmacy Services, United States of America; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, United States of America. Electronic address:

Purpose: To compare the ventilatory and clinical outcomes associated with a fixed-dose cisatracurium infusion versus a titrated infusion strategy in patients with Acute Respiratory Distress Syndrome (ARDS).

Materials And Methods: Single-center, retrospective, cohort study in a medical ICU of a tertiary care academic medical center. Adult patients ≥18 years old with a continuous infusion of cisatracurium for ≥12 h for treatment of ARDS were included. Read More

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A comparison of the effects of fire needle and routine acupuncture for myofascitis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e25473

Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.

Background: Myofascitis is a common disease in clinic. The main cause of the disease is aseptic inflammation of local muscles and connective tissues such as myofascial, which can be manifested as paralysis, distension, and other discomfort, local muscle stiffness, spasm or palpable strain-like nodules. Chinese medicine ascribes it to "bi disease" and "Arthralgia disease," while Western medicine believes that the disease is mainly due to local muscle and fascia edema and exudation caused by trauma or long-term strain, forcing nerves to jam and producing pain and other abnormal feelings. Read More

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Case report: early onset narcolepsy initially misdiagnosed as obstructive sleep apnea syndrome.

Turk J Pediatr 2021 ;63(2):334-338

Pediatric Neurology, Ağrı State Hospital, Ağrı, Turkey.

Background: Narcolepsy is a chronic neurological syndrome, which is characterized by excessive sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis during the rapid eye movement period of sleep. This disease is commonly diagnosed within adulthood. However, the first symptoms often appear in childhood and/or adolescence. Read More

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January 2021

[The effect of steroid injection treatment with carpal tunnel syndrome on sleep hygiene].

Agri 2021 Apr;33(2):96-102

Department of Neurology, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, Turkey.

Objectives: Carpal tunnel syndrome (CTS) is the most seen entrapment neuropathy. CTS is a complex syndrome arisen with entrapment of median nerve at wrist. Pain worst at night, paresthesia, hypoesthesia, paralysis, and muscle atrophy can be seen through nerve entrapment level. Read More

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Type 1 narcolepsy without cataplexy and treatment progress: a case report.

Ann Palliat Med 2021 Mar;10(3):3491-3494

Department of Neurology, Shenzhen University General Hospital, Shenzhen University Clinical Research Center for Neurological Diseases, Shenzhen, China.

Narcolepsy is a sleep disorder with the main manifestations of excessive daytime sleepiness, cataplexy, sleep paralysis, sleep hallucinations, and nighttime sleep disturbance. It is still not fully recognized by clinicians, and many patients are often misdiagnosed with epilepsy, syncope, or mental disorders. In the present study, we report the first case of narcolepsy diagnosed at the district, with a complete medical history, objective examinations, and cerebrospinal fluid and hematological tests, but no cataplexy. Read More

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Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.

Neurotherapeutics 2021 01 5;18(1):1-5. Epub 2021 Apr 5.

Divisions of Sleep Medicine and Movement Disorders, Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA.

We find ourselves at our present crossroads with a well-traveled toolkit, perhaps too well worn but with aspirational hopes and dreams for the field of sleep neurotherapeutics. This volume is organized thematically into six topical domains that parallel the major subspecialty areas of contemporary clinical sleep neurology practice, as well as novel directions and opportunities. The issue begins with an overview of the central disorders of hypersomnolence, including narcolepsy, idiopathic hypersomnia and other hypersomnia disorders, and the related use of the entire broad range of stimulant and wake-promoting pharmacotherapies. Read More

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January 2021

The Implementation of Protocol-Based Utilization of Neuromuscular Blocking Agent Using Clinical Variables in Acute Respiratory Distress Syndrome Patients.

Crit Care Explor 2021 Mar 19;3(3):e0371. Epub 2021 Mar 19.

Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, Morgantown, WV.

Objectives: The recent conflicting data on the mortality benefit of neuromuscular blocking agents in acute respiratory distress syndrome and the potential adverse effects of continuous neuromuscular blocking agent necessitates that these medications should be used judiciously with dose reduction in mind. The aims of the study were to improve the process of care by provider education of neuromuscular blocking agent titration and monitoring and to determine the impact of clinical endpoint based neuromuscular blocking agent titration protocol.

Design: We conducted a proof-of-concept historically controlled study of protocol-based intervention standardizing paralytic monitoring and titration using clinical variables. Read More

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Morbidity, Mortality, and Conversion to Neurodegenerative Diseases in Patients with REM Sleep Behavior Disorder and REM Sleep without Atonia.

Neuroepidemiology 2021 29;55(2):141-153. Epub 2021 Mar 29.

Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Faculty of Health Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Introduction: The underlying pathophysiology of idiopathic REM sleep behavior disorder (iRBD) is not fully understood, although the condition is currently recognized as an early-stage alpha-synuclein disorder. We evaluated the morbidity, mortality, and rate of conversion to a neurodegenerative disorder in a national group of patients.

Methods: All patients in Denmark with a diagnosis of RBD between 2006 and 2013 were identified from the Danish National Patient Registry (NPR) records. Read More

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Pain as a significant symptom in patients with periodic paralysis-A cross-sectional survey.

Muscle Nerve 2021 Jun 5;63(6):897-901. Epub 2021 Apr 5.

Department of Neurology, University of Florida, Gainesville, Florida, USA.

Introduction: Periodic paralysis (PP) is thought to be limited to episodes of muscle weakness, but there are reports of fibromyalgia-like pain in PP. We aimed to evaluate pain and comorbid sleep, fatigue, and mood disorders in PP patients.

Methods: We administered a cross-sectional survey to PP patients at the 2019 Periodic Paralysis Conference. Read More

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The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy.

Front Neurosci 2021 4;15:644757. Epub 2021 Mar 4.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.

Narcolepsy is a sleep disorder caused by selective death of the orexin neurons that often begins in childhood. Orexin neuron loss disinhibits REM sleep during the active period and produces cataplexy, episodes of paralysis during wakefulness. Cataplexy is often worse when narcolepsy develops in children compared to adults, but the reason for this difference remains unknown. Read More

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Neurophysiological aspects of the completely locked-in syndrome in patients with advanced amyotrophic lateral sclerosis.

Clin Neurophysiol 2021 May 3;132(5):1064-1076. Epub 2021 Feb 3.

Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany.

Objective: Amyotrophic lateral sclerosis (ALS) patients in completely locked-in syndrome (CLIS) are incapable of expressing themselves, and their state of consciousness and awareness is difficult to evaluate. Due to the complete paralysis included paralysis of eye muscles, any assessment of the perceptual and psychophysiological state can only be implemented in passive experimental paradigms with neurophysiological recordings.

Methods: Four patients in CLIS were investigated in several experiments including resting state, visual stimulation (eyes open vs eyes closed), auditory stimulation (modified local-global paradigm), somatosensory stimulation (electrical stimulation of the median nerve), and during sleep. Read More

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Improvement in mild anti-IgLON5 encephalopathy without immunotherapy: a case report.

BMC Neurol 2021 Mar 17;21(1):120. Epub 2021 Mar 17.

Department of Neurology, Tangshan Gongren Hospital, 27 Wenhua Road, Tangshan, 063000, Hebei, People's Republic of China.

Background: Anti-IgLON5 antibody-related encephalopathy is a recently discovered and rare autoimmune disease, and its diagnosis and treatment are more challenging than for other autoimmune encephalopathic diseases. Sleep disorder is the most prominent symptom of the disease. It can also present with gait instability, dysarthria, dysphagia, dementia, ataxia, autonomic nervous system dysfunction, chorea, vertical gaze paralysis, and other symptoms. Read More

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[The impact of unilateral diaphragmatic paralysis on sleep-disordered breathing: a scoping review].

Can J Anaesth 2021 Jul 16;68(7):1064-1076. Epub 2021 Mar 16.

Department of Anesthesiology and Pain Management, Women's College Hospital, Toronto, ON, Canada.

Background: Unilateral diaphragm paralysis (UDP) may potentially worsen sleep-disordered breathing (SDB). Unilateral diaphragm paralysis has been associated with proximal brachial plexus blockade, such as interscalene and supraclavicular block. The impact of UDP in patients with SDB is not known in this context. Read More

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A Review of Acute Respiratory Distress Syndrome Management and Treatment.

Zubair Hasan

Am J Ther 2021 Mar-Apr 01;28(2):e189-e195

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

Background: Acute respiratory distress syndrome (ARDS) was first described in 1967, but its definition has evolved considerably since then. ARDS is defined as the onset of hypoxemia, tachypnea, and loss of lung compliance due to some stimulus. In the United States, the incidence of ARDS has been growing because it is being increasingly recognized. Read More

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Mitochondrial Redox Signaling Is Critical to the Normal Functioning of the Neuronal System.

Front Cell Dev Biol 2021 28;9:613036. Epub 2021 Jan 28.

Department of Biological Sciences, Southern Methodist University, Dallas, TX, United States.

Mitochondrial dysfunction often leads to neurodegeneration and is considered one of the main causes of neurological disorders, such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and other age-related diseases. Mitochondrial dysfunction is tightly linked to oxidative stress and accumulating evidence suggests the association between oxidative stress and neurological disorders. However, there is insufficient knowledge about the role of pro-oxidative shift in cellular redox and impairment of redox-sensitive signaling in the development of neurodegenerative pathological conditions. Read More

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January 2021

"Men Fear Most What They Cannot See." sleep paralysis "Ghost Intruders" and faceless "Shadow-People"-The role of the right hemisphere and economizing nature of vision.

Baland Jalal

Med Hypotheses 2021 Mar 28;148:110521. Epub 2021 Jan 28.

Harvard University, USA; University of Cambridge, UK. Electronic address:

Sleep paralysis is a curious condition where the paralyzed person may hallucinate terrifying ghosts. These hypnogogic and hypnopompic visions are common worldwide. They often entail seeing and sensing shadow beings; although hallucinating full-fledged figures (e. Read More

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Anti-IgLON5 disease with distinctive brain MRI findings responding to immunotherapy: A case report.

Medicine (Baltimore) 2021 Jan;100(4):e24384

Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), 10 Changjiangzhilu, Yuzhong District, Chongqing, China.

Rationale: Anti-IgLON5 disease was first described as a progressive antibody-associated encephalopathy, with multiple non-specific clinical symptoms including sleep dysfunction, bulbar symptoms, progressive supranuclear palsy-like syndrome, cognitive impairment, and a variety of movement disorders. This newly discovered disease presents with unremarkable or unspecific brain magnetic resonance imagings (MRI), and have poor responsiveness to immunotherapy.

Patient Concerns: In this case, a 37-year-old man presented with 4-day history of gait instability, dysarthria, and oculomotor abnormalities. Read More

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January 2021

A 65-Year-Old Woman With Dyspnea After Atrial Fibrillation Ablation.

Chest 2021 01;159(1):e29-e33

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University Ringgold standard institution, Atlanta, GA.

Case Presentation: A 65-year-old woman with a history of chronic persistent atrial fibrillation, tobacco use, and COPD was admitted to the hospital 2 months after catheter ablation for persistent atrial fibrillation and dyspnea. Her dyspnea was present at rest and worsened by exertion with limitation to ambulating less than two blocks. She also endorsed a 1-month history of cough with minimally productive whitish sputum with frequent nocturnal exacerbations and orthopnea. Read More

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January 2021

Initial assessment and management of respiratory infections in persons with spinal cord injuries and disorders in the COVID-19 era.

J Am Coll Emerg Physicians Open 2020 Dec 24;1(6):1404-1412. Epub 2020 Oct 24.

Department of Physical Medicine & Rehabilitation University of Miami Leonard M. Miller School of Medicine Miami Florida USA.

As the COVID-19 pandemic unfolds, emergency department (ED) personnel will face a higher caseload, including those with special medical needs such as persons living with spinal cord injuries and disorders (SCI/D). Individuals with SCI/D who develop COVID-19 are at higher risk for rapid decompensation and development of acute respiratory failure during respiratory infections due to the combination of chronic respiratory muscle paralysis and autonomic dysregulation causing neurogenic restrictive/obstructive lung disease and chronic immune dysfunction. Often, acute respiratory infections will lead to significant mucus production in individuals with SCI/D, and aggressive secretion management is an important component of successful medical treatment. Read More

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December 2020

Creativity in Narcolepsy Type 1: The Role of Dissociated REM Sleep Manifestations.

Nat Sci Sleep 2020 17;12:1191-1200. Epub 2020 Dec 17.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Purpose: A higher creative potential has been reported in narcoleptic patients and linked to lucid dreaming. The aim of the present study was to explore the role of narcolepsy symptoms (presence and severity) in predicting creativity.

Patients And Methods: Sixty-six consecutive type 1 narcolepsy patients (mean age 38. Read More

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December 2020

Successful use of an automated proning system to achieve prone positioning in a patient with severe ARDS requiring veno-venous ECMO.

Respir Med Case Rep 2020 4;31:101315. Epub 2020 Dec 4.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Langone Health, New York, NY, USA.

A morbidly obese middle aged woman in her 40's presented to another hospital with methicillin resistant staphylococcus aureus pneumonia and subsequently developed severe acute respiratory distress syndrome. Her oxygenation demonstrated no improvement with low tidal volume ventilation, paralysis, or prostagladin therapy. She was unable to be manually proned secondary to her habitus. Read More

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December 2020

Self-limited epilepsy with centro-temporal spikes: A study of 46 patients with unusual clinical manifestations.

Epilepsy Res 2021 Jan 21;169:106507. Epub 2020 Nov 21.

Hospital de Pediatría Prof. Dr.Juan P Garrahan Buenos Aires, Argentina. Electronic address:

Purpose: We retrospectively analyzed the seizure characteristics, EEG pattern, treatment, and outcome in a series of patients with self-limited epilepsy with centrotemporal spikes (SLECTS) who presented with unusual clinical manifestations.

Method: A retrospective, descriptive, multicenter study was conducted evaluating 46 patients with SLECTS who had seizures with an unusual semiology. We collected data from patients with SLECTS seen at eight Argentine centers between April 1998 and April 2018. Read More

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January 2021

Single center analysis of patients with H1N1 vaccine-related narcolepsy and sporadic narcolepsy presenting over the same time period.

J Clin Sleep Med 2021 May;17(5):885-895

Sleep Clinic, Mater Private Hospital, Dublin, Ireland.

Study Objectives: We aimed to describe the clinical features of narcolepsy in patients referred to our sleep center between 2009 and 2016, and to compare these features across age groups and between sporadic vs AS03-adjuvanted H1N1 influenza vaccine-related patients.

Methods: This is a retrospective, consecutive study of adult and pediatric narcolepsy patients in the Republic of Ireland. All participants underwent structured assessments, including polysomnography and the Multiple Sleep Latency Test. Read More

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Are sleep paralysis and false awakenings different from REM sleep and from lucid REM sleep? A spectral EEG analysis.

J Clin Sleep Med 2021 Apr;17(4):719-727

Sleep Disorder Unit, Pitié-Salpêtrière University Hospital, AP-HP, Paris, France.

Study Objectives: To determine the polysomnography characteristics during sleep paralysis, false awakenings, and lucid dreaming (which are states intermediate to rapid eye movement [REM] sleep and wake but exceptionally observed in sleep laboratory).

Methods: In 5 participants, we captured 5 episodes of sleep paralysis (2 time marked with the ocular left-right-left-right code normally used to signal lucid dreaming, 1 time marked by an external noise, and 2 retrospectively reported) and 2 episodes of false awakening. The sleep coding (using 3-second mini-epochs) and spectral electroencephalography analysis were compared during these episodes and normal REM sleep as well as wakefulness in the same 4 of 5 participants and vs lucid REM sleep in 4 other patients with narcolepsy. Read More

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Impact of COVID-19 pandemic lockdown on narcolepsy type 1 management.

Brain Behav 2021 01 28;11(1):e01955. Epub 2020 Nov 28.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Study Objectives: Narcolepsy type 1 (NT1) is a chronic rare hypersomnia of central origin requiring a combination of behavioral and pharmacological treatments. During the coronavirus disease 2019 (COVID-19) pandemic, in Italy the population was forced into a lockdown. With this study, we aimed to describe the lockdown impact on NT1 symptom management, according to different patients' working schedule. Read More

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January 2021

Correlation of Covid-19 With Stomatognathic System With Homeopathic Proposal for Adjunct Treatment to Increase Oral and General Health.

Altern Ther Health Med 2020 Aug;26(S2):112-116

Context: SARS-CoV-2 is a new virus responsible for the outbreak of COVID-19. Studies have shown that the expression of ACE2 was found in the smaller salivary glands was higher than that in the lungs, suggesting that salivary glands may be a potential target of the virus. This may indicate that one of the main gateways to coronavirus infection is the oral cavity. Read More

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Nightmare Disorder and Isolated Sleep Paralysis.

Neurotherapeutics 2021 01 23;18(1):100-106. Epub 2020 Nov 23.

Department of Neurology, Medical University of Innsbruck (MUI), Anichstrasse 35, 6020, Innsbruck, Austria.

Nightmare disorder and recurrent isolated sleep paralysis are rapid eye movement (REM) parasomnias that cause significant distress to those who suffer from them. Nightmare disorder can cause insomnia due to fear of falling asleep through dread of nightmare occurrence. Hyperarousal and impaired fear extinction are involved in nightmare generation, as well as brain areas involved in emotion regulation. Read More

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January 2021

A Primary Care Provider's Guide to Pain After Spinal Cord Injury: Screening and Management.

Top Spinal Cord Inj Rehabil 2020 ;26(3):133-143

Centre for Family Medicine-Family Health Team, Kitchener, Ontario, Canada.

Individuals with spinal cord injury (SCI) often experience chronic pain as a secondary complication. It can significantly impair mental health, sleep, mood, and overall quality of life. It is important for providers within a primary care setting to recognize the different types of pain such as nociceptive and neuropathic. Read More

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