4,080 results match your criteria sleep disruption

Disruption of entire locus leads to embryonic lethality by diminished gene expression and enhanced p53 pathway.

Elife 2021 May 5;10. Epub 2021 May 5.

Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire locus () caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic lethality in mice. Comparative transcriptome analysis revealed disruption of , 50% down-regulation of abutting on the locus, and up-regulation of p53-target genes in gastrulas. Read More

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Household chaos, family routines, and young child movement behaviors in the U.S. during the COVID-19 outbreak: a cross-sectional study.

BMC Public Health 2021 05 4;21(1):860. Epub 2021 May 4.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

Background: The home environment is an important facilitator of young child movement behaviors, including physical activity (PA), sleep, and screen-time. Household chaos, characterized by crowding, noise, and disorder in the home, may hinder efforts to obtain adequate amounts of movement behaviors. The COVID-19 outbreak impacted many families, and social distancing during this time may create conditions for more household chaos. Read More

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Social jetlag, a novel predictor for high cardiovascular risk in blue-collar workers following permanent atypical work schedules.

J Sleep Res 2021 May 4:e13380. Epub 2021 May 4.

Institute and Polyclinic for Occupational- Social- and Environmental Medicine, LMU Munich, Munich, Germany.

Cardiovascular diseases cause >4 million deaths each year in Europe alone. Preventive approaches that do not only consider individual risk factors but their interaction, such as the Systematic COronary Risk Evaluation (SCORE), are recommended by European guidelines. Increased cardiovascular risk is associated with shift-work, surely interacting with the concurrent conditions: disruption of sleep, unhealthy behaviours, and circadian misalignment. Read More

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The connections of Locus Coeruleus with hypothalamus: potential involvement in Alzheimer's disease.

J Neural Transm (Vienna) 2021 May 3. Epub 2021 May 3.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

The hypothalamus and Locus Coeruleus (LC) share a variety of functions, as both of them take part in the regulation of the sleep/wake cycle and in the modulation of autonomic and homeostatic activities. Such a functional interplay takes place due to the dense and complex anatomical connections linking the two brain structures. In Alzheimer's disease (AD), the occurrence of endocrine, autonomic and sleep disturbances have been associated with the disruption of the hypothalamic network; at the same time, in this disease, the occurrence of LC degeneration is receiving growing attention for the potential roles it may have both from a pathophysiological and pathogenetic point of view. Read More

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Non-convulsive status epilepticus induced by acute thalamic lesions: A report of three cases.

Seizure 2021 Apr 22;89:1-4. Epub 2021 Apr 22.

EEG/Sleep Laboratory, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal; Univ Lisboa, Fac Med, Clin Univ Neurol, Lisboa, Portugal; Centro de Referência para Epilepsias Refratárias do CHULN, Member of ERN EpiCare, Portugal.

The thalamocortical network appears to play a pivotal role in ictogenesis. We herein present three cases of non-convulsive status epilepticus (SE), in adult patients without previous history of epilepsy or seizures, precipitated by acute thalamic vascular and metabolic-induced lesions. In all cases the EEG showed patterns consistent with generalized SE confirmed either by a fast and complete clinical and EEG response to anti-seizure medication or definitive subtle motor signs consistent with SE. Read More

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Weekend light shifts evoke persistent Drosophila circadian neural network desynchrony.

J Neurosci 2021 Apr 30. Epub 2021 Apr 30.

Department of Physiology & Biophysics, University of California, Irvine. Irvine, CA 92697

We developed a method for single-cell resolution longitudinal bioluminescence imaging of PERIOD (PER) protein and TIMELESS (TIM) oscillations in cultured male adult brains that captures circadian circuit-wide cycling under simulated day/night cycles. Light input analysis confirms that CRYPTOCHROME (CRY) is the primary circadian photoreceptor and mediates clock disruption by constant light, and that eye light input is redundant to CRY. 3hr light phase delays (Friday) followed by 3hr light phase advances (Monday morning) simulate the common practice of staying up later at night on weekends, sleeping in later on weekend days then returning to standard schedule Monday morning (weekend light shift, WLS). Read More

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Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock.

Nutrients 2021 Apr 22;13(5). Epub 2021 Apr 22.

CRBS, UR3072: Mitochondria, Oxidative Stress and Muscular Protection, University of Strasbourg, 1 rue Eugène Boeckel, 67000 Strasbourg, France.

The importance of metabolic health is a major societal concern due to the increasing prevalence of metabolic diseases such as obesity, diabetes, and various cardiovascular diseases. The circadian clock is clearly implicated in the development of these metabolic diseases. Indeed, it regulates physiological processes by hormone modulation, thus helping the body to perform them at the ideal time of day. Read More

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Sleep Quality and Physical Activity as Predictors of Mental Wellbeing Variance in Older Adults during COVID-19 Lockdown: ECLB COVID-19 International Online Survey.

Int J Environ Res Public Health 2021 04 19;18(8). Epub 2021 Apr 19.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough E11 3TU, UK.

Background: The COVID-19 lockdown could engender disruption to lifestyle behaviors, thus impairing mental wellbeing in the general population. This study investigated whether sociodemographic variables, changes in physical activity, and sleep quality from pre- to during lockdown were predictors of change in mental wellbeing in quarantined older adults.

Methods: A 12-week international online survey was launched in 14 languages on 6 April 2020. Read More

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The impact of COVID-19 on the lives and mental health of Australian adolescents.

Eur Child Adolesc Psychiatry 2021 Apr 28. Epub 2021 Apr 28.

Black Dog Institute, UNSW, Hospital Road, Randwick, Sydney, 2022, Australia.

There has been significant disruption to the lives and mental health of adolescents during the COVID-19 pandemic. The purpose of this study was to assess the psychological and lifestyle impact of the pandemic on Australian adolescents, using an online survey, administered during the outbreak. Self-report surveys were administered online to a sample of 760 Australian adolescents aged 12-18 years assessing impact on a range of domains including behaviour, education, relationships, lifestyle factors (exercise, technology use, and sleep), and mental health outcomes (psychological distress, loneliness, health anxiety and well-being). Read More

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Phenotypic Spectrum of Seizure Disorders in MBD5-Associated Neurodevelopmental Disorder.

Neurol Genet 2021 Apr 18;7(2):e579. Epub 2021 Mar 18.

Research Institute of the McGill University Health Centre (K.M.), Montreal, PQ; Division of Child Neurology (K.M.), Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, PQ; Department of Neurology & Neurosurgery (K.M.), Montreal Children's Hospital, McGill University, Montreal, PQ; Child Neurology and Psychiatry (C.M.), Salesi Pediatric Hospital, United Hospitals of Ancona, Ancona, Italy; Division of Genetic Medicine (G.L.C., J.N., H.C.M.), Department of Pediatrics, University of Washington, Seattle, WA; Department of Neurology (A.M.), Great Ormond Street Hospital for Children, London, UK; Developmental Neurosciences Programme (A.M.), UCL Great Ormond Street Institute of Child Health, London, UK; Neurology Network Melbourne (J.P.), Melbourne, Victoria, Australia; Murdoch Children's Research Institute (C.S., I.E.S.), Parkville, Victoria, Australia; Department of Paediatrics and Child Health (T.S.), School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Division of Neurology (S.M.), Department of Pediatrics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Neurology Unit and Neurogenetic Laboratories (C.B., A.R., R.G.), Meyer Children's Hospital, Florence, Italy; Department of Clinical Genetics (R.H.S.), Great Ormond Street Hospital, London, UK; Epilepsy Research Centre (I.E.S.), Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia; Department of Paediatrics (I.E.S.), Royal Children's Hospital, The University of Melbourne, Parkville, Victoria, Australia; and The Florey Institute of Neuroscience and Mental Health (I.E.S.), Heidelberg, Victoria, Australia.

Objective: To describe the phenotypic spectrum in patients with MBD5-associated neurodevelopmental disorder (MAND) and seizures; features of MAND include intellectual disability, epilepsy, psychiatric features of aggression and hyperactivity, and dysmorphic features including short stature and microcephaly, sleep disturbance, and ataxia.

Methods: We performed phenotyping on patients with deletions, duplications, or point mutations and a history of seizures.

Results: Twenty-three patients with MAND and seizures were included. Read More

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Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS.

Sleep Med 2020 Aug 28;82:84-95. Epub 2020 Aug 28.

Department of Family Health Care Nursing, University of California at San Francisco, San Francisco, CA, USA.

Objective: To determine whether selected genes and plasma markers involved in energy homeostasis are associated with sleep disruption or duration in adults with HIV/AIDS.

Methods: A sample of 289 adults with HIV/AIDS wore a wrist actigraph for 72 h to estimate total sleep time (TST) and wake after sleep onset (WASO). Twenty-three single nucleotide polymorphisms (SNP) spanning 5 energy homeostasis genes (adiponectin [ADIPOQ], ghrelin [GHRL], leptin [LEP], peroxisome proliferator-activated receptor-alpha [PPARA], and -gamma [PPARG]) were genotyped using a custom array. Read More

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Sleep in the Hospitalized Child: A contemporary review.

Chest 2021 Apr 22. Epub 2021 Apr 22.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Acute illness and hospitalization introduce several risk factors for sleep disruption in children that can negatively affect recovery and healing and potentially compromise long-term cognition and executive function. The hospital setting is not optimized for pediatric sleep promotion, and many of the pharmacologic interventions intended to promote sleep in the hospital may actually have deleterious effects on sleep quality and quantity. To date, evidence to support pharmacologic sleep promotion in the pediatric inpatient setting is sparse. Read More

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The Molecular Clock and Neurodegenerative Disease: A Stressful Time.

Front Mol Biosci 2021 26;8:644747. Epub 2021 Mar 26.

Gamsby Laboratory, USF Health Byrd Alzheimer's Center and Research Institute, University of South Florida Health, Tampa, FL, United States.

Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This dysfunction manifests as sleep cycle mistiming, alterations in body temperature rhythms, and an increase in symptomatology during the early evening hours known as Sundown Syndrome. Disruption of circadian rhythm homeostasis has also been implicated in the etiology of neurodegenerative disease. Read More

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The role of the COVID-19 pandemic in altered psychological well-being, mental health and sleep: an online cross-sectional study.

Psychol Health Med 2021 Apr 20:1-9. Epub 2021 Apr 20.

Centre for Behavioural Science and Applied Psychology, Sheffield Hallam University, Sheffield, UK.

Coronavirus disease 2019 (COVID-19) is a global pandemic. Measures to reduce transmission of the virus have altered usual activities, routines, and livelihoods, and have had a significant impact on mental health. The current study aims to examine the potential alterations in psychological wellbeing, mental health, sleep and diurnal preference due to the COVID-19 pandemic. Read More

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Associations of sleep and female sexual function: good sleep quality matters.

Menopause 2021 Apr 19. Epub 2021 Apr 19.

Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ Mayo Clinic Center for Women's Health, Mayo Clinic, Rochester, MN Division of General Internal Medicine, Mayo Clinic, Rochester, MN Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL.

Objective: To evaluate associations between sleep and female sexual function.

Methods: A cross-sectional analysis from the Data Registry on Experiences of Aging, Menopause and Sexuality (DREAMS) was performed using questionnaires in women presenting for menopause or sexual health consult at Mayo Clinic from December, 2016 to September, 2019. Female Sexual Function Index (FSFI), Female Sexual Distress Scale-Revised (FSDS-R), and the Pittsburgh Sleep Quality Index (PSQI) assessed sexual function and sleep parameters, respectively. Read More

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Short-term physical health effects of sleep disruptions attributed to the acute hospital environment: a systematic review.

Sleep Health 2021 Apr 16. Epub 2021 Apr 16.

Department of Respiratory Medicine, Liverpool Hospital, South Western Sydney Local Health District, Australia; Faculty of Medicine, University of New South Wales, Sydney, Australia.

The sleep disruption experienced by patients admitted to hospital may have a negative effect on health but the nature and magnitude of the effect has not been conclusively outlined. The review was designed to examine the impact of sleep disruption associated with being a hospital inpatient, on short-term physical health outcomes in adult patients. Searches comprised journal databases, gray literature sources, and backward and forward citation searching. Read More

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K3.1 channels regulate the rate of critical period plasticity.

Neurosci Res 2021 Apr 16. Epub 2021 Apr 16.

Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan; International Research Center for Neurointelligence, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Center for Brain Science, Department of Molecular Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA. Electronic address:

Experience-dependent plasticity within visual cortex is controlled by postnatal maturation of inhibitory circuits, which are both morphologically diverse and precisely connected. Gene-targeted disruption of the voltage-dependent potassium channel K3.1 broadens action potentials and reduces net inhibitory function of parvalbumin (PV)-positive GABA subtypes within the neocortex. Read More

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Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.

Neurochem Res 2021 Apr 19. Epub 2021 Apr 19.

Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. Read More

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The Past, the Present, and the Future: A Qualitative Study Exploring How Refugees' Experience of Time Influences Their Mental Health and Well-Being.

Front Sociol 2020 21;5:46. Epub 2020 Aug 21.

Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway.

The experience of time has a decisive influence on refugees' well-being and suffering in all phases of their flight experiences. Basic safety is connected both developmentally and in present life with a feeling of continuity and predictability. Refugees often experience disruption of this basic sense of time in their home country due to war, persecution, and often severe traumatization, during flight, due to unpredictable and dangerous circumstances in the hands of smugglers, and after flight, due to unpredictable circumstances in asylum centers, e. Read More

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Measuring sleep regularity: Theoretical properties and practical usage of existing metrics.

Sleep 2021 Apr 17. Epub 2021 Apr 17.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.

Study Objectives: Sleep regularity predicts many health-related outcomes. Currently, however, there is no systematic approach to measuring sleep regularity. Traditionally, metrics have assessed deviations in sleep patterns from an individual's average. Read More

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Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation.

Front Genet 2021 30;12:664334. Epub 2021 Mar 30.

Center for Brain Science, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Inadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, to what extent acute sleep deprivation (SD) has impact on the circadian rhythms of peripheral tissues is not clear. Here, we show that in mouse lung, a 10-h acute sleep deprivation can alter the circadian expression of approximately 3,000 genes. Read More

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Effect of Inadequate Sleep on Clinician Performance.

Haleh Saadat

Anesth Analg 2021 05;132(5):1338-1343

From the Department of Anesthesiology, Frank H Netter School of Medicine, Quinnipiac University, Hartford Health Care, St. Vincent's Medical Center, Bridgeport, Connecticut.

The negative impacts of sleep deprivation and fatigue have long been recognized. Numerous studies have documented the ill effects of impaired alertness associated with the disruption of the sleep-wake cycle; these include an increased incidence of human error-related accidents, increased morbidity and mortality, and an overall decrement in social, financial, and human productivity. While there are multiple studies on the impact of sleep deprivation and fatigue in resident physicians, far fewer have examined the effects on attending physicians, and only a handful addresses the accumulated effects of chronic sleep disturbances on acute sleep loss during a night call-shift. Read More

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Open oral cavity has little effects on upper airway aerodynamics in children with obstructive sleep apnea syndrome: A computational fluid dynamics study based on patient-specific models.

J Biomech 2021 Apr 2;121:110383. Epub 2021 Apr 2.

School of Energy and Power Engineering, Shandong University, Jinan 250061, China.

Obstructive sleep apnea syndrome (OSAS) is a common disorder with recurrent pharyngeal airway collapse and sleep disruption. Recently, great progress has been made in investigating the physical mechanism of OSAS development and treatment using computational fluid dynamics (CFD). However, previous studies always neglected the oral cavity artificially in the patient's upper airway CFD model, but did not give any specific explanation. Read More

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Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease.

Neurobiol Dis 2021 Apr 10;155:105367. Epub 2021 Apr 10.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom. Electronic address:

Sleep disruption is a common invisible symptom of neurological dysfunction in Huntington's disease (HD) that takes an insidious toll on well-being of patients. Here we used electroencephalography (EEG) to examine sleep in 6 year old OVT73 transgenic sheep (Ovis aries) that we used as a presymptomatic model of HD. We hypothesized that despite the lack of overt symptoms of HD at this age, early alterations of the sleep-wake pattern and EEG powers may already be present. Read More

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A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses.

J Cell Biochem 2021 Apr 13. Epub 2021 Apr 13.

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.

G protein-coupled receptors regulate a variety of cellular responses and have been considered as therapeutic targets for human diseases. Lysophosphatidic acid receptor 1 (LPA1) is a receptor for bioactive lysophospholipid, LPA. LPA/LPA1-mediated signaling contributes to inflammatory and fibrotic responses in lung diseases; thus understanding regulation of LPA1 stability is important for modulating LPA/LPA1 signaling. Read More

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Enhancement of cue-induced reinstatement of alcohol seeking by acute total sleep restriction in male Wistar rats.

Pharmacol Biochem Behav 2021 Apr 9;205:173188. Epub 2021 Apr 9.

Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS 39216, USA; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address:

Clinical studies suggest that sleep impairment is a barrier to successful treatment in alcohol use disorder (AUD) patients, with sleep disruption associated with relapse to alcohol taking. To date, no preclinical study has evaluated the relationship between impaired sleep and alcohol relapse. In the present study, we used a self-administration model to investigate the effects of sleep restriction on reinstatement induced by alcohol-paired environmental cues. Read More

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Inconsistent social rhythms are associated with abdominal adiposity after involuntary job loss: An observational study.

Obes Sci Pract 2021 Apr 21;7(2):208-216. Epub 2021 Jan 21.

Asthma and Airway Disease Research Center University of Arizona College of Medicine Tucson Arizona USA.

Objective: Unemployment is an established risk factor for obesity. However, few studies have examined obesity-related health behavior after involuntary job loss specifically. Job loss confers a disruption in daily time structure that could lead to negative metabolic and psychological outcomes through chronobiological mechanisms. Read More

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Effects of dim artificial light at night on locomotor activity, cardiovascular physiology, and circadian clock genes in a diurnal songbird.

Environ Pollut 2021 Mar 31;282:117036. Epub 2021 Mar 31.

Department of Biology, University of Nevada, Reno, Reno, NV, USA.

Artificial light is transforming the nighttime environment and quickly becoming one of the most pervasive pollutants on earth. Across taxa, light entrains endogenous circadian clocks that function to synchronize behavioral and physiological rhythms with natural photoperiod. Artificial light at night (ALAN) disrupts these photoperiodic cues and has consequences for humans and wildlife including sleep disruption, physiological stress and increased risk of cardiovascular disease. Read More

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The Neurophysiology of Sleep in Parkinson's Disease.

Mov Disord 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Sleep disturbances are among the most common nonmotor complications of Parkinson's disease (PD), can present in prodromal stages, and progress with advancing disease. In addition to being a symptom of neurodegeneration, sleep disturbances may also contribute to disease progression. Currently, limited options exist to modulate sleep disturbances in PD. Read More

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Cross-Sectional and Prospective Associations of Rest-Activity Rhythms with Circulating Inflammatory Markers in Older Men.

J Gerontol A Biol Sci Med Sci 2021 Apr 5. Epub 2021 Apr 5.

Research Institute, California Pacific Medical Center, San Francisco, CA, USA.

Chronic increases in pro-inflammatory cytokines in older adults, known as inflammaging, is an important risk factor for morbidity and mortality in the aging population. It has been suggested that circadian disruption may play a role in chronic inflammation, but there has been limited study that investigated the overall profile of 24-hour rest-activity rhythms in relation to inflammation using longitudinal data. In the Outcomes of Sleep Disorders in Older Men Study, we applied the extended cosine model to derive multiple rest-activity rhythm characteristics using multi-day actigraphy, and examined their associations with six inflammatory markers (i. Read More

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