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Sexual Function and Mood Disorders Among Menopausal Women: A Systematic Scoping Review.

J Sex Med 2022 Jul;19(7):1098-1115

Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Kiel, Germany.

Background: Changes in sex hormones during menopause may have detrimental effects on a woman's sexual function and cause mood disorders. The treatment of both conditions is a challenge in gynecology.

Aim: To review the published literature on sexual function and mood disorders among peri- and postmenopausal women. Read More

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Environmental exposure to per- and polyfluoroalkyl substances and sleep disturbance in pregnant women: A prospective cohort study.

Sci Total Environ 2022 Jun 22:156869. Epub 2022 Jun 22.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200052, China. Electronic address:

Previous studies on the association between exposure to per- and polyfluoroalkyl substances (PFAS) and sleep patterns in pregnant women are limited. This cohort study aims to assess the associations between PFAS and sleep quality in pregnant women. Of the 4127 women who participated in the Shanghai Birth Cohort, 3174, 3070, and 2887 women in their first, second, and third trimesters of gestation, respectively, were included in our analysis. Read More

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Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy.

Biochimie 2022 Jun 22. Epub 2022 Jun 22.

Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Clinical Biochemistry, Faculty of Medicine, Golestan University of Medical Sciences, Babol, Iran. Electronic address:

Melatonin, the major secretory product of the pineal gland, not only regulates circadian rhythms, mood, and sleep but also has actions in neoplastic processes which are being intensively investigated. Melatonin is a promising molecule which considered a differentiating agent in some cancer cells at both physiological and pharmacological concentrations. It can also reduce invasive and metastatic status through receptors MT1 and MT2 cytosolic binding sites, including calmodulin and quinone reductase II enzyme, and nuclear receptors related to orphan members of the superfamily RZR/ROR. Read More

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The interaction of P11 methylation and early-life stress impacts the antidepressant response in patients with major depressive disorder.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, PR China; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Southeast university, Nanjing 210009, PR China. Electronic address:

Purpose: The present research investigates the influence of P11 gene DNA methylation combined with life stress on the response to antidepressants in the first two weeks.

Methods: A total of 291 Han Chinese patients with major depressive disorder and 100 healthy controls were included. The Life Events Scale and the Childhood Trauma Questionnaire were used to assess stress. Read More

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Sleep and affective disorders in relation to Parkinson's disease risk among older women from the Women's Health Initiative.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD 21225, USA.

Objectives: To evaluate sleep and affective (mood/anxiety) disorders as clinical predictors of incident Parkinson's disease (PD) among women ≥65 years of age.

Methods: We performed secondary analyses with available data from the Women's Health Initiative Clinical Trials and Observational Study linked to Medicare claims. Sleep, mood and anxiety disorders at baseline were defined using diagnostic codes. Read More

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Association between trajectories of problematic mobile phone use and chronotype among Chinese college students.

Addict Behav 2022 Jun 9;134:107398. Epub 2022 Jun 9.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, China. Electronic address:

Aims: This study aimed to describe the prevalence of problematic mobile phone use (PMPU) and chronotype among Chinese college students, estimate PMPU development trajectories, and further examine the effect of PMPU trajectories on chronotype.

Design: In a stratified cluster sampling design, PMPU and chronotype were evaluated in 999 college students from two universities in a 2-year prospective investigation from April 2019 to April 2021, and an investigation was conducted every six months (time 1 ∼ time 5, T1 ∼ T5).

Participants: N = 999 college students (mean age at T1: 18. Read More

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Clinical Conundrum: Dysphagia Associated with Sleep Disorders.

Dysphagia 2022 Jun 25. Epub 2022 Jun 25.

Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 4, 73039, Tricase, Lecce, Italy.

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Prognostic values of muscle mass assessed by dual-energy X-ray absorptiometry and bioelectrical impedance analysis in older patients with heart failure.

Geriatr Gerontol Int 2022 Jun 25. Epub 2022 Jun 25.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: This study aimed to compare bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) in measuring skeletal muscle mass (MM), and its prognostic implications in old patients with heart failure.

Methods: We prospectively evaluated MM measured by both BIA and DEXA in 226 hospitalized elderly (≥65 years) patients with heart failure. The cut-off values proposed by the Asian Working Group in Sarcopenia were used to define low MM. Read More

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Social support mediates the effect of morningness on changes in subjective well-being over 6 months.

J Sleep Res 2022 Jun 25. Epub 2022 Jun 25.

Faculty of Psychology, University of Warsaw, Warsaw, Poland.

Studies show that morningness is positively associated with subjective well-being. Our previous research investigated factors that could underlie this relationship, finding that the association between morningness-eveningness and subjective well-being can be partially attributed to the higher levels of perceived social support received by morning-oriented individuals. In the present study, we examine the longitudinal effects of perceived social support in mediating the relationship between morningness-eveningness and subjective well-being. Read More

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Automated sleep scoring system using multi-channel data and machine learning.

Comput Biol Med 2022 Jul 21;146:105653. Epub 2022 May 21.

Department of Chest Diseases, Faculty of Medicine, Yuksek Ihtisas University, Ankara, Turkey.

Sleep staging is one of the most important parts of sleep assessment and it has an important role in early diagnosis and intervention of sleep disorders. Manual sleep staging requires a specialist and time which can be affected by subjective factors. So that, automatic sleep-scoring method with high accuracy is beneficial. Read More

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Two-bronchoscope technique for cryoextraction: An alternative approach for the removal of endobronchial thrombi in children.

Pediatr Pulmonol 2022 Jun 24. Epub 2022 Jun 24.

Division of Pediatric Pulmonary and Sleep Medicine, University of Alabama at Birmingham, 1600 7th Avenue South, Birmingham, AL, 35233, Birmingham.

Cryotherapy has become an important aspect of pediatric interventional bronchoscopy. Through application of the Joule-Thompson effect, cryotherapy utilizes freeze-thaw cycles via rapid expansion of pressurized gas This article is protected by copyright. All rights reserved. Read More

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Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data.

J Neurodev Disord 2022 Jun 24;14(1):39. Epub 2022 Jun 24.

Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Numerous genes are implicated in autism spectrum disorder (ASD). ASD encompasses a wide-range and severity of symptoms and co-occurring conditions; however, the details of how genetic variation contributes to phenotypic differences are unclear. This creates a challenge for translating genetic evidence into clinically useful knowledge. Read More

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The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.

Neurosci Bull 2022 Jun 25. Epub 2022 Jun 25.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.

Adverse experiences in early life have long-lasting negative impacts on behavior and the brain in adulthood, one of which is sleep disturbance. As the corticotropin-releasing hormone (CRH)-corticotropin-releasing hormone receptor 1 (CRHR1) system and nucleus accumbens (NAc) play important roles in both stress responses and sleep-wake regulation, in this study we investigated whether the NAc CRH-CRHR1 system mediates early-life stress-induced abnormalities in sleep-wake behavior in adult mice. Using the limited nesting and bedding material paradigm from postnatal days 2 to 9, we found that early-life stress disrupted sleep-wake behaviors during adulthood, including increased wakefulness and decreased non-rapid eye movement (NREM) sleep time during the dark period and increased rapid eye movement (REM) sleep time during the light period. Read More

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Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort.

Neurol Sci 2022 Jun 25. Epub 2022 Jun 25.

Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Università di Modena e Reggio-Emilia, Modena, Italy.

Introduction: Narcolepsy is a chronic and rare hypersomnia of central origin characterized by excessive daytime sleepiness and a complex array of symptoms as well as by several medical comorbidities. With growing pharmacological options, polytherapy may increase the possibility of a patient-centered management of narcolepsy symptoms. The aims of our study are to describe a large cohort of Italian patients with narcolepsy who were candidates for pitolisant treatment and to compare patients' subgroups based on current drug prescription (drug-naïve patients in whom pitolisant was the first-choice treatment, switching to pitolisant from other monotherapy treatments, and adding on in polytherapy). Read More

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Continuous positive airway pressure treatment of obstructive sleep apnea and hypertensive complications in high-risk pregnancy.

Sleep Breath 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, Wisconsin Sleep, Wisconsin Institute for Sleep and Consciousness, School of Medicine and Public Health, University of Wisconsin-Madison, 1685 Highland Ave, Madison, WI, 53705, USA.

Purpose: To evaluate whether or not continuous positive airway pressure (CPAP) treatment in pregnancies complicated by obstructive sleep apnea (OSA) is associated with a decrease in hypertensive disorders of pregnancy.

Methods: This was a retrospective cohort study of perinatal outcomes in women who underwent objective OSA testing and treatment as part of routine clinical care during pregnancy. Where diagnostic criteria for OSA were reached (respiratory event index (REI) ≥ 5 events per hour), patients were offered CPAP therapy. Read More

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Leptin Attenuates Fear Memory by Inhibiting Astrocytic NLRP3 Inflammasome in Post-traumatic Stress Disorder Model.

Neurochem Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.

Accumulating evidence suggests that the activation of nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome contributes to the pathophysiology of post-traumatic stress disorder (PTSD). Astrocytes, the homeostatic cells of the central nervous system are intimately involved into pathophysiology of various mental disorders including PTSD. We demonstrated previously that leptin exerts neuroprotection and ameliorates chronic sleep deprivation-induced depressive-like behaviours. Read More

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The Feasibility and Effectiveness of Virtual Reality Meditation on Reducing Chronic Pain for Older Adults with Knee Osteoarthritis.

Pain Pract 2022 Jun 24. Epub 2022 Jun 24.

Brigham and Women's Pain Management Center, Pain Research, Chestnut Hill, MA.

There is an urgent need for safe and effective non-pharmacologic approaches to treat chronic knee pain in older adults. Although virtual reality (VR) has shown some effectiveness for acute pain, there is limited evidence on the effects of VR on chronic pain particularly with older adult populations. This single application, within-subject pilot study evaluated the feasibility and effectiveness of VR as a clinical treatment for older adults with chronic osteoarthritis knee pain. Read More

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Are sleep quality judgments comparable across individuals, places, and spaces? An interdisciplinary analysis of data from 207,608 individuals across 68 countries.

Sleep Health 2022 Jun 21. Epub 2022 Jun 21.

Department of Psychology, Northumbria University, Newcastle, UK.

Objectives: Significant research has shown that health is a heterogeneous concept, and one person's poor health may not be comparable with another's. Yet, little consideration has been given to whether sleep quality judgments are also heterogeneous or whether they cohere between individuals. Another possibility is that there are group differences in the ways in which sleep quality is perceived. Read More

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Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial.

BMJ Open 2022 Jun 24;12(6):e061287. Epub 2022 Jun 24.

School of Second Clinical Medicine/The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan, China

Introduction: Migraine is a common neurological disorder with a higher prevalence occurring in women. Migraine without aura (MwoA) is the most common type of migraine. In recent years, the safety and effectiveness of acupuncture for migraines have been internationally recognised. Read More

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Retrospective analysis of comorbidities in stroke patients with a history of obstructive sleep apnea treated with thrombolytic therapy.

J Vasc Nurs 2022 Jun 15;40(2):74-85. Epub 2022 Feb 15.

University of South Carolina School of Medicine-Greenville, Greenville, SC, USA. Electronic address:

Background: The eligibility criteria for thrombolytic therapy may differ between acute ischemic stroke patients (AIS) patients with and without incidence of obstructive sleep apnea (OSA). In this study, we determine the effect of specific comorbidities in the exclusion and inclusion for recombinant tissue plasminogen activator (rtPA) administration in the AIS population with OSA.

Methods: Retrospective data from a stroke registry were analyzed for baseline clinical and demographic factors in AIS patients with OSA for rtPA therapy from January 2010 to June 2016. Read More

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Single-cell RNA-Seq Reveals the Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within the Microenvironment in Vestibular Schwannoma.

Am J Pathol 2022 Jun 21. Epub 2022 Jun 21.

Otolaryngology Institute of Shanghai Jiao Tong University, the Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Vestibular schwannomas (VSs), which develop from Schwann cells (SCs) of the vestibular nerve, are the most prevalent benign tumors of the cerebellopontine angle and internal auditory canal. Despite advances in treatment, the cellular components and mechanisms of VS tumor progression remain unclear. Here, we performed single-cell RNA-seq on clinically surgically isolated VS samples and clarified their cellular composition in a sophisticated manner, including the heterogeneous Schwann cell subtypes. Read More

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Disruptions of circadian rhythms, sleep, and stress responses in zebrafish: New infrared-based activity monitoring assays for toxicity assessment.

Chemosphere 2022 Jun 21:135449. Epub 2022 Jun 21.

UCIBIO-REQUIMTE - Applied Molecular Biosciences Unit, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, Portugal. Electronic address:

Behavioural disruptions are sensitive indicators of alterations to normal animal physiology and can be used for toxicity assessment. The small vertebrate zebrafish is a leading model organism for toxicological studies. The ability to continuously monitor the toxicity of drugs, pollutants, or environmental changes over several days in zebrafish can have high practical application. Read More

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Slow wave sleep deficits in the flinders sensitive line rodent model of depression: effects of medial forebrain bundle deep-brain stimulation.

Neuroscience 2022 Jun 21. Epub 2022 Jun 21.

Laboratoire de Neurosciences Cognitives et Adaptatives, University of Strasbourg, Strasbourg, France. Electronic address:

Major Depressive Disorder is an affective disorder typically accompanied by sleep disturbances. Deep brain stimulation of the medial forebrain bundle is an emerging intervention for treatment-resistant depression, but its effect on sleep has not been closely examined. Here we aimed to characterise sleep deficits in the Flinders sensitive line, an established rodent model of depression, and investigate the consequences of medial forebrain bundle stimulation on sleep-related phenotypes. Read More

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Towards a tailored psychotherapy for patients with functional neurological disorders.

J Affect Disord 2022 Jun 21. Epub 2022 Jun 21.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

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Post-traumatic stress disorder prevalence and sleep quality in fire victims and rescue workers in southern Brazil: a cross-sectional study.

Public Health 2022 Jun 21;209:4-13. Epub 2022 Jun 21.

Chronobiology and Sleep Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Sleep Disorders Center, Pulmonary Service, HCPA, Porto Alegre, RS, Brazil.

Objectives: This survey was conducted to evaluate the prevalence of post-traumatic stress disorder (PTSD) and the sleep quality in victims and rescue team of the third deadliest nightclub fire in the world.

Study Design: A cross-sectional study.

Methods: Participants were victims and rescue workers exposed to a fire at a nightclub, which occurred in January 2013 in Southern Brazil. Read More

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The Sleep Well Baby project: an automated real-time sleep-wake state prediction algorithm in preterm infants.

Sleep 2022 Jun 24. Epub 2022 Jun 24.

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Study Objectives: Sleep is an important driver of early brain development. However, sleep is often disturbed in preterm infants admitted to the neonatal intensive care unit (NICU). We aimed to develop an automated algorithm based on routinely measured vital parameters to classify sleep-wake states of preterm infants in real-time at the bedside. Read More

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Ageing with Interstitial lung disease: preserving health and well being.

Curr Opin Pulm Med 2022 Jul;28(4):321-336

Exeter Respiratory Institute University of Exeter, Exeter.

Purpose Of Review: Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. Read More

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The influence of age and sex in sarcoidosis.

Curr Opin Pulm Med 2022 Jul;28(4):307-313

Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio.

Purpose Of Review: This review aims to describe how the clinical manifestations of sarcoidosis may be shaped by the effects of sex hormones and by age dependent changes in immune functions and physiology This review is intended to highlight the need to consider the effects of sex and sex in future studies of sarcoidosis.

Recent Findings: The clinical manifestations of sarcoidosis differ based on sex and gender There is emerging evidence that female and male hormones and X-linked genes are important determinants of immune responses to environmental antigens, which has important implications for granuloma formation in the context of sarcoidosis Furthermore, sex hormone levels predictably change throughout adolescence and adulthood, and this occurs in parallel with the onset immune senescence and changes in physiology with advanced age.

Summary: Recent studies indicate that sex and age are important variables shaping the immune response of humans to environmental antigens We posit herein that sex and age are important determinants of sarcoidosis clinical phenotypes Many gaps in our understanding of the roles played by sex and gender in sarcoidosis, and these need to be considered in future studies. Read More

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Therapeutic bronchoscopy for malignant central airway obstruction: impact on quality of life and risk-benefit analysis.

Curr Opin Pulm Med 2022 Jul;28(4):288-293

Pulmonary, Critical Care, and Sleep Medicine Section, Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas, USA.

Purpose Of Review: Malignant central airway obstruction (CAO) is a common complication in cancer and confers significant symptom burden and reduction in quality of life. Multiple bronchoscopic interventions exist for malignant CAO. In this review, we discuss the role of therapeutic bronchoscopy in the management of malignant CAO, emphasizing its impact on symptom control and quality of life while balancing the risks and benefits of intervention. Read More

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