29,327 results match your criteria skull base


A novel bone-thinning technique for transcranial stimulation motor-evoked potentials in rats.

Sci Rep 2021 Jun 14;11(1):12496. Epub 2021 Jun 14.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima, 734-8553, Japan.

Transcranial electrical stimulated motor-evoked potentials (tcMEPs) are widely used to evaluate motor function in humans, and even in animal studies, tcMEPs are used to evaluate neurological dysfunction. However, there is a dearth of reports on extended tcMEP recordings in both animal models and humans. Therefore, this study examined a new technique for stably recording tcMEPs over several weeks in six healthy female Sprague-Dawley rats. Read More

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Outcomes of sinonasal oncocytic papilloma by endoscopic approach in 69 patients.

Auris Nasus Larynx 2021 Jun 11. Epub 2021 Jun 11.

ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: Sinonasal oncocytic papilloma (SOP) is a rare subtype of sinonasal papilloma. There are currently few reports on its clinical features and outcomes after endoscopic surgical resection. This study aims to explore the clinical characteristics of SOP and potential factors predicting tumor recurrence through a single-center retrospective case series analysis. Read More

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The Sensorineural Hearing Loss Related to a Rare Infratentorial Developmental Venous Angioma: A Case Report and Review of Literature.

J Neurol Surg A Cent Eur Neurosurg 2021 Jun 14. Epub 2021 Jun 14.

Department of Neurosurgery, Skull Base Research Center, Shahid Beheshti University of Medical Sciences, Loghman Hakim Hospital, Tehran, Iran.

Background:  Developmental venous anomaly (DVA) is a benign venous abnormality draining normal brain parenchyma. It is mostly asymptomatic; however, rare complications such as hemorrhage may lead to symptomatic conditions. Headache and seizure are the most common symptoms. Read More

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Factors Associated With Unanticipated Admission After Outpatient Endoscopic Sinonasal Surgery.

Laryngoscope 2021 Jun 14. Epub 2021 Jun 14.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objectives/hypothesis: To identify factors that may increase the risk of unplanned admission following elective outpatient endoscopic sinonasal surgery (ESS).

Study Design: Retrospective analysis of the National Surgical Quality Improvement Program (NSQIP).

Methods: All cases of ESS were extracted from the 2010 to 2018 NSQIP database using Current Procedural Terminology codes. Read More

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Expression Analysis of VDR-Related LncRNAs in Autism Spectrum Disorder.

J Mol Neurosci 2021 Jun 14. Epub 2021 Jun 14.

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Vitamin D receptor (VDR) signaling has been reported to affect neurodevelopment, thus participating in the risk of autism spectrum disorder (ASD). We have measured expression amounts of VDR, CYP27B1, and two related long non-coding RNAs, namely SNHG6 and LINC00511, in the circulation of ASD patients compared with normal controls. Expression of CYP27B1 was remarkably higher in ASD cases compared with controls (posterior beta = 2. Read More

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Understanding giant cell sarcoma of the head and neck: A population-based study.

Head Neck 2021 Jun 14. Epub 2021 Jun 14.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Background: Giant cell sarcomas (GCS) are rare head and neck neoplasms.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.

Results: Four hundred and forty cases of GCS of the head and neck were identified. Read More

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Cerebrospinal Fluid Leaks from the Lateral Ventricle: A Case Series.

Otol Neurotol 2021 Jun 11. Epub 2021 Jun 11.

Department of Otolaryngology-Head and Neck Surgery Indiana University School of Medicine Department of Radiology - Section of Neuroradiology and Imaging Sciences Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, Indiana.

Objectives: Describe the diagnosis and management of lateral skull base (LSB) cerebrospinal fluid (CSF) leaks originating from the lateral ventricle.

Study Design: Retrospective case review.

Setting: Tertiary referral academic center. Read More

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Biological Treatments of Neurofibromatosis Type 2 and Other Skull Base Disorders.

Otolaryngol Clin North Am 2021 Jun 10. Epub 2021 Jun 10.

Gilbert Family Neurofibromatosis Institute, Children's National Hospital, 111 Michigan Avenue Northwest, Washington, DC 20010, USA; Department of Pediatric Hematology-Oncology; Center for Genetics Research, Children's National Hospital, 111 Michigan Avenue Northwest, Washington, DC 20010, USA. Electronic address:

Studies of genomic alterations that occur in skull base tumors have provided information regarding biological aberrations that are necessary for the growth and maintenance of these tumors. This has led to the development and initiation of clinical trials incorporating biological treatments for many skull base tumors. The exciting developments of molecularly targeted therapy for the treatment of skull base tumors may provide noninvasive therapeutic options for patients that can be used either alone or in combination with surgery and/or radiation therapy. Read More

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Emerging role of circular RNAs in the pathobiology of lung cancer.

Biomed Pharmacother 2021 Jun 11;141:111805. Epub 2021 Jun 11.

Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Lung cancer is among the leading causes of cancer mortality and incidence in both sexes. Different classes of transcripts have been proposed as molecular markers in this type of cancer. Circular RNAs (circRNAs) are a group of transcripts with circular enclosed and stable configuration. Read More

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Skull base chondrosarcoma presenting with parenchymal hemorrhage: A case report.

J Clin Neurosci 2021 Jul 12;89:223-225. Epub 2021 May 12.

Department of Neurosurgery, P. D. Hinduja Hospital, Mumbai, India. Electronic address:

Chondrosarcoma (CS) is a locally invasive, slow growing malignant neoplasm. Intracranial chondrosarcoma are extradural osseous lesions and intradural location with intratumoral hemorrhage is very rare. We report a rare case of 65-year-old male presenting with a small mass in left posterior skull base and later, suddenly deteriorating due to large cerebellar hemorrhage. Read More

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Sinonasal adenocarcinoma: A population-based analysis of demographic and socioeconomic disparities.

Head Neck 2021 Jun 12. Epub 2021 Jun 12.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Sinonasal adenocarcinoma (SNAC) is a rare tumor. The impact of health disparities on survival, stage at presentation, and utilization of surgery is not well understood in patients with SNAC.

Methods: The Surveillance, Epidemiology, and End Results database was queried for cases of SNAC from 1973 to 2015. Read More

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Does general comorbidity impact the postoperative outcomes after surgery for large and giant petroclival meningiomas?

Neurosurg Rev 2021 Jun 12. Epub 2021 Jun 12.

Service de Neurochirurgie, CHU Nord, APHM-AMU, Marseille, France.

We assessed the role of the general condition of the patient in addition to usual anatomical reasoning to improve the prediction of personalized surgical risk for patients harboring a large and giant petroclival meningiomas. Single-center, retrospective observational study including adult patients surgically treated for a large and giant petroclival meningioma between January 2002 and October 2019 in a French tertiary neurosurgical skull-base center by one Neurosurgeon. Inclusion criteria were as follows: (1) histopathologically proven meningioma; (2) larger than 3 cm in diameter; (3) located within the upper two-thirds of the clivus, the inferior petrosal sinus, or the petrous apex around the trigeminal incisura, medial to the trigeminal nerve. Read More

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Is Contrast Medium Really Needed for Follow-up MRI of Untreated Intracranial Meningiomas?

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

From the Division of Neuroradiology (J.B., A.F., M.I.V.), Geneva University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland.

Background And Purpose: Recent concerns relating to tissue deposition of gadolinium are favoring the use of noncontrast MR imaging whenever possible. The purpose of this study was to assess the necessity of gadolinium contrast for follow-up MR imaging of untreated intracranial meningiomas.

Materials And Methods: One-hundred twenty-two patients (35 men, 87 women) with meningiomas who underwent brain MR imaging between May 2007 and May 2019 in our institution were included in this retrospective cohort study. Read More

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Pneumocephalus with meningitis secondary to an old traumatic anterior cranial fossa defect.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Emergency Medicine, Kasturba Hospital Manipal, Manipal, Karnataka, India.

We report a case of a 30-year-old man who presented with altered mental status, fever, headache and vomiting for 3 days. An initial CT scan of the brain revealed the presence of pneumocephalus with a bony defect in the anterior cranial fossa. The pneumocephalus was not explained initially and the patient was re-examined for any signs of trauma to the face, and a review of the history revealed a series of three traumatic events months prior to this illness. Read More

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Biologics in Otolaryngology: Past, Present, and Future.

Otolaryngol Clin North Am 2021 Jun 8. Epub 2021 Jun 8.

Department of Otolaryngology - Head and Neck Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, 11th Floor Otolaryngology, Atlanta, GA 30308, USA.

Biologics have been widely adopted in multiple subspecialties of otolaryngology. This article provides an overview of past, present, and future uses of biologics in otolaryngology with emphasis on allergic rhinitis, chronic rhinosinusitis with polyposis, head and neck squamous cell carcinoma, salivary and skull base tumors, hearing loss, and other otologic disorders. Read More

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Retrosigmoid transhorizontal fissure approach to lateral pontine cavernous malformation: comparison to transpetrosal presigmoid retrolabyrinthine approach.

J Neurosurg 2021 Jun 11:1-10. Epub 2021 Jun 11.

Objective: The retrosigmoid (RS) approach is a classic route used to access deep-seated brainstem cavernous malformation (CM). The angle of access is limited, so alternatives such as the transpetrosal presigmoid retrolabyrinthine (TPPR) approach have been used to overcome this limitation. Here, the authors evaluated a modification to the RS approach, horizontal fissure dissection by using the RS transhorizontal (RSTH) approach. Read More

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MEG3 lncRNA is over-expressed in autism spectrum disorder.

Metab Brain Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Long non-coding RNAs (lncRNAs) comprise a group of regulatory transcripts which partake in the biological processes leading to development of neuropsychiatric disorders such as autism spectrum disorder (ASD). We measured circulatory levels of MEG3, GAS5, CYTOR, UCA1 lncRNAs and CRYBG3 gene in children with ASD and controls. Expression of MEG3 was remarkably higher in children with ASD when compared with controls (Posterior Beta = 2. Read More

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Giant skull base mass need not be a tumor - a rare presentation of IgG4-related disease.

Br J Neurosurg 2021 Jun 11:1-4. Epub 2021 Jun 11.

Department of Neurosurgery, PGIMER, Chandigarh, India.

Background: Giant intracranial 'IgG4-related' lesions are uncommon. They may present as pachymeningitis or localized mass. Here we report, probably, the largest IgG4 skull base mass ever to be reported. Read More

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Extirpation of Recurrent Petrous Apex Cholesterol Granuloma Through the Zygomatic Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Petrous apex cholesterol granulomas are believed to result from blockage of the normal aeration of the petrous air cells, resulting in a repetitive cycle of mucosal engorgement, hemorrhage, and granuloma formation.1 The lesion usually progressively expands causing compressive symptoms. The thick granulomatous wall envelopes various ages of breakdown products, including a cholesterol-containing fluid, which is typically hyperintense on T1 and T2 weighted magnetic resonance imaging. Read More

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Atypical Meningioma of the Sinonasal Tract.

Cureus 2021 May 8;13(5):e14908. Epub 2021 May 8.

Head and Neck-Plastics and Reconstructive Surgery, Erie County Medical Center, Buffalo, USA.

This case report describes a patient with intellectual disability who presented with a neglected midline nasal mass eroding the anterior skull base, which was found to be a Grade II meningioma likely of the olfactory bulb. Points of interest include differential diagnosis of this atypical mass of the sinonasal tract, as well as decision-making in balancing appropriate management and quality of life in a patient with developmental delay who could not make decisions for herself. Literature review regarding the role of adjuvant radiation based on final diagnosis and extent of disease suggests that radiation can improve locoregional control and overall survival with atypical meningioma. Read More

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Extradural anterior clinoidectomy through endoscopic transorbital approach: laboratory investigation for surgical perspective.

Acta Neurochir (Wien) 2021 Jun 10. Epub 2021 Jun 10.

Laboratory of Surgical Neuroanatomy, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

Background: The endoscopic transorbital approach (eTOA) is a new mini-invasive procedure used to explore different areas of the skull base. Authors propose an extradural anterior clinoidectomy (AC) through this corridor, defining the anatomical landmarks of the anterior clinoid process (ACP) projection onto the posterior orbit wall and the technical feasibility of this approach. We describe the exposure of the opticocarotid region and the surgical freedom and the angles of attack obtained with this novel approach. Read More

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Caution during endotracheal suctioning in case of skull base fractures!

Eur Rev Med Pharmacol Sci 2021 May;25(10):3803-3806

Department of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Objective: Cerebral exteriorization through the cribriform plate during routine endotracheal suctioning (ETS) in a coughing patient without sedation with multiple complex skull base fracture; this case has never been reported in the literature.

Clinical Presentation: We report the case of a polytrauma patient admitted in our ICU with severe traumatic brain injury (TBI) and multiple complex skull base fractures. After 48 hours of neurocritical care and stable neuromonitoring parameters, sedation was stopped for neurological assessment. Read More

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Intraorbital and intracranial extension of adenoid cystic carcinoma without clinical or radiological lacrimal gland involvement.

Orbit 2021 Jun 9:1-5. Epub 2021 Jun 9.

Discipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, Australia.

Adenoid cystic carcinoma (AdCC) is a rare epithelial neoplasm of the head and neck, most commonly found in the salivary glands. Orbital AdCC is an uncommon clinical entity arising from the lacrimal glands, however primary orbital AdCC has been previously described in a small number of case reports. The exact origin of the neoplasm with uninvolved lacrimal gland in the orbit is unknown, however it may arise from ectopic lacrimal or salivary gland tissue, or extension from nearby epithelial structures. Read More

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Case report of a man with multiple paragangliomas and pathogenic germline variants in both NF1 and SDHD.

Cancer Genet 2021 May 25;256-257:110-114. Epub 2021 May 25.

Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom; Department of Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, United Kingdom. Electronic address:

We report a novel case of multiple paragangliomas in a patient who was identified with pathogenic variants in both NF1 and SDHD genes. The proband is a man with known familial NF1 disease, diagnosed clinically in childhood. Multiple head and neck paragangliomas (HNPGL) were found during investigations for acute left sided neurological symptoms, in the region of his known plexiform neurofibroma. Read More

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Tailored Anterior Clinoidectomy: Beyond the Intradural and Extradural Concepts.

Cureus 2021 May 6;13(5):e14874. Epub 2021 May 6.

Neurosurgery, Hospital Universitario Antonio Pedro, Niterói, BRA.

Anterior clinoidectomy (AC) is a key microsurgical step for the safe and successful management of parasellar pathologies that involve the anterior clinoid process (ACP) and the optic canal. Traditionally, extra and intradural ACs are performed separately according to the surgeon's experience or preference. The objective is to present and discuss the tailored AC concept through illustrative cases. Read More

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A Combined Neutron and Proton Regimen for Advanced Salivary Tumors: Early Clinical Experience.

Cureus 2021 May 4;13(5):e14844. Epub 2021 May 4.

Department of Radiation Oncology, University of Washington, Seattle, USA.

Background and objective  Fast neutron radiotherapy (NRT) is a high linear energy transfer (LET) particle therapy that offers a local control (LC) advantage over low-LET X-rays in the treatment of advanced and unresectable salivary gland malignancies. However, in tumors approximating the base of skull (BOS), target volumes may be underdosed to minimize toxicity to the central nervous system (CNS). In this setting, a proton beam boost to the underdosed part of the tumor may improve LC. Read More

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Quality of Life and Morbidity after Endoscopic Endonasal Skull Base Surgeries Using the Sinonasal Outcomes Test (SNOT): A Tertiary Hospital Experience.

Int J Otolaryngol 2021 8;2021:6659221. Epub 2021 May 8.

Medical Student at Northern Border University, Arar City, Saudi Arabia.

Introduction: Endoscopic endonasal skull base surgery (EESBS) has been associated with a minimally invasive and effective approach for pathology of the anterior skull base and associated with less overall morbidity compared with open approaches. However, it is associated with its own potential morbidity related to surgical manipulation or resection of normal and noninflamed intranasal structures to gain adequate access. The assessment of sinonasal QOL (quality of life) postsurgery is therefore a vital aspect in follow-up of these patients. Read More

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Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19.

ACS Chem Neurosci 2021 Jun 8;12(12):2143-2150. Epub 2021 Jun 8.

Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.

The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. Read More

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Features and Management of Strabismus from Skull Base Chordoma: A Case Series.

Can J Ophthalmol 2021 Jun 4. Epub 2021 Jun 4.

Department of Ophthalmology and Visual Sciences, McGill University, and McGill Academic Eye Centre, Montreal, Que.. Electronic address:

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Endaural Endoscopic Atticoantrotomy (Retrograde Mastoidectomy) using a Constant Suction Bone-drilling Technique.

J Vis Exp 2021 May 23(171). Epub 2021 May 23.

Department of Otology and Skull Base Surgery, Eye & ENT Hospital, Fudan University; Shanghai Auditory Medical Center; NHC Key Laboratory of Hearing Medicine (Fudan University);

Endoscopic middle ear surgery is a widely employed minimally invasive surgical technique to address middle ear and mastoid pathology. Bone drilling is the main technical challenge of endoscopic middle ear surgery. The accompanying video describes the detailed protocol of a constant-suction bone-drilling technique and the procedure of endaural exclusive endoscopic atticoantrotomy (retrograde mastoidectomy) using this technique. Read More

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