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Int J Radiat Oncol Biol Phys 2022 May 16. Epub 2022 May 16.

Radiation Safety Unit, Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), 2-11-1 Iwado-kita, Komae, Tokyo 201-8511, Japan.

Purpose: Precise evaluation of the relative biological effectiveness (RBE) for skin reactions is indispensable for the treatment planning of particle therapy and boron-neutron capture therapy (BNCT). The evaluation is also needed for the future radiation protection system for mixed radiation fields. Such RBE is often evaluated based on in vitro cell survival data, but its validity remains incompletely understood. Read More

Lancet Diabetes Endocrinol 2022 May 16. Epub 2022 May 16.

Department of Surgery, University of Alberta, Edmonton, AB, Canada; Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. Electronic address:

Background: Islet transplantation offers an effective treatment for selected people with type 1 diabetes and intractable hypoglycaemia. Long-term experience, however, remains limited. We report outcomes from a single-centre cohort up to 20 years after islet transplantation. Read More

J Dermatolog Treat 2022 May 19:1-4. Epub 2022 May 19.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service.

Exp Dermatol 2022 May 19. Epub 2022 May 19.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark.

Chronic itch is a socioeconomic burden with limited management options. Non-histaminergic itch, involved in problematic pathological itch conditions, is transmitted by a subgroup of polymodal C-fibers. Cowhage is traditionally used for studying experimentally induced non-histaminergic itch in humans, but encounter some limitations. Read More

J Cosmet Dermatol 2022 May 19. Epub 2022 May 19.

Laboratory of Dermatological Physiology, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Saitama.

Background/aims: Hyaluronan (HA) oligosaccharides are involved in several biological processes, primarily collagen remodeling and wound healing. Collagen remodeling is retarded in aging skin and causes wrinkles. The aim of this study was to evaluate the effect of 2-kDa HA oligosaccharides (HA2k) on wrinkles by permeation through the stratum corneum and promotion of collagen remodeling. Read More

ACS Nano 2022 May 19. Epub 2022 May 19.

Department of Applied Physics, State Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, Chongqing University, Chongqing 400044, China.

The state of neck motion reflects cervical health. To detect the motion state of the human neck is of important significance to healthcare intelligence. A practical neck motion detector should be wearable, flexible, power efficient, and low cost. Read More

Biomater Sci 2022 May 19. Epub 2022 May 19.

Science Medical Center, Saratov State University, 410012 Saratov, Russia.

Superficial fungal infections are of serious concern worldwide due to their morbidity and increasing distribution across the globe in this era of growing antimicrobial resistance. The delivery of antifungals to the target regions of the skin and sustaining the effective drug concentration are essential for successful treatment of such mycoses. Topical formulations get extra benefits here if they penetrate into the hair follicles since fungal hyphae can proliferate and produce spores in such reservoirs. Read More

Front Genet 2022 2;13:890624. Epub 2022 May 2.

Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China.

The extensive involvement of interleukin enhancer binding factor 2 (ILF2) in RNA stability and the inflammatory response is well documented. Aberrant long noncoding RNA (lncRNA) expression contributes to the pathogenesis of psoriasis. However, little is known about the role of ILF2 in psoriasis. Read More

Clin Cosmet Investig Dermatol 2022 11;15:851-857. Epub 2022 May 11.

CHOLLEY SA, Pambio-Noranco, Switzerland.

Introduction: Acne is one of the most common pathologies and affects people of all ages, genders, and ethnicities. The assessment of the type and severity status of a patient with acne should be done by a dermatologist, but the ever-increasing waiting time for an examination makes the therapy not accessible as quickly and consequently less effective. This work, born from the collaboration with CHOLLEY, a Swiss company with decades of experience in the research and production of skin care products, with the aim of developing a deep learning system that, using images produced with a mobile device, could make assessments and be as effective as a dermatologist. Read More

Biol Pharm Bull 2022 May 17. Epub 2022 May 17.

Department of Pharmaceutical Sciences, Suzuka University of Medical Science.

Various diabetic drugs have been developed as the number of patients with type 2 diabetes has increased. Sodium-glucose cotransporter (SGLT)-2 inhibitors have been developed as novel therapeutic agents. However, SGLT-2 inhibitors cause skin dryness. Read More

Cell Rep 2022 May;39(7):110819

Department of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK. Electronic address:

T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute graft-versus-host disease (aGVHD) with analysis of patient samples, we demonstrate that pathology initiates dermis-specific macrophage differentiation and show that aGVHD-primed macrophages continue to dominate the dermal compartment at the relative expense of quiescent MHCII cells. Exposure of the altered dermal niche to topical haptens after disease resolution results in hyper-activation of regulatory T cells (Treg), but local breakdown in tolerance. Read More

Lymphat Res Biol 2022 May 17. Epub 2022 May 17.

Division of Plastic and Reconstructive Surgery and Keck School of Medicine of USC, Los Angeles, California, USA.

Patients undergoing surgical treatment for solid tumors are at risk for development of secondary lymphedema due to intraoperative lymphatic vessel injury. The damaged lymphatic vessels fail to adequately regenerate and lymphatic obstruction leads to fluid and protein accumulation in the interstitial space and chronic lymphedema develops as a result. There are currently no effective pharmacological agents that reduce the risk of developing lymphedema or treat pre-existing lymphedema, and management is largely palliative. Read More

Sci Transl Med 2022 May 18;14(645):eabj9152. Epub 2022 May 18.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Burns and other traumatic injuries represent a substantial biomedical burden. The current standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which frequently results in contractures, abnormal pigmentation, and loss of biomechanical function. Currently, there are no effective therapies that can prevent fibrosis and contracture after STSG. Read More

PLoS Biol 2022 May 18;20(5):e3001634. Epub 2022 May 18.

Immunometabolism Laboratory, National Institute of Immunology, New Delhi, India.

Therapeutic methods to modulate skin pigmentation has important implications for skin cancer prevention and for treating cutaneous hyperpigmentary conditions. Towards defining new potential targets, we followed temporal dynamics of melanogenesis using a cell-autonomous pigmentation model. Our study elucidates 3 dominant phases of synchronized metabolic and transcriptional reprogramming. Read More

Immunopharmacol Immunotoxicol 2022 May 18:1-8. Epub 2022 May 18.

Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Objectives: Fibrosis is a chronic inflammation caused by the loss of innate compensational mechanisms. Naringin (NR) is a flavonoid with antineoplastic and anti-inflammatory effects. Here, we aimed to investigate the antifibrotic effects of NR and underlying mechanisms in a Hypochlorous acid (HOCl)-induced mouse model of skin fibrosis. Read More

ACS Appl Bio Mater 2022 May 18. Epub 2022 May 18.

Smart Materials, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.

(MS) is a medicinal herb known worldwide for its beneficial effects due to the several active molecules present in its leaves and flowers. These compounds have shown antioxidant and anti-inflammatory properties and thus can be helpful in treatments of burns and chronic wounds, characterized mainly by high levels of free radicals and impairments of the inflammatory response. In this work, we propose bilayer films as wound dressings, based on poly(vinylpyrrolidone) (PVP) and sodium alginate loaded with extracts from leaves and flowers and fabricated by combining solvent-casting and rod-coating methods. Read More

Stem Cells Dev 2022 May 18. Epub 2022 May 18.

University of Groningen, Dept. Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands;

Insufficient vascularization is a recurring cause of impaired pedicled skin flap healing. The administration of adipose tissue-derived stromal cells' (ASC) secretome is a novel approach to augment vascularization. Yet, the secretome comprised soluble factors that require a sustained release vehicle to increase residence time. Read More

Mol Med Rep 2022 Jul 18;26(1). Epub 2022 May 18.

Department of Dermatology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.

IL‑17A, the effector cytokine of T helper (Th) 17 cells, plays a crucial role in the pathogenesis of psoriasis. The Notch1 and PI3K/AKT signaling pathways are implicated in Th17 cell differentiation and IL‑17A production. The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)‑PTEN/AKT/IL‑17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis. Read More

Asian J Pharm Sci 2022 Mar 27;17(2):268-283. Epub 2022 Feb 27.

Department of Pharmacy, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Psoriasis is a common chronic immune-mediated skin disease characterized by hyperproliferation and aberrant differentiation of keratinocytes and massive infiltration of inflammatory immune cells. Recent studies showed that Signal Transducer and Activator of Transcription 3 (STAT3), which plays an important role in cell survival, proliferation, differentiation, angiogenesis, and immune responses, is constitutively activated in epidermal keratinocytes of human psoriatic skin lesions. In addition, STAT3 promotes the differentiation and expansion of T cells and facilitates cytokine production, thereby exacerbating the condition of psoriasis. Read More

Open Life Sci 2022 26;17(1):426-437. Epub 2022 Apr 26.

Huadong Hospital Affiliated to Fudan University, 221 West Yan'an Road, Shanghai, 200040, China.

Growth differentiation factor 11 (GDF11) has been implicated in rejuvenating functions in age-related diseases. The molecular mechanisms connecting GDF11 with these anti-aging phenomena, including reverse age-related cardiac hypertrophy and vascular and neurogenic rejuvenation, remain unclear. In this study, we sought to uncover the molecular functions of GDF11 using bioinformatics and network-driven analyses at the human gene and transcription levels using the gene co-expression network analysis, the protein-protein interaction network analysis, and the transcription factor network analysis. Read More

NPJ Regen Med 2022 May 17;7(1):30. Epub 2022 May 17.

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo Street, Los Angeles, CA, 90089, USA.

Building and maintaining skeletal tissue requires the activity of skeletal stem and progenitor cells (SSPCs). Following injury, local pools of these SSPCs become active and coordinate to build new cartilage and bone tissues. While recent studies have identified specific markers for these SSPCs, how they become activated in different injury contexts is not well-understood. Read More

Exp Cell Res 2022 May 14:113207. Epub 2022 May 14.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, 14040-901, Brazil; School of Chemistry and Chemical Engineering, Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, Hefei, 230601, China. Electronic address:

Melanoma spheroid-loaded 3D skin models allow for the study of crucial tumor characteristics and factors at a superior level because the neoplastic cells are integrated into essential human skin components, permitting tumor-skin model communication. We designed a melanoma-containing artificial dermis by inserting multicellular tumor spheroids from the metastatic phase of WM 1617 melanoma cells into an artificial dermis. We cultured multicellular melanoma spheroids by hanging drop method (250 cells per drop) with a size of 420 μm in diameter after incubation for 14 days. Read More

J Invest Dermatol 2022 May 14. Epub 2022 May 14.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany; Center for Cardiology - Cardiology I, University Medical Center Mainz, Germany; German Center for Cardiovascular Research (DZHK) - Partner site RheinMain, Germany. Electronic address:

Macromol Biosci 2022 May 17:e2200067. Epub 2022 May 17.

Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.

The metabolic disorder diabetes mellitus affects an increasing proportion of the population, a number projected to double by 2060. Non-life-threatening comorbidities contribute to an interrupted healing process which is first delayed, then prolonged, and associated with increased susceptibility to infection and sustained and unresolved inflammation. This leads to chronic non-healing wounds and eventually potential amputation of extremities. Read More

Mol Biol Rep 2022 May 17. Epub 2022 May 17.

Department of Pharmacology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: The skin is constantly exposed to various external stimuli including humidity variations. Low humidity affects skin properties such as decreased water content of the stratum corneum, reduced skin elasticity, and itching. However, the effects of humidity on the skin cells are not completely understood. Read More

Drug Dev Ind Pharm 2022 May 17:1-18. Epub 2022 May 17.

Department of Pharmacy, Jiangxi Provincial People's Hospital, Nanchang 330006, China.

Objective: The purpose of this study was to develop pluronic F127/D-a-tocopheryl polyethylene glycol 1000 succinate mixed micelles-based hydrogel (MMs-gel) for topical delivery of GL to improve its skin permeability and atopic dermatitis (AD) treatment.

Significance: GL loaded MMs-gel (GL-MMs-gel) could be potentially used as a promising nanocarrier for the treatment of AD.

Methods: GL-MMs were prepared by thin film hydration method and then loaded into carbopol gel. Read More

Curr Drug Deliv 2022 May 9. Epub 2022 May 9.

Pharmaceutical Sciences Research Centre, Mazandaran University of Medical Sciences, Ramsar International Branch, Ramsar.

Background: Pelargonium graveolens L'Hér has traditionally been used to reduce skin inflammation, and recent studies have confirmed antioxidant compounds in the plant's extract. The present study aimed to prepare a lipogel formulation from P. graveolens hydroalcoholic extract and evaluate its efficacy on the wound healing process in an animal model. Read More

Curr Med Imaging 2022 May 16. Epub 2022 May 16.

School of Automation, Central South University, Changsha, China.

Background: Skin disease image analysis has drawn extensive attention from researchers, which can help doctors efficiently diagnose skin disease from medical images. Existing reviews have focused only on the specific task of skin disease diagnosis based on a single medical image type.

Discussion: This paper presents the latest and comprehensive review of image analysis methods in skin diseases, and summarizes over 350 contributions to the field, most of which appeared in the last three years. Read More

Pharm Res 2022 May 16. Epub 2022 May 16.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, 21201, USA.

Purpose: It is often unclear how complex topical product formulation factors influence the transport kinetics through skin tissue layers, because of multiple confounding attributes. Environmental factors such as temperature effect are also poorly understood. In vitro permeation testing (IVPT) is frequently used to evaluate drug absorption across skin, but the flux results from these studies are from a combination of mechanistic processes. Read More

Nat Commun 2022 May 16;13(1):2690. Epub 2022 May 16.

Departments of Pediatrics, Stanford University, Stanford, CA, USA.

The Notch pathway is a conserved cell-cell communication pathway that controls cell fate decisions. Here we sought to determine how Notch pathway activation inhibits the neuroendocrine cell fate in the lungs, an archetypal process for cell fate decisions orchestrated by Notch signaling that has remained poorly understood at the molecular level. Using intratumoral heterogeneity in small-cell lung cancer as a tractable model system, we uncovered a role for the transcriptional regulators REST and YAP as promoters of the neuroendocrine to non-neuroendocrine transition. Read More