79,549 results match your criteria skin lesions

Non-Bullous Pemphigoid: A Single-Center Retrospective Study.

Dermatology 2021 May 12:1-7. Epub 2021 May 12.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Introduction: Bullous pemphigoid (BP) is an autoimmune disease that typically presents with blisters, but sometimes early lesions may be eczematous, maculopapular, or urticarial. The aim of the present study was to highlight possible differences between typical bullous and non-bullous pemphigoid (NBP) and compare results with the literature. Material & methods: Patients receiving a diagnosis of BP between January 2000 and December 2019 were analyzed. Read More

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Valosin-containing Protein in Psoriasis: A Clinical and Immunohistochemical Study.

Appl Immunohistochem Mol Morphol 2021 May 12. Epub 2021 May 12.

Departments of Pathology Dermatology and Andrology, Faculty of Medicine, Menoufia University, Egypt.

Psoriasis is a chronic immune-mediated inflammatory skin disease, affects about 2% to 3% of the world population. Valosin-containing protein (VCP) is one of the newly discovered markers that is highly expressed in neoplasms and hyperproliferative lesions. This work aimed to study the role of VCP in psoriasis vulgaris by immunohistochemical study and correlate its expression with the available clinicopathologic data. Read More

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Efficacy and safety of dupilumab in two adolescents with severe atopic dermatitis.

Einstein (Sao Paulo) 2021 10;19:eRC6064. Epub 2021 May 10.

Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

We report the cases of two adolescent siblings with severe atopic dermatitis, who, despite weighing approximately 40kg, presented a good response to dupilumab with the off-label dose for individuals aged 12 years and weighing 60kg. Both had already used cyclosporine, azathioprine, methotrexate and oral corticosteroids for long periods, plus topical treatments with no adequate disease control. Skin lesions were constant and widespread, with frequent skin infections and very poor quality of life, with numerous physical and psychosocial consequences, such as dropping out of school activities due to severe itching, appearance and bullying. Read More

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First record of Trichodina heterodentata (Ciliophora: Trichodinidae) in banded knifefish Gymnotus carapo (Gymnotidae) cultured in Brazil.

Braz J Biol 2021 10;82:e240840. Epub 2021 May 10.

Universidade Federal de Jataí - UFJ, Programa de Pós-graduação em Biociência Animal, Unidade Acadêmica Especial de Ciências Agrárias, Jataí, GO, Brasil.

The aim of this study was to report the first record of Trichodina heterodentata in banded knifefish Gymnotus carapo. Banded knifefish cultivated in the municipality of Jataí, state of Goiás, in the central western region of Brazil, experienced fish mortality rates of 3-4% per tank. Macroscopic analysis found that fish had lesions on their skin and gills. Read More

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Toxicological and anti-tumor effects of a linden extract ( Scop.) in a HPV16-transgenic mouse model.

Food Funct 2021 May;12(9):4005-4014

Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.

Tilia platyphyllos Scop. is a popular broad-leaved tree, native to Central and Southern Europe. Hydroethanolic extracts rich in phenolic compounds obtained from T. Read More

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[Influence of connective tissue differentiation on scar tissue formation in children].

Khirurgiia (Mosk) 2021 (5):72-77

Stavropol State Medical University, Stavropol, Russia.

Objective: To study the immunohistochemical features of various scar tissues in children without connective tissue pathology and with undifferentiated connective tissue dysplasia syndrome.

Material And Methods: Tissue biopsy was performed in 217 children who underwent surgical treatment for various lesions, such as injuries, burns, as well as other procedures. There were 127 boys (58. Read More

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January 2021

Topical Band-pass Filter Cream (TBFC)-assisted home-based NB-UVB: A must-know Alternative to artificial phototherapy.

J Cosmet Dermatol 2021 May 12. Epub 2021 May 12.

Senior Consultant Dermatologist & Dermatosurgeon, Department of Dermatology & Dermatosurgery, Skinnocence: The Skin Clinic & Research Center, Gurugram, India.

Background: Treatment-refractory lesions of vitiligo, and psoriasis are typically associated with significant psychological morbidity. Although narrow band-ultra violet B (NB-UVB) phototherapy remains one of the safest and effective treatment modalities, the cost and logistics related to the access and high-cost of therapy delivered artificially via devices/chambers becomes highly restrictive. The use of topical Photocil®, a novel topical band-pass filter cream (TBFC), that selectively filters solar radiation, biasing towards delivery of 311-313 nm (action spectrum of NB-UVB) to the treated lesions, following the exposure of TBFC-smeared lesions to natural sunlight offsets many aforementioned limitations of artificial phototherapy. Read More

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Clinical and histopathological evaluation of cutaneous angiofibromas.

J Cutan Pathol 2021 May 11. Epub 2021 May 11.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Angiofibromas are common benign skin lesions that are diagnosed clinically and histopathologically. Fibrous papule (FP) is one of the clinical types of angiofibromas located primarily on the nose.

Methods: The cases with the confirmed diagnosis of angiofibroma were enrolled. Read More

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Sister Mary Joseph Nodules: A Case Report about a Rare Location of Skin Metastasis.

Case Rep Oncol 2021 Jan-Apr;14(1):664-670. Epub 2021 Apr 8.

Department of Medical Oncology, Centre Jean Perrin, Clermont-Ferrand, France.

Umbilical skin metastases (or Sister Mary Joseph nodules) are rare. Their presence typically indicates the late manifestation of deep-seated abdominopelvic malignancy. They occur mainly in gynecological cancers, and gastrointestinal cancers in men. Read More

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Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case-Control Study in Chinese Patients.

Ther Clin Risk Manag 2021 3;17:397-404. Epub 2021 May 3.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.

Purpose: Comparison of risk factors and comorbidities could help indicate the underlying mechanisms of diseases. This study aimed to compare behavioral factors and cardiometabolic comorbidities of PsA/psoriasis versus healthy controls to implicate the similarities and differences in potential pathogenic mechanisms for further research.

Patients And Methods: A case-control study in Chinese patients with PsA or psoriasis and healthy controls was conducted. Read More

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Severe cutaneous presentation of hydralazine-induced ANCA vasculitis without renal or pulmonary involvement, complicated by DIC.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Internal Medicine, Albany Medical Center, Albany, New York, USA.

Hydralazine is a common arterial vasodilator used in the management of congestive heart failure and hypertension. It can be associated with drug-induced lupus and less commonly antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Drug-induced AAV typically has a favourable long-term prognosis. Read More

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Wound Healing by Allogeneic Transplantation of Specific Subpopulation From Human Umbilical Cord Mesenchymal Stem Cells.

Cell Transplant 2021 Jan-Dec;30:963689721993774

Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.

In normal physiological conditions, restoration of a functional epidermal barrier is highly efficient; nevertheless, when it fails, one of the main consequences is a chronic ulcerative skin defect, one of the most frequently recognized complications of diabetes. Most of these chronic venous ulcers do not heal with conventional treatment, leading to the appearance of infections and complications in the patient. Treatments based on the use of autologous mesenchymal stem cells (MSC) have been successful; however, its implementation entails complications. Read More

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Biophysical and ultrasonographic changes in early patch/plaque stage of mycosis fungoides, compared with uninvolved skin.

Skin Res Technol 2021 May 11. Epub 2021 May 11.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: The goal of this study was evaluation of the skin biophysical properties in early patch/plaque stage of mycosis fungoides (MF) and its comparison with uninvolved skin in order to gain a better understanding of the pathogenesis of diseases.

Materials And Methods: The stratum corneum hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, R5), thickness, and echo density of epidermis and dermis were measured on lesions of 21 patients and compared with controls (average measures of uninvolved perilesional and symmetrical skins) by paired sample t test.

Results: Stratum corneum hydration (P < 0. Read More

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Dark corner artefact and diagnostic performance of a market-approved neural network for skin cancer classification.

J Dtsch Dermatol Ges 2021 May 10. Epub 2021 May 10.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Background And Objectives: Convolutional neural networks (CNN) have proven dermatologist-level performance in skin lesion classification. Prior to a broader clinical application, an assessment of limitations is crucial. Therefore, the influence of a dark tubular periphery in dermatoscopic images (also called dark corner artefact [DCA]) on the diagnostic performance of a market-approved CNN for skin lesion classification was investigated. Read More

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Scalp malignant trichilemmal tumour with bony erosion: a new clinical entity.

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Oral and Maxillofacial Surgery, Worcestershire Acute Hospitals NHS Trust, Worcester, UK.

Trichilemmoma is a benign tumour which arises from the hair follicle root sheath, and commonly occurs in the head and neck area. Malignant transformation and locally aggressive growth of these tumours are very rare. Surgical excision remains the mainstay of management, with scarce evidence for other treatment modalities. Read More

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Autologous platelet-rich plasma in the treatment of refractory wounds in cutaneous leukocytoclastic vasculitis complicated with hypertension (grade 2 moderate risk): A case report.

Transfus Apher Sci 2021 May 6:103157. Epub 2021 May 6.

Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address:

Introduction: Cutaneous leukocytoclastic vasculitis is an inflammatory variant of vasculitis with a variety of causes that only affects the skin. Its pathological manifestations include neutrophil infiltration and nuclear fragmentation. Clinically, it is characterised by a pleomorphic rash, including erythema, purpuric skin lesions, reticulocytosis, necrosis and ulceration. Read More

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COVID-19: The experience from Beijing, China.

Fen Peng

Clin Dermatol 2021 Jan-Feb;39(1):9-11. Epub 2020 Dec 15.

Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address:

The epidemiology of coronavirus disease 2019 (COVID-19) in Beijing, China, is summarized. This presentation highlights its main clinical manifestations, including the skin findings in Beijing and sums up the cutaneous damage to the medical staff in their epidemic preventative work. Although there had been few COVID-19 patients who reported skin lesions in Beijing and even in China, dermatologists still needed to pay attention to self-protection in their daily work. Read More

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December 2020

Clinicopathologic correlations of COVID-19-related cutaneous manifestations with special emphasis on histopathologic patterns.

Clin Dermatol 2021 Jan-Feb;39(1):149-162. Epub 2020 Dec 14.

Unit of Dermatology, Department Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Skin is one of target organs affected by the novel coronavirus SARS-CoV-2, and in response to the current COVID-19 pandemic, a fast body of literature has emerged on related cutaneous manifestations. Current perspective is that the skin is not only a bystander of the general cytokines storm with thrombophilic multiorgan injury, but it is directly affected by the epithelial tropism of the virus, as confirmed by the detection of SARS-CoV-2 in endothelial cells and epithelial cells of epidermis and eccrine glands. In contrast with the abundance of epidemiologic and clinical reports, histopathologic characterization of skin manifestations is limited. Read More

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December 2020

Red mark syndrome of trout (Oncorhynchus mykiss; Walbaum, 1792): Histopathological scoring and correlation with gross lesions.

J Fish Dis 2021 May 10. Epub 2021 May 10.

Veterinary Pathology Unit, DI4A, University of Udine, Udine, Italy.

Red mark syndrome (RMS) is a skin disorder affecting rainbow trout (Oncorhynchus mykiss). The present work aimed to correlate the gross skin lesions affecting 46 fish sampled from farms surveyed for RMS with their microscopic features, identifying histological parameters that may be suggestive of disease progression. Skin lesions were grossly included in one of three categories (types I, II and III) according to the progressive degree of severity. Read More

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Ticks infesting dogs and cats in North America: Biology, geographic distribution, and pathogen transmission.

Vet Parasitol 2021 Feb 19;294:109392. Epub 2021 Feb 19.

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, 74078, United States.

A diverse array of ixodid and argasid ticks infest dogs and cats in North America, resulting in skin lesions, blood loss, and disease. The ticks most commonly found on pets in this region are hard ticks of the genera Amblyomma, Dermacentor, Ixodes, and Rhipicephalus, as well as the more recently established Haemaphysalis longicornis. Soft tick genera, especially Otobius and Ornithodoros, are also reported from pets in some regions. Read More

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February 2021

Hepatogenous photosensitisation in cows grazing turnips (Brassica rapa) in South Africa.

J S Afr Vet Assoc 2021 May 6;92(0):e1-e6. Epub 2021 May 6.

Humansdorp Veterinary Clinic, Humansdorp.

Holstein cows on a farm in the Humansdorp district, Eastern Cape province, South Africa, developed reddened, painful teat skin 3 days after grazing a mixed forage crop dominated by bulb turnip (Brassica rapa, Barkant cultivar). The crop was grazed 45 days after planting and 10% of the herd developed symptoms. More characteristic non-pigmented skin lesions started manifesting 1-2 days after the appearance of the teat lesions. Read More

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Targeting Peritumoral Lesions Identified by Computed Tomography and Magnetic Resonance Imaging in Feline Injection-Site Sarcomas for Microscopic Examination.

Vet Pathol 2021 May 10:3009858211012949. Epub 2021 May 10.

2694Oregon State University, Corvallis, OR, USA.

Peritumoral lesions identified during in vivo imaging of feline injection-site sarcoma (FISS) are frequently interpreted as neoplastic. We recently showed that most peritumoral imaging-identified lesions (PTIILs) in FISS are non-neoplastic. In this article, we describe a protocol to target PTIIL for microscopic examination and report on the protocol's performance. Read More

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HTLV-1-Associated Lymphoma Presented as Massive Lymphadenopathy.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211013235

Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

Adult T-cell leukemia/lymphoma is an aggressive T-cell malignancy caused by the long-term infection of human T-cell lymphotropic virus type 1 (HTLV-1). Our understanding of clinical features still largely relies on the Shimoyama classification developed 30 years ago, which described the 4 clinical subtypes (the smoldering, chronic, lymphoma, and acute types) based on the manifestations of lymphocytosis, elevated lactate dehydrogenase, hypercalcemia, lymphadenopathy, and involvement of the skin, lung, liver, spleen, central nervous system, bone, ascites, pleural effusion, and gastrointestinal tract. HTLV-1-associated lymphoma has a variety of presentations but the presentation of massive lymphadenopathy and compression symptoms is rare and has not been emphasized in the literature. Read More

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Liposomal amphotericin B is more effective in polymorphic lesions of post kala-azar dermal leishmaniasis.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-6. Epub 2021 Apr 23.

Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, India.

Background: Post kala-azar dermal leishmaniasis (PKDL) is thought to be the reservoir of infection for visceral leishmaniasis in South Asia. The development of strategies for the diagnosis and treatment of PKDL are important for the implementation of the visceral leishmaniasis elimination program.

Aims: Liposomal amphotericin B (L-AMB) has been an overwhelming success in the treatment of visceral leishmaniasis. Read More

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Lipopolysaccharide from the commensal microbiota of the breast enhances cancer growth: role of S100A7 and TLR4.

Mol Oncol 2021 May 9. Epub 2021 May 9.

Department of Pathology, The Ohio State University, Wexner Medical Center.

The role of commensal bacterial microbiota in the pathogenesis of human malignancies has been a research field of incomparable progress in recent years. Although breast tissue is commonly assumed to be sterile, recent studies suggest that human breast tissue may contain a bacterial microbiota. In this study, we used an immune-competent orthotopic breast cancer mouse model to explore the existence of a unique and independent bacterial microbiota in breast tumors. Read More

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Characterizing the presence of neutrophil extracellular traps in neutrophilic dermatoses.

Exp Dermatol 2021 May 9. Epub 2021 May 9.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of multiple inflammatory dermatoses. However, characterization of NETs in neutrophilic dermatoses was performed on very limited number of patients; this limitation precluded definitive conclusions. In this case series of 57 patients, we compared the amounts of neutrophils producing NETs in cutaneous lesions of different entities of neutrophilic dermatoses (17 with pyoderma gangrenosum, 37 with Sweet's syndrome and three with subcorneal pustular dermatosis). Read More

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Misdiagnosed dystrophic epidermolysis bullosa pruriginosa: A case report.

World J Clin Cases 2021 May;9(13):3090-3094

Department of Dermatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100000, China.

Background: Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of DEB, characterized by recurrent pruritus of the extremities, pruritus papules, nodules, and mossy-like plaques. To date, fewer than 100 cases have been reported. We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment, thereby serving as a guide to correct diagnosis and treatment. Read More

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Comparative Analysis of Diagnostic Techniques for Melanoma Detection: A Systematic Review of Diagnostic Test Accuracy Studies and Meta-Analysis.

Front Med (Lausanne) 2021 21;8:637069. Epub 2021 Apr 21.

The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.

Melanoma has the highest mortality rate among skin cancers, and early-diagnosis is essential to maximize survival rate. The current procedure for melanoma diagnosis is based on dermoscopy, i.e. Read More

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Recurrent Primary Cutaneous Anaplastic Large Cell Lymphoma With Systemic Involvement: A Case Report and Literature Review.

Cureus 2021 Apr 4;13(4):e14284. Epub 2021 Apr 4.

Public Health, Broward County Health Department, Fort Lauderdale, USA.

Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare, aggressive neoplasm that frequently relapses and requires the use of multiple treatment modalities. PC-ALCL most commonly presents in patients around the age of 60 and clinically manifests as red, single or sometimes grouped nodular lesions in the skin that tend to ulcerate over time. Although cases are limited to the skin, the extracutaneous spread has been occasionally reported. Read More

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Subacute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats.

Exp Ther Med 2021 Jun 15;21(6):632. Epub 2021 Apr 15.

Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China.

As a novel heat shock protein 90 inhibitor, AT-533 exhibits various biological activities , including anti-viral, anti-tumor and anti-inflammatory activities. Moreover, AT-533 gel, a gel dosage form of AT-533, has been suggested to have anti-keratitis and herpes simplex virus type-1 infection-induced effects on the skin lesions of animals. However, the safety evaluation of AT-533 and AT-533 gel has, to the best of our knowledge, not been examined in toxicological tests. Read More

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