848,009 results match your criteria skin hair

Nail changes in diabetes.

Clin Exp Dermatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Dermatology, Bristol Royal Infirmary, Bristol, UK.

Diabetes is a common condition that is increasing in incidence all over the world. Even though the skin manifestations of this condition are well described, there is scant literature of its nail changes. In this review, we allude to the various clinical features of nail changes in those with diabetes. Read More

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The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas.

Mol Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Urology, Urological Research Laboratory, Translational UroOncology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Testicular germ cell tumors (GCTs) are stratified into seminomas and non-seminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the non-seminoma stem cell population - embryonal carcinoma (EC) - is pluripotent and thus able to differentiate into cells of all three germ layers (teratomas). Furthermore, ECs are capable of differentiating into extra-embryonic lineages (yolk-sac tumors, choriocarcinomas). Read More

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.

Br J Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Centre for Human Drug Research, Leiden, the Netherlands.

Introduction: Whereas intravenous administration of TLR4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intradermal LPS response in healthy volunteers, and as such qualify the method as local inflammation model for clinical pharmacology studies.

Methods: 18 healthy male volunteers received two or four intradermal 10 ng LPS injections and one saline injection on the forearms. Read More

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Blood Perfusion of Human Upper Eyelid Skin Flaps Is Better in Myocutaneous than in Cutaneous Flaps.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Clinical Sciences Lund, Ophthalmology, Skåne University Hospital, Lund University, Lund, Sweden Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.

Background: The aim of this study was to monitor blood perfusion in human upper eyelid skin flaps and examine how the perfusion is affected by the thickness of the flap.

Methods: Twenty upper eyelids were dissected as part of a blepharoplasty procedure in patients. The medial end of the blepharoplasty flap remained attached to mimic a flap design often used in reconstruction in the periocular area, a myocutaneous flap in which the blood supply follows the fibers of the orbicularis muscle and is thus parallel to the long axis of the flap. Read More

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Anatomic Distribution of Cherry Angiomas in the General Population.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

The University of Queensland Diamantina Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Queensland, Australia.

Background: Cherry angiomas are common benign vascular skin lesions of unknown aetiology, found largely on the trunk. However, their exact anatomic distribution besides their truncal predisposition, and how they manifest in the general population, has not been characterised.

Methods: Three-dimensional (3D) total body imaging was obtained from 163 adult participants of a general population cohort study in Brisbane, Australia. Read More

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Metabolic Disorders/Obesity Is a Primary Risk Factor in Hidradenitis Suppurativa: An Immunohistochemical Real-World Approach.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial results. Read More

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Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis.

Biomaterials 2021 Jul 15;276:121027. Epub 2021 Jul 15.

School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, GD Research Center for Functional Biomaterials Engineering and Technology, Sun Yat-sen University, 510275, Guangzhou, China. Electronic address:

Abnormal high level of cell free DNA (cfDNA) triggers chronic inflammation to exacerbate psoriasis symptoms. Scavenging cfDNA by topical cationic polymeric nanoparticles has been certified as an effective therapeutic strategy for treating psoriasis. However, cationic cfDNA scavengers have a great potential risk to organs after entering systemic circulation through skin barrier. Read More

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IL-17C in human mucosal immunity: More than just a middle child.

Cytokine 2021 Jul 19;146:155641. Epub 2021 Jul 19.

Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, United States; Departments of Pathology, Pharmacology, Medicine, and Pediatrics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, United States. Electronic address:

Interleukin-17C (IL-17C) is an understudied member of the IL-17 family of cytokines. Its synthesis is induced by both cytokines and pathogenic stimuli in a variety of cell types, most often expressed at mucosal and barrier surfaces. IL-17C expression is dysregulated in a variety of autoinflammatory and autoimmune diseases including inflammatory bowel disease, psoriasis, and atopic dermatitis, yet it is protective against bacterial infections of the gut, skin, and lungs. Read More

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Caspofungin resistance in clinical Aspergillus Flavus isolates.

J Mycol Med 2021 Jul 5;31(4):101166. Epub 2021 Jul 5.

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction And Aims: The present study was conducted to determine the candidate genes involved in caspofungin (CAS) resistance in clinical isolates of Aspergillus flavus (A. flavus).

Materials And Methods: The antifungal susceptibility assay of the CAS was performed on 14 clinical isolates of A. Read More

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Development of rivaroxaban microemulsion-based hydrogel for transdermal treatment and prevention of venous thromboembolism.

Colloids Surf B Biointerfaces 2021 Jul 16;206:111978. Epub 2021 Jul 16.

Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS, Cidade Universitária, Rio de Janeiro, 21.941-902, Brazil. Electronic address:

We have developed a microemulsion (ME)-based hydrogel, containing propylene glycol, Azone®, Labrasol®, isobutanol and water (20:3:18:3:56), for the transdermal delivery of rivaroxaban (RVX). Formulation ME-1:RVX, which was loaded with 0.3 mg/g of RVX, presented as a clear, homogenous fluid with a droplet size of 82. Read More

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An in vitro assessment for human skin exposure to parabens using magnetic solid phase extraction coupled with HPLC.

Chemosphere 2021 Jul 17;286(Pt 1):131593. Epub 2021 Jul 17.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, China. Electronic address:

Skin contact was a significant source of human exposure to parabens during the use of personal care products. In this study, a novel and simple in vitro evaluation method for human skin exposure to parabens was established for the first time. Firstly, magnetic porous carbon (MPC) derived from discarded cigarette butts was prepared as an adsorbent of magnetic solid-phase extraction (MSPE), which provided a fast and efficient sample preparation method with satisfactory extraction performance for parabens in cosmetics and was easy to couple with high performance liquid chromatography. Read More

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Establishing amoxicillin allergy in children through direct graded oral challenge (GOC): evaluating risk factors for positive challenges, safety, and risk of cross reactivity to cephalosporines.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada; Infectious Diseases and Immunity in Global Health Program, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

Background: Data on the diagnostic properties of direct oral challenges without the use of skin tests in children with suspected amoxicillin allergy is sparse.

Objective: Assess the use of direct oral challenges.

Methods: A cohort study was conducted between March 2013 and March 2020, in Montreal and Winnipeg. Read More

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Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial.

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Service de Dermatologie et Cancérologie Cutanée, Aix-Marseille University, Marseille, France.

Background: Pembrolizumab demonstrated clinically meaningful and durable antitumor activity with a manageable safety profile in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC).

Patients And Methods: KEYNOTE-629 was a global, open-label, nonrandomized, phase 2 trial of patients with locally advanced (LA) or R/M cSCC conducted at 59 centers. Eligible patients received intravenous pembrolizumab 200 mg every three weeks for up to 35 cycles. Read More

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Formulation development, in vitro and in vivo evaluation of topical hydrogel formulation of econazole nitrate-loaded β-cyclodextrin nanosponges.

J Pharm Sci 2021 Jul 19. Epub 2021 Jul 19.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address:

Econazole nitrate, an antifungal drug used in the handling of skin ailments, is commercially not efficient as these ailments typically require a more elevated concentration of the drug to offer an effective pharmacological retort. Like so, it is proposed to assess the effectiveness of the topical hydrogel of econazole-loaded nanosponge in the management of skin ailment(s). Econazole nitrate-laden β-cyclodextrin nanosponges were developed by employing the melt method using β-cyclodextrin as the organic polymer and N,N-carbonyldiimidazole as the crosslinker. Read More

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Internet Searches for Black Dermatologists during the Social Justice Movement of 2020.

J Am Acad Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Case Western Reserve University School of Medicine, Department of Dermatology, Cleveland, OH; University Hospitals Cleveland Medical Center, Department of Dermatology, Cleveland, OH.

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Cutaneous manifestations of chimeric antigen receptor T cell therapy: an introduction for dermatologists.

J Am Acad Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. Electronic address:

Chimeric antigen receptor T cell therapy is an emerging immunotherapy with promising efficacy for the treatment of previously refractory or relapsed malignancies. As a personalized medicine approach, T cells are genetically engineered to express a receptor designed to bind a specific tumor antigen, leading to selective immune-mediated destruction of tumor cells. Due to the novelty of chimeric antigen receptor T cell therapy, the safety profile continues to evolve with limited information currently available on cutaneous adverse events. Read More

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Incidence and risk factors for early mortality in adults with skin Merkel cell carcinoma: A SEER-based study.

J Am Acad Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address:

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Highly Branched Poly(β-amino ester)s for Gene Delivery in Hereditary Skin Diseases.

Adv Drug Deliv Rev 2021 Jul 19:113842. Epub 2021 Jul 19.

Charles Institute of Dermatology, University College Dublin, Dublin 4, Ireland. Electronic address:

Non-viral gene therapy for hereditary skin diseases is an attractive prospect. However, research efforts dedicated to this area are rare. Taking advantage of the branched structural possibilities of polymeric vectors, we have developed a gene delivery platform for the treatment of an incurable monogenic skin disease - recessive dystrophic epidermolysis bullosa (RDEB) - based on highly branched poly(β-amino ester)s (HPAEs). Read More

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PDL1 triggered by binding eIF3I contributes to the amelioration of diabetes-associated wound healing defects by regulating IRS4.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China. Electronic address:

Persistent chronic inflammation and delayed epithelialization lead to stalled healing in diabetic ulcers (DUs). PDL1 shows anti-inflammatory and proliferative activities in healing defects, while its function in DU pathogenesis remains unknown. Lower levels of PDL1 were found in DU tissues, and exogenous PDL1 has therapeutic effects in healing process by accelerating re-epithelialization and attenuating prolonged inflammation, which contributed to the delayed wound closure. Read More

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Inhibition of CtBP-regulated proinflammatory gene transcription attenuates psoriatic skin inflammation.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:

Psoriasis is a chronic immune-mediated disease characterized by excessive proliferation of epidermal keratinocytes and increased immune cell infiltration to the skin. Although it is well known that psoriasis pathogenesis is driven by aberrant production of proinflammatory cytokines, the mechanisms underlying the imbalance between proinflammatory and anti-inflammatory cytokine expression are incompletely understood. Here we report that the transcriptional coregulators C-terminal-binding protein (CtBP) 1 and 2 can transactivate a common set of proinflammatory genes both in the skin of imiquimod-induced mouse psoriasis model and in human keratinocytes and macrophages stimulated by imiquimod. Read More

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Nuclear IL-33 plays an important role in IL-31-mediated downregulation of filaggrin, keratin 1, and keratin 10 by regulating STAT3 activation in human keratinocytes.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.

Interleukin (IL)-33, a chromatin-associated multifunctional cytokine, is implicated in the pathogenesis of atopic dermatitis (AD), an inflammatory skin disorder characterized by skin barrier dysfunction. IL-33 accumulates in the nuclei of epidermal keratinocytes in AD lesions. However, it is unclear whether nuclear IL-33 directly contributes to the pathogenesis of AD. Read More

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Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA; Monasterium Laboratory, Münster, Germany; Centre for Dermatology Research, University of Manchester, Manchester, UK. Electronic address:

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Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms.

Am J Hum Genet 2021 Jul 15. Epub 2021 Jul 15.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

Although expression quantitative trait loci (eQTLs) have been powerful in identifying susceptibility genes from genome-wide association study (GWAS) findings, most trait-associated loci are not explained by eQTLs alone. Alternative QTLs, including DNA methylation QTLs (meQTLs), are emerging, but cell-type-specific meQTLs using cells of disease origin have been lacking. Here, we established an meQTL dataset by using primary melanocytes from 106 individuals and identified 1,497,502 significant cis-meQTLs. Read More

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Updated understanding of Staphylococcus aureus in atopic dermatitis: from virulence factors to commensals and clonal complexes.

Exp Dermatol 2021 Jul 22. Epub 2021 Jul 22.

University of Arkansas for Medical Sciences, Department of Dermatology, 4301 West Markham, Slot 576, Little Rock, Arkansas, 72205, USA.

Atopic dermatitis (AD) is a common inflammatory dermatosis that has multiple contributing factors including genetic, immunologic, and environmental. Staphylococcus aureus (SA) has long been associated with exacerbation of AD. SA produces many virulence factors that interact with the human skin and immune system. Read More

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Differences between perceived age and chronological age in women: a multi-ethnic and multi-centre study.

Int J Cosmet Sci 2021 Jul 22. Epub 2021 Jul 22.

Biosocial Science Information, Ortsstrasse 63, 2362, Biedermannsdorf, Austria.

Objective: Accuracy in assessing age from facial cues is important in social perception given reports of strong negative correlations between perceived age and assessments of health and attractiveness. In a multi-ethnic and multi-centre study, we previously documented similar patterns of female facial age assessments across ethnicities, influenced by gender and ethnicity of assessors.

Methods: Here we extend these findings by examining differences between estimated age from digital portraits and chronological age (Δ age) for 180 women from three age groups (20-34, 35-49, 50-66 years) and five ethnicities (36 images of each ethnicity, assessed for age on a continuous scale by 120 female and male raters of each ethnicity). Read More

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Occupational Contact Dermatitis: Return to Work Using a Multidisciplinary Clinic Model.

Contact Dermatitis 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, University of Toronto, Toronto, CANADA.

Background: Occupational contact dermatitis often results in work disruption. Return-to-work (RTW) is an important outcome.

Objective: The objective of this study was to determine RTW outcomes and factors associated with such outcomes using a multidisciplinary clinic model. Read More

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A baseline patch test series for New Zealand.

Australas J Dermatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Dermatology, Auckland District Health Board, Auckland, New Zealand.

Background: Patch testing is the gold standard diagnostic test for allergic contact dermatitis and needs to be relevant to the region and the population being tested. The aim of this study was to develop a specific New Zealand baseline series (NZBS).

Method: We performed a retrospective case note review of patients attending four regional patch test centres between 2008 and 2020. Read More

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Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer.

PLoS One 2021 22;16(7):e0254765. Epub 2021 Jul 22.

Halozyme Therapeutics, Inc., San Diego, CA, United States of America.

Background: Recombinant human hyaluronidase PH20 (rHuPH20) facilitates the dispersion and absorption of subcutaneously administered therapeutic agents. This study aimed to characterize the transient, local action of rHuPH20 in the subcutaneous (SC) space using focused biodistribution and dye dispersion studies conducted in mice.

Materials And Methods: To evaluate the biodistribution of rHuPH20, mice were intradermally administered rHuPH20 (80 U). Read More

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Pain modulation by your partner: An experimental investigation from a social-affective perspective.

PLoS One 2021 22;16(7):e0254069. Epub 2021 Jul 22.

Department of Clinical Psychology, Justus-Liebig-University Giessen, Giessen, Germany.

Background: Social context such as the relationship between a person experiencing pain and a caregiver has been shown to affect the experience of pain, yet, results are not consistent. Possibly, differential effects of interpersonal relationships are modulated by affective states expressed by social partners. Viewing partner pictures in experimental designs is not only associated with lowered perceived pain intensity, but also affects neural responses. Read More

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A review of the leishmanin skin test: A neglected test for a neglected disease.

PLoS Negl Trop Dis 2021 Jul 22;15(7):e0009531. Epub 2021 Jul 22.

Department of Microbiology and Immunology, McGill University, Montreal, Canada.

The leishmanin skin test (LST) has been used for decades to detect exposure and immunity to the parasite Leishmania, the causative agent of the neglected tropical disease leishmaniasis. In the LST, Leishmania antigen (leishmanin) is intradermally injected into the forearm. In an individual who has been previously infected, a delayed-type hypersensitivity (DTH) reaction results in a measurable induration at the site of the injection, indicating that previous exposure to Leishmania has resulted in the development of cell-mediated immunity. Read More

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