200,596 results match your criteria skin cancer


The cost of living with cancer during the second wave of COVID-19: A mixed methods study of Danish cancer patients' perspectives.

Eur J Oncol Nurs 2021 Apr 17;52:101958. Epub 2021 Apr 17.

Research Unit of Oncology, The Academy of Geriatric Cancer Research (www.agecare.org), Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, DK-5000 Odense C, Denmark.

Purpose: This study investigated experiences and levels of distress and resilience of Danish cancer patients during the second wave of the COVID-19 pandemic.

Methods: The mixed methods design included a subset of cancer patients who responded to a cross-sectional survey in May 2020. Data were collected through telephone interviews. Read More

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Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes.

Dev Cell 2021 Apr 13. Epub 2021 Apr 13.

Stowers Institute for Medical Research, Kansas City, MO 64110, USA. Electronic address:

Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduce environmental signals. Actively maintained ionic homeostasis of the mammalian inner ear endolymph is essential for HC function. In contrast, fish lateral line HCs are exposed to the fluctuating ionic composition of the aqueous environment. Read More

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Evaluation of anti-tyrosinase activity and mechanism, anti-oxidation and UV filter properties of theaflavin.

Biotechnol Appl Biochem 2021 Apr 20. Epub 2021 Apr 20.

School of Pharmacy and Medical technology, Putian University, Fujian, China.

Tyrosinase is a key metalloenzyme for biosynthesis of melanin that plays critical role in prevention of skin damage caused by ultraviolet (UV) radiation. However, overproduction of melanin may cause a variety of skin diseases. Due to the toxicity and inefficiency of existing tyrosinase inhibitors, it is urgent to identify safe and potent alternatives from natural sources. Read More

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Fluorescence-guided surgery for non-melanoma and melanoma skin cancer: Case-series and a brief review of the literature.

Photodermatol Photoimmunol Photomed 2021 Apr 20. Epub 2021 Apr 20.

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region.

surgery is the primary mode of treatment for non-melanoma (NMSC) and melanoma skin cancer (MSC). The main purpose of surgery is to completely remove the neoplastic lesion, since the presence of residual tumor cells is considered a strong predictor of tumor recurrence, new surgical approach and, therefore, survival. Read More

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Identification of hub prognosis-associated oxidative stress genes in skin cutaneous melanoma using integrated bioinformatic analysis.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):2927-2940

Department of Spine and Joint Surgery, Guilin Peoples' Hospital, Guilin, China.

Objective: Oxidative stress (OS) significantly correlates with cancer progression. However, targeting OS has not been considered as a therapeutic strategy in skin cutaneous melanoma (SKCM) due to a lack of systematical studies on validated biomarkers. The work presented here aimed to identify hub prognosis-associated OS genes in SKCM and generated an effective predictive model. Read More

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Antineoplastic Effects and Mechanisms of a New RGD Chimeric Peptide from Bullfrog Skin on the Proliferation and Apoptosis of B16F10 Cells.

Protein J 2021 Apr 20. Epub 2021 Apr 20.

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.

Malignant melanoma, an increasingly common form of skin cancer, poses a significant threat to public health, especially when the disease progresses past skin lesions to the stage of advanced metastasis. In this work, a new anti-tumor peptide, temporin La (T-La), was selected from a cDNA library generated from bullfrog skin. Two new derivative antitumor peptides, T-La (S) and T-La (FS), were designed by bioinformatics analysis and coupled with the RGD small molecule peptide to create chimeric RGD peptides, (RGD-T-La [S] and RGD-T-La [FS]). Read More

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Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia.

JA Clin Rep 2021 Apr 20;7(1):37. Epub 2021 Apr 20.

Department of Anesthesiology and Critical Care, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-ku, Hiroshima, 734-8551, Japan.

Background: Prophylactic antibiotics and neuromuscular blocking agents (NMBA) are two of the major causative agents of anaphylaxis after induction of anesthesia.

Case Presentation: One female and one male patients (aged 29 and 69 years, respectively) had Ring and Messmer scale grade III anaphylaxis after administration of prophylactic antibiotics following induction of anesthesia. They showed typical hemodynamic and respiratory features of life-threatening anaphylaxis. Read More

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High-frequency ultrasound in clinical dermatology: a review.

Ultrasound J 2021 Apr 20;13(1):24. Epub 2021 Apr 20.

Department of Dermatology, Duke University School of Medicine, Duke Clinic, 40 Duke Medicine Cir, Clinic 3K, Durham, NC, 27710-4000, USA.

Background: Ultrasound was first introduced in clinical dermatology in 1979. Since that time, ultrasound technology has continued to develop along with its popularity and utility. Today, high-frequency ultrasound (HFUS), or ultrasound using a frequency of at least 10 megahertz (MHz), allows for high-resolution imaging of the skin from the stratum corneum to the deep fascia. Read More

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Sequential chemotherapy regimen of induction with panitumumab and paclitaxel followed by radiotherapy and panitumumab in patients with locally advanced head and neck cancer unfit for platinum derivatives. The phase II, PANTERA/TTCC-2010-06 study.

Clin Transl Oncol 2021 Apr 19. Epub 2021 Apr 19.

Medical Oncology Service, Institut Català D'Oncologia (ICO) Hospitalet, Barcelona, Spain.

Background: Sequential treatment of Panitumumab (Pb) plus Paclitaxel (Px) as induction treatment (IT) followed by concurrent bioradiotherapy (Bio-RT) with Pb may be an alternative for locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) in patients ineligible for high-dose cisplatin therapy.

Methods: Phase II, single-arm, multicentre study, with two-stage design, in patients ≥ 18 years with stage III-IVa-b LA-SCCHN unfit for platinum. Patients received Px + Pb (9 weeks) as IT followed by Bio-RT + Pb. Read More

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Interventional radiologists have a higher rate of chromosomal damage due to occupational radiation exposure: a dicentric chromosome assay.

Eur Radiol 2021 Apr 19. Epub 2021 Apr 19.

Laboratory of Biological Dosimetry, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.

Objectives: There are growing concerns regarding radiation exposure in medical workers who perform interventional fluoroscopy procedures. Owing to the nature of certain interventional procedures, workers may be subjected to partial-body radiation exposure that is high enough to cause local damage. We aimed to investigate the level of radiation exposure in interventional radiologists in South Korea by performing cytogenetic biodosimetry, particularly focusing on partial-body exposure. Read More

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Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis.

Sci Rep 2021 Apr 19;11(1):8524. Epub 2021 Apr 19.

Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.

Non-melanoma skin cancers (NMSC) are more frequent among men, but women (especially those aged < 40 years) have experienced steeper growth in their incidence rates in recent years. Hormonal factors were hypothesized to be playing a role in modulating NMSC risk, but the studies published to date provided conflicting results. We systematically reviewed and meta-analysed the studies focusing on the association between hormone-related characteristics (use of exogenous sex hormones, and aspects of menstrual and reproductive history) and the risk of NMSC among women. Read More

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Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Chemokine Biology Laboratory, Department of Molecular and Biomedical Science, School of Biological Science, The University of Adelaide, Adelaide, SA 5005, Australia;

Leukocyte homing driven by the chemokine CCL21 is pivotal for adaptive immunity because it controls dendritic cell (DC) and T cell migration through CCR7. ACKR4 scavenges CCL21 and has been shown to play an essential role in DC trafficking at the steady state and during immune responses to tumors and cutaneous inflammation. However, the mechanism by which ACKR4 regulates peripheral DC migration is unknown, and the extent to which it regulates CCL21 in steady-state skin and lymph nodes (LNs) is contested. Read More

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A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial.

Trials 2021 Apr 19;22(1):288. Epub 2021 Apr 19.

Royal College of Surgeons in Ireland, Dublin, Ireland.

Objectives: The primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin®(plasma-purified alpha-1 antitrypsin) reduces circulating plasma levels of interleukin-6 (IL-6). Secondary objectives are to determine the effects of intravenous Prolastin® on important clinical outcomes including the incidence of adverse events (AEs) and serious adverse events (SAEs).

Trial Design: Phase 2, randomised, double-blind, placebo-controlled, pilot trial. Read More

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Growth patterns and clinical outcomes in association with breastfeeding duration in HIV exposed and unexposed infants: a cohort study in KwaZulu Natal, South Africa.

BMC Pediatr 2021 Apr 19;21(1):183. Epub 2021 Apr 19.

Department of Paediatrics and Child Health, School of Clinical Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Congella, 4013, South Africa.

Background: Exclusive breastfeeding for 6 months and breastfeeding with complementary feeds until 12 months for HIV exposed and uninfected (HEU) infants or 24 months for HIV unexposed (HU) infants is the current World Health Organisation (WHO) recommendation for low and middle income countries (LMICs) to improve clinical outcomes and growth trajectories in infants. In a post-hoc evaluation of HEU and HU cohorts, we examine growth patterns and clinical outcomes in the first 9 months of infancy in association with breastfeeding duration.

Methods: Two cohorts of infants, HEU and HU from a low-socioeconomic township in South Africa, were evaluated from birth until 9 months of age. Read More

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How to conduct integrated pharmaceutical care for patients with hand-foot syndrome associated with chemotherapeutic agents and targeted drugs.

J Oncol Pharm Pract 2021 Apr 19:10781552211009291. Epub 2021 Apr 19.

Department of Pharmacy, Changhai Hospital of Shanghai, Shanghai, China.

Objective: The objective of this article was to offer practical operational process for pharmacists to successfully conduct integrated pharmaceutical care for patients with hand-foot syndrome associated with chemotherapeutic agents and targeted drugs which may facilitate the work of first-line clinical pharmacist. A literature review was conducted in March 2020 of Pubmed, Medline, and EMBASE (2010-2020) using terms such as: hand-foot syndrome, hand-foot skin reaction, palmar-plantar erythrodysesthesia, chemotherapeutic agent, and multikinase inhibitor. Appropriate references from selected articles were also used. Read More

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Not Just Uterine Adenocarcinoma-Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (): A Review.

Authors:
Berit Baum

Vet Pathol 2021 Apr 20:3009858211002190. Epub 2021 Apr 20.

Vet Med Labor GmbH, Kornwestheim, Germany.

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Read More

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Literature Review and Our Experience With Bleomycin-Based Electrochemotherapy for Cutaneous Vulvar Metastases From Endometrial Cancer.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211010134

Department of Gynecological Oncology, 68196Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Endometrial carcinoma is the most common gynecological malignancy and the fifth most common malignancy in women. The worldwide incidence is 15.9 new cases per 100,000 women per year, and the incidence in Europe is 22. Read More

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Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases.

Pharmacol Res 2021 Apr 16:105615. Epub 2021 Apr 16.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR 999078, China. Electronic address:

Naturally occurring coumestans are known as a collection of plant-derived polycyclic aromatic secondary metabolites which are characterized by the presence of an oxygen heterocyclic four-ring system comprising a coumarin moiety and a benzofuran moiety sharing a C=C bond. Recently, there is an increasing attention in excavating the medicinal potential of coumestans, particularly coumestrol, wedelolactone, psoralidin and glycyrol, in a variety of diseases. This review is a comprehensive inventory of the chemical structures of coumestans isolated from various plant sources during the period of 1956-2020, together with their reported biological activities. Read More

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Biocompatible Ionic Liquids Assisted Transdermal Co-Delivery of Antigenic Protein and Adjuvant for Cancer Immunotherapy.

Int J Pharm 2021 Apr 16:120582. Epub 2021 Apr 16.

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan; Advanced Transdermal Drug Delivery System Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan; Division of Biotechnology, Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address:

Human skin contains numerous antigen-presenting cells that are a potential target for several immune-based therapies, including vaccination and cancer immunotherapy. However, the outermost layer of the skin-the stratum corneum-acts as a major physical barrier against the permeation of antigens that have a molecular weight > 500 Da. In this study, an ionic liquid-assisted delivery system (ILDS) was developed, which enabled the successful transdermal delivery of an antigenic protein, ovalbumin (OVA), with a toll-like receptor agonist, imiquimod, as an adjuvant, to stimulate a specific immune response. Read More

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Identification of patient benefit from proton beam therapy in brain tumour patients based on dosimetric and NTCP analyses.

Radiother Oncol 2021 Apr 16. Epub 2021 Apr 16.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany. Electronic address:

Background: The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies, such as the model-based approach. In this study, we assessed the dosimetric benefit of PBT compared to photon therapy (XRT), analysed the corresponding changes in normal tissue complication probability (NTCP) on a variety of available models, and illustrated model-based patient selection in an in-silico study for patients with brain tumours.

Methods: For 92 patients treated at two PBT centres, volumetric modulated arc therapy treatment plans were retrospectively created for comparison with the clinically applied PBT plans. Read More

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Biochemical impact of solar radiation exposure on human keratinocytes monitored by Raman spectroscopy; effects of cell culture environment.

J Biophotonics 2021 Apr 19. Epub 2021 Apr 19.

FOCAS Research Institute, Technological University Dublin, Dublin, Ireland.

Understanding and amelioration of the effects of solar radiation exposure are critical in preventing the occurrence of skin cancer. Towards this end, many studies have been conducted in 2D cell culture models under simplified and unrealistic conditions. 3D culture models better capture the complexity of in vivo physiology, although the effects of the 3D extracellular matrix have not been well studied. Read More

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Melanoma-specific expression of the tumor suppressor proteins p16 and PTEN is a favorable prognostic factor in established melanoma brain metastases.

Melanoma Res 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology and Laboratory Medicine Department of Biostatistics Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Melanoma and Skin Cancer Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

PTEN and p16 frequently undergo (epi)genetic aberrations in melanoma resulting in decreased, or absent, protein levels. We investigated the prognostic significance of these tumor suppressor genes in melanoma brain metastases (MBMs). Immunohistochemical analysis was performed on archived tissue sections from craniotomies. Read More

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Response durability after cessation of immune checkpoint inhibitors in patients with metastatic Merkel cell carcinoma: a retrospective multicenter DeCOG study.

Cancer Immunol Immunother 2021 Apr 18. Epub 2021 Apr 18.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Background: Immune checkpoint inhibitors (ICI) have led to a prolongation of progression-free and overall survival in patients with metastatic Merkel cell carcinoma (MCC). However, immune-mediated adverse events due to ICI therapy are common and often lead to treatment discontinuation. The response duration after cessation of ICI treatment is unknown. Read More

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First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors.

EClinicalMedicine 2021 Apr 30;34:100797. Epub 2021 Mar 30.

Sarah Cannon Research Institute, 1100 Martin L. King Jr. Boulevard, Nashville, TN 37203 United States.

Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane.

Methods: This completed open-label outpatient study was conducted at 11 sites in the United States and United Kingdom. Patients with previously-treated advanced metastatic solid tumors and adequate performance status and organ function were eligible. Read More

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Microcystic adnexal carcinoma of the glabella in a liver transplant recipient.

JAAD Case Rep 2021 Apr 4;10:126-129. Epub 2020 May 4.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

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A Nomogram Combining a Four-Gene Biomarker and Clinical Factors for Predicting Survival of Melanoma.

Front Oncol 2021 1;11:593587. Epub 2021 Apr 1.

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: Currently there is no effective prognostic indicator for melanoma, the deadliest skin cancer. Thus, we aimed to develop and validate a nomogram predictive model for predicting survival of melanoma.

Methods: Four hundred forty-nine melanoma cases with RNA sequencing (RNA-seq) data from TCGA were randomly divided into the training set I (n = 224) and validation set I (n = 225), 210 melanoma cases with RNA-seq data from Lund cohort of Lund University (available in GSE65904) were used as an external test set. Read More

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Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma.

Oncotarget 2021 Mar 30;12(7):638-648. Epub 2021 Mar 30.

Department of Oncology, University Hospital Lausanne (CHUV/UNIL), Lausanne, Switzerland.

Although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy. The role of lymphatic vessels in skin squamous-cell carcinoma (sSCC), the second most common form of skin cancer, remains mostly unknown. Although anti-PD-1 therapy is beneficial for some patients with advanced sSCC, a greater understanding of disease mechanisms is still needed to develop better therapies. Read More

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Olaparib in hormone receptor-positive, HER2-negative metastatic breast cancer with a somatic mutation.

Ther Adv Med Oncol 2021 5;13:17588359211006962. Epub 2021 Apr 5.

Department of Medical Affairs, Guardant Health, Inc., Redwood City, CA, USA.

The oral poly(adenosine diphosphate-ribose) polymerase inhibitor olaparib is approved for the treatment of patients with human epidermal growth factor 2-negative (HER2-) metastatic breast cancer (mBC) and a germline breast cancer susceptibility gene (BRCA) mutation who have been treated with chemotherapy. This case report describes a 63-year-old postmenopausal woman with somatic -mutated mBC who responded to olaparib treatment following multiple prior lines of therapy. The patient presented in January 2012 with locally advanced, hormone receptor-positive (HR+), HER2- BC which, despite initial response to neoadjuvant chemotherapy, recurred as bone disease in February 2014, and subsequently skin (June 2016) and liver (October 2016) metastases. Read More

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