63,322 results match your criteria skin biopsies

Generation of three human induced pluripotent stem cell sublines (UCLAi005-A, UCLAi005-B and UCLAi005-C) for reproductive science research.

Stem Cell Res 2021 Jun 8;54:102409. Epub 2021 Jun 8.

Department of Molecular, Cell and Developmental Biology, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA USA; Molecular Biology Institute, University of California, Los Angeles, CA, USA. Electronic address:

We generated three human induced pluripotent stem cell (hiPSC) sublines from human dermal fibroblasts (HDF) (MZT05) generated from a skin biopsy donated from a previously fertile woman. The skin biopsy was broadly consented for generating hiPSC lines for biomedical research, including unique consent specifically for studying human fertility, infertility and germ cell differentiation. hiPSCs were reprogrammed using Sendai virus vectors and were subsequently positive for markers of self-renewal. Read More

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Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism.

Free Radic Biol Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences; Linda Crnic Institute for Down Syndrome, School of Medicine, University of Colorado, Aurora, Colorado, USA. Electronic address:

Down syndrome (DS) is the most common genetic cause of intellectual disability. Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological factors for many of the DS-related comorbidities and have previously been reported in a number of in vitro and in vivo models of DS. The purpose of this study was to test for the presence of mitochondrial dysfunction in fibroblast cells obtained via skin biopsy from individuals with DS, and to assess the impact of trisomy 21 on central carbon metabolism. Read More

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Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats.

Wound Repair Regen 2021 Jun 15. Epub 2021 Jun 15.

Boston University School of Medicine, Boston, Massachusetts, USA.

Vaping is suggested to be a risk factor for poor wound healing akin to smoking. However, the molecular and histologic mechanisms underlying this postulation remain unknown. Our study sought to compare molecular and histologic changes in cutaneous flap and non-flap tissue between vaping, smoking and control cohorts. Read More

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Pyoderma Gangrenosum Mimicking Wound Infection after Breast Cancer Surgery.

J Breast Cancer 2021 Apr 29. Epub 2021 Apr 29.

Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Postoperative pyoderma gangrenosum (PPG) is rare, and its diagnosis is often delayed because of its wound infection-mimicking course. A 53-year-old breast cancer patient who underwent breast-conserving surgery of the right breast presented with fever, leukocytosis, C-reactive protein elevation, and redness of the right breast on postoperative day (POD) 3. The breast wound showed desquamation with painful ulcerative changes from POD 6, and fever was sustained under antibiotic administration. Read More

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Leg ulceration due to cutaneous melioidosis in a returning traveller.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Hospital for Tropical Diseases and Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.

A 26-year-old man, returned to the UK having travelled extensively in Asia. He was referred with a 3-month history of distal leg ulceration following an insect bite while in Thailand. Despite multiple courses of oral antibiotics, he developed two adjacent ulcers. Read More

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A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-weber syndrome.

Hum Mol Genet 2021 Jun 14. Epub 2021 Jun 14.

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterised by vascular malformations affecting skin, eyes and leptomeninges of the brain, which can lead to glaucoma, seizures and intellectual disability. The discovery of a disease-causing somatic missense mutation in the GNAQ gene, encoding an alpha chain of heterotrimeric G-proteins, has initiated efforts to understand how G-proteins contribute to SWS pathogenesis. The mutation is predominantly detected in endothelial cells and is currently believed to affect downstream MAPK-signalling. Read More

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Reflectance Confocal Microscopy of Aging Skin and Skin Cancer.

Dermatol Pract Concept 2021 May 20;11(3):e2021068. Epub 2021 May 20.

Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Skin aging is a complex process that causes morphologic variations. Some of these variations have been hypothesized to be involved in skin cancer development. This paper reviews current knowledge of the features of aged skin as seen with reflectance confocal microscopy (RCM). Read More

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FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis.

Dermatol Pract Concept 2021 May 20;11(3):e2021057. Epub 2021 May 20.

Department of Dermatology, S N Medical College, Bagalkot, Karnataka, India.

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis. Read More

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Henoch-Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis.

Case Rep Endocrinol 2021 22;2021:6669653. Epub 2021 May 22.

Pathology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Graves' disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch-Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch-Schönlein purpura (IgA vasculitis) as a side effect. Read More

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SLE strikes the heart! A rare presentation of SLE myocarditis presenting as cardiogenic shock.

BMC Cardiovasc Disord 2021 Jun 13;21(1):294. Epub 2021 Jun 13.

Division of Rheumatology, Department of Internal Medicine, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134, USA.

Background: Although systemic lupus erythematosus (SLE) can affect the cardiovascular system in many ways with diverse presentations, a severe cardiogenic shock secondary to SLE myocarditis is infrequently described in the medical literature. Variable presenting features of SLE myocarditis can also make the diagnosis challenging. This case report will allow learners to consider SLE myocarditis in the differential and appreciate the diagnostic uncertainty. Read More

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Interstitial granuloma annulare triggered by Lyme disease.

Dermatol Online J 2021 May 15;27(5). Epub 2021 May 15.

Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH.

Granuloma annulare is a non-infectious granulomatous skin condition with multiple different associations. We present a case of a man in his 60s with a three-week history of progressive targetoid plaques on his arms, legs, and trunk. Skin biopsy demonstrated interstitial granuloma annulare. Read More

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Is Melanoma Overdiagnosed? A Review of the Evidence.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; University of Florida Dermatology Department, Gainesville, FL. Electronic address:

Background: Melanoma is one of the most commonly diagnosed malignancies in the United States (US) and is responsible for the majority of deaths from skin cancer.

Objective: Since the 1970s, the incidence of melanoma has risen appreciably while melanoma-specific mortality has remained stable. This has raised a debate about potential overdiagnosis of melanoma. Read More

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Histological Skin Changes After Treatment with 675 nm Laser.

Photobiomodul Photomed Laser Surg 2021 May 25. Epub 2021 May 25.

Unit of Dermatology, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.

To evaluate the histological effects of a new 675-nm laser device on the skin. Innovative technologies based on physical principles have been proposed in recent years to improve the treatment of aging skin. Laser technology is currently being studied for its potential in skin care treatments. Read More

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Simultaneous Application of High-Intensity Focused Electromagnetic and Synchronized Radiofrequency for Fat Disruption: Histological and Electron Microscopy Porcine Model Study.

Dermatol Surg 2021 Jun 2. Epub 2021 Jun 2.

Maryland Laser Skin, & Vein Institute, Hunt Valley, Maryland; Veterinary Research Institute, Brno, CZ; Department of Anatomy and Histology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, CZ.

Background: Radiofrequency (RF) and high-intensity focused electromagnetic (HIFEM) technologies are used for noninvasive body shaping as standalone modalities.

Objective: To examine the effects of novel synchronized RF and HIFEM on subcutaneous adipose tissue in a porcine animal model.

Materials And Methods: Seven large white pigs aged 6 months received 3 abdominal treatments of simultaneous application of synchronized RF and HIFEM (30 minutes, once per week). Read More

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Cutaneous metastasis as a first sign of breast carcinoma.

Radiol Case Rep 2021 Jul 26;16(7):1899-1901. Epub 2021 May 26.

Radiology department, Military Hospital Mohammed V, Rabat, Morocco.

Unlike visceral, lymphonodal or bone metastases, skin metastases are rare and their identification portends of a bad prognosis. They may appear as the first sign revealing the primary tumour, synchronous or developing late in the course of neglected primary cancer. We report a case of 86 year-old women witch belongs to this rare group of patients in whom cutaneous metastasis were identified before the primary cancer. Read More

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IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy.

Ther Clin Risk Manag 2021 3;17:571-575. Epub 2021 Jun 3.

Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.

A 72-year-old man with locally advanced lung squamous cell carcinoma experienced red purpura on the lower legs and hematuria when the disease progressed during definitive chemoradiotherapy. He had renal dysfunction and proteinuria. Biopsy specimens of the skin lesion and kidney revealed immunoglobulin A vasculitis. Read More

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Bilateral Chilblain-like Lesions of the Toes Characterized by Microvascular Remodeling in Adolescents During the COVID-19 Pandemic.

JAMA Netw Open 2021 06 1;4(6):e2111369. Epub 2021 Jun 1.

Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Naples, Italy.

Importance: Chilblain-like lesions have been one of the most frequently described cutaneous manifestations during the COVID-19 pandemic. Their etiopathogenesis, including the role of SARS-CoV-2, remains elusive.

Objective: To examine the association of chilblain-like lesions with SARS-CoV-2 infection. Read More

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Ultrasound-guided microwave ablation for multiple benign breast lesions: A prospective study.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of General Surgery, Hebei Province Traditional Chinese Medical Hospital, Shijiazhuang, China.

Aim: To provide medical evidence for the feasibility and clinical efficacy of microwave ablation (MWA) in the treatment of benign breast lesions, especially multiple benign breast lesions.

Methods: We included patients with multiple benign breast lesions who were seen at our hospital during the period from June 2016 to December 2017. After signed informed consent had been obtained and core breast biopsy, all included patients who underwent MWA at 2450 MHz with 30 W power adjustment. Read More

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Landscape condition influences energetics, reproduction, and stress biomarkers in grizzly bears.

Sci Rep 2021 Jun 9;11(1):12124. Epub 2021 Jun 9.

Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.

Environmental change has been shown to influence mammalian distribution, habitat use, and behavior; however, few studies have investigated the impact on physiological function. This study aimed to determine the influence of landscape condition on the expression of target proteins related to energetics, reproduction, and stress in grizzly bears. We hypothesized that changes in landscape condition explains protein expression. Read More

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Membranous nephropathy associated with multicentric Castleman's disease that was successfully treated with tocilizumab: a case report and review of the literature.

BMC Nephrol 2021 Jun 9;22(1):216. Epub 2021 Jun 9.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Multicentric Castleman's disease is a life-threatening disorder involving a systemic inflammatory response and multiple organ failure caused by the overproduction of interleukin-6. Although renal complications of Castleman's disease include AA amyloidosis, thrombotic microangiopathy, and membranoproliferative glomerulonephritis, membranous nephropathy is relatively rare. We experienced a case of secondary membranous nephropathy associated with Castleman's disease. Read More

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Primary gastric melanoma with pancreatic metastasis: a case report.

Ann Palliat Med 2021 May;10(5):5902-5907

Department of Pancreatic-Biliary Surgery, First Hospital of China Medical University, Shenyang, China.

We report an extremely rare case of primary gastric melanoma with pancreatic metastasis. As far as we know, the concept of primary gastrointestinal melanoma is currently controversial, because there are very few reports of primary gastrointestinal melanoma. At the same time, isolated pancreatic metastases are also very rare. Read More

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Blastic plasmacytoid dendritic cell neoplasm of the breast: A case report and review of the literature.

Medicine (Baltimore) 2021 May;100(19):e25699

Department of Radiology.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon and aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions with or without involvement of lymph nodes, peripheral blood, or bone marrow. However, breast involvement of BPDCN is rare and there has been no report describing the radiologic features of BPDCN within breast parenchyma. Read More

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A case of immune checkpoint inhibitor-related colitis with a distinctive endoscopic finding of colonic pseudolipomatosis.

Clin J Gastroenterol 2021 Jun 9. Epub 2021 Jun 9.

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

A man in his 70s received anticancer chemotherapy with the anti-programmed cell death protein-ligand 1 antibody atezolizumab for non-small cell lung cancer. Ten days later, he developed diarrhea and skin rash, which were suspected to be due to immune-related adverse events, and was treated with prednisolone for 2 weeks. Five weeks after atezolizumab administration, he was admitted to our hospital for Common Terminology Criteria for Adverse Events Grade 3 diarrhea and hematochezia. Read More

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Analysis of the Clinical Characteristics of Dipeptidyl Peptidase-4 Inhibitor-Induced Bullous Pemphigoid.

Ann Pharmacother 2021 Jun 9:10600280211022722. Epub 2021 Jun 9.

Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China.

Objective: To analyze and discuss the clinical characteristics of dipeptidyl peptidase-4 inhibitor (DPP4i)-induced bullous pemphigoid (BP).

Data Sources: We collected case reports of DPP4i-induced BP by searching databases from 2006 to mid-May 2021, as a retrospective analysis.

Study Selection And Data Extraction: Relevant case reports and case analyses of DPP4i-induced BP were included. Read More

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Very Early-Onset Inflammatory Bowel Disease (VEO-IBD) Presenting with Recurrent Leukocytoclastic Vasculitis Preceded by Streptococcal Pharyngitis.

Case Rep Pediatr 2021 20;2021:1996430. Epub 2021 May 20.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Nicklaus Children's Hospital, Miami, FL, USA.

Inflammatory bowel disease (IBD) that presents in children <6 years of age is known as very early-onset IBD (VEO-IBD). Extraintestinal manifestations in IBD, such as erythema nodosum (EN), pyoderma gangrenosum (PG), and, less likely, leukocytoclastic vasculitis (LV), are more commonly present in Crohn's disease. Association between LV and ulcerative colitis (UC) is not commonly seen. Read More

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A rare case of primary cutaneous diffuse large B-cell lymphoma, leg type, presenting as cellulitis: a case report.

J Surg Case Rep 2021 Jun 4;2021(6):rjab227. Epub 2021 Jun 4.

Division of Plastic Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Primary cutaneous diffuse large B-cell lymphoma, leg type, accounts for only 4% of all cutaneous lymphomas and bears a worse prognosis than other cutaneous B-cell lymphomas. Diagnosis at an early stage may be difficult due to its nonspecific manifestations. We report an 88-year-old female who was brought to our emergency department due to two rapidly growing painful skin lesions with local redness and swelling on her right lower leg. Read More

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The Role of TROP2 in BCC and Cutaneous SCC: A Clinical and Immunohistochemical Study.

Clin Cosmet Investig Dermatol 2021 1;14:591-600. Epub 2021 Jun 1.

Pathology Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.

Background: Nonmelanoma skin cancer (NMSC) mainly includes basal (BCC) and squamous (SCC) cell carcinoma. Trophoblast cell-surface antigen2 (TROP2), a cell-signal transduction, is one of the tumor-related calcium signal transducer gene family. TROP2 was highly expressed in many cancers, however, its role in BCC and SCC has not yet been studied. Read More

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Characterisation of the Hybrid Isolated from an Autochothonous Kala-Azar Patient: Preliminary Results of an Model

Turkiye Parazitol Derg 2021 06;45(2):95-100

Harran Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Şanlıurfa, Türkiye

Objective: In the present study, preliminary outcomes of the assessment of a hybrid isolated from a hospitalised patient with visceral leishmaniasis in Manisa and identified through analysis of the -specific and gene regions are presented in comparison with reference strains of and .

Methods: Three different study groups [(SG); n=16 mice each] and a control group (n=8 mice) were established with female Balb/C mice weighing 25-30 g. Reference (MHOM/IN/1980/DD8), reference (MHOM/TN/1980/IP1) and a hybrid (MHOM/TR/2014/CBVL-LI/ LD), stored in liquid nitrogen, were thawed, cultured and incubated at 25 °C. Read More

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Histological and immunohistochemical features suggesting aetiological differences in lymph node and (muco)cutaneous feline tuberculosis lesions.

J Small Anim Pract 2021 Jun 7. Epub 2021 Jun 7.

*Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Objectives: To identify and describe histological and immunohistochemical criteria that may differentiate between skin and lymph node lesions associated with Mycobacterium (M.) bovis and M. microti in a diagnostic pathology setting. Read More

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Pyoderma gangrenosum with primary sclerosing cholangitis-associated colitis successfully treated with concomitant granulocyte and monocyte adsorption apheresis with corticosteroids.

Clin J Gastroenterol 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Syogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

An 18-year-old woman was admitted to our hospital with fever, diarrhea and painful skin ulcers in both pretibial areas starting 19 days earlier. The skin lesions appeared deep necrotic ulcers with violaceous undermined borders. She had been diagnosed as ulcerative colitis and primary sclerosing cholangitis (PSC) 6 and 5 years before, respectively, and had stopped having regular check-up and refused medication for years. Read More

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