Search Our Scientific Publications & Authors

J Am Coll Cardiol 2022 May;79(21):2069-2081

Division of Cardiology, Weill Cornell Medicine, New York, New York, USA.

Background: The GenTAC (Genetically Triggered Thoracic Aortic Aneurysm and Cardiovascular Conditions) Registry enrolled patients with genetic aortopathies between 2007 and 2016.

Objectives: The purpose of this study was to compare age distribution and probability of elective surgery for proximal aortic aneurysm, any dissection surgery, and cardiovascular mortality among aortopathy etiologies.

Methods: The GenTAC study had a retrospective/prospective design. Read More

BMJ Open Qual 2022 May;11(2)

School of Medicine, University of St Andrews, St Andrews, UK.

Teledermatology is an important subspecialty of telemedicine that continues to evolve with advances in telecommunication and mobile phone technology. A 19-week primary care quality improvement project collected baseline data and tested three change ideas, using the Model for Improvement method, with primary and secondary aims: to increase the weekly percentage of remote dermatological consultations with supporting images that were successfully concluded remotely to greater than 80% and to reduce the weekly percentage of dermatological face-to-face consultations to less than 50%. We hypothesised that by improving the quality of patient images and the confidence of reception staff in triaging skin complaints, there would be a decrease in the weekly number of face-to-face dermatological appointments, thereby decreasing the risk of COVID-19 transmission within the practice and community. Read More

Photodiagnosis Photodyn Ther 2022 May 23:102918. Epub 2022 May 23.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Bowenoid papulosis (BP) is a rare infectious skin disease that occurs in sexually active young people. BP is associated with human papillomavirus (HPV)16 and 18 infections, spreads through sexual contact, and tends to become cancerous. Currently, there are different BP treatment methods, and few reports on the efficacy of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) (ALA-PDT). Read More

Environ Pollut 2022 May 23:119519. Epub 2022 May 23.

Department of Environmental Health Science, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

As a result of the efforts to introduce the principle of the 3Rs (replacement, reduction, and refinement) into animal testing, alternative in vitro skin corrosion test methods have been developed and standardized globally. However, alternative in vitro skin corrosion test methods have some limitations in terms of the use of humanely killed rats or commercial models and kits. The present study focused on the applicability of invertebrates as alternative in vivo skin models. Read More

Sci Total Environ 2022 May 23:156180. Epub 2022 May 23.

Univ Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:

We conducted a systematic review and meta-analysis of the available literature on the association between greenspace exposure and all-sites and site-specific cancer incidence, prevalence, and mortality in adults. We searched PubMed, Scopus, and Web of Science for original articles published, without language restriction until September 2021. We assessed the risk of bias in each study and the overall quality of evidence for exposure-outcome pairs that were reported in two or more studies. Read More

J Invest Dermatol 2022 May 23. Epub 2022 May 23.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China. Electronic address:

Epidermal growth factor receptor inhibitors (EGFRIs) have been established as first-line standard-of-care therapies for non-small cell lung cancer (NSCLC) but are frequently accompanied by adverse dermatological effects, in particular, acneiform rash. There is no effective clinical intervention, partially because of its poorly understood etiology. Here, we show that inhibition of EGFR initiated keratinocyte HaCaT cell cycle arrest and apoptosis, which fueled a robust secondary inflammatory response. Read More

Facial Plast Surg 2022 May 26. Epub 2022 May 26.

Otorhinolaryngology, Acibadem University, Istanbul, Turkey.

The attenuation of retaining ligaments with aging leads to downward displacement of facial fat compartments, and is responsible for many of the stigmata that occur with aging. The zygomatic cutaneous and masseteric cutaneous ligaments prevent the transmission of adequate traction to the malar portion of the dissection during traditional low SMAS facelift techniques which involve plication or imbrication of the exposed surface of the SMAS because they do not include surgical release of these ligaments. Inadequate release of these ligaments, especially the zygomatic cutaneous ligament may lead to an unbalanced, unnatural appearance with unopposed nasolabial folds. Read More

Nanotechnology 2022 May 26. Epub 2022 May 26.

University of California Berkeley, Department of Mechanical and Electrical Engineering, Berkeley, California, 94720, UNITED STATES.

Flexible force sensors are of great interests in healthcare, physiological signals, and aircraft smart skin applications for its compatibility to curved surfaces. However, the simultaneous detection of multi-directional forces remains an engineering challenge despite of great progresses in recent years. Herein, a flexible capacitive force sensor capable of efficiently distinguishing normal and sliding shear force is developed. Read More

Biofabrication 2022 May 26. Epub 2022 May 26.

Biomedical Material and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, Wuhan, Hubei, 430070, CHINA.

An ideal wound dressing for full-thickness wound regeneration should offer desirable biocompatibility, adequate mechanical properties, barrier function, and cellular regulation. Here, a bilayer scaffold resembling the hierarchical structure of human skin was developed using silk fibroin and sodium alginate. The upper membrane was prepared through casting and functioned as the epidermis, whereas the lower porous scaffold was prepared by freeze-drying and mimicked extracellular matrix structures. Read More

J Infect Public Health 2022 Apr 28;15(6):648-653. Epub 2022 Apr 28.

Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia; Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia; King Saud bin Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address:

Background: The COVID-19 pandemic created many challenges for healthcare systems. Frontline workers and especially healthcare professionals were the most severely affected through increased working hours, burnout and major psychological distress.

Objectives: To evaluate the changes in standard care elements which occurred during the COVID-19 pandemic, specifically the physician clinical rounds and nursing care provided to non-COVID-19 infected patients. Read More

Aquat Toxicol 2022 May 19;248:106203. Epub 2022 May 19.

Department of Life Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan; Biodiversity Program, Taiwan International Graduate Program, Biodiversity Research Center, Academia Sinica and National Taiwan Normal University, Taipei, Taiwan. Electronic address:

The presence of nanoplastics in aquatic environments is a global problem. Accumulating evidence shows that nanoplastics can accumulate in fish and influence internal organs. However, it is still unknown if nanoplastics can impair skin cells (keratinocytes and ionocytes), which play critical roles in maintaining body fluid homeostasis. Read More

Int J Surg Case Rep 2022 May 20;95:107229. Epub 2022 May 20.

Dept of General Surgery, Apollo Hospitals Int Ltd, Gandhinagar, Gujarat, India.

Introduction And Importance: Necrotizing soft tissue infections (NSTI) are caused by toxin-producing bacteria and fungi that results in rapid progression of disease with significant local tissue destruction.

Case Presentation: We present a case report of a 57-year-old male patient in line with the SCARE 2020 criteria. He was admitted to the emergency department with a small abrasion on the right antero-lateral chest wall, and a diffuse necrotic patch of skin and soft tissues with purulent discharge. Read More

Blood Adv 2022 May 26. Epub 2022 May 26.

Dana-Farber Cancer Institute; Harvard Medical School, Boston, Massachusetts, United States.

Despite new therapeutic options, treatment of steroid-refractory chronic graft-versus-host disease (SR-cGVHD) remains challenging as organ involvement and clinical manifestations are highly variable. In previous trials of low-dose interleukin-2 (LD IL-2), we established the safety and efficacy of LD IL-2 for treatment of SR-cGVHD. In the present report, we combined 5 phase I or II clinical trials conducted at our center to investigate organ-specific response rate, co-involvement of organs, predictors of organ-specific response and its possible association with immune response. Read More

J Patient Saf 2022 Jun 17;18(4):325-330. Epub 2021 Dec 17.

Department of Medicine, South Älvsborg Hospital, Region Västra Götaland, Borås, Sweden.

Objectives: This study aimed to investigate how many preventable adverse events (PAEs) and near misses are identified through the methods structured record review, Web-based incident reporting (IR), and daily safety briefings, and to distinguish the type of events identified by each method.

Methods: One year of retrospective data from 2017 were collected from one patient cohort in a 422-bed acute care hospital. Preventable adverse events and near misses were collected from the hospital's existing resources and presented descriptively as number per 1000 patient-days. Read More

Clin Cancer Res 2022 May 26. Epub 2022 May 26.

Kindai University Hospital, Osakasayama, Osaka, Japan.

Purpose: To explore the efficacy of retreatment with immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC) patients who responded to prior ICI and had adequate ICI-free interval.

Patients And Methods: Advanced NSCLC patients who had achieved complete response (CR), partial response (PR), or stable disease for {greater than or equal to}6 months with prior ICI therapy preceding progression were prospectively enrolled. All patients should have had ICI-free interval {greater than or equal to} 60 days before registration. Read More

ACS Nano 2022 May 26. Epub 2022 May 26.

Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.

Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports a minimally invasive and convenient approach to obtaining scarless tissue using a silk fibroin microneedle patch (SF MNs). We found that by tuning the MN size and density only, the biocompatible MNs significantly decreased the scar elevation index in the rabbit ear hypertrophic scar model and increased ultimate tensile strength close to regular skin. Read More

J Vis Exp 2022 May 26(183). Epub 2022 May 26.

An erratum was issued for: Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model. The Protocol and Discussion sections were updated. Step 3. Read More

Dermatol Ther 2022 May 26:e15594. Epub 2022 May 26.

Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.

Disseminated facial verruca plana is a chronic disorder that causes significant psychological distress. However, safe and effective treatment is lacking. This study aimed to explore the efficacy and safety of 35% glycolic acid for the treatment of disseminated facial verruca plana. Read More

Science 2022 May 26;376(6596):940-945. Epub 2022 May 26.

Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic insults. Our skin also defines our outward appearance, protects our internal tissues and organs, acts as a sensory interface, and prevents dehydration. Crucial to the skin's barrier function is the colonizing microbiota, which provides protection against pathogens, tunes immune responses, and fortifies the epithelium. Read More

Science 2022 May 26;376(6596):1006-1012. Epub 2022 May 26.

Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. Read More

PLoS One 2022 26;17(5):e0268801. Epub 2022 May 26.

Faculty of Biological Sciences, Department of Zoology, Kohat University of Science and Technology, Khyber Pakhtunkhwa, Pakistan.

Background: Cutaneous leishmaniasis is a neglected tropical disease caused by Leishmania spp. and transmitted by female sandflies. Terrorism and counter-insurgency military operations in Federally Administered Tribal Areas (FATA) lead to a large-scale migration of internally displaced persons (IDPs) in Khyber Pakhtunkhwa and thus, new outbreaks of several infectious diseases such as cutaneous leishmaniasis occurred. Read More

PLoS Pathog 2022 May 26;18(5):e1010512. Epub 2022 May 26.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.

Skin health is influenced by the composition and integrity of the skin barrier. The healthy skin surface is an acidic, hypertonic, proteinaceous, and lipid-rich environment that microorganisms must adapt to for survival, and disruption of this environment can result in dysbiosis and increase risk for infectious diseases. This work provides a brief overview of skin barrier function and skin surface composition from the perspective of how the most common skin pathogen, Staphylococcus aureus, combats acid stress. Read More

J Eur Acad Dermatol Venereol 2022 May 26. Epub 2022 May 26.

Clinical Laboratory for Epidemiology and Applied Research in Skin (CLEARS), Department of Dermatology, Beth Israel Deaconess Medical Center, Boston.

Dermatol Surg 2022 May 24. Epub 2022 May 24.

Laser & Skin Surgery Center of New York, New York, New York.

Dermatol Surg 2022 May 24. Epub 2022 May 24.

All authors are affiliated with the Skin Centre, Tauranga, New Zealand.

Biomacromolecules 2022 May 26. Epub 2022 May 26.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 North Third Ring Road East, Chaoyang District, Beijing 100029, P. R. China.

As a classic flexible material, hydrogels show great potential in wearable electronic devices. The application of strain sensors prepared using them in human health monitoring and humanoid robotics is developing rapidly. However, it is still a challenge to fabricate a high-toughness, large-tensile-deformation, strain-sensitive. Read More

J Clin Invest 2022 May 26. Epub 2022 May 26.

Department of Neurology, Columbia University Irving Medical Center, New York, United States of America.

Mitochondrial DNA (mtDNA) depletion/deletions syndromes (MDDS) encompass a clinically and etiologically heterogenous group of mitochondrial disorders due to impaired mtDNA maintenance. Among the most frequent causes of MDDS are defects in nucleoside/nucleotide metabolism, which is critical for synthesis and homeostasis of the deoxynucleoside triphosphate (dNTP) substrates of mtDNA replication. A central enzyme for generating dNTPs is ribonucleotide reductase, a critical mediator of de novo nucleotide synthesis composed of catalytic RRM1 subunits in complex with RRM2 or p53R2. Read More

JMIR Mhealth Uhealth 2022 May 26;10(5):e34017. Epub 2022 May 26.

Department of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Würzburg, Germany.

Background: Psoriasis is a chronic inflammatory skin disease. The visibility of erythematous plaques on the skin as well as the pain and itchiness caused by the skin lesions frequently leads to psychological distress in patients. Smartphone apps are widespread and easily accessible. Read More

JAMA Oncol 2022 May 26. Epub 2022 May 26.

Department of Physics and Atmospheric Science, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Importance: Women with large breast size treated with adjuvant breast radiotherapy (RT) have a high rate of acute toxic effects of the skin. Breast RT in the prone position is one strategy that may decrease these toxic effects.

Objective: To determine if breast RT in the prone position reduces acute toxic effects of the skin when compared with treatment in the supine position. Read More

Pediatr Allergy Immunol 2022 May;33(5):e13781

Tropical Futures Institute, James Cook University Singapore, Singapore.

Background: Clinical cross-reactivity between bony fish, cartilaginous fish, frog, and chicken muscle has previously been demonstrated in fish-allergic patients. In indicative studies, two reports of anaphylaxis following the consumption of crocodile meat and IgE-cross-binding were linked to the major fish allergen parvalbumin (PV). This study investigates IgE-binding proteins in crocodile meat with a focus on PV and their clinical relevance. Read More