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Biosens Bioelectron 2021 Mar 28;183:113204. Epub 2021 Mar 28.

Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Strasse 1, 52428, Jülich, Germany; Forschungszentrum Jülich GmbH, Institute of Biological Information Processing (IBI-3), Wilhelm-Johnen-Strasse 6, 52425, Jülich, Germany. Electronic address:

In modern days, there is an increasing relevance of and demand for flexible and biocompatible sensors for in-vivo and epidermal applications. One promising strategy is the implementation of biological (natural) polymers, which offer new opportunities for flexible biosensor devices due to their high biocompatibility and adjustable biodegradability. As a proof-of-concept experiment, a biosensor was fabricated by combining thin- (for Pt working- and counter electrode) and thick-film (for Ag/AgCl quasi-reference electrode) technologies: The biosensor consists of a fully bio-based and biodegradable fibroin substrate derived from silk fibroin of the silkworm Bombyx mori combined with immobilized enzyme glucose oxidase. Read More

Food Chem 2021 Mar 27;356:129713. Epub 2021 Mar 27.

College of Horticulture, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

In this study, we investigated the effects of melatonin application on berry coloration, sugar accumulation, and nutrient absorption in 'Summer Black' grapes. Melatonin spraying at 100 μmol L on grapes during veraison induced skin coloration earlier than that in controls, as well as higher transcript abundance of anthocyanin biosynthesis-related genes and transcription factors MYBA1 and MYBA2. Melatonin treatment increased the soluble sugar content, especially of sucrose, by promoting the activity of sucrose phosphate synthase, and also increased endogenous melatonin content and the concentrations of mineral nutrients N, K, Cu, Fe, and Zn in grape berries. Read More

Semin Cancer Biol 2021 Apr 6. Epub 2021 Apr 6.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

Arsenic exposure in contaminated drinking water is a global health issue, as more than 200 million people are affected globally. Arsenic has been known to cause skin, liver, lung, bladder and prostate cancers. Accordingly, it has been categorized as a group I human carcinogen by the International Agency for Research on Cancer (IARC). Read More

Food Chem Toxicol 2021 Apr 6:112172. Epub 2021 Apr 6.

The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

The existing information supports the use of this material as described in this safety assessment. 5- and 6-Decenoic acid was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog oleic acid (CAS # 112-80-1) show that 5- and 6-decenoic acid is not expected to be genotoxic. Read More

J Invest Dermatol 2021 Apr 6. Epub 2021 Apr 6.

Laboratory of Dermato-Immunology, College of Medicine, The Catholic University of Korea, 06591, Seoul, Republic of Korea. Electronic address:

With aging, the skin becomes thin and drastically losses collagen. Extracellular (EC) Superoxide dismutase (SOD), also known as SOD3 is the major SOD in the extracellular matrix of the tissues, and is well known to maintain the redox homeostasis and matrix components of such tissues. However, the role of EC-SOD in aging-associated reductions of skin thickness and collagen production is not well studied. Read More

Lancet Psychiatry 2021 Apr 1. Epub 2021 Apr 1.

Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Oxford, UK. Electronic address:

Background: Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis.

Methods: For this retrospective cohort study and time-to-event analysis, we used data obtained from the TriNetX electronic health records network (with over 81 million patients). Read More

Biosci Biotechnol Biochem 2021 Apr 9. Epub 2021 Apr 9.

Biological Science Research, Kao Corporation; 5-3-28 Kotobuki-cho, Odawara-shi, Kanagawa 250-0002, Japan.

Regulation of hyaluronan (HA) is important for the maintenance of epidermal homeostasis. Here we examined the mechanism by which 1-ethyl-β-N-acetylglucosaminide (β-NAG2), a newly developed N-acetylglucosamine (NAG) derivative, increases HA production in cultured human epidermal keratinocytes. When keratinocytes were treated with β-NAG2, mRNA expression of HA synthase 3, which is responsible for HA production in human keratinocytes, was not influenced, but the intracellular level of UDP-NAG, a substrate used for HA synthesis, was increased. Read More

J Burn Care Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Medical Cosmetology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous, China.

Auto-skin grafting is the current treatment of choice for extensive burns. Nevertheless, the lack of donor sites for skin grafting remains one of the greatest limiting factors for the treatment of extensively burned patients. We present the case of a 53-year-old male patient with deep and full thickness burns on 91% of the total body surface area. Read More

J Bras Nefrol 2021 Apr 9. Epub 2021 Apr 9.

Instituto de Cardiologia do Distrito Federal, Brasília, DF, Brasil.

Introduction: Tuberculosis (TB) is a possible serious complication of solid organ transplantation, associated with high mortality and morbidity. Post-transplant TB has varied pathogenesis with many approaches to its prevention, which is the most important way to reduce its incidence. Treatment of TB in organ recipients is challenging because of drug toxicity and interaction with immunosuppressants. Read More

PLoS Negl Trop Dis 2021 Apr 9;15(4):e0009267. Epub 2021 Apr 9.

INSERM Centre d'Investigation Clinique Antilles-Guyane, Cayenne, France.

Background: In 2014, a first outbreak of chikungunya hit the Caribbean area where chikungunya virus (CHIKV) had never circulated before.

Methodology/principal Findings: We conducted a cross-sectional study to measure the seroprevalence of CHIKV immediately after the end of the 2014 outbreak in HIV-infected people followed up in two clinical cohorts at the University hospitals of Guadeloupe and Martinique. Study patients were identified during the first months of 2015 and randomly selected to match the age and sex distribution of the general population in the two islands. Read More

J Child Adolesc Psychopharmacol 2021 Apr 9. Epub 2021 Apr 9.

Section of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, University of Perugia, Perugia, Italy.

J Phys Chem B 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemistry, University of California Irvine, Irvine, California 92697, United States.

Human skin oils are significant scavengers of atmospheric oxidants in occupied indoor environments, and squalene is a major ozone-active constituent. Here, we present a combined spectroscopic and atomistic modeling approach to elucidate the conformational and orientational preferences of squalene at the air/oil interface and their implications for reactions with ozone. We find that squalene chains have a tendency to align with the surface normal, resulting in different concentrations of the various types of its double bonds and thus different reactivities. Read More

Int J Rheum Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey.

Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis. Secukinumab is a monoclonal antibody against interleukin (IL)-17A. Metformin, a widely used antidiabetic medication, has anti-proliferative, immunomodulating and anti-fibrotic activities. Read More

J Cosmet Dermatol 2021 Apr 9. Epub 2021 Apr 9.

Stempeutics Research Pvt Ltd, Shirdi Sai Baba Cancer Hospital, Manipal, Karnataka, 576104, India.

Background: Under-eye dark circles is a common condition observed in dermatology practice. Mesenchymal stromal cell derived conditioned medium (MSC-CM) contains an array of growth factors and cytokines reported to promote periorbital rejuvenation and may be useful in removing the dark circle around the eyes.

Methods: We tested the safety profile of MSC-CM along with antioxidants, in vitro using human melanocytes cultures. Read More

Transpl Infect Dis 2021 Apr 9:e13613. Epub 2021 Apr 9.

Dermatology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Dermatophytes are common keratinophilic fungi responsible for superficial skin infections. Deep dermatophytosis is a rare form of invasive skin infection described in immunocompromised patients. We report the case of a 65-year-old man with a history of an orthotopic liver transplant for hepatocarcinoma 6 months earlier, who presented with small painless erythematous papules in lower limbs, some of which were umbilicated. Read More

Oral Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Oral Surgery, Nihon University, School of Dentistry at Matsudo, japan.

Objective: The objective of this study was to evaluate the frequency of upper aerodigestive tract involvement in patients with mucous membrane pemphigoid associated with desquamative gingivitis.

Subjects And Methods: Data from 25 patients were collected by retrospective chart review. Their upper aerodigestive had been evaluated using a conventional flexible fiberscope. Read More

Wound Repair Regen 2021 Apr 9. Epub 2021 Apr 9.

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center, Hannover Medical School, Hannover, Germany.

Pyoderma gangrenosum is a diagnosis of exclusion. It occurs rarely and is frequently misdiagnosed. It can result in severe tissue loss, particularly in surgical units with little experience. Read More

Vet Rec 2021 Apr;188(7):276

Reviewed by Eilidh Hunter, a clinical teaching assistant at Langford Vets. Read More

Br J Dermatol 2021 Apr;184(4):e126-e147

Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing skin cancer that is primarily treated with surgery. Because this cancer can spread deep into the skin and surrounding tissue in an irregular way, it is notoriously difficult to ensure that it has been completely removed after conventional surgery and histological examination. Standard treatment in the UK is either wide local excision (WLE) or Mohs micrographic surgery (MMS). Read More

Int J Dermatol 2021 Apr 9. Epub 2021 Apr 9.

Instituto de Biología, Universidad de Antioquia, Medellin, Colombia.

Cutaneous T-cell lymphomas (CTCL) result from the infiltration and proliferation of a population of T cells in the skin, inducing changes in the activity of both T cells and surrounding skin cells. In the CTCL microenvironment, cell interactions mediated by cell signaling pathways are altered. Defining changes in cell signaling enables to understand T-cell deregulations in the CTCL microenvironment and thus the progression of the disease. Read More

Tokai J Exp Clin Med 2021 Apr 20;46(1):33-43. Epub 2021 Apr 20.

Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-Ku, Tokyo 113-0033, Japan.

Objective: Scar formation is an inevitable outcome after craniofacial surgery in the congenital facial anomaly. Scarless healing is the ultimate treatment after the surgery. Therefore, we elucidate the mechanism underlying scarless healing during fetal development. Read More

Pharm Res 2021 Apr 9. Epub 2021 Apr 9.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam, 52828, Republic of Korea.

Purpose: To develop a hydrogel film containing bovine serum albumin (BSA)-coated silver nanoparticles (BSA/AgNP) and evaluate its applicability for topical photothermal treatment (PTT) of skin cancer.

Methods: BSA/AgNP-loaded hydrogel films were prepared and their swelling, bioadhesive, mechanical, and photothermal properties were characterized in vitro and in vivo.

Results: The synthesized BSA/AgNP exhibited a narrow size distribution with good size stability and, notably, possessed great photothermal activity that could stably maintain through repetitive laser irradiation. Read More

AAPS PharmSciTech 2021 Apr 9;22(3):130. Epub 2021 Apr 9.

Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Dist. Ajmer, Bandarsindri, Rajasthan, 305 817, India.

Skin cancer is an alarming concern due to increased radiation and chemical exposure. Doxorubicin is a drug prescribed for various cancers by parenteral route. Apart from the pharmaceutical challenge of being a biopharmaceutical classification system (BCS) Class III drug, the side effects of doxorubicin are also a great concern. Read More

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, Meander Medical Center, Maatweg 3, 3813 TZ, Amersfoort, The Netherlands.

Background: The current standard treatment for external rectal prolapse and symptomatic high-grade internal rectal prolapse is surgical correction with minimally invasive ventral mesh rectopexy using either laparoscopy or robotic assistance. This study examines the number of procedures needed to complete the learning curve for robot-assisted ventral mesh rectopexy (RVMR) and reach adequate performance.

Methods: A retrospective analysis of all primary RVMR from 2011 to 2019 performed in a tertiary pelvic floor clinic by two colorectal surgeons (A and B) was performed. Read More

Cancer Chemother Pharmacol 2021 Apr 9. Epub 2021 Apr 9.

Pfizer Inc, San Diego, CA, USA.

Purpose: This phase 1, open-label, single-arm clinical trial evaluated pharmacokinetics, safety, and biomarker activity of palbociclib-letrozole as first-line treatment for estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer (ABC) in postmenopausal Chinese women to support palbociclib approval in China.

Methods: Patients received palbociclib 125 mg once daily (3/1 schedule) plus letrozole 2.5 mg once daily. Read More

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From private practice.

Background: Cone-beam computed tomography has recently rapidly developed worldwide as a versatile and convenient alternative to traditional computed tomography for imaging of the maxillofacial region. However, most surgeons performing rhinoplasty are surprisingly unfamiliar with it, in both the plastic surgery and ear, nose, and throat communities.

Methods: The broad clinical experience of a single center over the past 5 years is reviewed. Read More

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine.

Background: Mastectomy flap necrosis affects 7 to 40 percent of patients undergoing immediate breast reconstruction, with many cases resulting in infection and/or explantation. The Intra.Ox near-infrared spectrometer is one of several novel devices that assesses tissue perfusion by measuring the interactions of light with oxygenated and deoxygenated hemoglobin. Read More

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From McGill University and the Division of Surgical Oncology, Jewish General Hospital.

Background: Prepectoral breast reconstruction is being increasingly popularized, largely because of technical advances. Patients with ptotic breasts and active cancer require mastectomies through a mastopexy excision pattern to achieve proper pocket control in a prepectoral single-stage operation. This article presents a single-surgeon experience with direct-to-implant, prepectoral reconstruction following skin-reducing mastectomies. Read More

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Plastic, Reconstructive, and Aesthetic Surgery, Hospital Sud, INSERM U1236, and the Department of Hepatobiliary and Digestive Surgery, University of Rennes 1; SITI Laboratory, Etablissement Français du Sang Bretagne, Rennes University Hospital; and the Department of Plastic, Reconstructive, and Aesthetic Surgery, Cliniques Universitaires Saint-Luc.

Summary: Postoperative tracheoesophageal or bronchoesophageal fistulas represent a major surgical challenge. The authors report the description of an original perforator-based intercostal artery muscle flap, aiming to cover all types of intrathoracic fistulas, from any location, in difficult cases such as postoperative fistulas after esophagectomy in an irradiated field. Between June of 2016 and January of 2019, eight male patients were treated with a perforator-based intercostal artery muscle flap. Read More

J Postgrad Med 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, Karnataka, India.

A 15-year-old boy presented with fever, skin, and oral lesions for 4 weeks. The cutaneous lesions were suggestive of subacute cutaneous lupus erythematosus and erythema multiforme. His clinical, histopathological, and immunological features were indicative of Rowell syndrome and he satisfied the diagnostic criteria of Rowell syndrome proposed by Zeitouni et al. Read More