22 results match your criteria skeo

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essential oil prevents doxorubicin-induced apoptosis extrinsic and intrinsic mitochondrial pathways.

Res Pharm Sci 2020 Oct 19;15(5):481-490. Epub 2020 Oct 19.

Department of Biochemistry, School of Veterinary Medicine, Lorestan University, Khorramabad, I.R. Iran.

Background And Purpose: In addition to hepato-cardiotoxicity, doxorubicin (DOX) also induces nephrotoxicity which is considered as the limiting factor for this drug in cancer therapy. The effect of carvacrol, the main active ingredient of essential oil (SKEO), in the amelioration of DOX- induced cardiotoxicity is well established. The aim of the present study was to evaluate the possible protective effects of SKEO against DOX-induced nephrotoxicity. Read More

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October 2020

Reduced Efflux Pumps Expression of with Essential Oil.

Iran J Med Sci 2020 Nov;45(6):463-468

Applied Microbiology Research Center, Department of Microbiology, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: Efflux pumps such as MexEF-OprN and mexXY-OprM play an important role in the resistance of () to antibiotics. The present study aimed to assess the reduced expression of efflux pump genes of with essential oil (SKEO).

Methods: The present cross-sectional study was conducted in 2016 at the Microbiology Laboratory of Baqiyatallah University of Medical Sciences, Tehran, Iran. Read More

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November 2020

Independent and combined effects of Satureja khuzistanica essential oils and dietary acetic acid on fatty acid profile in thigh meat in male broiler chicken.

Poult Sci 2020 Apr 5;99(4):2266-2274. Epub 2020 Feb 5.

Department of Animal Sciences, Agriculture Faculty, Lorestan University, Lorestan, Iran.

A 2 × 6 factorial experiment was conducted to evaluate the effect of Satureja khuzistanica essential oils (SkEO; 0, 200, 300, 400, 500, and 600 mg/bird/day) administered via oral gavage and dietary acetic acid (AA; 0 and 20 g/1 kg) on fatty acids (FA) composition in thigh meat of Ross 308 broiler chickens at days 34, 38, and 42 of age. Dietary AA reduced DWG, DFI, and European economic efficiency index, and increased FCR compared with the nonacidified diet. In day 34 of age, saturated FA (SFA) percentage reduced and polyunsaturated FA (PUFA), n-3, and n-6 percentages increased in the birds that received 400 mg SkEO. Read More

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Independent and combined effects of Satureja khuzistanica essential oils and acetic acid on prevalence and intensity of fatty liver syndrome in broiler chickens.

J Anim Physiol Anim Nutr (Berl) 2020 Jan 17;104(1):166-177. Epub 2019 Oct 17.

Department of Animal Sciences, Agriculture Faculty, Lorestan University, Lorestan, Iran.

Two hundred fifty two male Ross 308 broiler chicks were raised to examine the effects of Satureja khuzistanica essential oils (SkEO; 0, 200, 300, 400, 500 and 600 mg/bird/day) administrated via oral gavage and dietary supplementation of acetic acid (AA; 0 or 20 g/kg) in a 6 × 2 factorial fashion using a complete randomized block design with seven replicates of three birds each. In Day 34 of age, liver fat percentage decreased by increasing SkEO levels in a quadratic trend (p < .05). Read More

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January 2020

Effect of essential oil (SKEO) extract on expression of A and B genes in .

Iran J Microbiol 2019 Feb;11(1):55-59

Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute and Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background And Objectives: Expressions of A and B genes of are associated with bacterium pathogenicity. The present study was aimed to assess the effect of essential oil (SKEO) extract on expression of A and B genes in .

Materials And Methods: isolates were cultured in Mueller Hinton broth containing sub-inhibitory concentrations of SKEO and total RNA extracted using Trizol method. Read More

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February 2019

Busulfan-mediated oxidative stress and genotoxicity decrease in sperm of Satureja Khuzestanica essential oil-administered mice.

Syst Biol Reprod Med 2018 Oct 20;64(5):348-357. Epub 2018 Mar 20.

c Department of Biology, Faculty of Sciences , University of Guilan , Rasht , Iran.

Here, we studied the protective effects of Satureja Khuzestanica essential oil (SKEO) as a potent anti-oxidant, against damage caused by chemotherapy with busulfan in testis and epididymal sperm of adult mice. The NMRI adult mice were assigned: G1: control, G2: was treated with busulfan (4 days, 3.2 mg/kg), G3: was treated with busulfan (4 days, 3. Read More

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October 2018

Effect of Satureja essential oil against fertility disorders induced by busulfan in female mice.

Vet Res Forum 2017 15;8(4):281-286. Epub 2017 Dec 15.

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Busulfan is an alkylating agent affects ovarian follicles growth by oxidative stress induction. has antioxidant effects. The aim of this study was to examine whether essential oil (SKEO) exhibits protective effects on busulfan-induced ovarian failure. Read More

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December 2017

Effect of feed supplementation with Satureja khuzistanica essential oil on performance and physiological parameters of broilers fed on wheat- or maize-based diets.

Br Poult Sci 2017 Aug 6;58(4):425-434. Epub 2017 Jun 6.

b Department of Animal Science, Faculty of Agriculture , Lorestan University , Khorramabad , Lorestan , Iran.

1. The aim of this study was to evaluate various levels of Satureja khuzistanica essential oil (SKEO) on performance and physiological parameters of broilers fed on wheat- or maize-based diets. 2. Read More

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The anti-inflammatory properties of Satureja khuzistanica Jamzad essential oil attenuate the effects of traumatic brain injuries in rats.

Sci Rep 2016 08 18;6:31866. Epub 2016 Aug 18.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Traumatic brain injury (TBI) is a major health concern affecting the general public as well as military personnel. However, there is no FDA-approved therapy for the treatment of TBIs. In this work, we investigated the neurotherapeutic effects of the well-known natural Iranian medicine Satureja Khuzistanica Jamzad (SKJ) essential oil (SKEO) on the outcomes of diffused experimental TBI, with particular attention paid to its anti-inflammatory and anti-apoptotic effects. Read More

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Effects of essential oil of Satureja khuzestanica on the oxidative stress in experimental hyperthyroid male rat.

Vet Res Forum 2015 15;6(3):233-8. Epub 2015 Sep 15.

Reproductive Biology Department, School of Advanced Medical Sciences and Technologies, Shiraz, Iran; ; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

This work analyzes the effects of Satureja khuzestanica essential oil (SKEO) on the thyroid and antioxidant system, assessed by measuring levels of tri-iodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), reduced glutathione (GSH), and glutathione peroxidase (GPx) activity. Forty adult male Sprague Dawley rats (225 ± 25 g) were divided into five equal groups: one control and four hyperthyroid groups that received placebo, 200 mg kg(-1) body weight of vitamin (Vit.) E, 225 mg kg(-1) body weight of SKEO, 200 and 225 mg kg(-1) body weight of Vit. Read More

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February 2016

Cytoprotective and anti-apoptotic effects of Satureja khuzestanica essential oil against busulfan-mediated sperm damage and seminiferous tubules destruction in adult male mice.

Andrologia 2016 Feb 25;48(1):74-81. Epub 2015 May 25.

Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

We studied the protective effect of Satureja khuzestanica essential oil (SKEO) against damage caused by busulfan on testis in male mice. The NMRI mice (n = 40) were assigned to four groups including: G1: control, G2: treated with busulfan for 4 days (3.2 mg kg(-1)), G3: receive busulfan (4 days, 3. Read More

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February 2016

Effects of Satureja khuzistanica essential oils in drinking water on mortality, production performance, water intake, and organ weights in broiler chickens reared under heat stress condition.

Authors:
H Khosravinia

Int J Biometeorol 2015 Nov 20;59(11):1711-9. Epub 2015 Mar 20.

Department of Animal Science, Faculty of Agriculture, Lorestan University, P.B. 465, Khorramabad, 6813717133, Lorestan, Iran.

An experiment was conducted to examine the effects on mortality, production performance, water intake (WI), and organ weight of Satureja khuzistanica essential oil (SkEO) using 720 1-day-old Arian broiler chicks in a 42-day trial. Experimental treatments were addition of 0 (control(-)), 200, 300, 400, and 500 mg/L SkEO or 500 mg/L polysorbate 80 (control(+)) into drinking water. The birds were kept under natural ambient temperatures 4 to 6 °C above standard recommendation from days 22 to 42 of age. Read More

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November 2015

Hepatoprotective effect of satureja khuzestanica essential oil and vitamin e in experimental hyperthyroid rats: evidence for role of antioxidant effect.

Iran J Med Sci 2014 Sep;39(5):459-66

Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. The hepatoprotective effect of Satureja Khuzestanica Essential Oil (SKEO), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated.

Methods: Adult male sprague dawley rats were divided into categories of; control (group C), hyperthyroid (group H), hyperthyroid with olive oil (group H+O), hyperthyroid with vitamin E (group H+E), hyperthyroid with SKEO (group H+S), combination of hyperthyroid with vitamin E and SKEO (group H+S+E). Read More

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September 2014

Antioxidants and infertility treatment, the role of Satureja Khuzestanica: A mini-systematic review.

Iran J Reprod Med 2011 ;9(2):61-70

Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ; Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: The use of antioxidants in the treatment of infertility has been suggested and recent studies have indicated that oral administration of Satureja Khuzestanica essential oil (SKEO) to rats induces significant antioxidative effects.

Objective: This systematic review was conducted to evaluate the effectiveness of antioxidants in infertility and also to assess the effectiveness of Satureja Khuzestanica in infertility management.

Materials And Methods: Pubmed, Scopus, and Cochrane Library were searched for relevant trials published from respective database inception dates to August 2010. Read More

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January 2015

Satureja khozestanica essential oil ameliorates progression of diabetic nephropathy in uninephrectomized diabetic rats.

Tissue Cell 2011 Feb 24;43(1):45-51. Epub 2010 Dec 24.

Department of Anatomy, Lorestan University of Medical Sciences, Faculty of Medicine, Khoram Abad, Iran.

Diabetic nephropathy is the common cause of leading to end stage of renal disease (ESRD). Satureja khozestanica essential oil (SKEO) was used as an antioxidant and antidiabetic for the inhibition of diabetic nephropathy. Forty male rats were uninephrectomized and divided in four groups randomly; group one as control, group two diabetic untreatment, groups three and four treatment with SKEO by 250 or 500 ppm in drinking water, respectively. Read More

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February 2011

Plasma glucose lowering effect of the wild Satureja khuzestanica Jamzad essential oil in diabetic rats: role of decreased gluconeogenesis.

Pak J Biol Sci 2009 Jan;12(2):140-5

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran.

This study was to evaluate the effect of the wild SKEO on activities and genes expression of hepatic Glycogen Phosphorylase (GP) and phosphoenolpyruvate carboxykinase (PEPCK) in normal and diabetic rats. The wild SKEO was orally administered at different doses (50 and 100 mg/kg/day) to normal as well as diabetic rats for 21 days. The levels of mRNA were determined using the quantitative real-time RT-PCR technique. Read More

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January 2009

Benefit of Satureja khuzestanica in subchronically rat model of cyclophosphamide-induced hemorrhagic cystitis.

Exp Toxicol Pathol 2010 May 23;62(3):323-30. Epub 2009 Jun 23.

Laboratory of Histology, Department of Embryology and Histology, Faculty of Veterinary Medicine, Urmia University, Iran.

Cyclophosphamide (CP) as a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Regarding established antioxidant potential of Satureja khuzestanica (Lamiaceae) essential oil (SKEO), we aimed to investigate its protective effects in a subchronic rat model of CP-induced HC. CP (6mg/kg/day) and SKEO (225mg/kg/day) were administered alone or in combination by gavage for 28 days. Read More

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Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stress.

Hum Exp Toxicol 2008 Dec;27(12):901-10

Department of Embryology and Histology, Urmia University, Urmia, Iran.

Cyclophosphamide (CP) as an anticancer alkylating agent has been known as a male reproductive tract toxicant. The aim of this study was to examine whether Satureja khuzestanica essential oil (SKEO) as an established herbal antioxidant, might protect tract rat reproductive system from toxicity of CP. To reach this aim, total antioxidant power (TAP) and lipid peroxidation (LPO) in testis and plasma, blood levels of sex hormones, sperm characteristics, DNA integrity and chromatin quality, and fertility in male rats were tested. Read More

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December 2008

Effect of Satureja khuzestanica essential oil on male rat fertility.

Fitoterapia 2006 Dec 6;77(7-8):495-9. Epub 2006 Jul 6.

Laboratory of Toxicology, Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Iran.

This study was undertaken to study the effect of Satureja khuzestanica essential oil (SKEO) in male rat fertility. SKEO was administered orally at doses of 75, 150, and 225 mg/kg/day for 45 days through drinking water. Treated and control rats were mated with female on day 45 of treatment. Read More

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December 2006

Biochemical and histopathological evidences for beneficial effects of satureja khuzestanica jamzad essential oil on the mouse model of inflammatory bowel diseases.

Toxicol Mech Methods 2006 ;16(7):365-72

Laboratory of Toxicology, Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

The essential oil from Satureja Khuzestanica Jamzad (SKEO), an endemic plant from Iran, was evaluated for its activity against inflammatory bowel disease (IBD). SKEO was examined on the experimental mouse model of inflammatory bowel disease, which is acetic acid-induced colitis. Prednisolone was used as the standard drug for comparison. Read More

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October 2012

Alteration of rat hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities by Satureja khuzestanica Jamzad essential oil.

J Pharm Pharm Sci 2004 Sep 24;7(3):310-4. Epub 2004 Sep 24.

Laboratory of Toxicology, Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran.

Purpose: Regarding reported antidiabetic effect of Satureja khuzestanica essential oil (SKEO) and important role of liver on body glucose metabolism by glycogenolysis and gluconeogenesis, we were interested to examine effect of SKEO treatment on rat hepatic key enzymes of glycogenolysis and gluconeogenesis in vivo.

Methods: Effective antidiabetic dose of SKEO (1000 ppm) was administered to rats through drinking water for 2 weeks. After 18 hours fasting post treatment under general anesthesia, the liver was removed by transverse abdominal incision and perfused with cold 0. Read More

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September 2004

Antioxidant, antidiabetic, antihyperlipidemic,reproduction stimulatory properties and safety of essential oil of Satureja Khuzestanica in rat in vivo: a oxicopharmacological study.

Med Sci Monit 2003 Sep;9(9):BR331-5

Department of Toxicology, Pharmaceutical Sciences Research Center and Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Satureja Khuzestanica is an endemic plant of Iran that is widely distributed in the southern part of the country. It is famous for its medical uses as an analgesic and antiseptic in folk medicine. The present study was designed to explore the toxicological and pharmacological effects of essential oil of Satureja Khuzestanica (SKEO) in vivo. Read More

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September 2003
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