344,927 results match your criteria skeletal muscle

Generating an iPSC line (with isogenic control) from the PBMCs of an ACTA1 (p.Gly148Asp) nemaline myopathy patient.

Stem Cell Res 2021 Jun 17;54:102429. Epub 2021 Jun 17.

Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Pediatrics, The University of Melbourne, Victoria, Australia. Electronic address:

To produce an in vitro model of nemaline myopathy, we reprogrammed the peripheral blood mononuclear cells (PBMCs) of a patient with a heterozygous p.Gly148Asp mutation in exon 3 of the ACTA1 gene to iPSCs. Using CRISPR/Cas9 gene editing we corrected the mutation to generate an isogenic control line. Read More

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Association between dietary protein intake and skeletal muscle mass in older Korean adults.

Eur Geriatr Med 2021 Jun 22. Epub 2021 Jun 22.

Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93, Jungbu-daero, Paldal-gu, Suwon, Gyeonggi, 16247, Republic of Korea.

Purpose: We investigated the association of low and high daily protein intakes on skeletal muscle mass status in Korean adults aged 60 years and older.

Methods: This cross-sectional study used data from the Korean National Health and Nutrition Examination Survey conducted between 2008 and 2011. The participants' dietary protein intake was assessed using the 24-h dietary recall method and was classified as low (< 0. Read More

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FLT PET/CT and FDG PET/CT of Skeletal Muscle Sarcoidosis.

Radiology 2021 Jun 22:204714. Epub 2021 Jun 22.

From the Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan.

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Hyperpolarized C MR Spectroscopy Depicts in Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle.

Radiology 2021 Jun 22:204500. Epub 2021 Jun 22.

From the Advanced Imaging Research Center (J.M.P., C.E.H., J.M., J.C., J.R., J.L., G.D.R., A.C., C.R.M.), Department of Radiology (J.M.P., A.C., C.R.M.), Department of Neurology and Neurotherapeutics (R.G.H.), and Department of Internal Medicine (C.R.M.), University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8568; Department of Electrical and Computer Engineering, University of Texas at Dallas, Dallas, Tex (J.M.P.); Department of Diagnostic Imaging and Radiology, Developing Brain Institute, Children's National Hospital, Washington, DC (Z.Z.); Department of Pediatrics and Radiology, George Washington University, Washington, DC (Z.Z.); GE Healthcare, Dallas, Tex (G.D.R.); Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, Calif (T.J.); and Veterans Affairs North Texas Healthcare System, Dallas, Tex (C.R.M.).

Background Pyruvate dehydrogenase (PDH) and lactate dehydrogenase are essential for adenosine triphosphate production in skeletal muscle. At the onset of exercise, oxidation of glucose and glycogen is quickly enabled by dephosphorylation of PDH. However, direct measurement of PDH flux in exercising human muscle is daunting, and the net effect of covalent modification and other control mechanisms on PDH flux has not been assessed. Read More

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p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets.

JCI Insight 2021 Jun 22;6(12). Epub 2021 Jun 22.

Rare Disease Research Unit, Pfizer Inc., Cambridge, Massachusetts, USA.

p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression. Read More

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Wiad Lek 2021 ;74(4):1032-1036


At all ages, skeletal muscle weakness characterizes Pompe disease, causes mobility problems and affects the respiratory system. We aimed to provide a narrative review of terminology, etiology, epidemiology, clinical manifestations, complications, and prognosis of Pompe disease, supported with a clinical case presentation. The clinical manifestation and complications of Pompe disease are illustrated with the clinical case presentation of a late-onset form in a white child. Read More

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January 2021

High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats.

Sci Rep 2021 Jun 21;11(1):12924. Epub 2021 Jun 21.

Centre for Molecular Biology, Central University of Jammu, Jammu, UT of Jammu and Kashmir, 184311, India.

Metabolic disorders are becoming more common in young population due to increased consumption of carbohydrate rich diet, lack of physical activity and stress. Fructose is used as a sweetener in many carbonated beverages and is a known inducer of oxidative stress and hypertension. Up-regulation of the double-stranded RNA-dependent protein kinase (PKR) causes impairment in insulin signaling pathway and metabolic dysfunctions in type 2 diabetes mellitus. Read More

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Neuromuscular complications of coronavirus disease-19.

Curr Opin Neurol 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Since its outbreak in Wuhan, China in late 2019, coronavirus disease-19 (COVID-19) has become a global pandemic. The number of affected cases and deaths continues to rise. Primarily a respiratory illness, COVID-19 is now known to affect various organ systems including peripheral nerve and skeletal muscle. Read More

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The effect of a 24-week training focused on activities of daily living, muscle strengthening, and stability in idiopathic inflammatory myopathies: a monocentric controlled study with follow-up.

Arthritis Res Ther 2021 Jun 21;23(1):173. Epub 2021 Jun 21.

Institute of Rheumatology, Na Slupi 4, 128 00, Prague 2, Czech Republic.

Background: The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation and immune changes can be severely disabling. The objective of this study was to assess the effect of a 24-week program combining a supervised training of activities of daily living (ADL), resistance, and stability with home exercise for improving muscle function, compared to a daily home-based exercise representing the regular outpatient care.

Methods: Fifty-seven patients with IIM were consecutively and non-selectively enrolled in an intervention (IG, n = 30) or control (CG, n = 27) group. Read More

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Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study.

J Int Soc Sports Nutr 2021 Jun 21;18(1):50. Epub 2021 Jun 21.

Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), "Ministro Petrônio Portella" Campus, PI, 64049-550, Teresina, Brazil.

Background: Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflammatory response and performance in untrained men.

Methods: Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design. Read More

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[Sarcopenia and Cachexia-associated Risk in Surgery].

Zentralbl Chir 2021 Jun 21;146(3):277-282. Epub 2021 Jun 21.

Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik RWTH Aachen, Deutschland.

Cachexia is defined as a multifactorial syndrome characterised by involuntary progressive weight loss due to a decrease in skeletal muscle mass, with or without a reduction in adipose tissue. The breakdown of muscle tissue is known as sarcopenia. This is clinically defined as loss of muscle mass and/or muscle strength, with loss of muscle strength being more important than muscle mass. Read More

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Exploring overweight and obesity beyond body mass index: A body composition analysis in people with and without patellofemoral pain: Body composition in patellofemoral pain.

J Sport Health Sci 2021 Jun 18. Epub 2021 Jun 18.

La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC 3086, Australia.

Purpose: To compare body mass index (BMI), body fat, and skeletal muscle mass between (i) a mixed-sex non-athletic cohort of people with patellofemoral pain (PFP) and pain-free people, and (ii) a non-athletic cohort of people with PFP and pain-free people subgrouped by sex (i.e., men and women with PFP vs. Read More

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Recycled algae-based carbon materials as electroconductive 3D printed skeletal muscle tissue engineering scaffolds.

J Mater Sci Mater Med 2021 Jun 21;32(7):73. Epub 2021 Jun 21.

Department of Biomedical Engineering, Ankara University Faculty of Engineering, Ankara, Turkey.

Skeletal muscle is an electrically and mechanically active tissue that contains highly oriented, densely packed myofibrils. The tissue has self-regeneration capacity upon injury, which is limited in the cases of volumetric muscle loss. Several regenerative therapies have been developed in order to enhance this capacity, as well as to structurally and mechanically support the defect site during regeneration. Read More

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Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator.

J Gen Physiol 2021 Jul 21;153(7). Epub 2021 Jun 21.

Department of Physiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Muscle ankyrin repeat protein 1 (MARP1) is frequently up-regulated in stressed muscle, but its effect on skeletal muscle function is poorly understood. Here, we focused on its interaction with the titin-N2A element, found in titin's molecular spring region. We show that MARP1 binds to F-actin, and that this interaction is stronger when MARP1 forms a complex with titin-N2A. Read More

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Simple manipulative of gross organization of skeletal muscle: enhancing learning among students offline and online.

Adv Physiol Educ 2021 Sep;45(3):461-463

Department of Physiology, All India Institute of Medical Sciences Raipur, Chhattisgarh, India.

Understanding the gross organization of skeletal muscle is critical to understanding the mechanism of action of muscle physiology. Due to coronavirus disease-19 (COVID-19), many colleges have had to discontinue or curtail teaching and laboratory activities. Whether students are in the classroom or learning online, it is important for them to understand the basics of skeletal muscle organization that allows for movement. Read More

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September 2021

Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity.

Am J Physiol Endocrinol Metab 2021 06 21. Epub 2021 Jun 21.

Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.

OBJECTIVE To determine whether interrupting prolonged sitting improves glycemic control and the metabolic profile of free-living adults with obesity. METHODS Sixteen sedentary individuals (10 women/6 men; median [IQR] age 50 [44-53] years, BMI 32 [32-35.8] kg/m) were fitted with continuous glucose and activity monitors for 4 weeks. Read More

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Sarcopenia in geriatric psychiatry: feasibility of the diagnostic process and estimation of prevalence within a hospital context.

J Cachexia Sarcopenia Muscle 2021 Jun 21. Epub 2021 Jun 21.

Institute of Movement and Sport Gerontology, German Sport University Cologne, Cologne, Germany.

Background: Sarcopenia is an age-related progressive and general skeletal muscle disease associated with negative consequences such as falls, disability, and mortality. An early-stage diagnosis is important to enable adequate treatment, especially in geriatric psychiatry. However, there presently is little information about the feasibility of diagnostic procedures and the prevalence of sarcopenia in clinical geriatric psychiatry settings. Read More

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Proteomic profiling of low muscle and high fat mass: a machine learning approach in the KORA S4/FF4 study.

J Cachexia Sarcopenia Muscle 2021 Jun 20. Epub 2021 Jun 20.

Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Background: The coexistence of low muscle mass and high fat mass, two interrelated conditions strongly associated with declining health status, has been characterized by only a few protein biomarkers. High-throughput proteomics enable concurrent measurement of numerous proteins, facilitating the discovery of potentially new biomarkers.

Methods: Data derived from the prospective population-based Cooperative Health Research in the Region of Augsburg S4/FF4 cohort study (median follow-up time: 13. Read More

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Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7.

EMBO Mol Med 2021 Jun 21:e13695. Epub 2021 Jun 21.

Randall Centre for Cell and Molecular Biophysics, King's College London, London, UK.

Facioscapulohumeral muscular dystrophy (FSHD) is characterised by progressive skeletal muscle weakness and wasting. FSHD is linked to epigenetic derepression of the subtelomeric D4Z4 macrosatellite at chromosome 4q35. Epigenetic derepression permits the distal-most D4Z4 unit to transcribe DUX4, with transcripts stabilised by splicing to a poly(A) signal on permissive 4qA haplotypes. Read More

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Regulation of Skeletal Muscle Satellite Cell Differentiation by Omega-3 Polyunsaturated Fatty Acids: A Critical Review.

Front Physiol 2021 3;12:682091. Epub 2021 Jun 3.

Division of Human Nutrition, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada.

Skeletal muscle is composed of multinuclear cells called myofibres, which are formed by the fusion of myoblasts during development. The size of the muscle fiber and mass of skeletal muscle are altered in response to several pathological and physiological conditions. Skeletal muscle regeneration is primarily mediated by muscle stem cells called satellite cells (SCs). Read More

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Myofibre Hypertrophy in the Absence of Changes to Satellite Cell Content Following Concurrent Exercise Training in Young Healthy Men.

Front Physiol 2021 4;12:625044. Epub 2021 Jun 4.

Exercise and Nutrition Research Programme, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.

Concurrent exercise training has been suggested to create an 'interference effect,' attenuating resistance training-based skeletal muscle adaptations, including myofibre hypertrophy. Satellite cells support myofibre hypertrophy and are influenced by exercise mode. To determine whether satellite cells contribute to the 'interference effect' changes in satellite cell and myonuclear content were assessed following a period of training in 32 recreationally active males (age: 25 ± 5 year; body mass index: 24 ± 3 kg⋅m; mean ± SD) who undertook 12-week of either isolated (3 d⋅w) resistance (RES; = 10), endurance (END; = 10), or alternate day (6 d⋅w) concurrent (CET, = 12) training. Read More

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Retrospective study of phaeohyphomycosis in aquarium-housed fish, with first descriptions of Exophiala lecanii-corni and Neodevriesia cladophorae in fish.

J Fish Dis 2021 Jun 20. Epub 2021 Jun 20.

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

A broadening fish host range is affected by novel and known pigmented fungal pathogens. A review of 2,250 piscine submissions received by the Aquatic Pathology Service, University of Georgia, revealed 47 phaeohyphomycosis cases (2.1%), representing 34 bony and cartilaginous fish species. Read More

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Myosteatosis predicting risk of transition to severe COVID-19 infection.

Clin Nutr 2021 Jun 7. Epub 2021 Jun 7.

Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, USA.

Background: About 10-20% of patients with Coronavirus disease 2019 (COVID-19) infection progressed to severe illness within a week or so after initially diagnosed as mild infection. Identification of this subgroup of patients was crucial for early aggressive intervention to improve survival. The purpose of this study was to evaluate whether computer tomography (CT) - derived measurements of body composition such as myosteatosis indicating fat deposition inside the muscles could be used to predict the risk of transition to severe illness in patients with initial diagnosis of mild COVID-19 infection. Read More

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Old and new biomarkers for volumetric muscle loss.

Curr Opin Pharmacol 2021 Jun 16;59:61-69. Epub 2021 Jun 16.

Bone-Muscle Collaborative Sciences, College of Nursing & Health Innovation, The University of Texas at Arlington, Arlington, TX 76010, USA. Electronic address:

Volumetric muscle loss (VML) impacts skeletal muscles and causes damage to associated tissues such as blood vessels and other structural tissues. Despite progress in the VML field, current preclinical approaches are often ineffective at restoring muscle volume. Additional research is paramount to develop strategies that improve muscle mass and function, while restoring supporting tissues. Read More

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Machine learning model for predicting excessive muscle loss during neoadjuvant chemoradiotherapy in oesophageal cancer.

J Cachexia Sarcopenia Muscle 2021 Jun 17. Epub 2021 Jun 17.

Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.

Background: Excessive skeletal muscle loss during neoadjuvant concurrent chemoradiotherapy (NACRT) is significantly related to survival outcomes of oesophageal cancer. However, the conventional method for measuring skeletal muscle mass requires computed tomography (CT) images, and the calculation process is labour-intensive. In this study, we built machine-learning models to predict excessive skeletal muscle loss, using only body mass index data and blood laboratory test results. Read More

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The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.

Sci Rep 2021 Jun 18;11(1):12904. Epub 2021 Jun 18.

Institute for Biological and Chemical Systems-Biological Information Processing (IBCS-BIP), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.

The process of myogenesis which operates during skeletal muscle regeneration involves the activation of muscle stem cells, the so-called satellite cells. These then give rise to proliferating progenitors, the myoblasts which subsequently exit the cell cycle and differentiate into committed precursors, the myocytes. Ultimately, the fusion of myocytes leads to myofiber formation. Read More

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J Pharmacol Exp Ther 2021 Jun 18. Epub 2021 Jun 18.

Department of Pharmacology, University of California San Diego, United States

Inhibition of acetylcholinesterase (AChE) by certain organophosphates (OP) can be life-threatening and requires reactivating antidote accessibility to the peripheral and central nervous systems to reverse symptoms and enhance survival parameters. In considering dosing requirements for oxime antidotes in OP exposures that inactivate AChE, clearance of proton ionizable, zwitterionic antidotes is rapid and proceeds with largely the parent antidotal compound being cleared by renal transporters. Such transporters may also control disposition between target tissues and plasma as well as overall elimination from the body. Read More

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Age-related changes in muscle quality and development of diagnostic cutoff points for myosteatosis in lumbar skeletal muscles measured by CT scan.

Clin Nutr 2021 Apr 17;40(6):4022-4028. Epub 2021 Apr 17.

Health Screening and Promotion Center, Asan Medical Center, Seoul, Republic of Korea.

Background & Aims: We have sought to develop proper and useful indices for muscle quality measurements other than muscle attenuation (Hounsfield unit; HU) and to determine the diagnostic cutoff points for myosteatosis by using those indices measured at the L3 lumbar vertebrae level by CT scan.

Methods: This cross-sectional analysis included 20,664 healthy adult subjects (12,697 men and 7967 women) who underwent abdominal CT scans. Total abdominal muscle area (TAMA), on the L3 vertebra was demarcated using predetermined thresholds. Read More

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Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease.

FEBS J 2021 Jun 18. Epub 2021 Jun 18.

Department of Biology, University of Rome "Tor Vergata", 00133, Rome, Italy.

The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has contributed to modify the monocentric view of muscle regeneration beyond muscle satellite cells (MuSCs). Now, we are aware that each population of the muscle niche plays a critical role in modulating homeostasis and regeneration. In the healthy muscle, FAPs contribute to maintain tissue homeostasis and assist MuSCs to cope with limited insults. Read More

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Insulin-like growth factor-1 positively associated with bone formation markers and creatine kinase in adults with general physical activity.

J Clin Lab Anal 2021 Jun 18:e23799. Epub 2021 Jun 18.

Department of Public Health and Environmental Medicine, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: The Insulin-like growth factor-1 (IGF-1) is primarily synthesized by hepatocytes in a growth hormone (GH)-dependent manner, it is also produced by bone and muscle. The effects of exercise on the associations between IGF-1 levels and bone turnover markers (BTM) were found in the previous studies. However, the associations between the levels of IGF-1 and BTM, liver function tests, and skeletal muscle markers in adults with general physical activity were not clear. Read More

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