1,856 results match your criteria skeletal hyperostosis


Posterior spinal fixation using penetrating endplate screws in patients with diffuse idiopathic skeletal hyperostosis-related thoracolumbar fractures.

J Neurosurg Spine 2021 Apr 9:1-6. Epub 2021 Apr 9.

1Orthopedic Surgery, Sanmu Medical Center, Chiba, Japan; and.

Objective: Diffuse idiopathic skeletal hyperostosis (DISH)-related vertebral fractures essentially require operative treatment due to severe fracture site instability and high potential risk of posttraumatic neurological deficit. However, the optimal surgical procedure remains unclear. The purpose of this study was to assess the efficacy of posterior spinal fixation with penetrating endplate screws (PESs) for DISH-related thoracolumbar fractures. Read More

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[Frontometaphyseal dysplasia 1 caused by variant of FLNA gene in a case].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Apr;38(4):355-358

Shanghai Chindren's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Objective: To explore the clinical and genetic characteristics of a child with frontometaphyseal dysplasia 1 (FMD1) due to variant of FLNA gene.

Methods: Clinical phenotype of the patient was analyzed. Whole exome sequencing (WES) was carried out to detect pathogenic genetic variants. Read More

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Usefulness of dynamic stabilisation with mobile percutaneous pedicle screw for thoracic vertebral fractures in diffuse idiopathic skeletal hyperostosis.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Chiba University, Chiba, Japan.

We report a case of vertebral fracture with diffuse idiopathic skeletal hyperostosis (DISH) who underwent posterior dynamic stabilisation using mobile percutaneous pedicle screws (PPS) with 1 above-1 below and obtained good bone fusion. A 76-year-old man experienced severe low back pain after he fell backward 1 m off a stepladder during work. A 12th thoracic vertebral fracture with DISH was observed. Read More

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Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH).

Bone Res 2020 Apr 2;8(1):16. Epub 2020 Apr 2.

Bone and Joint Institute, The University of Western Ontario, London, ON, N6G 2V4, Canada.

Diffuse idiopathic skeletal hyperostosis (DISH) is a prevalent noninflammatory spondyloarthropathy characterized by ectopic mineral formation along the anterolateral aspect of the vertebral column, yet little is known about its underlying pathogenesis. Our objective was to evaluate the histopathological features and composition of ectopic mineral within spinal tissues affected by DISH in humans. Thoracic spine segments from six embalmed cadaveric donors (one female and five males; median age 82 years) meeting the radiographic diagnostic criteria for DISH were evaluated using radiological, histological, and physical analyses. Read More

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Using a multimethod life history approach to navigate the osteological paradox: A case study from Prehispanic Nasca, Peru.

Am J Phys Anthropol 2021 Mar 30. Epub 2021 Mar 30.

Department of Anthropology, University of California, Santa Barbara, California, USA.

Objectives: We leverage recent bioarchaeological approaches and life history theory to address the implications of the osteological paradox in a study population. The goal of this article is to evaluate morbidity and mortality patterns as well as variability in the risk of disease and death during the Late Intermediate period (LIP; 950-1450 C.E. Read More

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Idiopathic dorsal spinal cord herniation perforating the lamina: a case report and review of the literature.

Acta Neurochir (Wien) 2021 Mar 21. Epub 2021 Mar 21.

Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 852 Hatakeda, Narita City, Chiba, 286-0124, Japan.

Spinal cord herniation (SCH) is a rare condition associated with tethering of the spinal cord at the ventral dural defect. Idiopathic dorsal spinal cord herniation (IDSCH) is an extremely rare clinical entity. Here, we report the first case of IDSCH perforating the lamina in a patient with a history of ossification of the ligamentum flavum and diffuse idiopathic skeletal hyperostosis. Read More

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An Unrecognized Ligament and its Ossification in the Craniocervical Junction: Prevalence, Patient Characteristics, and Anatomic Evidence.

Clin Orthop Relat Res 2021 Mar 15. Epub 2021 Mar 15.

B. Wu, W. Cui, T. Rong, D. Sang, B. Xiao, D. Wang, J. Zhang, B. Liu, Department of Orthopaedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: In the craniocervical junction, the ligaments between the anterior foramen magnum and the anterior arch of the atlas are not well defined, and ossification of the ligaments in this region has rarely been reported. Characterizing the anatomy and ossification of these ligaments may help in the diagnosis and treatment of disorders in this region.

Questions/purposes: (1) What is the prevalence of an unrecognized ossification at the craniocervical junction in patients with cervical spine disorders, and what are the patient characteristics associated with this ossification? (2) Do patients with this ossification have a greater risk of ossification of other structures at the craniocervical junction or cervical spine? (3) Is there an unreported ligament at this ossified site?

Methods: We conducted a retrospective study of 578 hospitalized patients who underwent CT for cervical spine disorders between January 2016 and July 2020. Read More

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Cervical Myelopathy and Lumbar Spondylolisthesis in Elderly Patients with Diffuse Idiopathic Skeletal Hyperostosis (DISH) - A Case Series.

J Orthop Case Rep 2020 Nov;10(8):48-52

Department of Orthopaedics, Grant Government Medical College and sir JJ group of hospitals, Mumbai, Maharashtra, India.

Introduction: Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory disease, which causes the ossification of spinal longitudinal ligaments and enthesis leads to stiffness in the affected segment of the spine and neurological deficit due to compression of spinal cord or nerve roots by osteophytes.

Case Presentation: We present three cases of DISH, presented with cervical myelopathy, lumbar spondylolisthesis, and dysphagia. All three patients had neurodeficit and radiological examination showed cord compression, canal stenosis, listhesis, and contiguous ossification in the spine with normal sacroiliac joints. Read More

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November 2020

Atypical Occipitocervical Dissociation Associated with Ossification of the Posterior Longitudinal Ligament and Diffuse Idiopathic Skeletal Hyperostosis in Low-Energy Trauma.

J Orthop Case Rep 2020 Nov;10(8):11-14

Department of Orthopedics, King Fahad General Hospital, Almadinah Almunawwarah, Saudi Arabia.

Introduction: Traumatic posterior occipitocervical dissociation (OCD) is a rare injury, and only a few cases have been reported in the literature. The diagnosis can be delayed or even missed because of its uncommon presentation. We present this rare case report and its management to highlight this unusual injury to increase the awareness of the existence of this pathology and prevent delayed diagnosis and treatment. Read More

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November 2020

Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndrome: the AGES-Reykjavik Study.

Scand J Rheumatol 2021 Mar 7:1-5. Epub 2021 Mar 7.

Faculty of Medicine, University of Iceland, Reykjavík, Iceland.

: To describe the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in a large population-based study of elderly Icelanders, with particular reference to weight-related factors and the metabolic syndrome.: The study population comprised 5321 participants aged 68-96 years (2276 males, mean ± sd age 76 ± 5 , and 3045 females, age 77 ± 6) from the AGES-Reykjavik Study. DISH diagnosis was based on computed tomography (CT) scans, and interpreted strictly by the Resnick criteria and additional suggestions for CT interpretation by Oudkerk et al. Read More

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Sternocostoclavicular Hyperostosis: Positive Clinical and Radiological Response on Pamidronate.

Front Endocrinol (Lausanne) 2021 18;12:621604. Epub 2021 Feb 18.

Center for Bone Quality, Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands.

Background: Sternocostoclavicular hyperostosis (SCCH) is a rare disease, constituting a chronic sterile osteomyelitis with elevated bone turnover in the axial skeleton, causing pain and shoulder dysfunction. SCCH severely interferes with daily activities, work, and quality of life. SCCH has a relapse-remitting disease course, but inflammatory-induced sclerotic transformation in the affected area is slowly progressive. Read More

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February 2021

A Scoring System for Anterior Longitudinal Ligament Ossification of the Lumbar Spine in Diffuse Idiopathic Skeletal Hyperostosis: Relationship Between the Extent of Ligament Ossification and the Range of Motion.

Global Spine J 2021 Mar 3:2192568221996681. Epub 2021 Mar 3.

Department of Orthopedic Surgery, Ehime University School of Medicine, Shitsukawa, Tohon City, Ehime, Japan.

Study Design: Retrospective observational study.

Objective: To investigate the relationship between the extent of ligament ossification and the range of motion (ROM) of the lumbar spine and develop a new scoring system.

Methods: Forty-three patients (30 men and 13 women) with lumbar spinal canal stenosis who underwent decompression from January to December 2018. Read More

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Sagittal Deformity Correction in a Patient Suffering From Diffuse Idiopathic Skeletal Hyperostosis Who Previously Underwent a Total Hip and Bilateral Knee Replacement.

Geriatr Orthop Surg Rehabil 2021 11;12:2151459321992745. Epub 2021 Feb 11.

Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

Introduction: Physiological aging frequently leads to degenerative changes and spinal deformity. In patients with hypolordotic fusions or ankylosing illnesses such as diffuse idiopathic skeletal hyperostosis or ankylosing spondylitis, compensation mechanisms can be altered causing severe pain and disability. In addition, if a total hip replacement and/or knee replacement is performed, both pelvic and lower limbs compensation mechanisms could be damaged and prosthetic dislocation or impingement syndrome could be present. Read More

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February 2021

Thoracic spondylotic myelopathy presumably caused by diffuse idiopathic skeletal hyperostosis in a patient who underwent decompression and percutaneous pedicle screw fixation.

SAGE Open Med Case Rep 2021 21;9:2050313X20987796. Epub 2021 Jan 21.

Department of Orthopedic Surgery, Ehime University School of Medicine, Tohon, Japan.

A 74-year-old man developed bilateral lower limb spastic paresis. He was diagnosed with thoracic spondylotic myelopathy presumably caused by mechanical stress that was generated in the intervertebral space (T1-T2) between a vertebral bone bridge (C5-T1) due to diffuse idiopathic skeletal hyperostosis after anterior fixation of the lower cervical spine and a vertebral bone bridge (T2-T7) due to diffuse idiopathic skeletal hyperostosis in the upper thoracic spine. Treatment included posterior decompression (T1-T2 laminectomy) and percutaneous pedicle screw fixation at the C7-T4 level. Read More

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January 2021

Surgical Treatment of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Cervical Spine: Technical Nuances and Outcome of a Multicenter Experience.

Global Spine J 2021 Feb 16:2192568220988272. Epub 2021 Feb 16.

Department of Neurosurgery, S. Anna University Hospital, Ferrara, Italy.

Study Design: Retrospective multicenter.

Objectives: diffuse idiopathic skeletal hyperostosis (DISH) involving the cervical spine is a rare condition determining disabling aero-digestive symptoms. We analyzed impact of preoperative settings and intraoperative techniques on outcome of patients undergoing surgery for DISH. Read More

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February 2021

Ossification of Posterior Longitudinal Ligament in Cervical Spine and Its Association With Ossified Lesions in the Whole Spine: A Cross-Sectional Study of 2500 CT Scans.

Global Spine J 2021 Feb 11:2192568221993440. Epub 2021 Feb 11.

Orthopaedic and Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.

Study Design: A retrospective study.

Objective: To identify the prevalence and characteristics of ossified posterior longitudinal ligament (OPLL) in the cervical spine and its association with other spinal ligament ossifications.

Method: This study is a retrospective review of whole spine CT scans of polytrauma patients from 2009 to 2018. Read More

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February 2021

A rare case of an unexpected difficult airway management in a diffuse idiopathic skeletal hyperostosis patient and post-operative airway evaluation with 3D printing technique.

Ann Transl Med 2021 Jan;9(1):75

Department of Anesthesiology, Peking University Third Hospital, Beijing, China.

Diffuse idiopathic skeletal hyperostosis (DISH), asymptomatic in most cases, is a degenerative condition that commonly leads to anterior cervical osteophytes in most elderly patients. Clinically significant airway compression is rare. However, in some cases, the seemingly insignificant osteophytes could become a threat to airway management during intubation. Read More

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January 2021

Two Cases of Severe Type 2 Respiratory Failure Associated with Diffuse Idiopathic Skeletal Hyperostosis.

Ann Geriatr Med Res 2021 Mar 8;25(1):55-59. Epub 2021 Feb 8.

Department of Neurology, Tokyo Teishin Hospital, Tokyo, Japan.

Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory process characterized by hyperostosis at tendon insertions and around joint capsules and ossification of the anterior longitudinal ligament of the spine. The flexibility of the spinal column is reduced in DISH and affects the movement of the thorax, leading to restrictive ventilatory function. In this report, we describe the first two cases of severe type 2 (hypercapnic) respiratory failure associated with DISH. Read More

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Musculoskeletal manifestations among diabetic patients in Saudi Arabia.

J Family Med Prim Care 2020 Nov 30;9(11):5597-5600. Epub 2020 Nov 30.

Department of Family Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Context: Diabetes mellitus (DM) is one of the most common diseases worldwide. Patients with DM are prone to develop multiple musculoskeletal (MSK) manifestations, which may lead to disability and an impact on patients' quality of life. These manifestations include but not limited to, adhesive capsulitis, shoulder hand syndrome, diabetic hand syndrome, diffuse idiopathic skeletal hyperostosis, Dupuytren's contracture. Read More

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November 2020

Diffuse Idiopathic Skeletal Hyperostosis (DISH) and a Possible Inflammatory Component.

Curr Rheumatol Rep 2021 Jan 26;23(1). Epub 2021 Jan 26.

Case Western Reserve University, Cleveland, OH, USA.

Purpose Of Review: Diffuse Idiopathic Skeletal Hyperostosis (DISH) is considered a metabolic condition, characterized by new bone formation affecting mainly at entheseal sites. Enthesitis and enthesopathies occur not only in the axial skeleton but also at some peripheral sites, and they resemble to some extent the enthesitis that is a cardinal feature in spondyloarthritis (SpA), which is an inflammatory disease.

Recent Findings: We review the possible non-metabolic mechanism such as inflammation that may also be involved at some stage and help promote new bone formation in DISH. Read More

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January 2021

Dysostosis in mucopolysaccharidosis type 2: A case of longitudinal follow up and literature review.

Radiol Case Rep 2021 Mar 8;16(3):656-660. Epub 2021 Jan 8.

Department of Radiology, Asahikawa Medical University, Asahikawa, Japan.

Mucopolysaccharidosis type 2 is a congenital lysosomal disease characterized by iduronate-2-sulfatase deficiency, which leads to excessive accumulation of glycosaminoglycans in tissue. Dysostosis, which primarily involves decreased bone mineralization with morphological changes in the bone, is a major skeletal condition in mucopolysaccharidosis, but its pathophysiology is not well known. Here, we report a case of mucopolysaccharidosis type 2 diagnosed at the age of 2 years with longitudinal follow-up data for more than 15 years. Read More

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DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS IN CAPTIVE GORILLAS ( SPP.): APPEARANCES AND DIAGNOSIS.

J Zoo Wildl Med 2020 Nov;51(3):578-590

Life Sciences Department, Natural History Museum, London SW7 5BD, United Kingdom.

Diffuse idiopathic skeletal hyperostosis (DISH) is a disorder of unknown cause, in which new bone forms in soft tissues attached to the skeleton. Originally described in humans, in whom it is quite common, it is usually asymptomatic. New bone may completely bridge across joints, especially in the spine. Read More

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November 2020

Restriction of Dietary Phosphate Ameliorates Skeletal Abnormalities in a Mouse Model for Craniometaphyseal Dysplasia.

J Bone Miner Res 2020 10 12;35(10):2070-2081. Epub 2020 Jul 12.

Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.

Craniometaphyseal dysplasia (CMD), a rare genetic bone disorder, is characterized by lifelong progressive thickening of craniofacial bones and metaphyseal flaring of long bones. The autosomal dominant form of CMD is caused by mutations in the progressive ankylosis gene ANKH (mouse ortholog Ank), encoding a pyrophosphate (PPi) transporter. We previously reported reduced formation and function of osteoblasts and osteoclasts in a knockin (KI) mouse model for CMD (Ank) and in CMD patients. Read More

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October 2020

Dysphonia, Stridor, and Dysphagia Caused By Diffuse Idiopathic Skeletal Hyperostosis: Case Report and Review of Literature.

Adv Biomed Res 2020 30;9:47. Epub 2020 Sep 30.

Department of Orthopedics, Tehran University of Medical Sciences, Tehran, Iran.

Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier disease is a noninflammatory, systemic skeletal disease of unknown etiology. DISH is usually asymptomatic but may compress the posterior wall of the aero digestive tract and lead to dysphagia, globus, hoarseness, stridor, dyspnea, and neurological problems. Although dysphagia is not uncommon among the presenting symptoms of DISH but dysphonia and stridor are rarely reported. Read More

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September 2020

Pathomechanism and prevention of further surgery after posterior decompression for lumbar spinal canal stenosis in patients with diffuse idiopathic skeletal hyperostosis.

Spine J 2021 Jan 13. Epub 2021 Jan 13.

Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

Background Context: Diffuse idiopathic skeletal hyperostosis (DISH) is a risk factor for further surgery after posterior decompression without fusion for patients with lumbar spinal canal stenosis (LSS). However, a strategy to prevent revision surgery has not been described.

Purpose: The aim of this study was to review clinical and imaging findings in LSS patients with DISH extending to the lumbar segment and to propose countermeasures for prevention of revision surgery. Read More

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January 2021

Post-traumatic spinal hematoma in ankylosing spondylitis.

Emerg Radiol 2021 Jan 16. Epub 2021 Jan 16.

HUS Diagnostic Center, HUS Medical Imaging Center, Department of Radiology, Töölö Trauma Center, Helsinki University Hospital, Topeliuksenkatu 5, FIN-00029, Helsinki, Finland.

Purpose: The purpose of this study is to examine the incidence, location, and magnetic resonance imaging (MRI) features of spinal epidural hematoma (SEH) and spinal subdural hematoma (SSH) in post-traumatic ankylosing spondylitis (AS) patients.

Methods: A total of 2256 consecutive referrals for urgent and emergency MRI scans of the spine over a period of eight years and nine months were manually reviewed for any mentions indicating axial ankylosis and post-traumatic spinal hematoma. We found 164 patients with ankylosed spines complicated by spinal fracture, of whom 32 had AS. Read More

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January 2021

Jacques Forestier: Forgotten Contributions of a Rheumatologist to Spine Surgery.

World Neurosurg 2021 Apr 11;148:136-140. Epub 2021 Jan 11.

Department of Neurosurgery, Rutgers- Robert Wood Johnson Medical School and University Hospital, New Brunswick, New Jersey, USA. Electronic address:

Jacques Forestier (1890-1978) was a well-known rheumatologist and radiologist whose innovations have revolutionized spinal neurosurgery and rheumatology. He was well known as "Doctor Lipiodol" for his accidental discovery of spinal myelography, which he later extrapolated for use in many body cavities and their pathologies. He was the first to describe "senile ankylosing hyperostosis of the spine," which was later renamed "diffuse idiopathic skeletal hyperostosis. Read More

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Comparative analysis of clinical factors associated with pedicle screw pull-out during or immediately after surgery between intraoperative cone-beam computed tomography and postoperative computed tomography.

BMC Musculoskelet Disord 2021 Jan 9;22(1):55. Epub 2021 Jan 9.

Department of Orthopaedic Surgery, Saku Central Hospital Advanced Care Center, 3400-28 Nakagomi, 385-0051, Saku City, Nagano, Japan.

Background: No studies to date have elucidated the clinical factors associated with pedicle screw pull-out during or immediately after surgery. The aim of this study was to assess the frequency of pedicle screw pull-out by comparing intraoperative scans obtained using cone-beam computed tomography (CBCT) with postoperative scans obtained using computed tomography (CT). We also sought to determine the incidence of pedicle screw pull-out and identify relevant risk factors. Read More

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January 2021

Minimally Invasive versus Conventional Open Surgery for Fixation of Spinal Fracture in Ankylosed Spine.

Malays Orthop J 2020 Nov;14(3):22-31

Department of Orthopaedic Surgery, University of Malaya, Kuala Lumpur, Malaysia.

Introduction: This was a retrospective study aimed to investigate the perioperative outcomes of long construct minimally invasive spinal stabilisation (MISt) using percutaneous pedicle screws (PPS) versus conventional open spinal surgery in the treatment of spinal fracture in ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH).

Material And Methods: Twenty-one patients with AS and DISH who were surgically treated between 2009 and 2017 were recruited. Outcomes of interest included operative time, intra-operative blood loss, complications, duration of hospital stay and fracture union rate. Read More

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November 2020

Frontometaphyseal dysplasia 1 in a patient from Sri Lanka.

Am J Med Genet A 2021 04 29;185(4):1317-1320. Epub 2020 Dec 29.

Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

A Sri Lankan male child with supraorbital hyperostosis, broad nasal bridge, small mandible, severe kyphoscoliosis, distal joint contractures of the hands and long second and third toes is described. A hemizygous pathogenic variant in exon 22 of the filamin A (FLNA) gene [NM_001110556.1: c. Read More

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