49 results match your criteria sjw preparations

Clinical relevance of St. John's wort drug interactions revisited.

Br J Pharmacol 2020 03 17;177(6):1212-1226. Epub 2020 Jan 17.

Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine with anti-depressant effects, interacting with other drugs, altering their bioavailability and efficacy, were published about 20 years ago. In 2000, a pharmacokinetic interaction between SJW and cyclosporine caused acute rejection in two heart transplant patients. Read More

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Interaction of herbal products with prescribed medications: A systematic review and meta-analysis.

Pharmacol Res 2019 03 17;141:397-408. Epub 2019 Jan 17.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address:

Although several studies on pharmacokinetic and/or pharmacodynamic herb-drug interactions (HDI) have been conducted in healthy volunteers, there is large uncertainty on the validity of these studies. A qualitative review and a meta-analysis were performed to establish the clinical evidence of these interaction studies. Out of 4026 screened abstracts, 32 studies were included into the qualitative analysis. Read More

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Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1.

Mol Pharmacol 2019 03 20;95(3):313-323. Epub 2018 Dec 20.

Laboratories of origin: Biopharmacy (A.M.S., I.S., H.E.M.z.S.) and Pharmaceutical Biology (O.P., O.F.), Department Pharmaceutical Sciences, University of Basel, Basel, Switzerland

The herbal remedy St. John's wort (SJW) is used in the treatment of mild depressive symptoms and is known for its drug-drug interaction potential when enhanced expression of CYP3A4 modifies clearance of concomitantly applied substrate drugs. Hyperforin is one constituent of SJW that alters CYP3A4 expression by activation of the nuclear receptor pregnane X receptor (PXR). Read More

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Current Role of Herbal and Natural Preparations.

Handb Exp Pharmacol 2019 ;250:225-252

Department of Psychiatry, Emory University, Atlanta, GA, USA.

Depression remains difficult to manage, despite the many registered treatments available. For many depressed individuals, particularly those who have not responded to and/or had adverse effects from standard therapies, herbal and natural medications represent a potentially valuable alternative. This chapter will review several natural remedies used in the treatment of depression. Read More

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The safety of St John's wort (Hypericum perforatum) in pregnancy and lactation: A systematic review of rodent studies.

Phytother Res 2018 Aug 30;32(8):1488-1500. Epub 2018 Apr 30.

School of Health and Human Sciences, Southern Cross University, Lismore, NSW, 2480, Australia.

Herbal products are popular among women during the perinatal period. St John's wort (SJW), Hypericum perforatum, is a common remedy for mild depression, a problem prevalent in this population. Although the safety of herbal products must be investigated, ethical issues constrain intervention studies in humans. Read More

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Comprehensive phytochemical characterization of St. John's wort ( L.) oil macerates obtained by different extraction protocols via analytical tools applicable in routine control.

Pharmazie 2017 Mar;72(3):131-138

The aim of the present study was to investigate the impact of crucial process parameters, i.e. of light and temperature conditions, during the preparation of St. Read More

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Clinical risks of St John's Wort (Hypericum perforatum) co-administration.

Expert Opin Drug Metab Toxicol 2017 Oct 13;13(10):1047-1062. Epub 2017 Sep 13.

d Toxicology and Diseases Group, Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , Tehran , Iran.

Introduction: St. John's wort (SJW) is a common medicinal herb used for the treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW, plays an important role in the induction of cytochrome P450 enzymes (CYP) and P-glycoprotein transporter (P-gp), and therefore, affects the pharmacokinetics of various drugs. Read More

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October 2017

St John's wort for depression: scoping review about perceptions and use by general practitioners in clinical practice.

J Pharm Pharmacol 2019 Jan 27;71(1):117-128. Epub 2017 Jun 27.

Department of General Practice, The University of Melbourne, Carlton, Vic., Australia.

Background: Extracts of Hypericum perforatum, more commonly known as St John's wort (SJW), have good evidence for treating depression. The herb is easily accessible and widely used by consumers, although it has potential for interaction with other medicines. Consumers' use of SJW is often not discussed with their general practitioners (GPs). Read More

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January 2019

Elemental fingerprinting of Hypericum perforatum (St John's Wort) herb and preparations using ICP-OES and chemometrics.

J Pharm Biomed Anal 2016 Jun 4;125:15-21. Epub 2016 Mar 4.

University of Hertfordshire, Department of Pharmacy, School of Life and Medical Sciences, College Lane, Hatfield, Hertfordshire AL10 9AB, United Kingdom,. Electronic address:

St. John's wort (SJW) (Hypericum perforatum) is a herbal remedy commonly used to treat mild depression. The elemental profiles of 54 samples (i. Read More

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The mechanisms of action of St. John's wort: an update.

Wien Med Wochenschr 2015 Jun 17;165(11-12):229-35. Epub 2015 Jul 17.

Herbresearch Germany, Wartbergweg 15, 86874, Tussenhausen, Germany,

Pharmacological research confirms and supports the clinically observed antidepressant efficacy of St. John's wort (Hypericum perforatum L., SJW). Read More

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Cerebral ABC transporter-common mechanisms may modulate neurodegenerative diseases and depression in elderly subjects.

Arch Med Res 2014 Nov 11;45(8):738-43. Epub 2014 Nov 11.

Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.

In elderly subjects, depression and dementia often coincide but the actual reason is currently unknown. Does a causal link exist or is it just a reactive effect of the knowledge to suffer from dementia? The ABC transporter superfamily may represent a causal link between these mental disorders. Since the transporters ABCB1 and ABCC1 have been discovered as major β-amyloid-exporting molecules at the blood-brain barrier and ABCC1 was found to be directly activated by St. Read More

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November 2014

Drug interactions with phytotherapeutics in oncology.

Expert Opin Drug Metab Toxicol 2014 Mar 6;10(3):359-77. Epub 2014 Jan 6.

University Hospital of Heidelberg, Department Clinical Pharmacology and Pharmacoepidemiology , Im Neuenheimer Feld 410, 69120 Heidelberg , Germany +49 6221 56 8740 ; +49 6221 56 4642 ;

Introduction: Because 30 to 70% of tumour patients use complementary and alternative medicines; herb-drug combinations are particularly frequent in this population. Some of these combinations can critically alter exposure of anti-neoplastic and palliative treatment.

Areas Covered: This review summarises pharmacokinetic drug interactions caused by the herbal products most frequently used by tumour patients (garlic, ginkgo, ginseng, echinacea and St John's wort [SJW]). Read More

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Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.

Curr Alzheimer Res 2013 Dec;10(10):1057-69

University of Magdeburg, Department of Neurology, Neurodegeneration Research Laboratory (NRL), Leipziger Str. 44, Bldg 64, 39120 Magdeburg, Germany.

Soluble β-amyloid peptides (Aβ) and small Aβ oligomers represent the most toxic peptide moieties recognized in brains affected by Alzheimer's disease (AD). Here we provide the first evidence that specific St. John's wort (SJW) extracts both attenuate Aβ-induced histopathology and alleviate memory impairments in APP-transgenic mice. Read More

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December 2013

An overview of the evidences of herbals for smoking cessation.

Complement Ther Med 2013 Oct 19;21(5):557-64. Epub 2013 Aug 19.

Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand; Pharmaceutical Care Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand. Electronic address:

Background: Despite availability of several therapeutic options for smoking cessation, their usages are limited due to high cost and adverse effect profiles. Recently, more attention has been paid to investigating herbals for smoking cessation.

Objectives: To review relevant evidences on the efficacy and safety of herbals for smoking cessation. Read More

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October 2013

Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients.

Cancer Treat Rev 2013 Nov 8;39(7):773-83. Epub 2013 Feb 8.

Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, The Netherlands.

The use of complementary and alternative medicines (CAM) by cancer patients is increasing. Concomitant use of CAM and anticancer drugs could lead to serious safety issues in patients. CAM have the potential to cause pharmacokinetic interactions with anticancer drugs, leading to either increased or decreased plasma levels of anticancer drugs. Read More

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November 2013

Economic evaluation of St. John's wort (Hypericum perforatum) for the treatment of mild to moderate depression.

J Affect Disord 2013 Jun 3;148(2-3):228-34. Epub 2013 Jan 3.

School of Population Health, University of Queensland, Herston Road Herston, QLD 4006, Australia.

Background: The burden of rising health care expenditures has created a demand for information regarding the clinical and economic outcomes associated with Complementary and Alternative Medicines. Clinical controlled trials have found St. John's wort to be as effective as antidepressants in the treatment of mild to moderate depression. Read More

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Update on St. John's Wort.

Robert H Howland

J Psychosoc Nurs Ment Health Serv 2010 Nov 22;48(11):20-4. Epub 2010 Oct 22.

University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, 15213, USA.

Herbal preparations for depression are often preferred over pharmaceutical drugs because they are available without prescription and because they are commonly assumed to be safe. St. John's wort (SJW) is one of the best-known and best-selling herbal therapies for depression. Read More

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November 2010

Hypericum perforatum L. (St John's wort) extract Ze 117 inhibits dopamine re-uptake in rat striatal brain slices. An implication for use in smoking cessation treatment?

Phytother Res 2010 Feb;24(2):249-51

Department of Pharmacology, University of Bern, Bern, Switzerland.

Classic synthetic antidepressant drugs, as well as St John's wort extract (SJW), directly inhibit the re-uptake of norepinephrine (NE) and/or serotonin (5-HT) into pre-synaptic axons. With chronic treatment they induce adaptive changes in a number of neurotransmitter receptors in synaptic membranes. The immediate effects of SJW Ze 117, an extract low in hyperforin content, on the specific dopamine (DA) uptake were studied in rat striatal brain slices and compared with the effects on NE and 5-HT uptake in rat cortical brain slices. Read More

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February 2010

Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.

Br J Clin Pharmacol 2009 Feb 1;67(2):255-61. Epub 2008 Dec 1.

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, 74 Zhongshan Road, section 2, Guangzhou, China.

What Is Already Known About This Subject: Human pregnane X receptor (PXR/NR1I2) is a key regulator of cytochrome P450 3A4. To date, there are 198 reported SNPs for the human PXR/NR1I2 gene. Some of these SNPs are found to affect the inducing ability of PXR to CYP3A4. Read More

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February 2009

St. John's Wort modulates brain regional serotonin metabolism in swim stressed rats.

Pak J Pharm Sci 2009 Jan;22(1):94-101

Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan.

Present study has investigated acute effects of Saint Johns Wort (SJW, 500mg/kg) administration on behavioral, neuroendocrine responses and serotonergic activity following forced swim test (FST) exposure in rats. The results show that SJW increased swimming and climbing behaviour of rats during FST exposure. Swim stress produced significant reduction in serum total tryptophan (P<0. Read More

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January 2009

No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.

Eur J Clin Pharmacol 2009 Jan 3;65(1):81-7. Epub 2008 Sep 3.

Center of Pharmacology and Toxicology, Institute of Clinical Pharmacology, University of Rostock, Schillingallee 70, 18057 Rostock, Germany.

Objective: Induction of CYP3A by St. John's wort (SJW) products with high hyperforin content is well described. Since CYP3A induction is mediated by hyperforin in a concentration-dependent manner, and SJW preparations differ significantly in hyperforin content, the aim of the study was to evaluate the effect of an SJW powder with low hyperforin content on CYP3A function. Read More

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January 2009

Clinical drugs that interact with St. John's wort and implication in drug development.

Curr Pharm Des 2008 ;14(17):1723-42

Divison of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia.

St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal antidepressants for the treatment of minor to moderate depression. A major safety concern about SJW is its ability to alter the pharmacokinetics and/or clinical response of a variety of clinically important drugs that have distinctive chemical structure, mechanism of action and metabolic pathways. Read More

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October 2008

An update on clinical drug interactions with the herbal antidepressant St. John's wort.

Curr Drug Metab 2008 Jun;9(5):394-409

School of Health Sciences, World Health Organization Collaborating Centre for Traditional Medicine, RMIT University, Bundoora, Victoria 3083, Australia.

St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal antidepressants for the treatment of minor to moderate depression. Limited clinical trials suggest that hypericum and standard antidepressants have similar beneficial effects, but current evidence regarding the antidepression effects of SJW extracts is inconsistent. Read More

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Review article: cytochrome P450 enzyme, and transport protein mediated herb-drug interactions in renal transplant patients: grapefruit juice, St John's Wort - and beyond!

Rainer Nowack

Nephrology (Carlton) 2008 Jun 17;13(4):337-47. Epub 2008 Mar 17.

Center for Nephrology and Dialysis, Lindau/Bodensee, Germany.

Aim: To survey the evidence for plant-products to modify cytochrome P450 enzyme, and transport protein mediated drug metabolism in renal transplant patients.

Methods: A literature search was performed to identify "in vitro" and "in vivo" research on plant-products that might cause overdosage or loss of efficacy of immunosuppressive drugs in transplant patients by the interaction mechanisms already characterized for grapefruit juice and St. John's Wort. Read More

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Lack of pharmacokinetic interaction between St. John's wort and prednisone.

Ann Pharmacother 2007 Nov 9;41(11):1819-24. Epub 2007 Oct 9.

College of Pharmacy & Health Sciences, Texas Southern University, Houston, TX 77004, USA.

Background: St. John's wort (SJW) is a popular dietary supplement involved in numerous dietary supplement-drug interactions with prescription and non-prescription drugs. The supplement has been shown to affect the metabolism of various CYP3A4 substrates. Read More

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November 2007

Analysis and stability of the constituents of St. John's wort oils prepared with different methods.

J Pharm Biomed Anal 2007 Dec 1;45(5):756-61. Epub 2007 Sep 1.

Department of Pharmaceutical Sciences, University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

St. John's wort is a medicinal plant with a long history of use in traditional medicine all over Europe. Traditional preparations and in particular the infused oil from SJW flowers remains one of the most popular and curative topical remedy against ulcerations and burns. Read More

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December 2007

Self medication with St. John's wort in depressive disorders: an observational study in community pharmacies.

J Affect Disord 2008 Apr 17;107(1-3):205-10. Epub 2007 Aug 17.

Research Group Psychosomatic Rehabilitation at the Charité University Medicine Berlin, Germany.

Background: Depressive disorders are frequent. They are frequently unrecognised or sufferers use self help or self medication, e.g. Read More

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Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.

Naunyn Schmiedebergs Arch Pharmacol 2007 Aug 26;375(6):377-82. Epub 2007 Jun 26.

Institut für Pharmakologie, Johannes Gutenberg Universität, Obere Zahlbacher Str. 67, 55131 Mainz, Germany.

St. John's wort (SJW, Hypericum perforatum) is a well-tolerated herbal medicine widely used for the treatment of mild and moderate depressions. In the last 5 years, SJW has been implicated in drug interactions, which are largely mediated by the induction of the drug metabolizing enzymes, especially CYP3A4. Read More

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