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Modified "Blumgart-Type" Suture for Wirsung-Pancreaticogastrostomy: Technique and Results of a Pilot Study.

Eur Surg Res 2021 May 11:1-10. Epub 2021 May 11.

University of Bari "Aldo Moro" Medical School, Bari, Italy.

Introduction: Postoperative pancreatic fistula (POPF) represents the principal determinant of morbidity and mortality after pancreaticoduodenectomy. Since 1994 we have been performing pancreaticogastrostomy with duct-to-mucosa anastomosis (Wirsung-pancreaticogastric anastomosis [WPGA]), but postoperative morbidity, although limited, was still a concern. An original pancreas-transfixing suture technique, named "Blumgart's anastomosis" (BA), has shown efficacy at reducing fistula rates from pancreaticojejunostomy. Read More

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Speed agility trends in children according to growth.

Ann Hum Biol 2021 May 11:1-26. Epub 2021 May 11.

Faculty of Education, Health and Wellbeing, University of Wolverhampton, Walsall WV1 1SB, UK.

Background: Speed agility is considered as the whole assessment of speed of movement, agility and coordination. The 10x4m test has been broadly used to evaluate physical fitness and overall health in children of developmental ages. A myriad of studies have investigated the ecology of speed agility (SA). Read More

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Altered nuclear architecture in blood cells from Huntington's disease patients.

Neurol Sci 2021 May 11. Epub 2021 May 11.

CompuMAINE Lab, Department of Chemical and Biomedical Engineering, University of Maine, Orono, ME, 04469, USA.

Background: Cell nuclear architecture has been explored in cancer and laminopathies but not in neurodegenerative disorders. Huntington's disease (HD) is a neurodegenerative disorder that leads to neuronal death. Chromosome-wide changes in gene expression have been reported in HD, not only in the brain but also in peripheral blood cells, but whether this translates into nuclear and chromosome architecture alterations has not yet been studied. Read More

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Safety of Routine Pedicle Division during Delayed Breast Augmentation following Free Flap Breast Reconstruction.

Plast Reconstr Surg 2021 May 10. Epub 2021 May 10.

From the Division of Plastic and Reconstructive Surgery, University of Texas Health Science Center at Houston; and the Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine.

Background: Autologous free flap breast reconstruction is a common reconstructive procedure, with the ability to produce a natural breast shape and a long history of success. Despite its benefits, there are special situations in which patients lack sufficient donor-site tissue to achieve adequate breast size and projection. With this study, the authors describe their institutional experience of delayed implant augmentation after autologous breast reconstruction with a particular focus on pedicle division as a technique to improve aesthetic results. Read More

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When Is Diagnostic Subtraction Angiography Indicated Before Clipping of Unruptured and Ruptured Intracranial Aneurysms? An International Survey of Current Practice.

Acta Neurochir Suppl 2021 ;132:9-17

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Introduction: The goal of this survey is to investigate the indications for preoperative digital subtraction angiography (DSA) before clipping of ruptured and unruptured intracranial aneurysms in an international panel of neurovascular specialists.

Methods: An anonymous survey of 23 multiple-choice questions relating to indications for DSA before clipping of an intracranial aneurysm was distributed to the international panel of attendees of the European-Japanese Cerebrovascular Congress (EJCVC), which took place in Milan, Italy on 7-9 June 2018. The survey was collected during the same conference. Read More

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January 2021

Automatic wavelet-based 3D nuclei segmentation and analysis for multicellular embryo quantification.

Sci Rep 2021 May 10;11(1):9847. Epub 2021 May 10.

Department of Agriculture and Biological Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Identification of individual cells in tissues, organs, and in various developing systems is a well-studied problem because it is an essential part of objectively analyzing quantitative images in numerous biological contexts. We developed a size-dependent wavelet-based segmentation method that provides robust segmentation without any preprocessing, filtering or fine-tuning steps, and is robust to the signal-to-noise ratio. The wavelet-based method achieves robust segmentation results with respect to True Positive rate, Precision, and segmentation accuracy compared with other commonly used methods. Read More

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Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development.

BMC Plant Biol 2021 May 10;21(1):210. Epub 2021 May 10.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Horticulture, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit, and yet their functions have not been characterized. Especially, their involvement in early fruit development, which directly determines the size, shape, yield and quality of the watermelon fruit, remains unclear. Read More

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Green surfactant-dendrimer aggreplexes: An ingenious way to launch dual attack on arch-enemy cancer.

Colloids Surf B Biointerfaces 2021 May 5;204:111821. Epub 2021 May 5.

Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, 160062, Punjab, India. Electronic address:

Combination therapy, which combines anti-cancer drugs with different oligonucleotides, have shown potential in cancer treatment. However, delivering a hydrophobic anti-cancer drug and a hydrophilic oligonucleotide simultaneously is a herculean task. This study takes advantage of interactions between histidine-lauric acid-based green surfactant and poly(amidoamine) dendrimers to achieve this aim. Read More

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Strain sensors fabricated by surface assembly of nanoparticles.

Biosens Bioelectron 2021 May 1;186:113268. Epub 2021 May 1.

Department of Chemistry, State University of New York at Binghamton, Binghamton, NY, 13902, USA. Electronic address:

Harnessing interparticle spatial properties of surface assembly of nanoparticles (SAN) on flexible substrates is a rapidly emerging front of research in the design and fabrication of highly-sensitive strain sensors. It has recently shown promising potentials for applications in wearable sensors and skin electronics. SANs feature 3D structural tunability of the interparticle spatial properties at both molecular and nanoscale levels, which is transformative for the design of intriguing strain sensors. Read More

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Introducing Point-of-Interest as an alternative to Area-of-Interest for fixation duration analysis.

PLoS One 2021 10;16(5):e0250170. Epub 2021 May 10.

Department of Psychology, The University of Chicago, Chicago, Illinois, United States of America.

Many eye-tracking data analyses rely on the Area-of-Interest (AOI) methodology, which utilizes AOIs to analyze metrics such as fixations. However, AOI-based methods have some inherent limitations including variability and subjectivity in shape, size, and location of AOIs. In this article, we propose an alternative approach to the traditional AOI dwell time analysis: Weighted Sum Durations (WSD). Read More

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Local Polarization Reversal by Ion Beam Irradiation in SBN Single Crystals Covered by Dielectric Layer.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 10;PP. Epub 2021 May 10.

Formation of the domain structure by ion beam irradiation was studied in thermally depolarized Ce-doped strontium barium niobate single crystals covered by a dielectric layer. Three types of irradiation regimes were used: dot exposure, stripe exposure, and line exposure. The dependences of the domain size and depth on the irradiated dose were measured. Read More

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Tuning Organic Microcrystal Morphologies through Crystal Engineering Strategies toward Anisotropic Optical Waveguide.

J Phys Chem Lett 2021 May 10:4585-4592. Epub 2021 May 10.

Engineering Research Center of Organic and Polymer Optoelectronic Materials, Ministry of Education, State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

The construction of organic optoelectronic materials with desirable size and morphology remains a challenge now. Crystal engineering strategies (polymorphs and cocrystals) provide convenience for tailoring molecular packing and further controlling the growth morphology and photofunctionality of materials. Herein, we prepare polymorphic 2D plate crystals and 3D microhelixes by assembly of a cyanostilbene derivative (2-(3',5'-bis(trifluoromethyl)-biphenyl-4-yl)-3-(4-(pyridin-4-yl)phenyl)acrylonitrile, CF-CN-Py). Read More

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First Report of Causing Target Spot on Soybean in Taiwan.

Plant Dis 2021 May 10. Epub 2021 May 10.

Michigan State University, Plant, Soil and Microbial Sciences, 578 Wilson Rd, CIPS104, East Lansing, United States, 48824;

Soybean ( [L.] Merr.) is an important crop in Taiwan. Read More

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First report of Corynespora cassicola causing black spot on Sarcandra glabra in China.

Plant Dis 2021 May 10. Epub 2021 May 10.

Guangxi Botanical Garden of Medicinal Plants, 248907, Nanning, Guangxi, China;

Sarcandra glabra is an important Chinese medicinal plant, which was widely cultivated under forest in south China. Guangxi province is the main producing areas of this herb. In June 2019, a serious leaf disease was found causing severe defoliation in the S. Read More

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First report of causing leaf spots on in China.

Plant Dis 2021 May 10. Epub 2021 May 10.

Guangdong Academy of Agricultural Sciences, 117866, Institute of Plant Protection, Guangzhou, Guangdong, China;

Gladiolus ( Van Houtte) is a perennial plant in the family Iridaceae, which shows sword-shaped leaves and spikes of brilliantly colored irregular flowers arising from corms. It is one of the most important fresh cut flowers and is widely cultivated worldwide, including in China. In September 2020, white pinpoints were first observed on gladiolus leaves in Jiangmen City, Guangdong Province, China. Read More

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The golden proportion concept: smile makeover with an 18-month follow-up.

Int J Esthet Dent 2021 May;16(2):216-230

Aim: The altered size, shape or position of the teeth affect their proper alignment, the harmony of the smile, and the dentofacial composition. The aim of this article is to describe a minimally invasive approach to improve the esthetics of a patient through the golden proportion (GP) concept with the use of direct composite resin stratification.

Materials And Methods: A 26-year-old female complained about the appearance of her smile due to the existing spaces between her anterior teeth; her small, peg-shaped lateral incisors; the wear of her canines; and the color of her teeth. Read More

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Micromorphological differentiation of Korean Disporum species using light and scanning electron microscopy.

Microsc Res Tech 2021 May 10. Epub 2021 May 10.

Department of Biological Science, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea.

The genus Disporum Salisb. is widely distributed in East Asia, yet phylogenetically relevant morphological traits useful for differentiating many of the small, perennial, herbaceous species remain poorly described. To address this, leaf, floral, pollen, and orbicule micromorphology of four Korean Disporum species was investigated using light and scanning electron microscopy. Read More

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Laser-Scanning-Guided Assembly of Quasi-3D Patterned Arrays of Plasmonic Dimers for Information Encryption.

Adv Mater 2021 May 10:e2100325. Epub 2021 May 10.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.

The application of plasmonic dimeric nanostructures in color displays, data storage, and especially metamaterials necessitates the patterning of dimers into ordered arrays, but controllable assembly of plasmonic nanoparticles into patterned dimer arrays on substrates still remains a challenge. Here, a facile laser-scanning-based strategy to fabricate quasi-3D patterned arrays of plasmonic nanoparticle dimers with controlled orientation for plasmonic information encryption is reported. Laser scanning of polymer-covered plasmonic nanoparticle (e. Read More

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Over-Expression: A Colorectal Carcinoma Initiator not an Invasive Factor.

Rep Biochem Mol Biol 2021 Jan;9(4):442-451

Department of Surgical Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Background: Cyclooxygenase-2 (COX-2) main product is Prostaglandin E2 (PGE2) which cause mitogenesis and inflammation. COX-2 is the product of prostaglandin-endoperoxide synthase 2 () gene expression. COX-2 dysregulation can cause angiogenesis, differentiation, and promotion of cancer and its suppression related to control of the tumor's size, number, and cell shape. Read More

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January 2021

Breast Implant Utilization Trends in USA versus Europe and the Impact of BIA-ALCL Publications.

Plast Reconstr Surg Glob Open 2021 Mar 19;9(3):e3449. Epub 2021 Mar 19.

Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, Tex.

Background: The goals of this study were to analyze and compare breast implant preferences between US and European surgeons in terms of size, shape, and surface texturing. Furthermore, we set out to investigate the impact of BIA-ALCL scientific publications on surgeon practice patterns.

Methods: Breast implant sales data from the USA and Europe dating from June 2013 to September 2018 were provided by one of the world's leading breast implant manufactures (Mentor Worldwide LLC). Read More

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Monitoring Mortality Caused by COVID-19 Using Gamma-Distributed Variables Based on Generalized Multiple Dependent State Sampling.

Comput Math Methods Med 2021 22;2021:6634887. Epub 2021 Apr 22.

Department of Industrial and Management Engineering, POSTECH, Pohang 790-784, Republic of Korea.

More recently in statistical quality control studies, researchers are paying more attention to quality characteristics having nonnormal distributions. In the present article, a generalized multiple dependent state (GMDS) sampling control chart is proposed based on the transformation of gamma quality characteristics into a normal distribution. The parameters for the proposed control charts are obtained using in-control average run length (ARL) at specified shape parametric values for different specified average run lengths. Read More

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Induced Autophagy of Macrophages and the Regulation of Inflammatory Effects by Perovskite Nanomaterial LaNiO.

Front Immunol 2021 22;12:676773. Epub 2021 Apr 22.

CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety & CAS-HKU Joint Laboratory of Metallomics on Health and Environment, and Beijing Metallomics Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.

Perovskite nanomaterials (NMs) possess excellent physicochemical properties and have promising applications in light-emitting diodes (LEDs), lasers, photodetectors, and artificial synapse electronics. Potential exposure to these NMs happens in the manufacture and application of the perovskite-based products, however, the biological safety of these NMs is still unknown. Here, we used the LaNiO NM (LNO), a typical kind of perovskite nanostructures to study the interaction with macrophages (J774A. Read More

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Green Synthesized Silver Nanoparticles: Antibacterial and Anticancer Activities, Biocompatibility, and Analyses of Surface-Attached Proteins.

Front Microbiol 2021 22;12:632505. Epub 2021 Apr 22.

Department of Microbiology, Nicolaus Copernicus University, Toruń, Poland.

The increasing number of multi-drug-resistant bacteria and cancer cases, that are a real threat to humankind, forces research world to develop new weapons to deal with it. Biogenic silver nanoparticles (AgNPs) are considered as a solution to this problem. Biosynthesis of AgNPs is regarded as a green, eco-friendly, low-priced process that provides small and biocompatible nanostructures with antimicrobial and anticancer activities and potential application in medicine. Read More

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Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective.

Front Pharmacol 2021 22;12:664123. Epub 2021 Apr 22.

State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. Read More

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Locoregional recurrence of parathyroid carcinoma: how to identify this rare but fatal condition using ultrasonography.

Endocr J 2021 May 8. Epub 2021 May 8.

Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Parathyroid carcinoma (PC) is a rare condition with propensity to relapse. The purpose of this study was to evaluate the sonographic findings of locoregional recurrences of parathyroid carcinoma, in order to facilitate diagnosis of this condition using ultrasound (US). This was a retrospective observational study including 21 patients confirmed with pathologically confirmed locoregional recurrence of parathyroid carcinoma. Read More

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Size-Resolved Single Entity Collision Biosensing for Dual Quantification of MicroRNAs in a Single Run.

ACS Appl Mater Interfaces 2021 May 9. Epub 2021 May 9.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China.

Limited to the accuracy of size resolution, single entity collision biosensing (SECBS) for multiplex immunoassays remains challenging, because it is difficult to get the true value of nanoparticle (NP) sizes based on the current intensity due to the complex movement of NPs on the electrode surface. Considering that the size-dependent movement of NPs meanwhile will generate a characteristic current shape, in this work, the huge difference in the current rise time of 5 and 15 nm Pt NPs colliding on an Au ultramicroelectrode ( = 30 μm) was originally used to develop a size-resolved SECBS for multiplex immunoassays of miRNAs. The limit concentration that can be detected was 0. Read More

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Postsurgical Size-Changing Temporal Lobe Arachnoid Cysts in Patients with Trigonocephaly Who Underwent Reconstructive Surgery: A Two-Case Report.

Pediatr Neurosurg 2021 May 7:1-6. Epub 2021 May 7.

Department of Radiology, Gaziosmanpaşa Hospital, Istanbul Yeni Yüzyil University, Istanbul, Turkey.

Introduction: Trigonocephaly (TC), the tapering of the metopic suture toward the anterior, lateral inadequacy of supraorbital bar, hypoplasia of the ethmoid bone, and hypotelorism due to orbital medialization leads to a triangular shape in the head together with frontotemporal stenosis and widening of the biparietal diameter. Arachnoid cysts (ACs) are benign cysts, which are formed by cerebrospinal-fluid entrapment into the arachnoid membrane due to duplication or separation of the arachnoid membrane layers. ACs are typically located in the middle cranial fossa and Sylvian fissure region. Read More

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Bone accrual in children and adolescents with type 1 diabetes: current knowledge and future directions.

David R Weber

Curr Opin Endocrinol Diabetes Obes 2021 May 6. Epub 2021 May 6.

Division of Pediatric Endocrinology and Diabetes, The Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Skeletal fragility is now recognized as a significant complication of type 1 diabetes (T1D). Many patients with T1D develop the disease in childhood and prior to the attainment of peak bone mass and strength. This manuscript will review recent studies investigating the effects of T1D on skeletal development. Read More

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The gold nanoparticle reduces Vibrio cholerae pathogenesis by inhibition of biofilm formation and disruption of the production and structure of cholera toxin.

Colloids Surf B Biointerfaces 2021 Apr 30;204:111811. Epub 2021 Apr 30.

Department of Biochemistry, Bose Institute, P1/12 CIT Scheme VIIM, Kolkata, 700054, India.

Formation of biofilm by Vibrio cholerae plays a crucial role in pathogenesis and transmission of cholera. Lower infective dose of the biofilm form of V. cholerae compared to the planktonic counterpart, and its antibiotic resistance, make it challenging to combat cholera. Read More

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Innovative production of lignin nanoparticles using deep eutectic solvents for multifunctional nanocomposites.

Int J Biol Macromol 2021 May 6;183:781-789. Epub 2021 May 6.

State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong 250353, China. Electronic address:

A green and simple lignin nanoparticles (LNPs) production strategy was developed using deep eutectic solvents (DES). The LNPs were formed with corncob alkali lignin by sequential DES dissolution and self-assembling process. Uniform size and spherical shape of LNPs were observed by scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential analyzer and gel permeation chromatography (GPC). Read More

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