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Preparation of Montmorillonite Nanosheets with a High Aspect Ratio through Heating/Rehydrating and Gas-Pushing Exfoliation.

Langmuir 2022 Aug 18. Epub 2022 Aug 18.

Center of Nanomaterials for Renewable Energy (CNRE), State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, P. R. China.

Montmorillonite (MMT) is an abundant silicate mineral with ultrahigh stability. The exfoliation of stacked MMT into high-aspect-ratio nanosheets is of crucial importance for various applications such as toxic gas suppression, barrier property enhancement, flame retardancy, and ion conduction. In this work, we develop a new heating/rehydrating and gas-pushing method that can successfully exfoliate MMT into nanosheets with aspect ratios (600-5000) far higher than the currently reported values (1-120). Read More

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Recent Advances on the Metal-Organic Frameworks-Based Biosensing Methods for Cancer Biomarkers Detection.

Crit Rev Anal Chem 2022 Aug 18:1-17. Epub 2022 Aug 18.

Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.

Sensitive and selective detection of cancer biomarkers is crucial for early diagnosis and treatment of cancer, one of the most dangerous diseases in the world. Metal-organic frameworks (MOFs), a class of hybrid porous materials fabricated through the assembly of metal ions/clusters and organic ligands, have attracted increasing attention in the sensing of cancer biomarkers, due to the advantages of adjustable size, high porosity, large surface area and ease of modification. MOFs have been utilized to not only fabricate active sensing interfaces but also arouse a variety of measurable signals. Read More

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Genomic investigation of the Chinese alligator reveals wild-extinct genetic diversity and genomic consequences of their continuous decline.

Mol Ecol Resour 2022 Aug 18. Epub 2022 Aug 18.

MOE Key Laboratory of Biosystems Homeostasis & Protection, State Conservation Centre for Gene Resources of Endangered Wildlife, College of Life Sciences, Zhejiang University, Hangzhou, China.

Critically endangered species are usually restricted to small and isolated populations. High inbreeding without gene flow among populations further aggravates their threatened condition and reduces the likelihood of their long-term survival. Chinese alligator (Alligator sinensis) is one of the most endangered crocodiles in the world and has experienced a continuous decline over the past ca. Read More

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Improving cervical cancer screening rates: a scoping review of resources and interventions.

Cancer Causes Control 2022 Aug 18. Epub 2022 Aug 18.

Department of Family and Community Medicine, Penn State College of Medicine, Hershey, PA, USA.

Introduction: Cervical cancer mortality can be prevented through early detection with screening methods such as Pap and high-risk human papillomavirus (hrHPV) tests; however, only 81% of women aged 21-65 are up-to-date on screening. Many interventions to increase cervical cancer screening have been implemented, but there is limited understanding about which intervention components are most successful.

Methods: We conducted a scoping review of existing literature and available resources for cervical cancer screening interventions to identify gaps in the research. Read More

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Spruce versus Arabidopsis: different strategies of photosynthetic acclimation to light intensity change.

Photosynth Res 2022 Aug 18. Epub 2022 Aug 18.

Department of Biophysics, Faculty of Science, Palacký University, 783 71, Olomouc, Czech Republic.

The acclimation of higher plants to different light intensities is associated with a reorganization of the photosynthetic apparatus. These modifications, namely, changes in the amount of peripheral antenna (LHCII) of photosystem (PS) II and changes in PSII/PSI stoichiometry, typically lead to an altered chlorophyll (Chl) a/b ratio. However, our previous studies show that in spruce, this ratio is not affected by changes in growth light intensity. Read More

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Classification of white matter lesions and characteristics of small vessel disease markers.

Eur Radiol 2022 Aug 18. Epub 2022 Aug 18.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Objectives: Radiological markers for cerebral small vessel disease (SVD) may have different biological underpinnings in their development. We attempted to categorize SVD burden by integrating white matter signal abnormalities (WMSA) features and secondary presence of lacunes, microbleeds, and enlarged perivascular spaces.

Methods: Data were acquired from 610 older adults (aged > 40 years) who underwent brain magnetic resonance imaging exam as part of a health checkup. Read More

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[Application of anterior serratus branch of thoracodorsal vessel in repairing chest wall defect].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Aug;36(8):1021-1025

Department of Oncology Plastic Surgery, Hunan Province Cancer Hospital, Changsha Hunan, 410008, P. R. China.

Objective: To investigate the application of anterior serratus branch of thoracodorsal vessel in repairing chest wall defect.

Methods: Between October 2018 and March 2021, bilateral free lower abdominal flaps were used to repair large-area complex defects after chest wall tumor surgery in 23 patients. The patients were all female; the age ranged from 23 to 71 years, with an average age of 48. Read More

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Prediction of atomic stress fields using cycle-consistent adversarial neural networks based on unpaired and unmatched sparse datasets.

Markus J Buehler

Mater Adv 2022 Aug 24;3(15):6280-6290. Epub 2022 Jun 24.

Laboratory for Atomistic and Molecular Mechanics (LAMM), Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA

Deep learning holds great promise for applications in materials science, including the discovery of physical laws and materials design. However, the availability of proper data remains a challenge - often, data lacks labels, or does not contain direct pairing between input and output property of interest. Here we report an approach based on an adversarial neural network model - composed of four individual deep neural nets - to yield atomistic-level prediction of stress fields directly from an input atomic microstructure, illustrated here for defected graphene sheets under tension. Read More

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Prognostic significance of the preoperative hemoglobin to albumin ratio for the short-term survival of gastric cancer patients.

World J Gastrointest Surg 2022 Jun;14(6):580-593

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.

Background: Hemoglobin and albumin are associated with the prognosis of gastric cancer (GC) patients. However, the prognostic value of the hemoglobin to albumin ratio (HAR) for the short-term survival of GC patients with D2 radical resection has not been studied.

Aim: To investigate the significance of the HAR in evaluating the short-term survival of GC patients after D2 radical resection and to construct a nomogram to predict the prognosis in GC patients after surgery, thus providing a reference for the development of postoperative individualized treatment and follow-up plans. Read More

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Efficient graph convolutional networks for seizure prediction using scalp EEG.

Front Neurosci 2022 1;16:967116. Epub 2022 Aug 1.

School of Integrated Circuits and Electronics, Beijing Institute of Technology, Beijing, China.

Epilepsy is a chronic brain disease that causes persistent and severe damage to the physical and mental health of patients. Daily effective prediction of epileptic seizures is crucial for epilepsy patients especially those with refractory epilepsy. At present, a large number of deep learning algorithms such as Convolutional Neural Networks and Recurrent Neural Networks have been used to predict epileptic seizures and have obtained better performance than traditional machine learning methods. Read More

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Giant retroperitoneal liposarcoma treated with radical conservative surgery: A case report and review of literature.

World J Clin Cases 2022 Jul;10(19):6636-6646

Department of Traslational Medical Sciences, University of Campania "L. Vanvitelli", Naples 80128, Campania, Italy.

Background: Retroperitoneal liposarcoma (RLPS) is a rare malignant tumor of the connective tissue and usually grows to a large size, undetected. Diagnosis is currently based on collective findings from clinical examinations and computed tomography (CT) and magnetic resonance imaging, the latter of which show a fat density mass and possible surrounding organ involvement. Surgical resection is the main therapeutic strategy. Read More

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New use for old drug: Local delivery of puerarin facilitates critical-size defect repair in rats by promoting angiogenesis and osteogenesis.

J Orthop Translat 2022 Sep 31;36:52-63. Epub 2022 Jul 31.

Centre for Translational Medicine Research & Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China.

Objectives: Large bone defect repair is a challenging clinical problem due to limited self-repair ability. A well-designed bone filling product should possess the ability to induce tissue in-growth and facilitate neovascularization and new bone formation. Puerarin has been used in clinics for a long time, and recently it was found to be able to promote osteogenesis. Read More

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September 2022

Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect.

J Orthop Translat 2022 Sep 4;36:64-74. Epub 2022 Aug 4.

Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.

Background: A critical size bone defect is a clinical scenario in which bone is lost or excised due to trauma, infection, tumor, or other causes, and cannot completely heal spontaneously. The most common treatment for this condition is autologous bone grafting to the defect site. However, autologous bone graft is often insufficient in quantity or quality for transplantation to these large defects. Read More

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September 2022

Unilateral adrenal tuberculosis whose computed tomography imaging characteristics mimic a malignant tumor: A case report.

World J Clin Cases 2022 Jun;10(17):5783-5788

Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Adrenal tuberculosis usually presents with bilateral involvement. It has special characteristics in computed tomography (CT) images, such as small size, low attenuation in the center, and peripheral rim enhancement, which differ from those of primary tumors.

Case Summary: A 42-year-old female presented to the hospital with low back pain. Read More

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Evaluation of Mucous Retention Cyst Prevalence on Digital Panoramic Radiographs in the Local Population of Iran.

Radiol Res Pract 2022 8;2022:8650027. Epub 2022 Aug 8.

Department of Epidemiology and Health, Birjand University of Medical Sciences, Birjand, Iran.

Introduction: Inflammatory diseases and cysts such as mucous retention cysts (MRCs) and benign tumors include a large proportion of lesions of the mouth, teeth, and jaw. The most common complication of this lesion is sinusitis. Due to the high frequency of these cysts in panoramic radiography of patients referred to dentistry, this study aimed to evaluate the frequency of mucous retention cysts in the maxillary sinus on panoramic images of the local population in Birjand in the year 2020. Read More

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Case report: I seed implantation for rare malignant solitary fibrous tumor in the pelvic cavity: a case report.

Front Oncol 2022 1;12:884491. Epub 2022 Aug 1.

Department of Oncology, The Hebei General Hospital, Shijiazhuang, China.

Solitary fibrous tumor (SFT) is a rare spindle cell tumor, benign or low-grade malignant, with an extremely low possibility of occurrence of malignant solitary fibrous tumor (MSFT). Surgery is an effective way for treating SFT, but it is often difficult to resect completely due to a large size, with a high recurrence rate and mortality rate after operation. Additionally, SFT is relatively resistant to chemotherapy, and there is a lack of effective systemic drug treatment. Read More

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Effects of the COVID-19 pandemic on acute coronary syndromes in Germany during the first wave: the COVID-19 collateral damage study.

Clin Res Cardiol 2022 Aug 17. Epub 2022 Aug 17.

Department of Cardiology, Heart Center Leipzig at University of Leipzig, Strümpellstraße 39, 04289, Leipzig, Germany.

Background: Reports about the influence of the COVID-19 pandemic on the number of hospital admissions and in-hospital mortality during the first wave between March and May 2020 showed conflicting results and are limited by single-center or limited regional multicenter datasets. Aim of this analysis covering all German federal states was the comprehensive description of hospital admissions and in-hospital mortality during the first wave of the COVID-19 pandemic.

Methods And Results: We conducted an observational study on hospital routine data (§21 KHEntgG) and included patients with the main diagnosis of acute myocardial infarction (ICD 21 and ICD 22). Read More

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Nucleation and growth of gold nanoparticles in the presence of different surfactants. A dissipative particle dynamics study.

Sci Rep 2022 Aug 17;12(1):13926. Epub 2022 Aug 17.

Departament de Química, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193, Barcelona, Spain.

Nanoparticles (NPs) show promising applications in biomedicine, catalysis, and energy harvesting. This applicability relies on controlling the material's features at the nanometer scale. Surfactants, a unique class of surface-active molecules, have a remarkable ability to tune NPs activity; provide specific functions, avoid their aggregation, and create stable colloidal solutions. Read More

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Large scale screening of CRISPR guide RNAs using an optimized high throughput robotics system.

Sci Rep 2022 Aug 17;12(1):13953. Epub 2022 Aug 17.

Center for Bio/Molecular Science & Engineering (Code 6900), US Naval Research Laboratory, Washington, DC, USA.

All CRISPR/CAS systems utilize CRISPR guide RNAs (crRNAs), the design of which depend on the type of CAS protein, genetic target and the environment/matrix. While machine learning approaches have recently been developed to optimize some crRNA designs, candidate crRNAs must still be screened for efficacy under relevant conditions. Here, we demonstrate a high-throughput method to screen hundreds of candidate crRNAs for activation of Cas13a collateral RNA cleavage. Read More

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Facility Size and Risk Factors for Mortality in Pediatric Trauma.

Am Surg 2022 Aug 17:31348221121555. Epub 2022 Aug 17.

Department of Surgery, 12278Brody School of Medicine at East Carolina University, Greenville, NC, USA.

Background: Pediatric trauma outcomes can vary across facilities, yet evidence on the relationship between facility bed size and pediatric trauma outcomes has been mixed. We aimed to identify how facility bed size might modify the impact of patient-level risk factors on mortality in pediatric trauma. We hypothesized that patient-level risk factors would have a stronger association with mortality at smaller trauma centers, and a weaker association with mortality at larger centers. Read More

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Estrogen-related receptor is critical for testicular mitochondrial homeostasis and sperm motility: a Drosophila-based study.

F S Sci 2022 Aug 14;3(3):217-227. Epub 2022 Feb 14.

Embryotoxicology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India. Electronic address:

Objective: To study the role of estrogen-related receptors (ERRs) in testicular function, with particular emphasis on mitochondrial homeostasis, testicular steroidogenesis, and sperm motility using Drosophila as a model.

Design: Experimental study.

Setting: Academic research laboratory. Read More

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Effects of Plasticity on Elevational Range Size and Species Richness.

Am Nat 2022 Sep 26;200(3):316-329. Epub 2022 Jul 26.

AbstractElevational ranges within many taxa are greater in the north temperate region than the tropics. Two hypotheses to explain the pattern are, first, that large elevational ranges in the temperate region arise because species have evolved broad tolerance curves in response to seasonality and, second, that a low diversification rate in the temperate region (speciation minus extinction) has led to relatively few species, each of which occupies a large elevational range in the absence of competitors (character release). We build a quantitative genetic model of selection on a phenotypic trait, whereby increased tolerance is modeled as arising from plasticity in the trait. Read More

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September 2022

Strategies targeting the NO pathway to counteract extra-pulmonary manifestations of COPD: A systematic review and meta-analysis.

Nitric Oxide 2022 Aug 14. Epub 2022 Aug 14.

Department of Kinesiology, University of Massachusetts Amherst, USA; Institute of Applied Life Science, University of Massachusetts Amherst, USA. Electronic address:

The clinical symptoms of chronic obstructive pulmonary disease (COPD) disease are accompanied by severely debilitating extra-pulmonary manifestations, including vascular dysfunction and hypertension. This systematic review evaluated the current evidence for several therapeutic interventions, targeting the nitric oxide (NO) pathway on hemodynamics and, secondarily, exercise capacity in patients with COPD. A comprehensive search on COPD and NO donors was performed on online databases. Read More

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Enhanced toxicity effects of iron particles together with PFOA in drinking water.

Environ Pollut 2022 Aug 14:119919. Epub 2022 Aug 14.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

Iron particles present in drinking water distribution systems (DWDSs) could cause discoloration, while organic pollutants in DWDSs, such as perfluorooctanoic acid (PFOA), could be enriched by iron particles. However, little is known about the enhanced effects of PFOA and iron particles in DWDSs. To fill in these knowledge gaps, herein, iron-PFOA (FEP) particles were generated using residual chlorine as an oxidant in drinking water conditions and then separated into different sizes (ranging from small to large: FEP-S, FEP-M and FEP-L). Read More

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Membrane Fusion Biophysical Analysis of Fusogenic Liposomes.

Langmuir 2022 Aug 17. Epub 2022 Aug 17.

Departamento de Biofísica, Universidade Federal de São Paulo, CEP 04039-032, São Paulo, Brazil.

Liposomes represent important drug carrier vehicles in biological systems. A fusogenic liposomal system composed of equimolar mixtures of the cationic lipid DOTAP and the phospholipid DOPE showed high fusion and delivery efficiencies with cells and lipid vesicles. However, aspects of the thermodynamics involving the interaction of these fusogenic liposomes and biomimetic systems remain unclear. Read More

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Fec: a fast error correction method based on two-rounds overlapping and caching.

Bioinformatics 2022 Aug 17. Epub 2022 Aug 17.

School of Computer Science and Engineering, Central South University, Changsha, 410083, China.

: The third-generation sequencing technology has advanced genome analysis with long read length, but the reads need error correction due to the high error rate. Error correction is a time-consuming process especially when the sequencing coverage is high. Generally, for a pair of overlapping reads A and B, the existing error correction methods perform a base-level alignment from B to A when correcting the read A. Read More

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Functional Fiber Materials to Smart Fiber Devices.

Chem Rev 2022 Aug 17. Epub 2022 Aug 17.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.

The development of fiber materials has accompanied the evolution of human civilization for centuries. Recent advances in materials science and chemistry offered fibers new applications with various functions, including energy harvesting, energy storing, displaying, health monitoring and treating, and computing. The unique one-dimensional shape of fiber devices endows them advantages to work as human-interfaced electronics due to the small size, lightweight, flexibility, and feasibility for integration into large-scale textile systems. Read More

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Time and Financial Costs for Physician Practices to Participate in the Medicare Merit-based Incentive Payment System: A Qualitative Study.

JAMA Health Forum 2021 May 14;2(5):e210527. Epub 2021 May 14.

Division of Health Policy and Economics, Department of Population Health Sciences, Weill Cornell Medical College, New York, New York.

Importance: The Merit-based Incentive Payment System (MIPS) is a major Medicare value-based purchasing program, influencing payment for more than 1 million clinicians annually. There is a growing concern that MIPS increases administrative burden, and little is known about what it costs physician practices to participate in the program.

Objective: To examine the costs for independent physician practices to participate in MIPS in 2019. Read More

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Cognition contra camouflage: How the brain mediates predator-driven crypsis evolution.

Sci Adv 2022 Aug 17;8(33):eabq1878. Epub 2022 Aug 17.

Behavioral Ecology, Department of Animal Sciences, Wageningen University, Wageningen, Netherlands.

While crypsis is a prominent antipredator adaptation, the role of the brain in predator-driven evolution remains controversial. Resolving this controversy requires contextualizing the brain with established antipredator traits and predation pressure. We hypothesize that the reduced predation risk through crypsis relaxes predation-driven selection on the brain and provide comparative evidence across 102 Chinese frog species for our hypothesis. Read More

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The extinct shark was a transoceanic superpredator: Inferences from 3D modeling.

Sci Adv 2022 Aug 17;8(33):eabm9424. Epub 2022 Aug 17.

Department of Biosciences, Swansea University, Swansea SA2 8PP, UK.

Although shark teeth are abundant in the fossil record, their bodies are rarely preserved. Thus, our understanding of the anatomy of the extinct remains rudimentary. We used an exceptionally well-preserved fossil to create the first three-dimensional model of the body of this giant shark and used it to infer its movement and feeding ecology. Read More

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