Radiology 2021 Aug 3:204743. Epub 2021 Aug 3.
From the Dept of Radiology, Massachusetts General Hosp, 55 Fruit Street, WAC-240, Boston, MA 02114 (S.H.S.C., C.D.L.); Ctr for Statistical Sciences, Brown Univ School of Public Health, Providence, RI (J.R., I.F.G., B.S.S., C.G.); Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Chicago, Ill (S.A.K.); Dept of Radiology, Univ of Michigan Health System, Ann Arbor, Mich (R.C.); Depts of Pathology and Laboratory Medicine (S.S.B.) and Medicine (K.D.M.), Indiana Univ School of Medicine, Indianapolis, Ind; Dept of Radiology (J.X., H.R.) and Surgery (S.H.J.), Univ of Washington School of Medicine, Seattle, Wash; Dept of Surgery, Tulane Univ School of Medicine, New Orleans, La (R.L.C.); Community Oncology Research Program, Gulf-South National Cancer Inst, New Orleans, La (D.W.S.); Dept of Surgery, Parkview Cancer Inst, Fort Wayne, Ind (L.K.H.); Dept of Surgery, Lankenau Medical Ctr, Wynnewood, Pa (J.L.S.); Dept of Surgery, Mercy Hosp Springfield, Springfield, Mo (J.R.B.); Depts of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC (L.I.W.); Dept of Oncology, Johns Hopkins Univ School of Medicine, Baltimore, Md (A.C.W.); Dept of Medicine (Oncology), Montefiore Medical Center-Weiler Hosp, Bronx, NY (J.A.S.); and Dept of Radiology, Memorial Sloan-Kettering Cancer Ctr, New York, NY (C.E.C.).
Background There are limited data from clinical trials describing preoperative MRI features and performance in the evaluation of mammographically detected ductal carcinoma in situ (DCIS). Purpose To report qualitative MRI features of DCIS, MRI performance in the identification of additional disease, and associations of imaging features with pathologic, genomic, and surgical outcomes from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) E4112 trial. Materials and Methods Secondary analyses of a multicenter prospective clinical trial from the ECOG-ACRIN Cancer Research Group included women with DCIS diagnosed with conventional imaging techniques (mammography and US), confirmed via core-needle biopsy (CNB), and enrolled between March 2015 and April 2016 who were candidates for wide local excision (WLE) based on conventional imaging and clinical examination results. Read More