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Design study of a PET detector with 0.5 mm crystal pitch for high-resolution preclinical imaging.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Biomedical Engineering , Shenzhen Bay Laboratory, Shenzhen, CHINA.

Preclinical positron emission tomography (PET) is a sensitive and quantitative molecule imaging modality widely used in characterizing the biological processes and diseases in small animals. The purpose of this study is to investigate the methods to optimize a PET detector for high-resolution preclinical imaging. The PET detector proposed in this study consists of a 28×28 array of LYSO crystals 0. Read More

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Photodiode Behaviors of the AgSbSNanocrystals in a Schottky structure.

Nanotechnology 2021 Jun 15. Epub 2021 Jun 15.

Selcuk Universitesi, Department of Biotechnology, Konya, 42130, TURKEY.

Cubic phase AgSbSnanocrystals (NCs) were synthesized by hot-injection method, and they were inserted between the Al and-Si to fabricate Al/AgSbS/-Si photodiode by the thermal evaporation method. AgSbSnanocrystals were characterized by XRD, SEM and TEM instruments to confirm the crystal phase, surface morphology as well as crystalline size. The XRD pattern revealed the cubic crystalline structure of the AgSbS. Read More

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Validation of the German Day-to-Day Impact of Vaginal Aging (DIVA) Questionnaire in Peri- and Postmenopausal Women.

Sex Med 2021 Jun 12;9(4):100382. Epub 2021 Jun 12.

Institute of Social Medicine and Health Systems Research, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

Background: The Day-to-Day Impact of Vaginal Aging (DIVA) questionnaire is a validated patient-reported outcome measure (PROM) capturing the impacts of vaginal symptoms in postmenopausal women.

Aim: We aimed to psychometrically validate the German version of the DIVA questionnaire.

Methods: Data was collected online and by paper-pencil. Read More

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Antimicrobial use, biosecurity, herd characteristics, and antimicrobial resistance in indicator Escherichia coli in ten Finnish pig farms.

Prev Vet Med 2021 Jun 10;193:105408. Epub 2021 Jun 10.

Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.

We investigated connections between antimicrobial use (AMU), biosecurity, and the numbers of pigs and staff in ten Finnish farrow-to-finish herds. Data on AMU in each herd were collected for 12 months. AMU was quantified as treatment incidences per 1000 days at risk (TI) using the consensus defined daily dose calculation. Read More

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Isoflavones alter male and female fertility in different development windows.

Biomed Pharmacother 2021 Jun 12;140:111448. Epub 2021 Jun 12.

Department of Pharmacy, State University of Centro-Oeste, Parana, Brazil; Program in Biotechnology in Human and Animal Health - (PPGBiotec), State University of Ceará, Ceará, Brazil. Electronic address:

Isoflavones are a group of secondary metabolites found in plants belonging to the class of phytoestrogens. These, because they have a chemical structure similar to the endogenous hormone 17β-estradiol, act as endocrine disruptors over the different development window periods. This study aimed to evaluate male and female reproductive systems' responses when exposed to isoflavones during the development window. Read More

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Effects of dynamic adsorption on bubble formation and coalescence in partitioned-EDGE devices.

J Colloid Interface Sci 2021 Jun 4;602:316-324. Epub 2021 Jun 4.

Wageningen University, Food Process Engineering Group, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands. Electronic address:

Hypothesis: Dynamic adsorption effects can play a crucial role in bubble formation and stabilization. We hypothesize that microfluidic tools provide direct insights to these effects, and that the final bubble size depends on the intersection of time scales for bubble formation versus adsorption of proteins.

Experiments: We use a microfluidic device to study Laplace pressure-driven formation of bubbles that are stabilized by whey proteins. Read More

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Microplastic degradation methods and corresponding degradation mechanism: Research status and future perspectives.

J Hazard Mater 2021 Jun 10;418:126377. Epub 2021 Jun 10.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

Microplastics (MPs) pollution has become a global environmental concern because of their severe threat to biota. However, limited studies on the elimination of MPs pollution were reported. The conventional treatment methods were not suitable for MPs owing to their smaller size than plastic items. Read More

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Synergistic adsorption and degradation of sulfamethoxazole from synthetic urine by hickory-sawdust-derived biochar: The critical role of the aromatic structure.

J Hazard Mater 2021 Jun 9;418:126366. Epub 2021 Jun 9.

Department of Civil Engineering, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA; Energy Institute of Louisiana, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA. Electronic address:

This study investigated the adsorptive removal and subsequent degradation of sulfamethoxazole (SMX) from a synthetic urine by biochar (BC). The BCs used in this study were prepared using two different feedstocks with different temperatures. Element analysis and Fourier transform infrared spectroscopy (FTIR) results suggested that the aromaticity of one of the BCs, 700HSBC was significantly different from the 700PSBC although both of them were prepared at the same temperature (700 °C) with similar pore size distributions and specific surface areas. Read More

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Repellent activity of acetylcarvacrol and its effects on salivary gland morphology in unfed Rhipicephalus sanguineus sensu lato ticks (Acari: Ixodidae).

Ticks Tick Borne Dis 2021 Jun 4;12(5):101760. Epub 2021 Jun 4.

Department of Health Sciences, Federal University of Lavras (UFLA), Av. Dr. Sylvio, Menicucci, 1001 Lavras, MG, Brazil. Electronic address:

Rhipicephalus sanguineus sensu lato (s.l.), commonly known as brown dog tick, is a widely distributed tick species that is substantially important for human and veterinary medicine. Read More

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The crucial role of heavy metals on the interaction of engineered nanoparticles with polystyrene microplastics.

Water Res 2021 Jun 1;201:117317. Epub 2021 Jun 1.

Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, HKSAR, P.R.China; HKBU Institute of Research and Continuing Education, Shenzhen Virtual University Park, Shenzhen, P.R.China. Electronic address:

Despite continuous research on microplastics (MPs), studies exploring the complexity of interaction between MPs and other aqueous constituents in multi-solute systems are scarce. In this study, the uptake and release of nanoceria (CeNPs) by various polystyrene MPs (PSMPs) were investigated. Results showed that PSMPs in the presence of heavy metals (HMs) exhibited a substantially higher sorption affinity for isotropic charged CeNPs than PSMPs alone; this enhanced affinity was attributed to the formation of PSMP-HM-CeNP complexes. Read More

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An unexpectedly high incidence of refeeding syndrome in patients with total parenteral nutrition in a reference university hospital.

Clin Nutr 2021 Apr 17;40(6):3702-3707. Epub 2021 Apr 17.

Gastroenterology Service, Hospital de Clínicas de Porto Alegre - RS, Ramiro Barcelos 2350, Rio Grande do Sul, 90035-903, Brazil.

Introduction: Refeeding syndrome occurs with the reintroduction of food after an individual has undergone a substantial period of malnutrition. The development of this condition is not uncommon but is neglected in most cases.

Objective: To identify the incidence of refeeding syndrome in hospitalized patients undergoing total parenteral nutrition and factors that may be associated with this condition. Read More

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Saliva based non invasive screening of Oral Submucous Fibrosis using ATR-FTIR spectroscopy.

J Pharm Biomed Anal 2021 Jun 8;203:114202. Epub 2021 Jun 8.

Department of Life Science, School of Sciences, Gujarat University, India. Electronic address:

Oral Submucous Fibrosis (OSMF) is a type of precancerous condition of Oral cancer and considered to have the greatest malignant potential. Biopsy is an ultimate option for the conformation of the malignancy. But the invasiveness of the procedure makes it interdict. Read More

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In vivo evaluation of deer antler trabecular bone as a reconstruction material for bone defects.

Res Vet Sci 2021 Jun 11;138:116-124. Epub 2021 Jun 11.

Department of Clinical Sciences, FARAH, Faculty of Veterinary Medicine, University of Liège, Quartier Vallée 2, Avenue de Cureghem 1 - B67, Liège, Belgium.

Availability of graft materials to fill up osseous defects has always been a concern in orthopaedic surgeries. Deer antler material is a primary bone structure that is easy to collect and could serve as a xenograft. This study examines the behaviour of red deer antler trabecular cylinders in critical size distal femoral epiphyseal defects in 11 rabbits, and evaluates the effect of the decellularization protocols. Read More

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Prevalence of multidrug-resistant bacteria in Ethiopia: a systematic review and meta-analysis.

J Glob Antimicrob Resist 2021 Jun 12. Epub 2021 Jun 12.

Hawassa University College of Medicine and Health Science, School of Medical Laboratory, Hawassa Ethiopia. Electronic address:

Background: Multidrug-resistant (MDR) bacteria are the most significant current threats to public health worldwide. Their presence and impact are more severe in low- and middle-income countries like Ethiopia. To understand the real magnitude of multiple drug-resistant bacteria comprehensive data is important as such data is not present in Ethiopia. Read More

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Treatment Outcomes After Single-Device Flow Diversion for Large or Giant Aneurysms.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Here, we aimed to evaluate the efficacy and safety of single-device flow diversion in patients with aneurysms measuring ≥15 mm in diameter.

Methods: For this retrospective study, we extracted medical record data for patients with unruptured intracranial aneurysms, who underwent flow diversion, at the authors' institution between July 2014 and August 2019. The primary effectiveness outcome was defined as angiographic occlusion of the target aneurysm within 18 months without major (>50%) parent artery stenosis, major adverse events, or additional treatment. Read More

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3D two-photon polymerization of smart cell gelatin - collagen matrixes with incorporated ruthenium complexes for the monitoring of local oxygen tensions.

Acta Biomater 2021 Jun 12. Epub 2021 Jun 12.

MoVe, Laboratoire interdisciplinaire de physique, CNRS UMR 5588, Université Grenoble Alpes, St-Martin d'Hères, France.

The extra cellular matrix plays a major role in the biomechanical properties of tissues that impact cell behavior and fate. It is therefore crucial to mimic these complex cell-matrix interactions in 3D cell cultures. Here, two-photon polymerization is applied to produce gelatin methacryloyl (GelMA) - collagen matrixes that further enable local pO measurement, when ruthenium complexes are used as photo-activators. Read More

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Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs.

Mol Cell Proteomics 2021 Jun 12:100109. Epub 2021 Jun 12.

Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Many small open reading frames (smORFs) embedded in lncRNA transcripts have been shown to encode biologically functional polypeptides (smORFs-encoded polypeptides, SEPs) in different organisms. Despite significant advances in genomics, bioinformatics and proteomics that largely enabled the discovery of novel SEPs, their identification across different biological samples is still hampered by their poor predictability, diminutive size and low relative abundance. Here, we take advantage of NONCODE, a repository containing the most complete collection and annotation of lncRNA transcripts from different species, to build a novel database that attempts to maximize a collection of SEPs from human and mouse lncRNA transcripts. Read More

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Endoscopic Septotomy Of Zenker's Diverticulum With Stag-Beetle Knife: A Descriptive Observational Study And Literature Review.

Gastroenterol Hepatol 2021 Jun 12. Epub 2021 Jun 12.

UGC Aparato Digestivo Hospital Universitario Virgen de la Victoria, Málaga, Spain.

Introduction: Zenker's diverticulum (ZD) is a protrusion of the hypopharyngeal mucosa with a prevalence of 2 / 100,000 inhabitants. The symptoms of the patients determine the need for treatment, which can be surgical or endoscopic. The latter, known as endoscopic septotomy or diverticulotomy (ED), this involves dissecting the diverticular septum, which can be performed with different dissection devices. Read More

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Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats.

Eur J Pharmacol 2021 Jun 12:174257. Epub 2021 Jun 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)-induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. Read More

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Global analysis of a cancer model with drug resistance due to Lamarckian induction and microvesicle transfer.

J Theor Biol 2021 Jun 12:110812. Epub 2021 Jun 12.

Bolyai Institute, University of Szeged, Szeged H-6720, Hungary.

Development of resistance to chemotherapy in cancer patients strongly effects the outcome of the treatment. Due to chemotherapeutic agents, resistance can emerge by Darwinian evolution. Besides this, acquired drug resistance may arise via changes in gene expression. Read More

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Transgenerational plasticity in the eye size of .

Biol Lett 2021 Jun 16;17(6):20210143. Epub 2021 Jun 16.

Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.

It is well established that environmental signals can induce phenotypic responses that persist for multiple generations. The induction of such 'transgenerational plasticity' (TGP) depends upon the ability of organisms to accurately receive and process information from environmental signals. Thus, sensory systems are likely intertwined with TGP. Read More

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Is the diatom sex clock a clock?

J R Soc Interface 2021 Jun 16;18(179):20210146. Epub 2021 Jun 16.

Algorithmic Algebra and Discrete Mathematics, Institute of Mathematics, Faculty of Mathematics and Natural Sciences, University of Kassel, 34109 Kassel, Germany.

The unique life cycle of diatoms with continuous decreasing and restoration of the cell size leads to periodic fluctuations in cell size distribution and has been regarded as a multi-annual clock. To understand the long-term behaviour of a population analytically, generic mathematical models are investigated algebraically and numerically for their capability to describe periodic oscillations. Whereas the generally accepted simple concepts for the proliferation dynamics do not sustain oscillating behaviour owing to broadening of the size distribution, simulations show that a proposed limited lifetime of a newly synthesized cell wall slows down the relaxation towards a time-invariant equilibrium state to the order of a hundred thousand generations. Read More

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Correlation between protein secondary structure and mechanical performance for the ultra-tough dragline silk of Darwin's bark spider.

J R Soc Interface 2021 Jun 16;18(179):20210320. Epub 2021 Jun 16.

School of Polymer Science and Polymer Engineering, The University of Akron, Akron, OH 44325, USA.

The spider major ampullate (MA) silk exhibits high tensile strength and extensibility and is typically a blend of MaSp1 and MaSp2 proteins with the latter comprising glycine-proline-glycine-glycine-X repeating motifs that promote extensibility and supercontraction. The MA silk from Darwin's bark spider () is estimated to be two to three times tougher than the MA silk from other spider species. Previous research suggests that a unique MaSp4 protein incorporates proline into a novel glycine-proline-glycine-proline motif and may explain MA silk's extraordinary toughness. Read More

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Microanatomical and secretory characterization of the salivary gland of the (Hemiptera, Reduviidae, Triatominae), a main vector of Chagas disease.

Open Biol 2021 Jun 16;11(6):210028. Epub 2021 Jun 16.

Instituto René Rachou, Fundação Oswaldo Cruz, Minas Gerais, Av. Augusto de Lima, 1715, CEP 30190-002, Belo Horizonte, MG, Brazil.

is the principal vector of , the aetiological agent of Chagas disease in American countries. This insect is haematophagous during all life cycles and, to antagonize its haemostatic, inflammatory and immune systems, it secretes saliva while feeding on the vertebrate host's blood. Here, we investigated characteristic changes of the salivary glands (SG) that occur during insect development. Read More

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Big and deep seated lipomatous tumours in children : results of surgical treatment.

Acta Orthop Belg 2021 Mar;87(1):197-200

The objective of the study is aimed to evaluate results of our pediatric patients with big and deep-seated lipomatous tumors Results of 32 children who underwent resection for 5 cm or larger and deep-seated lipomas were evaluated. The mean age of the patients was 9.1 years (range, 0-16 ; 11 female/21 male), and median follow-up period was 3. Read More

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Capture and Separation of SO2 Traces in Metal-Organic Frameworks via Pre-synthetic Pore Environment Tailoring by Methyl Groups.

Angew Chem Int Ed Engl 2021 Jun 15. Epub 2021 Jun 15.

Universität Düsseldorf, Institut für Anorganische Chemie und Strukturchemie, Universitätsstr. 1, 40225, Düsseldorf, GERMANY.

Herein, we report a pre-synthetic pore environment design strategy to achieve stable methyl-functionalized metal-organic frameworks (MOFs) for preferential SO2 binding and thus enhanced low (partial) pressure SO2 adsorption and SO2/CO2 separation. The enhanced sorption performance is for the first time attributed to an optimal pore size by increasing methyl group densities at the benzenedicarboxylate linker in [Ni2(BDC-X)2DABCO] (BDC-X = mono-, di- and tetramethyl-1,4-benzenedicarboxylate/terephthalate; DABCO = 1,4-diazabicyclo[2,2,2]octane). Monte Carlo simulations and first-principles density-functional theory (DFT) calculations demonstrate the key role of methyl groups within the pore surface on the preferential SO2 affinity over the parent MOF. Read More

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Salen-decorated Periodic Mesoporous Organosilica: From Metal-assisted Epoxidation to Metal-free CO Insertion.

Chem Asian J 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemistry, Center for Ordered Materials, Organometallics and Catalysis (COMOC), Ghent University, Krijgslaan 281-S3, 9000, Ghent, Belgium.

We clicked a salen ligand onto a thiol-ethane bridged periodic mesoporous organosilica (Salen-PMO) using a photo-initiated thiol-ene click reaction. This process resulted in a covalently bonded salen ligand on the PMO material. The final BET surface area amounts 511 m /g and the pore size diameter is approximately 7 nm. Read More

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Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold.

Wound Repair Regen 2021 Jun 15. Epub 2021 Jun 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Duke University, Durham, North Carolina, USA.

Dermal scarring from motor vehicle accidents, severe burns, military blasts, etc. is a major problem affecting over 80 million people worldwide annually, many of whom suffer from debilitating hypertrophic scar contractures. These stiff, shrunken scars limit mobility, impact quality of life, and cost millions of dollars each year in surgical treatment and physical therapy. Read More

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Reply to: HEP-21-1047 The sample size determination for the development of clinical prediction models remains an open issue.

Yong Lv Guohong Han

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

We greatly appreciate Shi and colleague for their interest in our work . An important question they raise is whether our sample size is large enough with sufficient statistical power to predict the 6-week death or further bleeding in patients with Child-Pugh B cirrhosis and acute variceal bleeding. Read More

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Development and psychometric properties of the Nursing Student Academic Resilience Inventory (NSARI): A mixed-method study.

PLoS One 2021 15;16(6):e0252473. Epub 2021 Jun 15.

Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Introduction: Resilience has been proposed as a suitable solution to better deal with nursing students in cases of challenges but the complex and multidimensional nature of resilience has made its measurement challenging. This study aimed to develop and validate a new inventory theory-driven labeled Nursing Student Academic Resilience Inventory.

Methods: This study was performed with an exploratory sequential mixed-method design. Read More

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