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Methotrexate treatment in hand osteoarthritis refractory to usual treatments: A randomised, double-blind, placebo-controlled trial.

Semin Arthritis Rheum 2021 May 6;51(4):831-838. Epub 2021 May 6.

Department of Rheumatology, Pasteur Hospital, Nice University Hospital, Cote d'Azur University, Nice F-06000, France; Department of Rheumatology, University of Cote d'Azur, Nice Hospital, Laboratory LAMHESS, EA6312, IBV CNRS IMR 7277 INSERM U1091 UNS, France.

Objective: To examine the effect of methotrexate (MTX) on pain and structural progression in symptomatic erosive hand osteoarthritis (HOA).

Methods: This 1-year prospective, single-centre, randomised, double-blind, placebo-controlled study (www.ClinicalTrial. Read More

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Appendiceal pseudomyxoma peritonei: predictors of recurrence and iterative surgery.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Aim: Appendiceal pseudomyxoma peritonei (PMP) is a rare entity, with recurrence rates up to 26% despite optimal cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Evidence specific to PMP originating from non-infiltrative appendiceal mucinous neoplasms (Low grade - LAMN and high grade - HAMN) is lacking. The aim of this study was to identify patterns of recurrence and predictive factors for patients appropriate for iterative surgery. Read More

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Anti-Tumour Necrosis Factor Therapy is Associated with Denovo Crohn's Disease After Ileal Pouch-Anal Anastomosis.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Division of Colorectal Surgery, Department of Gastroenterology - Widjaja Foundation Inflammatory Bowel.

Aim: Tumour necrosis factor inhibitors (TNFi) have revolutionized the management of moderate to severe ulcerative colitis (UC) since their approval for UC in 2005. Still, many patients ultimately require surgery with ileal pouch-anal anastomosis (IPAA). Development of denovo Crohn's disease (CD) following IPAA is an increasingly common and devastating complication, sometimes progressing to pouch failure. Read More

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Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia.

J Clin Oncol 2021 Jun 22:JCO2001739. Epub 2021 Jun 22.

Cellerant Therapeutics, San Carlos, CA.

Purpose: Standard cytotoxic induction chemotherapy for acute myeloid leukemia (AML) results in prolonged neutropenia and risk of infection. Romyelocel-L is a universal, allogeneic myeloid progenitor cell product being studied to reduce infection during induction chemotherapy.

Patients And Methods: One hundred sixty-three patients with de novo AML (age ≥ 55 years) receiving induction chemotherapy were randomly assigned on day 0 (d0), of whom 120 were evaluable. Read More

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Analysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: a retrospective study.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):4149-4155

Infectious Diseases and Clinical Microbiology, Bezmialem Vakif University, Istanbul, Turkey.

Objective: SARS-CoV-2 primarily infects the respiratory tract and leads to severe pneumonia by binding to the ACE-2 receptor. The virus can also interact with ACE-2 receptors expressed in other tissues as in thyroid. This study predicted the complications involving the thyroid in patients with suspected SARS-CoV-2. Read More

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Efficacy and tolerability of a novel galactomannan-based formulation for symptomatic treatment of gastroesophageal reflux disease: a randomized, double-blind, placebo-controlled study.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):4128-4138

Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.

Objective: Proton Pump Inhibitors (PPIs) and traditional antacids are the common standard set of therapy for the management of gastroesophageal reflux disease (GERD) symptoms. The aim of the current study was to evaluate efficacy and safety of a novel galactomannan-based liquid formulation in reducing typical GERD symptoms in patients not taking PPIs.

Patients And Methods: This was a single-center, randomized, double-blind, placebo-controlled study. Read More

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[Trigeminal radiculopathy in vestibular schwannomas].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(3):29-43

Treatment and Rehabilitation Center, Moscow, Russia.

Objective: To evaluate the correlation of trigeminal radiculopathy with anatomical relationships of trigeminal nerve root, brainstem, tumors and vessels in patients with vestibular schwannomas.

Material And Methods: A retrospective analysis included 153 patients (106 females and 47 males aged 22-82 years) with vestibular schwannomas who underwent surgery via retromastoid approach. Preoperative trigeminal radiculopathy (facial pain and sensory disturbances) was examined after microsurgical resection. Read More

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January 2021

Extracorporeal Membrane Oxygenation for Septic Shock in Children.

ASAIO J 2021 May 10. Epub 2021 May 10.

From the *ECMO Centre Karolinska, Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden †Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Extracorporeal membrane oxygenation (ECMO) is a rescue treatment used in children and adults with reversible cardiorespiratory failure. The role of ECMO is not fully established in pediatric sepsis. In this retrospective single-center study, we aimed to investigate risk factors and survival in pediatric septic shock supported with peripheral cannulation ECMO. Read More

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The prognostic value of squamous differentiation in endometrioid type endometrial cancer: a matched analysis.

J Obstet Gynaecol 2021 Jun 22:1-7. Epub 2021 Jun 22.

Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey.

We aimed to examine the effect of the squamous differentiation on survival outcomes of women with endometrioid adenocarcinoma. We retrospectively reviewed the patients with endometrioid adenocarcinoma who underwent primary surgical treatment in a tertiary referral hospital. Sixty-nine patients having squamous differentiation constituted the case group. Read More

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The Prevalence of Anaemia in a District General Hospital in the United Kingdom.

Cureus 2021 May 18;13(5):e15086. Epub 2021 May 18.

Gastroenterology and Hepatology, Royal Wolverhampton Hospital Trust, Wolverhampton, GBR.

Aim Investigating the prevalence of hospital-acquired anaemia in a United Kingdom (UK) secondary care setting to describe the level of appropriate management prior to discharge back to primary care. Design and settings An observational study of 13 medical and surgical wards in a UK district general hospital. Method Single-day examination of notes, blood results and drug charts, with a 30-day follow up, using pre-set definitions of anaemia and exclusion criteria. Read More

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Intraoperative Radiotherapy for Breast Cancer in Elderly Women.

Clin Breast Cancer 2021 May 15. Epub 2021 May 15.

Radiation Oncology Department, Saint-Louis Hospital, Paris, France; Breast Cancer Unit, Saint-Louis Hospital, Paris, France. Electronic address:

Purpose: To evaluate outcomes and postoperative toxicities after intraoperative radiotherapy (IORT) in elderly women.

Population: Women older than 65 years, with infiltrating ductal breast cancer ≤3 cm, expressing estrogen receptor (ER+) without Her2 overexpression, and with negative axillary nodes.

Treatment: Treatment consisted of partial mastectomy with a sentinel lymph node biopsy (SLNB) procedure; in case of positive SLNB, IORT was cancelled. Read More

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Factors affecting prognosis of the patients with severe hyponatremia.

Nefrologia 2021 Jun 18. Epub 2021 Jun 18.

Nephrology, Bahcelievler Medical Park Hospital, Altinbas University, Istanbul, Turkey.

Introduction: Hyponatremia is one of the most common electrolyte abnormalities in clinical practice. Data regarding factors that have impact on mortality of severe hyponatremia and outcomes of its therapeutic management is insufficient. The present study aimed to examine the factors associated with mortality and the outcomes of treatment in patients with severe hyponatremia. Read More

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Prevalence and Phenotype Associations of Complement Factor I Mutations in Geographic Atrophy.

Hum Mutat 2021 Jun 21. Epub 2021 Jun 21.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Rare variants in the Complement Factor I (CFI) gene, associated with low serum Factor I (FI) levels, are strong risk factors for developing the advanced stages of Age-Related Macular Degeneration (AMD). No studies have been undertaken on the prevalence of disease-causing CFI mutations in patients with Geographic Atrophy (GA) secondary to AMD. A multi-centre, cross-sectional, non-interventional study was undertaken to identify the prevalence of pathogenic rare CFI gene variants in an unselected cohort of patients with GA and low FI levels. Read More

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Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.

PLoS One 2021 21;16(6):e0252859. Epub 2021 Jun 21.

Faculty of Dentistry, Department of Restorative Dentistry, Unit of Periodontology, Universiti Kebangsaaan Malaysia, Kuala Lumpur, Malaysia.

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Read More

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Biomarkers of fatty acid intake are independently associated with preclinical atherosclerosis in individuals with type 1 diabetes.

Eur J Nutr 2021 Jun 18. Epub 2021 Jun 18.

Endocrinology and Nutrition Department, Hospital Clinic de Barcelona, Carrer de Villarroel, 170, 08036, Barcelona, Spain.

Purpose: Information on the association between diet and cardiovascular disease (CVD) in type 1 diabetes (T1D) is scarce. We assessed the association between biomarkers of fatty acid (FA) intake and the presence of carotid plaques (a surrogate marker of future CVD events) in this high-risk population.

Methods: Cross-sectional study in 167 consecutive T1D patients without CVD and with at least one of the following: ≥ 40 years, diabetic nephropathy, or ≥ 10 years of T1D duration with another CVD risk factor. Read More

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Characteristics of persistent postural perceptual dizziness patients in a multidisciplinary dizziness clinic.

J Vestib Res 2021 Jun 11. Epub 2021 Jun 11.

Division of Neurology, Department of Internal Medicine, University of Ottawa, Ontario, Canada.

Background: Persistent Postural Perceptual Dizziness (PPPD) is a newly defined condition which was added to the International Classification of Vestibular Disorders in 2017. Little is known about its impact on patients.

Objective: The goal of this study was to analyze the symptomology, epidemiology and impact of PPPD on patients. Read More

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Chronic low back pain changes the latissmus dorsi and gluteus maximus muscles activation pattern and upward scapular rotation: A cross-sectional study.

J Back Musculoskelet Rehabil 2021 Jun 18. Epub 2021 Jun 18.

Basic Science Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Patients with chronic low back pain (LBP) have an impaired dynamic spinal stability, which may lead to arm injuries.

Objectives: To examine the latissimus dorsi and gluteus maximus muscles activation pattern and the upward scapular rotation in patients with chronic LBP.

Methods: Sixty-one right-handed males were divided into two groups: chronic LBP group (n= 31) and healthy controls (n= 30). Read More

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Using a novel smartphone application for capturing of patient-reported outcome measures among patients with inflammatory arthritis:A randomized, crossover, agreement study.

Scand J Rheumatol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.

: In Denmark, patients with inflammatory arthritis (IA) have completed patient-reported outcome measures (PROMs) via touchscreens in the outpatient clinic since 2006. However, current technology makes it possible for patients to use their own smartphone via an application (app) developed for the Danish Rheumatology Database (DANBIO). This study aims to evaluate the agreement of PROMs between the DANBIO app and outpatient touchscreen in patients with IA. Read More

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Psychosocial Health Effects Of Covid-19 Infection On Persons In Treatment Centers In Lagos, Nigeria.

Brain Behav Immun Health 2021 Jun 15:100284. Epub 2021 Jun 15.

Department of Community Health and Primary Care, College of Medicine University of Lagos, Lagos, Nigeria.

Introduction: Prior research has highlighted the psychosocial impact of infectious diseases on individuals and the community at large. However, little is known about the psychosocial implications of COVID-19. This study set out to determine the rate as well as correlates of anxiety and depressive symptoms among persons managed as in-patients for COVID-19 in Lagos, Nigeria. Read More

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Prediction of Impending Septic Shock in Children With Sepsis.

Crit Care Explor 2021 Jun 15;3(6):e0442. Epub 2021 Jun 15.

Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD.

Objectives: Sepsis and septic shock are leading causes of in-hospital mortality. Timely treatment is crucial in improving patient outcome, yet treatment delays remain common. Early prediction of those patients with sepsis who will progress to its most severe form, septic shock, can increase the actionable window for interventions. Read More

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Skin lesions in children during the first wave of the SARS-CoV-2 pandemic.

Med Clin (Engl Ed) 2021 Jun 12. Epub 2021 Jun 12.

Unidad de Reumatología Pediátrica, UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: Cutaneous manifestations have been included in COVID-19 patients' clinical spectrum. Our objective was to determine the association between skin lesions in children and SARS-CoV2 infection, analyzing others possible infectious/autoimmune etiologies.

Material And Methods: Observational, multicenter, cross-sectional study, about children with skin manifestations from April to May 2020. Read More

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The Possible Factors Correlated with The Higher Risk of Getting Infected by COVID-19 in Emergency Medical Technicians; A Case-Control Study.

Bull Emerg Trauma 2021 Apr;9(2):67-72

School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: To assess the possible factors associated with increasing risk of COVID-19 among EMTs.

Methods: This study was a case-control study conducted in Tehran, Iran. Case group was consisted of confirmed COVID-19 EMTs based on the results of reverse transcriptase polymerase chain reaction and/or lung computed tomography scan. Read More

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Adding Ozone to Dextrose and Somatropin for Intra-articular Knee Prolotherapy: A Randomized Single-Blinded Controlled Trial.

Anesth Pain Med 2020 Oct 7;10(5):e110277. Epub 2020 Nov 7.

Division of Pain Medicine, Department of Anesthesiology, College of Medicine, University of Illinois, Chicago, USA.

Background: Prolotherapy, as an alternative therapy, has emerged as an effective treatment for chronic musculoskeletal injury, including knee osteoarthritis (OA). Several studies have mention ozone as a potential treatment for these diseases, which is based on analgesic, anti-inflammatory, and anti-oxidant.

Objectives: The current study aimed to investigate the effect of adding ozone gas to hypertonic dextrose and somatropin for knee prolotherapy in patients with knee OA. Read More

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October 2020

Trigger Site Deactivation Surgery for Headaches is Associated with Decreased Postoperative Medication Use.

Plast Reconstr Surg Glob Open 2021 Jun 15;9(6):e3634. Epub 2021 Jun 15.

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

Patients with chronic headaches suffer debilitating pain, which often leads to the use of numerous medications. Trigger site deactivation surgery has emerged as an effective treatment for select headache patients. This study aims to describe the preoperative and postoperative medication use among patients undergoing trigger site deactivation. Read More

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Diagnostic value of nuclear medicine imaging and ultrasonography in subacute thyroiditis.

Am J Transl Res 2021 15;13(5):5629-5634. Epub 2021 May 15.

Department of Ultrasound, The Second People's Hospital of Dongying Dongying, Shandong Province, China.

Objective: To analyze and compare the diagnostic value of nuclear medicine and ultrasonography in subacute thyroiditis.

Methods: Sixty patients with subacute thyroiditis admitted to our hospital were included into the observation group, and 60 healthy controls who underwent physical examination in our hospital during the same period were enrolled into the control group. Examinations of nuclear medicine and ultrasonography were performed in the neck, and the results were compared between the two groups. Read More

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Application of regional cerebral oxygen saturation monitoring with near-infrared spectroscopy in peri-anesthesia management of elderly hypertensive patients undergoing shoulder arthroscopic surgery.

Authors:
Zhili Jing Di Wu

Am J Transl Res 2021 15;13(5):5568-5574. Epub 2021 May 15.

Department of Anesthesiology, Beijing Luhe Hospital, Capital Medical University Beijing, China.

Objective: To explore the effect of using regional cerebral oxygen saturation (rScO) monitoring with near-infrared spectroscopy in peri-anesthesia management of elderly hypertensive patients undergoing shoulder arthroscopic surgery.

Methods: Sixty elderly patients with hypertension undergoing shoulder arthroscopic surgery under general anesthesia were enrolled as the research objects for this prospective study, and they were randomly divided into an observation group and a control group. The observation group received bispectral index (BIS) + rScO, while the control group only adopted BIS. Read More

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Accuracy of Urinary Etiocholanolone/Androsterone Ratio as Alternative to Serum Testosterone/Dihydrotestosterone Ratio for Diagnosis of 5 Alpha-reductase Type 2 Deficiency Patients and Carriers in Indonesia.

Int J Endocrinol Metab 2021 Apr 18;19(2):e109510. Epub 2021 Apr 18.

Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: The 5 Alpha-reductase type 2 deficiency (5ARD2) is an inherited condition, which clinically presents as variable degrees of under virilization in affected 46,XY individuals. In the diagnostic pathway of 5ARD2, the testosterone/dihydrotestosterone (T/DHT) ratio is broadly employed before molecular analysis of the SRD5A2 gene. However, due to cost-benefit considerations, the DHT test in our country is routinely lacking in clinical settings; therefore, we considered applying the urinary etiocholanolone/androsterone (Et/An) ratio as an alternative test. Read More

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Pain associated with arteriovenous fistula cannulation: Still a problem.

Nephrol Ther 2021 Jun 17. Epub 2021 Jun 17.

Centre de néphrologie de Montargis, Bbraun-Avitum, 658 bis, rue des Bourgoins, 45200 Amilly, France.

Context: Puncture-related pain during arteriovenous fistula cannulation is a crucial influential factor in the quality of life of chronic hemodialysis patients.

Objectives/methods: In this prospective single center study, we used a questionnaire to evaluate the patterns of pain of arteriovenous fistula cannulation in a group of hemodialysis patients.

Results: From a total of 123 eligible patients with arteriovenous fistula invited to participate, 83 (58 M/25 F) (median age 58 y. Read More

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[Clinical features and prognosis of anastomotic leak after anterior resection for rectal cancer following neoadjuvant chemoradiotherapy].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Jun;24(6):513-522

Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou 510655, China.

To explore clinical features and prognosis of anastomotic leak (AL) after anterior resection following neoadjuvant chemoradiotherapy for rectal cancer patients. A retrospective cohort study was performed. Data were retrieved from colorectal cancer database of the Sixth Affiliated Hospital, Sun Yat-sen University. Read More

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Lateral Wall Dysfunction Signals Onset of Progressive Heart Failure in Left Bundle Branch Block.

JACC Cardiovasc Imaging 2021 Jun 10. Epub 2021 Jun 10.

Institute for Surgical Research, Rikshospitalet, Oslo University Hospital and University of Oslo, Oslo, Norway; Department of Cardiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

Objectives: This study sought to investigate if contractile asymmetry between septum and left ventricular (LV) lateral wall drives heart failure development in patients with left bundle branch block (LBBB) and whether the presence of lateral wall dysfunction affects potential for recovery of LV function with cardiac resynchronization therapy (CRT).

Background: LBBB may induce or aggravate heart failure. Understanding the underlying mechanisms is important to optimize timing of CRT. Read More

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