74 results match your criteria sixth bacteraemia


DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages.

Biochem Pharmacol 2021 02 28;184:114399. Epub 2020 Dec 28.

Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China. Electronic address:

Dedicator of cytokinesis 2 (DOCK2), an atypical Rac activator, has important anti-inflammatory properties in blepharitis, enteric bacterial infection and colitis. However, the roles of DOCK2 in macrophage activation and acute lung injury (ALI) are still poorly elucidated. In vitro studies demonstrated that DOCK2 was essential for the nucleotide-sensing Toll-like receptor (TLR) 4-mediated inflammatory response in macrophages. Read More

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February 2021

Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Sepsis Outcome Programme (GNSOP) Annual Report 2019.

Commun Dis Intell (2018) 2020 Oct 15;44. Epub 2020 Oct 15.

Antimicrobial Resistance and Infectious Diseases (AMRID) Research Laboratory, Murdoch University, Murdoch, Western Australia, Australia.

The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric gram-negative pathogens. The 2018 survey was the sixth year to focus on bloodstream infections, and included Enterobacterales, and species. Eight thousand eight hundred and fifty-seven isolates, comprising Enterobacterales (7,983; 90. Read More

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October 2020

Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Sepsis Outcome Programme (GNSOP) Annual Report 2018.

Commun Dis Intell (2018) 2020 Oct 15;44. Epub 2020 Oct 15.

Antimicrobial Resistance and Infectious Diseases (AMRID) Research Laboratory, Murdoch University, Murdoch, Western Australia, Australia; and Department of Microbiology, PathWest Laboratory Medicine-WA, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric gram-negative pathogens. The 2018 survey was the sixth year to focus on bloodstream infections, and included Enterobacterales, and species. Eight thousand three hundred and fifty isolates, comprising Enterobacterales (7,512, 90. Read More

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October 2020

[Diagnostic Value of ROC Curve Evaluating Serum Related Indexes for Bloodstream Infection in Patients with Hematopathy].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Oct;28(5):1746-1749

Department of Laboratorial Medicine, The First Hospital of Ningbo, Ningbo 315010, Zhejiang Province, China.

AbstractObjective: To evaluate the diagnostic value of serum PCT, CRP and SAA for bloodstream infection(BSI) in patients with hematopathy.

Methods: Sixty hematopathy patients with bloodstream infection from July 2016 to June 2018 were selected and enroued in bloodstream infection group. Sixty-five patients with negative blood culture during the same period were selected and enrolled in non-bloodstream infection group. Read More

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October 2020

Periodontitis and Cardiovascular Diseases. Consensus Report.

Glob Heart 2020 02 3;15(1). Epub 2020 Feb 3.

Department of Prosthetic Dentistry, School of Dental Medicine, Karl-Franzens University Graz, AT.

Background: In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths. Periodontitis is also a chronic non-communicable disease (NCD) with a high prevalence, being severe periodontitis, affecting 11. Read More

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February 2020

Multiorganism sepsis secondary to enteric aorto-iliac graft fistulation.

BMJ Case Rep 2020 May 27;13(5). Epub 2020 May 27.

Gastroenterology, Mater Dei Hospital, Msida, Malta.

A woman in her early 70s with a history of infrarenal aortic endarterectomy and aorto-bi-iliac Dacron grafting 4 years before presented with recurrent septicaemias, occasionally polymicrobial and caused by a wide variety of organisms. After treatment for her sixth bacteraemia, enteroscopy showed a small area of ulceration with synthetic graft material protruding into the distal duodenal lumen. This was followed by positron emission tomography/CT, which showed mild increase in tracer uptake in the same region localised by a previously placed haemoclip. Read More

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Intestinal methicillin-resistant causes prosthetic infection via 'Trojan Horse' mechanism: Evidence from a rat model.

Bone Joint Res 2020 Apr 16;9(4):152-161. Epub 2020 May 16.

Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China; Institute of Microsurgery on Extremities, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.

Aims: Methicillin-resistant (MRSA) can cause wound infections via a 'Trojan Horse' mechanism, in which neutrophils engulf intestinal MRSA and travel to the wound, releasing MRSA after apoptosis. The possible role of intestinal MRSA in prosthetic joint infection (PJI) is unknown.

Methods: Rats underwent intestinal colonization with green fluorescent protein (GFP)-tagged MRSA by gavage and an intra-articular wire was then surgically implanted. Read More

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Improved oral hygiene is associated with decreased risk of new-onset diabetes: a nationwide population-based cohort study.

Diabetologia 2020 05 2;63(5):924-933. Epub 2020 Mar 2.

Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, 260, Gonghang-daero, Gangseo-gu, 07804, Seoul, Republic of Korea.

Aims/hypothesis: Inflammation plays an important role in the development of diabetes, a major global health problem. Periodontal disease is also common in the general population. Because periodontal disease and poor oral hygiene can provoke transient bacteraemia and systemic inflammation, we hypothesised that periodontal disease and oral hygiene indicators would be associated with the occurrence of new-onset diabetes. Read More

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[Meningococcemia: Different Serotypes in the Same Region].

Mikrobiyol Bul 2020 Jan;54(1):163-170

Ministry of Health, General Directorate of Public Health, National Respiratory Pathogens Reference Laboratory, Ankara, Turkey.

Meningococcal infections are important health problems causing high morbidity and mortality. Neisseria meningitidis have 13 serogroups. A, B, C, Y and W135 are the most common causes of invasive disease among those serogroups. Read More

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January 2020

Bilateral abducens nerve palsy due to septic thrombophlebitis.

Am J Ophthalmol Case Rep 2019 Dec 31;16:100566. Epub 2019 Oct 31.

Ratner Children's Eye Center at the University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, USA.

Purpose: To report a case of septic thrombophlebitis producing bilateral abducens nerve palsy.

Observation: A 65 year-old woman with recent sinus surgery experienced the onset of horizontal diplopia during treatment for bacteremia. Computer tomography of head and a neck ultrasonography showed right internal jugular vein occlusion. Read More

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December 2019

Ovarian abscess caused by Salmonella enterica serovar Typhi: a case report.

J Med Case Rep 2019 Sep 25;13(1):303. Epub 2019 Sep 25.

Labasa Hospital, Ministry of Health and Medical Services, Labasa, Fiji.

Background: Typhoid fever is a human-specific disease caused by a bacterium, Salmonella enterica subspecies enterica serovar Typhi. It is transmitted through ingestion of contaminated food or water. It is mostly diagnosed by blood culture. Read More

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September 2019

Candidemia complicating biliary atresia in an infant with hemoglobinopathy.

Turk Pediatri Ars 2019 11;54(2):129-132. Epub 2019 Jul 11.

Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Both biliary atresia and hemoglobinopathies have been associated with a higher incidence of bloodstream infections. We hereby present the case of a female infant of Nigerian descent with extrahepatic biliary atresia and double heterozygocity for sickle cell disease and alpha-thalassemia. Kasai hepatoportoenterostomy was performed in the child's sixth week of life. Read More

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Refractory bacteraemia from a consolidation pneumonia lasting more than 7 weeks, successfully treated with systemic antibiotics and nebulised meropenem.

BMJ Case Rep 2019 Aug 2;12(8). Epub 2019 Aug 2.

Department of Medicine (Division of Infectious Diseases), University of the Philippines-Philippine General Hospital, Manila, Philippines.

We present a case of a 55-year-old Filipino man who was transferred from another institution where he was recently diagnosed with Crohn's disease but not started on any immunosuppressants. He underwent laparoscopic cholecystectomy with T-tube placement a few weeks prior to admission. On workup, abdominal CT scan was unremarkable, but blood cultures on the third hospital day grew Antibiotic regimen was shifted to ceftazidime and levofloxacin. Read More

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Mortality dynamics of Pseudomonas aeruginosa bloodstream infections and the influence of defective OprD on mortality: prospective observational study.

J Antimicrob Chemother 2019 09;74(9):2774-2783

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.

Background: To assess the mortality dynamics of patients with Pseudomonas aeruginosa bloodstream infections (BSIs) and the influence of OprD deficiencies of the microorganism on early mortality.

Methods: A prospective multicentre observational study was conducted with 120 patients with P. aeruginosa BSIs occurring between May 2016 and April 2017 in six general hospitals in South Korea. Read More

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September 2019

Etiology, Risk Factors and Outcome of 1003 Cases of Infective Endocarditis from a 33-year National Survey in the Slovak Republic: An increasing proportion of elderly patients.

Neuro Endocrinol Lett 2019 Mar;39(8):544-549

North London Postgraduate Medical School, London, UK.

Background: Infective endocarditis (IE) is still a significant cause of mortality in European hospitals, despite of the fact, that large nationwide studies were performed in last twenty years and pathogens are well known. The aim of the study was to assess risk factors, mortality, etiology and proportion of elderly patients within a longitudinal nation wide survey of infectious endocarditis in Slovakia.

Patients And Methods: Etiology, risk factors and outcome of 1003 cases of infective endocarditis (IE) in Slovakia over the last 33 years have been assessed. Read More

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Tigecycline treatment in an infant with extensively drug-resistant Acinetobacter baumannii bacteremia.

Int J Infect Dis 2017 Aug 29;61:23-26. Epub 2017 May 29.

Department of Pediatric Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

The successful use of tigecycline in a 12-month old liver transplant recipient with extensively drug-resistant Acinetobacter baumannii bacteremia is presented. Tigecycline serum concentrations were monitored to help improve antibiotic efficacy and minimize side effects. A literature review identified 11 additional pediatric cases of A. Read More

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[Successful Prophylactic Minocycline Treatment for Recurrent Helicobacter Cinaedi Sepsis during Chemotherapy in a Patient with Follicular Lymphoma].

Gan To Kagaku Ryoho 2017 May;44(5):433-435

Dept. of Internal Medicine, Kohsei Chuo General Hospital.

A 63-year-old man with follicular lymphoma was administered standard R-CHOP chemotherapy. Six days after the second course of chemotherapy, the patient developed fever and chills. Blood cultures yielded rod-shaped gram-negative bacteria, but no further identification was obtained. Read More

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A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection.

Int J Nanomedicine 2017 18;12:3121-3136. Epub 2017 Apr 18.

Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University.

Bloodstream infection, especially with implants involved, is an often life-threatening condition with high mortality rates, imposing a heavy burden on patients and medical systems. Herein, we firstly deposited homogeneous vanadium metal, VO, VO, and VO nanofilms on quartz glass by magnetron sputtering. Using these platforms, we further investigated the potential antimicrobial efficiency of these nano-VO films and the interactions of human erythrocytes and bacteria (methicillin-resistant and ) with our samples in a novel cell-bacteria coculture model. Read More

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September 2017

A Standardized Regimen for the Treatment of Acute Postoperative Infections and Acute Hematogenous Infections Associated With Hip and Knee Arthroplasties.

J Arthroplasty 2017 04 20;32(4):1255-1261. Epub 2016 Oct 20.

Clinic of Joint Replacement, General and Rheumatic Orthopaedics, Orthopaedic Clinic Markgröningen gGmbH, Markgröningen, Germany.

Background: Papers concerning the treatment of periprosthetic infections and acute hematogenous infections often concern inhomogeneous treatment concepts or low numbers of patients; this results in inconsistent rates of treatment success.

Methods: Thirty-nine patients with early periprosthetic infections and 28 patients with acute hematogenous infections were treated with a homogeneous concept and followed with a mean period of 41.8 (24-132) months in order to investigate the success rate and influencing factors. Read More

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Intra-Abdominal Abscess and Primary Peritonitis Caused by Streptococcus anginosus.

Jundishapur J Microbiol 2016 Jun 17;9(6):e33863. Epub 2016 May 17.

Department of Clinical Microbiology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Introduction: The Streptococcus anginosus group of bacteria are low-virulence bacteria existing as commensals in the oral flora and gastrointestinal tracts of humans. S. anginosus may spread to the blood in individuals with poor oral hygiene in cases of oral infections, such as gingivitis and tooth abscesses, that develop following the loss of mucosal unity. Read More

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[Analysis of 117 episodes of enterococcal bacteremia: Study of epidemiology, microbiology and antimicrobial susceptibility].

Rev Argent Microbiol 2016 Oct - Dec;48(4):298-302. Epub 2016 Aug 24.

Departamento Bacteriología, Laboratorio Central, Hospital Nacional de Clínicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Enterococcal bacteremia has acquired considerable importance in recent years, mainly due to an increased number of cases that occur during hospital admission. We describe the episodes of enterococcal bacteremia in adult patients recorded at our hospital. Between January 2000 and December 2013, 117 episodes were analyzed. Read More

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Characterization of Teicoplanin Nonsusceptible Staphylococcus epidermidis Clinical Isolates Belonging Predominantly to ST267.

Microb Drug Resist 2017 Apr 17;23(3):321-327. Epub 2016 Jun 17.

1 Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, People's Republic of China .

Staphylococcus epidermidis is the main cause of bacteremia and infections of indwelling catheters, glycopeptide antibiotics are often considered as the choice of empirical drugs for the treatment of staphylococcal infections. In the present study, 12 teicoplanin nonsusceptible S. epidermidis isolates were collected between January and October 2013. Read More

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The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial.

Oncotarget 2016 Feb;7(7):8432-40

Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.

This study was designed to mainly evaluate the anti-infective effects of perioperative probiotic treatment in patients receiving confined colorectal cancer (CRC) respective surgery. From November 2011 to September 2012, a total of 60 patients diagnosed with CRC were randomly assigned to receive probiotic (n = 30) or placebo (n = 30) treatment. The operative and post-operative clinical results including intestinal cleanliness, days to first - flatus, defecation, fluid diet, solid diet, duration of pyrexia, average heart rate, length of intraperitoneal drainage, length of antibiotic therapy, blood index changes, rate of infectious and non-infectious complications, postoperative hospital stay, and mortality were investigated. Read More

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February 2016

Antimicrobial Resistance and Molecular Epidemiology of Escherichia coli Causing Bloodstream Infections in Three Hospitals in Shanghai, China.

PLoS One 2016 29;11(1):e0147740. Epub 2016 Jan 29.

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Escherichia coli (E. coli) is one of the most frequent and lethal causes of bloodstream infections (BSIs). We carried out a retrospective multicenter study on antimicrobial resistance and phylogenetic background of clinical E. Read More

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Vascular Access Creation and Care--Perspective From India.

Adv Chronic Kidney Dis 2015 Nov;22(6):466-70

Department of Nephrology, Meenakshi Mission Hospital and Research Centre, Madurai, Tamil Nadu, India; Department of Nephrology, KEM Hospital, Pune, Maharashtra, India; Department of Nephrology, Kidney Care Centre, Tirunelveli, Tamil Nadu, India; Department of Nephrology, Goa Medical College, Goa, India; Department of Nephrology, University of Wisconsin, Madison, WI; Department of Nephrology, Henry Ford Hospital, Detroit, MI.

India has one of the fastest growing economies in the world and is home to nearly one sixth of world's population. Chronic diseases such as diabetes mellitus and hypertension are common. Kidney disease is a known complication of these chronic diseases and is on the rise. Read More

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November 2015

[Brucellosis as a cause of hemophagocytic syndrome].

Mikrobiyol Bul 2015 Apr;49(2):292-4

Samsun Education and Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.

Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of excessive inflammation and tissue destruction due to abnormal immune activation and inflammation. HLH can occur primarily due to genetic etiology, or secondarily associated with malignancies, autoimmmune diseases or infections. There are a number of reports that revealed the relationship of hemophagocytosis with brucellosis. Read More

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Staphylococcus lugdunensis bacteremia and endocarditis treated with cefazolin and rifampin.

Am J Health Syst Pharm 2015 Jul;72(13):1114-8

Bryson Duhon, Pharm.D., BCPS, is Clinical Assistant Professor, Division of Pharmacotherapy, College of Pharmacy, University of Texas at Austin, Austin, and Clinical Pharmacist, University Health System (UHS), San Antonio, TX. Steven Dallas, Ph.D., D(ABMM), MT(ASCP)SM, is Assistant Professor, Department of Clinical Laboratory Sciences, University of Texas Health Science Center (UTHSC) at San Antonio, San Antonio, and Director, Microbiology Laboratory, UHS. Sadie T. Velasquez, M.D., is Assistant Professor of Medicine, Department of Medicine, Division of Hospital Medicine, UTHSC at San Antonio. Elizabeth Hand, Pharm.D., BCPS, is Clinical Pharmacist, UHS, and Clinical Assistant Professor, Division of Pharmacotherapy, College of Pharmacy, University of Texas at Austin.

Purpose: This case report describes the treatment of a rare infection caused by Staphylococcus lugdunensis with cefazolin and rifampin.

Summary: A 48-year-old man with significant comorbidities was admitted to our institution with complaints of malaise, shortness of breath, and vague persistent pain. He was diagnosed with S. Read More

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A coagulase-negative and non-haemolytic strain of Staphylococcus aureus for investigating the roles of SrtA in a murine model of bloodstream infection.

Pathog Dis 2015 Aug 7;73(6):ftv042. Epub 2015 Jun 7.

College of Animal Science, Jilin University, Changchun 130062, China

Sortase A (SrtA) is a cysteine transpeptidase and virulence factor from Staphylococcus aureus (S. aureus) that catalyses the attachment and display of surface proteins on the cell wall, thereby mediating bacterial adhesion to host tissues, host-cell entry and evasion of the immune response. As a result, SrtA has become an important target in the development of therapies for S. Read More

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Transfusion-associated Anaplasma phagocytophilum infection in a pregnant patient with thalassemia trait: a case report.

Transfusion 2015 Apr 11;55(4):719-25. Epub 2014 Nov 11.

Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Background: Human granulocytic anaplasmosis (HGA) is an acute nonspecific febrile illness caused by the bacterium Anaplasma phagocytophilum. Although usually transmitted via tick bite, HGA may rarely also be acquired through transfusion. HGA during pregnancy may pose significant gestational risks due to altered maternal immune status and the potential for perinatal transmission. Read More

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[Diabetes and periodontitis: A bidirectional relationship].

Med Clin (Barc) 2015 Jul 3;145(1):31-5. Epub 2014 Sep 3.

Departamento de Odontología Conservadora, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, España.

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, a defect in insulin action or a combination of both. Periodontitis is now considered a chronic localized infection of the oral cavity that can trigger inflammatory host immune responses at local and systemic levels, and can also be a source of bacteremia. It is now known that periodontitis has an influence on the pathogenesis of certain systemic diseases. Read More

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