28,186 results match your criteria sinusitis


Benralizumab Improves Symptoms of Patients with Severe, Eosinophilic Asthma with a Diagnosis of Nasal Polyposis.

Allergy 2021 May 12. Epub 2021 May 12.

AstraZeneca, Barcelona, Spain.

Background: Clinically meaningful improvement in the Sino-Nasal Outcome Test-22 (SNOT-22) was observed in patients with severe, eosinophilic asthma and nasal polyposis (NP) treated with benralizumab in the ANDHI trial. Apost-hoc assessment of the effects of benralizumab on SNOT-22 response and asthma efficacy measures in these patients was conductedfor further characterization of the efficacy and safety of benralizumab for patients with severe asthma and NP.

Methods: Adults with severe, eosinophilic asthma who had experienced ≥2 prior-year exacerbations despite high-dosage inhaled corticosteroid plus additional controller[s] were randomised to 24 weeks of benralizumab or placebo. Read More

View Article and Full-Text PDF

Central Retinal Artery Occlusion Due to Subperiosteal Orbital Abscess Caused by Acute Sinusitis in a Child: A Case Report.

Ear Nose Throat J 2021 May 12:1455613211016731. Epub 2021 May 12.

Department of Otolaryngology Head and Neck Surgery, 117747Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, Shandong Province, China.

Central retinal artery occlusion (CRAO) is an ophthalmic emergency and has poor visual prognosis. It is commonly found in elderly people and very rare in child. We reported an 8-year-old girl who suffered from acute sinusitis, periorbital swelling, and the visual acuity of her right eye was only light perception. Read More

View Article and Full-Text PDF

Safety of a New Sinus Irrigation Device in Rhinosinusitis: A Pilot Study.

Ear Nose Throat J 2021 May 12:1455613211015417. Epub 2021 May 12.

26736Hillel Yaffe Medical Center, Hadera, Israel, Technion Faculty of Medicine, Haifa, Israel.

Background: Puncture and lavage of the paranasal sinuses, previously the primary treatment for unresponsive acute bacterial rhinosinusitis before surgery, has been abandoned due to procedural discomfort and advancements in antibiotic efficacy and endoscopic surgery. The rise in antibiotic-resistant bacteria has renewed the interest in minimally invasive sinus lavage to both avoid aggressive surgical interventions and identify appropriate antibiotic therapy. In this article, we describe the safety and feasibility of a new device in human patients and evaluate its efficacy as a treatment before the traditional sinus surgery in acute rhinosinusitis. Read More

View Article and Full-Text PDF

E-Cigarette Burns and Explosions: What are the Patterns of Oromaxillofacial Injury?

J Oral Maxillofac Surg 2021 Mar 29. Epub 2021 Mar 29.

William Beaumont Hospital - Royal Oak, Department of Otolaryngology, Royal Oak, MI.

Purpose: With the recent increase in popularity of electronic cigarette use in the United States, its harmful effects are not only limited to smoke inhalation, but also to the possibility of e-cigarette device malfunction. The purpose of this review is to characterize oromaxillofacial trauma secondary to electronic cigarette device explosion.

Methods: For this systematic review, PubMed and Embase were searched in October 2019 using the following search terms: e-cigarette burns, e-cigarette injury, and e-cigarette explosions, which yielded 400 studies. Read More

View Article and Full-Text PDF

Infantile orbital abscess: clinical presentation, microbiological profile, and management outcomes.

Orbit 2021 May 11:1-7. Epub 2021 May 11.

Department of Orbit, Oculoplasty, Reconstructive and Aesthetics, Chennai, India.

: Orbital abscesses in children are not uncommon. Unless managed in a timely fashion, they can potentially lead to vision-threatening as well as life-threatening complications. The objective of this study is to report the clinical and microbiological profile and management outcomes in infants presenting with orbital abscesses. Read More

View Article and Full-Text PDF

Serious fungal disease incidence and prevalence in Indonesia.

Mycoses 2021 May 10. Epub 2021 May 10.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Background: Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden helps policy makers and clinicians.

Objectives: We have estimated the incidence and prevalence of serious fungal diseases. Read More

View Article and Full-Text PDF

Successful early introduction of mepolizumab for peripheral neuropathy with a peripheral circulatory disorder in a patient with myeloperoxidase anti-neutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis.

Mod Rheumatol Case Rep 2021 May 10:1-6. Epub 2021 May 10.

Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

A 26-year-old woman presented with abdominal pain, diarrhoea, vomiting, fever, and progressive paralysis in the lower limbs. She had a history of bronchial asthma and experienced sinusitis, progressive peripheral neuropathy, polyarthritis, and leukocytosis with prominent eosinophilia. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Read More

View Article and Full-Text PDF

The Role of Imaging in the Preoperative Assessment of Patients with Nasal Obstruction and Septal Deviation-A Retrospective Cohort Study.

Int Arch Otorhinolaryngol 2021 Apr 23;25(2):e242-e248. Epub 2020 Jun 23.

Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

 Isolated nasal obstruction (INO) is a common complaint of multiple etiology. The preoperative evaluation of patients presenting with nasal obstruction and deviated nasal septum (DNS) does not typically include imaging. The benefits of performing computed tomography (CT) in the preoperative setting are inconclusive. Read More

View Article and Full-Text PDF

Bacterial Flora in the Sphenoid Sinus Changes with Perioperative Prophylactic Antibiotic Administration.

Neurol Med Chir (Tokyo) 2021 May 8. Epub 2021 May 8.

Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School.

The complications of endonasal transsphenoidal surgery (ETSS) include meningitis and sinusitis, and these complications are troublesome. Some reports have investigated the type of bacteria and the susceptibility of sphenoid sinus mucosal flora to drugs. However, most specimens can be collected after perioperative antibiotic administration. Read More

View Article and Full-Text PDF

Effects of large volume, isotonic nasal saline irrigation for acute rhinosinusitis: a randomized controlled study.

Int Forum Allergy Rhinol 2021 May 7. Epub 2021 May 7.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: The purpose of this study was to compare the effects of nasal saline irrigation (large volume, positive pressure isotonic saline) in addition to standard treatment in patients with acute rhinosinusitis (ARS).

Methods: This parallel, randomized controlled trial was conducted at a tertiary hospital. The adult patients with ARS (age ≥18 years) were randomly assigned to two groups. Read More

View Article and Full-Text PDF

Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis.

Eur Arch Otorhinolaryngol 2021 May 6. Epub 2021 May 6.

Department of Otorhinolaryngology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, Korea.

Purpose: The serum galactomannan test has been used for diagnosing acute invasive fungal sinusitis (AIFS), especially invasive Aspergillus. We aimed to assess the accuracy of the test to diagnose acute invasive Aspergillus sinusitis (AIAS).

Methods: We searched all relevant articles published in PubMed, Embase, the Cochrane Library, and Web of Science databases up until September 14, 2020. Read More

View Article and Full-Text PDF

ANCA-Negative Churg-Strauss Syndrome Presenting as Bilateral Central Retinal Artery Occlusion: A Case Report

Turk J Ophthalmol 2021 04;51(2):127-130

Birjand University of Medical Sciences Valiasr Hospital, Department of Internal Medicine, Birjand, Iran

A 42-year-old man with undiagnosed Churg-Strauss syndrome (CSS) developed bilateral central retinal artery occlusion (CRAO). His medical history included bronchial asthma and irregular prednisolone usage but no atherosclerotic risk factors. At presentation, visual acuity (VA) was hand motion in the right eye and counting fingers in left eye. Read More

View Article and Full-Text PDF

Nasal nitric oxide testing for allergic rhinitis patients: Systematic review and meta-analysis.

Immun Inflamm Dis 2021 May 5. Epub 2021 May 5.

Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: Nasal nitric oxide (nNO) levels in allergic rhinitis (AR), healthy people or nonallergic rhinitis (NAR) have shown contradicting results in previous studies. By meta-analysis, we reviewed studies that measured nNO in AR patients to assess nNO's ability to discriminate AR from healthy people or NAR.

Methods: We systematically searched PubMed, Cochrane, Embase, Ovid, Web of Science, Wanfang Data, CNKI until December 15, 2020. Read More

View Article and Full-Text PDF

Association Between Microbiota and Nasal Mucosal Diseases in terms of Immunity.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea.

The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. Read More

View Article and Full-Text PDF

Microbiology of Acute Maxillary Sinusitis in Children.

Laryngoscope 2021 May 3. Epub 2021 May 3.

Department of Otolaryngology, Matsubara ENT Clinic, Gifu, Japan.

Objectives/hypothesis: Acute rhinosinusitis is a frequent common cold-related complication in children. Despite the need for appropriate treatment, its underlying microbiology remains unclear. This study aimed to investigate the microbiology of acute rhinosinusitis in children. Read More

View Article and Full-Text PDF

Distinct Histopathologic Features of Complicated Sinusitis.

Ann Otol Rhinol Laryngol 2021 May 3:34894211012598. Epub 2021 May 3.

Rush Sinus Program, Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA.

Background: Sinusitis complicated by intracranial or orbital extension can be life-threatening and require emergent intervention. Histologic features of complicated sinusitis have yet to be determined and may have significant implications for understanding pathophysiology.

Methods: A structured histopathology report was utilized to analyze sinus tissue extracted during functional endoscopic sinus surgery (FESS). Read More

View Article and Full-Text PDF

Unexpected foreign body induced refractory maxillary sinusitis.

Clin Case Rep 2021 Apr 20;9(4):2185-2188. Epub 2021 Feb 20.

Department of Otorhinolaryngology- Head and Neck Surgery Sion Hospital Sion Switzerland.

Maxillary sinusitis induced by ipsilateral dental manipulation often carries the risk of sinusal foreign body impaction. Adequate evaluation mandates radiological exploration of the sinus. Management requires complete foreign body removal, surgical drainage of the sinus, and closure of any oroantral communication or fistula. Read More

View Article and Full-Text PDF

Uncommon clinical presentation of a common bug: Group A meningitis.

Paediatr Child Health 2021 Jun 28;26(3):e129-e131. Epub 2020 May 28.

Division of Infectious Diseases, Immunology and Allergy, Department of Pediatrics, University of Ottawa, Ottawa, Ontario.

Group A (GAS) is a common pathogen in paediatric infections. However, it is a rare etiologic agent of bacterial meningitis. We describe a case of meningitis complicated by sensorineural hearing loss in an immunocompetent 7-year-old boy. Read More

View Article and Full-Text PDF

Ultrasonography used in the diagnosis of chronic rhinosinusitis: From experimental imaging to clinical practice.

Exp Ther Med 2021 Jun 14;21(6):611. Epub 2021 Apr 14.

Department of Anatomy, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

There is an increasing incidence of sinusitis cases in outpatient clinics; therefore, new methods for screening and triage are required. Performance of sinus sonography in our outpatient protocol was assessed in order to ascertain the specificity and sensitivity of this imaging method to detect rhinosinusitis. A total of 81 consecutive cases with clinical signs of sinusitis were collected and clinical data compared with sinus sonography results. Read More

View Article and Full-Text PDF

Association of Preinjury Medical Diagnoses With Pediatric Persistent Postconcussion Symptoms in Electronic Health Records.

J Head Trauma Rehabil 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurological Surgery (Drs Yengo-Kahn, Bonfield, and Zuckerman), Vanderbilt Sport Concussion Center (Drs Yengo-Kahn, Bonfield, Gifford, Zuckerman, and Dennis and Ms Hibshman), Division of Epidemiology, Department of Medicine (Mr Torstenson), Vanderbilt Epidemiology Center, Institute for Medicine and Public Health (Mr Torstenson), Vanderbilt Genetics Institute (Mr Torstenson and Drs Davis and Dennis), Department of Neurology (Dr Gifford), and Division of Genetic Medicine, Department of Medicine (Drs Davis and Dennis), Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University School of Medicine, Nashville, Tennessee (Ms Hibshman); British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada (Ms Belikau and Dr Dennis); and Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada (Dr Dennis).

Objective: To identify risk factors and generate hypotheses for pediatric persistent postconcussion symptoms (PPCS).

Setting: A regional healthcare system in the Southeastern United States.

Participants: An electronic health record-based algorithm was developed and validated to identify PPCS cases and controls from an institutional database of more than 2. Read More

View Article and Full-Text PDF

Diversity of cystic fibrosis chronic rhinosinusitis microbiota correlates with different pathogen dominance.

J Cyst Fibros 2021 Apr 27. Epub 2021 Apr 27.

Department of Microbiology & Immunology, University of Minnesota, USA. Electronic address:

Chronic rhinosinusitis (CRS) affects nearly all individuals with cystic fibrosis (CF) and is thought to serve as a reservoir for microbiota that subsequently colonize the lung. To better understand the microbial ecology of CRS, we generated a 16S rRNA gene sequencing profile of sinus mucus from CF-CRS patients. We show that CF-CRS sinuses harbor bacterial diversity not entirely captured by clinical culture. Read More

View Article and Full-Text PDF

Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat sub-inhibitory concentrations.

Allergy 2021 Apr 30. Epub 2021 Apr 30.

Department of Surgery-Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville South, Australia.

Staphylococcus aureus is a pathogen of major concern in both acute infections as well as chronic conditions such as chronic rhinosinusitis (CRS). Bacteriophage (phage) therapy has been considered in Western countries as early as the 1920s and has recently regained interest for its potential to treat infections caused by antibiotic resistant strains including Methicillin Resistant Staphylococcus aureus (MRSA). However, bacteria can adapt and become resistant to phages. Read More

View Article and Full-Text PDF

[Widespread of Scleroma. A rare clinical case].

Vestn Otorinolaringol 2021 ;86(2):93-98

Peoples' Friendship University of Russian, Moscow, Russia.

Scleroma is a chronic infectious disease characterized by developing inflammation nye granulomas, mainly of the upper respiratory tract, with subsequent scarring. The reasons for the development of scleroma remain unclear, but it is generally accepted that the gram-negative coccal bacterium Klebsiella rhinoscleromatis (pas-Volkovich's loch - Frisch) is the causative agent of this disease. Endemic in the spread of scleroma is considered There are tropical and temperate zones such as Africa, Asia, Eastern Europe, South America and Central America. Read More

View Article and Full-Text PDF

[Impact of reslizumab on the course of chronic rhinosinusitis in patients with eosinophilic asthma].

Vestn Otorinolaringol 2021 ;86(2):43-48

Regional clinic hospital, Rostov-on-Don, Russia.

Chronic rhinosinusitis (CRS) with polyps is associated with eosinophilic inflammation, in which the key mediator is interleukin - 5 (IL-5) and is often combined with asthma.

Research Objectives: To evaluate the therapeutic potential of reslizumab-humanized anti-IL-5 monoclonal antibody for the treatment of CRS with polyps in patients with severe asthma.

Patients And Methods: We investigated the cases of 9 patients with severe asthma treated with intravenous reslizumab at a dose of 3 mg per 1 kg of weight with regularity once in 4 weeks. Read More

View Article and Full-Text PDF

Isolated Primary Sinonasal Adenocarcinoma of the Sphenoid Sinus.

Cureus 2021 Mar 26;13(3):e14127. Epub 2021 Mar 26.

Division of Neurological Surgery, University of Missouri School of Medicine, Columbia, USA.

Isolated lesions of the sphenoid sinus, particularly malignancies, are rarely reported and exist largely within the Otolaryngology literature. Delayed diagnosis may necessitate neurosurgical involvement; therefore, neurosurgeons must be aware of the range of pathologies in this region in order to provide adequate treatment. We present an unusual case of an 89-year-old female with several weeks of worsening headaches, vision loss, and cranial neuropathies. Read More

View Article and Full-Text PDF

Exploratory research on asthma exacerbation risk factors using the Japanese claims database and machine learning: A retrospective cohort study.

J Asthma 2021 Apr 29:1-19. Epub 2021 Apr 29.

Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.

Objective: Analytical studies of risk factor assessment using machine learning have recently been reported. We performed an exploratory detection study of asthma exacerbation-related factors using health insurance claims data and machine learning to explore risk factors that have high generalizability and can be easily obtained in daily practice.

Methods: A dataset of asthma patients during May 2014-April 2019 from Japanese health insurance claims database, MediScope® (DB) was used. Read More

View Article and Full-Text PDF

MicroRNA Expression in Extracellular Vesicles from Nasal Lavage Fluid in Chronic Rhinosinusitis.

Biomedicines 2021 Apr 26;9(5). Epub 2021 Apr 26.

Research Institute of Medical Science, Konkuk University School of Medicine, Seoul 05030, Korea.

Extracellular vesicles (EVs) are nanovesicles of endocytic origin released by cells and found in human bodily fluids. EVs contain both mRNA and microRNA (miRNA), which can be shuttled between cells, indicating their role in cell communication. This study investigated whether nasal secretions contain EVs and whether these EVs contain RNA. Read More

View Article and Full-Text PDF

Complement Inactivation Strategy of Using Decay-Accelerating Factor and the Response of Infected HaCaT Cells.

Int J Mol Sci 2021 Apr 13;22(8). Epub 2021 Apr 13.

Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.

is a species of Gram-positive staphylococcus. It can cause sinusitis, respiratory infections, skin infections, and food poisoning. Recently, it was discovered that infects epithelial cells, but the interaction between and the host is not well known. Read More

View Article and Full-Text PDF

Prevalence of and Factors Associated with Antibiotic Prescriptions in Patients with Acute Lower and Upper Respiratory Tract Infections-A Case-Control Study.

Antibiotics (Basel) 2021 Apr 16;10(4). Epub 2021 Apr 16.

Epidemiology, IQVIA Germany, 60549 Frankfurt am Main, Germany.

Background: The goal of the present study was to estimate the prevalence of patient and physician related variables associated with antibiotic prescriptions in patients diagnosed with acute lower and upper respiratory tract infections (ALURTI), treated in general practices (GP) and pediatric practices, in Germany.

Methods: The analysis included 1,140,095 adult individuals in 1237 general practices and 309,059 children and adolescents in 236 pediatric practices, from the Disease Analyzer database (IQVIA), who had received at least one diagnosis of an ALURTI between 1 January 2015 and 31 March 2019. We estimated the association between 35 predefined variables and antibiotic prescription using multivariate logistic regression models, separately for general and pediatric practices. Read More

View Article and Full-Text PDF

(Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy.

Life (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. (Burm. f. Read More

View Article and Full-Text PDF