92 results match your criteria sinonasal renal

Sinonasal Renal Cell-Like Adenocarcinoma.

Cureus 2021 Apr 4;13(4):e14285. Epub 2021 Apr 4.

Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a newly defined, rare malignant tumor of the nasal cavity. The clinical course and response to treatment remain uncertain. The purpose of this study is to report a new case of SNRCLA and review the literature to determine clinical characteristics, treatment options, and outcomes. Read More

View Article and Full-Text PDF

Orbit and sinonasal metastasis as presenting sign of renal cell carcinoma.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA

Orbit and sinonasal metastases are rare. Renal cell carcinoma (RCC) can metastasise to this region. We present the case of a 49-year-old woman with weight loss, diplopia and a rapidly growing facial mass. Read More

View Article and Full-Text PDF

Stereotactic Body Radiotherapy of a Solitary Metachronous Sphenoid Metastasis from Renal Cell Cancer: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):269-273. Epub 2021 Mar 2.

Department of Radiotherapy, Institut Godinot, Reims, France.

Nasosinus metastases from kidney cancer are an unusual clinical presentation although some cases are reported in the literature. Among these cases, sphenoidal metastases are even rarer. Here we report a case of lone sphenoid metastasis in patients with papillary renal cell cancer. Read More

View Article and Full-Text PDF

Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis.

Arthritis Res Ther 2021 01 11;23(1):18. Epub 2021 Jan 11.

Institute of Clincal Medicine, University of Oslo, PB 1072 Blindern, Oslo, 0316, Norway.

Background: Granulomatosis with polyangiitis (GPA) causes a recurring inflammation in nose and paranasal sinuses that clinically resembles chronic rhinosinusitis (CRS) of other aetiologies. While sinonasal inflammation is not among the life-threatening features of GPA, patients report it to have major negative impact on quality of life. A relatively large proportion of GPA patients have severe CRS with extensive damage to nose and sinus structures evident by CT, but risk factors for severe CRS development remain largely unknown. Read More

View Article and Full-Text PDF
January 2021

Transnasal Endoscopic Resection of the Intraconal Metastases From Renal Cell Carcinoma: a Case Report and Review of Literature.

Indian J Surg Oncol 2020 Sep 28;11(Suppl 2):318-322. Epub 2020 Oct 28.

Department of Head Neck Surgical Oncology, Tata Memorial Hospital, HBNI University, Mumbai, India.

Renal cell carcinoma (RCC) is the most common malignancy to cause metastasis to sinonasal cavity. These metastases can occasional cause invasion into the orbit. Isolated intraconal intraorbital metastasis from RCC is very rare. Read More

View Article and Full-Text PDF
September 2020

Head and neck manifestations of granulomatosis with polyangiitis.

Br J Radiol 2021 Mar 22;94(1119):20200914. Epub 2020 Dec 22.

Department of Radiology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Granulomatosis with polyangiitis is a rare autoimmune condition which causes respiratory tract granulomas, small to medium vessel vasculitis and renal disease. Head and neck manifestations are some of the most common presentations of the condition, with a significant proportion of patients experiencing sinonasal disease alone. The recognition of suggestive imaging findings, in combination with clinical history and serology, aids the diagnosis and appropriate treatment. Read More

View Article and Full-Text PDF

[Sinonasal renal cell-like adenocarcinoma: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2020 Nov;49(11):1147-1151

Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, China.

To investigate the clinicopathological features, immunophenotype, differential diagnosis and prognosis of sinonasal renal cell-like adenocarcinoma. Retrospective analysis was performed on the cases of sinonasal carcinoma from August 2014 to December 2018 at Eye, Ear, Nose and Throat Hospital, Fudan University. Renal cell-like adenocarcinoma was screened for clinicopathologic feature analysis, and relevant literatures were reviewed. Read More

View Article and Full-Text PDF
November 2020

Health-Related Quality of Life in Patients With ANCA-Associated Vasculitis and Sinonasal Involvement: A Single-Center Cross-Sectional Study.

J Clin Rheumatol 2020 Oct 30. Epub 2020 Oct 30.

Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy.

Background/objective: The aim of this study was to assess the impact of sinonasal morbidity on quality of life (QoL) in antineutrophil cytoplasmic antibody-associated vasculitis (AAV).

Methods: This cross-sectional case-control study enrolled 71 patients-44 AAV cases with (ear, nose, and throat [ENT]-AAV) or without ENT involvement (non-ENT-AAV) undergoing multidisciplinary evaluations and 27 chronic rhinosinusitis (CRS) cases. Three validated QoL questionnaires (Sino-Nasal Outcomes Test-22 [SNOT-22], Nasal Obstruction Symptom Evaluation [NOSE], and Short-Form 36) were administered, and the 3 groups were compared. Read More

View Article and Full-Text PDF
October 2020

An Unusual Source of Sinonasal Disease in an Immunocompromised Patient: A Case Report of the Clinical Presentation, Diagnosis, and Treatment of Acanthamoeba Rhinosinusitis.

Ear Nose Throat J 2020 Oct 23:145561320968936. Epub 2020 Oct 23.

Department of Otolaryngology-Head and Neck Surgery, Hartford Hospital, Hartford, CT, USA.

Chronic nasal crusting is a commonly encountered entity in an otolaryngology office. Progressive, extensive nasal crusting with erosion is relatively unusual, however. We present the case a 58-year-old renal transplant patient with a history of vasculitis and immunosuppression who presents with subjective headache and facial pain, nasal crusting, and isolated left ethmoid sinusitis. Read More

View Article and Full-Text PDF
October 2020

Desmoplastic Small Round Cell Tumor of the Kidney: Report of a Case, Literature Review, and Comprehensive Discussion of the Distinctive Morphologic, Immunohistochemical, and Molecular Features in the Differential Diagnosis of Small Round Cell Tumors Affecting the Kidney.

Adv Anat Pathol 2020 Nov;27(6):408-421

Division of Pediatric Urology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive neoplasm typically presenting with widespread involvement of the abdominopelvic peritoneum of adolescent males, usually without organ-based primary. Although it is believed to originate from the serous (mainly peritoneal) membranes, intracranial, sinonasal, intraosseous, and other soft tissue sites are also documented. A chromosomal translocation t(11:22)(p13;q12) signature that fuses EWSR1 and WT1 genes results in the production of a chimeric protein with transcriptional regulatory activity that drives oncogenesis. Read More

View Article and Full-Text PDF
November 2020

Nasal congestion and nasal obstruction: An unusual presentation of renal cell carcinoma.

Radiol Case Rep 2020 Jul 7;15(7):970-974. Epub 2020 May 7.

Department of Pathology, Anatomy, and Laboratory Medicine, West Virginia University, Morgantown, WV, USA.

Renal cell cancer (RCC) is among the 10 most common cancers affecting both genders in the United States. Advanced RCC often remains clinically silent for much of its natural history. This can make the diagnosis challenging, especially when presenting symptoms arise from a metastasis. Read More

View Article and Full-Text PDF

Clinical management of emerging sinonasal malignancies.

Head Neck 2020 08 25;42(8):2202-2212. Epub 2020 Mar 25.

Head & Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Several emerging sinonasal malignancies have recently been described in the pathology literature. Although not all distinctly classified by the World Health Organization, these rare tumors present a management challenge to surgeons and oncologists. While prior studies have summarized histologic details, a clinically focused review is currently lacking in the literature. Read More

View Article and Full-Text PDF

The Specific Magnetic Resonance Imaging Indicators in Predicting Clear-Cell Renal Cell Carcinoma Metastatic to the Sinonasal Region.

J Comput Assist Tomogr 2020 Jan/Feb;44(1):70-74

From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: The aim of this study was to determine the valuable magnetic resonance imaging (MRI) features of sinonasal metastatic clear-cell renal cell carcinoma (cc-RCC), especially focusing on its dynamic-enhanced characteristics.

Methods: The conventional and dynamic-enhanced MRI findings of 8 patients with histopathologically confirmed sinonasal metastatic cc-RCC were reviewed by 2 radiologists. The control group of 8 patients with capillary hemangioma underwent the same MRI protocol. Read More

View Article and Full-Text PDF
January 2020

Sinonasal Metastatic Renal Cell Carcinoma: A Report of Two Cases with Varied Presentation and a Review of Literature.

Indian J Otolaryngol Head Neck Surg 2019 Nov 24;71(Suppl 3):2072-2077. Epub 2018 Aug 24.

Department of Otolaryngology - Head and Neck Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka India.

Renal cell carcinoma is usually slow growing with delayed vague symptoms and may not be detected until an advanced stage. In only 9% of the cases the classical triad of "haematuria, costovertebral pain and abdominal mass" is seen. Less commonly, sinonasal metastasis may also be the presenting feature of RCC. Read More

View Article and Full-Text PDF
November 2019

Follow-Up and Management of Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia: Review and Experience of Our Reference Centers.

J Clin Med 2019 Sep 19;8(9). Epub 2019 Sep 19.

National Institute of Health and Medical Research INSERM, U955, Mondor Institute of biomedical research (IMRB), U955, 94010 Créteil, France.

Chronic rhinosinusitis is the foremost manifestation in adult patients with primary ciliary dyskinesia (PCD). We present a retrospective series of 41 adult patients with a confirmed diagnosis of PCD followed in our reference centers. As part of the diagnostic work up in our centers, sinus computed tomography scans (CTs) are systematically performed. Read More

View Article and Full-Text PDF
September 2019

Imaging Review of New and Emerging Sinonasal Tumors and Tumor-Like Entities from the Fourth Edition of the .

AJNR Am J Neuroradiol 2019 04 14;40(4):584-590. Epub 2019 Feb 14.

From the Department of Radiology (K.E.D., C.D.P.), NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York.

The sinonasal tract is an environment diverse with neoplasia. Given the continued discovery of entities generally specific to the sinonasal tract, the fourth edition of the was released in 2017. It describes 3 new, well-defined entities and several less-defined, emerging entities. Read More

View Article and Full-Text PDF

Local recurrence of sinonasal renal cell-like adenocarcinoma: A CARE compliant case report.

Medicine (Baltimore) 2019 Feb;98(7):e14533

Department of Pathology.

Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it is necessary to differentiate SNRCLA from these tumors.

Patient Concerns: A 42-year-old man presented with complaints of epistaxis for 1 day. Read More

View Article and Full-Text PDF
February 2019

Effect of elderly status on postoperative complications in patients with sinonasal cancer.

Int Forum Allergy Rhinol 2019 02 23;9(2):220-224. Epub 2018 Nov 23.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Background: Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and complications of sinonasal cancer (SNC) patients receiving surgery. Read More

View Article and Full-Text PDF
February 2019

Renal cell carcinoma metastatic to the sinonasal cavity: A review and report of 8 cases.

Ear Nose Throat J 2018 Sep;97(9):E6-E12

Department of Otorhinolaryngology-Head and Neck Surgery, Bordeaux University Hospital, Place Amélie Raba-Leon, 33000 Bordeaux, France.

Renal cell carcinoma (RCC) metastatic in the sinonasal cavity is rare. In many cases, it represents the initial presentation of RCC. We conducted a retrospective chart review to report the clinical presentation, imaging, and treatment of RCC metastases in the sinonasal cavity at two tertiary care referral centers. Read More

View Article and Full-Text PDF
September 2018

Targeted immunotherapy strategies in ANCA-associated vasculitis.

Xavier Puéchal

Joint Bone Spine 2019 05 7;86(3):321-326. Epub 2018 Sep 7.

Centre de référence des maladies systémiques auto-immunes rares, département de médecine interne, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France; Institut Cochin, Inserm U1016, CNRS UMR 8104, Paris, France. Electronic address:

Targeted immunotherapy is substantially improving the management of ANCA-associated vasculitides (AAV), which include granulomatosis with polyangiitis (GPA, Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome). This article reviews the current role for targeted immunotherapy in AAV, its validated indications, and avenues for further development. Rituximab is a validated induction treatment for GPA and severe MPA. Read More

View Article and Full-Text PDF

Neuroendocrine Neoplasms in Rare Locations: Clinicopathological Features and Review of the Literature.

Indian J Endocrinol Metab 2018 May-Jun;22(3):308-315

Department of Surgical Pathology, Clínico San Carlos Hospital, Madrid, Spain.

Introduction: Neuroendocrine tumors (NETs) occur more often in lungs, gastrointestinal tract, or pancreas. Data about terminology and grading of NETs in rare locations are scarce and variable, and they have been reported mainly as case reports.

Materials And Methods: We here describe our experience with NETs in unusual locations. Read More

View Article and Full-Text PDF

Sinonasal renal cell-like adenocarcinoma: Easily misdiagnosed sinonasal tumor.

Head Neck 2018 09 26;40(9):E91-E95. Epub 2018 Jul 26.

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Sinonasal renal cell-like adenocarcinoma is rare and exhibits unique pathological and clinical manifestations. Correct diagnosis and treatment of this newly described entity are challenging for both clinicians and pathologists.

Methods: We report a female patient with sinonasal renal cell-like adenocarcinoma who initially presented with right intermittent epistaxis. Read More

View Article and Full-Text PDF
September 2018

A meta-analysis of survival factors in rhino-orbital-cerebral mucormycosis-has anything changed in the past 20 years?

Clin Otolaryngol 2018 12 8;43(6):1454-1464. Epub 2018 Aug 8.

Department of Otorhinolaryngology - Head and Neck Surgery, Aintree University Hospital NHS Foundation Trust, Liverpool, UK.

Background: Rhino-orbital-cerebral mucormycosis (ROCM) is an uncommon yet potentially lethal fungal infection. Although most cases originate from developing countries, an ageing population and increased prevalence of chronic illness may mean some clinicians practicing in developed countries will encounter ROCM cases in their careers. Yohai et al published a systematic review of 145 case reports from 1970 to 1993 assessing prognostic factors for patients presenting with ROCM. Read More

View Article and Full-Text PDF
December 2018

Predictors, costs, and causes of readmission after surgery for sinonasal cancer: a national perspective.

Int Forum Allergy Rhinol 2018 09 2;8(9):1056-1064. Epub 2018 May 2.

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA.

Background: Hospital readmissions are an increasingly scrutinized marker of surgical care delivery and quality. There is a paucity of information in the literature regarding the rate, risk factors, and common causes of readmission after surgery for sinonasal cancer.

Methods: We analyzed the Nationwide Readmissions Database for patients who underwent surgery for a diagnosis of sinonasal cancer between 2010 and 2014. Read More

View Article and Full-Text PDF
September 2018

Multiple metastases of clear-cell renal cell carcinoma to different region of the nasal cavity and paranasal sinus 3 times successively: A case report and literature review.

Medicine (Baltimore) 2018 Apr;97(14):e0286

Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University Department of Otolaryngology-Head and Neck Surgery, Qinhuangdao First Hospital, Hebei Medical University, China.

Rationale: Distant metastasis of clear-cell renal cell carcinoma (ccRCC) to the nasal cavity and paranasal sinus is rare. Endoscopic biopsy used to be performed for diagnosis when it is difficult for complete resection due to intense bleeding during surgery. According to previous literature, the outcomes of metastasis after endoscopic surgery remain unclear. Read More

View Article and Full-Text PDF

Clinical course of rhinosinusitis and efficacy of sinonasal evaluation in kidney transplant recipients: review of 1589 patients.

Eur Arch Otorhinolaryngol 2018 May 20;275(5):1183-1188. Epub 2018 Mar 20.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Introduction: Rhinosinusitis in patients who undergo kidney transplantation (KT) might have specific clinical characteristics due to immune status of recipients. The aim of this study was to identify the clinical course of rhinosinusitis after KT and to evaluate the efficacy of routine sinonasal evaluation before KT.

Methods: The study included 1589 kidney transplant adult patients who underwent preoperative sinonasal evaluation including sinonasal symptoms, nasal endoscopy, and plain X-ray between November 1994 and December 2013 (19 years). Read More

View Article and Full-Text PDF

A case of squamous cell carcinoma of the nasal cavity in a patient with granulomatosis with polyangiitis (Wegener granulomatosis).

Ear Nose Throat J 2018 Jan-Feb;97(1-2):E37-E41

Department of Head and Neck Surgery, Ronald Reagan UCLA Medical Center, 10833 Le Conte Ave., 62-132 CHS, Los Angeles, CA 90095, USA.

We report a rare case of squamous cell carcinoma (SCC) of the nasal cavity arising in a patient with granulomatosis with polyangiitis (GPA). The patient was a 35-year-old man who had been diagnosed 15 years earlier with GPA and treated medically for sinonasal, pulmonary, and renal involvement. He presented to us with left-sided orbital and cheek pain and nasal obstruction. Read More

View Article and Full-Text PDF
September 2018

Ear, nose and throat involvement in granulomatosis with polyangiitis: how it presents and how it determines disease severity and long-term outcomes.

Clin Rheumatol 2018 Apr 20;37(4):1075-1083. Epub 2018 Feb 20.

Operative Unit of Rheumatology, Department of Medicine DIMED, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.

Ear, nose and throat (ENT) manifestations in granulomatosis with polyangiitis (GPA) represent the most frequent symptoms at disease onset. The aim of the study was to analyse ENT involvement at diagnosis, as well as how it could influence relapse rate, mortality and disease severity. A retrospective non-controlled cohort study was performed including all consecutive diagnosed GPA from 1996 to 2016 in two rheumatology centres of Northern Italy, focusing particularly on ENT presenting signs and symptoms at baseline. Read More

View Article and Full-Text PDF

Sinonasal Adenoid Cystic Carcinoma with Rare Renal Metastasis on Fluorodeoxyglucose Positron Emission Tomography Scan: A Case Report and Literature Review.

Indian J Nucl Med 2018 Jan-Mar;33(1):52-54

Department of Radiology Imaging Services, Health Care Global Cancer Centre, Ahmedabad, Gujarat, India.

Adenoid cystic carcinoma (ACC) of sinonasal cavity is not the frequent entity. It is characterized by indolent growth and clinical course and high rate of recurrences, perineural spread, and late metastases. We represent a patient with rare renal metastasis from sinonasal ACC in pretreatment fluorodeoxyglucose positron emission tomography-computed tomography scan, and pathological confirmation has been obtained from both the primary and metastatic sites. Read More

View Article and Full-Text PDF
February 2018

SMARCB1-deficient Tumors of Childhood: A Practical Guide.

Bruce R Pawel

Pediatr Dev Pathol 2018 Jan-Feb;21(1):6-28. Epub 2017 Dec 27.

1 Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

The SMARCB1 gene ( INI1, BAF47) is a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, involved in the epigenetic regulation of gene transcription. SMARCB1 acts as a tumor suppressor gene, and loss of function of both alleles gives rise to SMARCB1-deficient tumors. The prototypical SMARCB1-deficient tumor is the malignant rhabdoid tumor (MRT) which was first described in the kidney but also occurs in soft tissue, viscera, and the brain (where it is referred to as atypical teratoid rhabdoid tumor or AT/RT). Read More

View Article and Full-Text PDF