Am J Gastroenterol 2021 Mar 2. Epub 2021 Mar 2.
SeLiver Group at Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; UCM Digestive Diseases, Virgen del Rocío University Hospital, Seville, Spain; Department of Immunology, Hospital Universitario Virgen del Rocío, Seville, Spain; IIS Isabial, Hospital Universitario de Alicante, Alicante, Spain; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain; Department of Gastroenterology, Hospital de la Santa Creu y Sant Pau, Barcelona, Spain.
Introduction: We aimed to define the impact of the genetic background on overt hepatic encephalopathy (HE) in patients with liver cirrhosis by developing a combined clinical-genetic risk score.
Methods: Patients suffering from liver cirrhosis from the outpatient clinics of 4 hospitals (n = 600) were included and followed up for at least 5 years until HE bouts, liver transplant, or death. Patients were genotyped for 60 candidate single nucleotide polymorphisms together with the microsatellite in the promoter region of the gene GLS. Read More