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Ameliorating activity of polyphenolic-rich extracts of L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Department of Biochemistry, Phytomedicine, Natural Products, Drug and Biochemical Toxicology Group, Landmark University, Omu Aran, PMB 1001, Kwara State, Nigeria.

Objectives: To assess the ameliorative activity of polyphenolic-rich extracts of leaves on β-cell dysfunction in type-II diabetes (T2DM).

Methods: Total phenolic and flavonoid contents; α-amylase and α-glucosidase inhibitory actions and qualitative analysis of the bioactive compounds of the polyphenolic-rich extract of leaves were investigated using gas chromatography-mass spectroscopy (GC-MS). Diabetes mellitus (DM) was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight) and the rats were orally given bound phenolic (BPE) and free phenolic extracts (FPE) of (B. Read More

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Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice.

Nucl Med Biol 2021 Apr 21;98-99:8-17. Epub 2021 Apr 21.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, CA, USA. Electronic address:

Background: A novel [Cu]Cu-NOTA-aCD40 immunoPET tracer was developed to image a CD40 pancreatic tumor model in C57BL/6 mice and to study the biodistribution profile of the agonist CD40 (aCD40) monoclonal antibody (mAb) alone or combined with other mAbs.

Procedures: Copper-64 ([Cu]Cu) labeled NOTA-aCD40 and NOTA-IgG (10 μg; 7 MBq) were injected intravenously into C57BL/6 mice with subcutaneous mT4 tumors to assess specificity 48 h post injection (p.i. Read More

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Single dose perioperative intrathecal ketamine as an adjuvant to intrathecal bupivacaine: A systematic review and meta-analysis of adult human randomized controlled trials.

J Clin Anesth 2021 May 4;73:110331. Epub 2021 May 4.

Zucker School of Medicine at Hofstra/Northwell, Department of Anesthesiology, Northwell Health, New Hyde Park, NY, United States of America.

Study Objective: To identify whether adding intrathecal ketamine to intrathecal bupivacaine prolongs the time to first analgesic request in adult humans.

Design: A meta-analysis of randomized controlled trials in humans.

Setting: The majority of data was obtained in an operating room and postoperative recovery area. Read More

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Development and validation of LC/MS/MS method for Triciribine and its monophosphate metabolite in plasma and RBC: Application to mice pharmacokinetic studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 20;1174:122714. Epub 2021 Apr 20.

Ayma Therapeutics Incorporated, USA. Electronic address:

Triciribine (TCN) is a tricyclic nucleoside analog of adenosine and an inhibitor of Akt kinase. Triciribine 5'-monophosphate (TCNP) is a water-soluble analog of Triciribine and has progressed to Phase I and II clinical trials in oncology. TCNP is also an endogenous anabolite of TCN similar to other nucleoside phosphates. Read More

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Diterpenoids from the seeds of Euphorbia lathyris and their anti-inflammatory activity.

Bioorg Chem 2021 Apr 26;112:104944. Epub 2021 Apr 26.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Twelve previously undescribed diterpenoids, euplarisans A-L (1-12), including one premyrsinane and eleven lathyranes, along with ten known analogues 13-22 were isolated from the seeds of Euphorbia lathyris. Their chemical structures were delineated by spectroscopic analysis and single-crystal X-ray diffraction. Interestingly, both 5 and 6 possessed an unusual trans-gem-dimethylcyclopropane as structural features and compound 8 was elucidated as premyrsinane-type diterpenoid. Read More

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Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats.

Eur J Pharmacol 2021 May 4:174148. Epub 2021 May 4.

Instituto de Investigaciones Psicológicas; Centro de Investigación en Neurociencias, Universidad de Costa Rica. Electronic address:

As drug addiction may result from pathological usurpations of learning and memory's neural mechanisms, we focused on the amphetamine-induced time-dependent neurochemical changes associated with neural plasticity. We used juvenile rats as the risk for drug abuse is higher during adolescence. Experiment 1 served to define the appropriate amphetamine dose and the neurochemical effects of a single administration. Read More

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Low dose of methylprednisolone for pain and immune function after thoracic surgery.

Ann Thorac Surg 2021 May 4. Epub 2021 May 4.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China. Electronic address:

Background: The purpose of this study was to evaluate the effects of single low-dose preoperative methylprednisolone (MP) on the immunological function and postoperative pain of patients undergoing elective video-assisted thoracoscopic surgery under general anesthesia.

Methods: Eighty-one patients who underwent elective video-assisted thoracoscopic surgery were randomly assigned to the MP Group or the Control Group. The T lymphocyte subsets of CD3, CD4, and CD8, the CD4/CD8 ratio at T (before anesthesia), T (after surgery), and T (24 h after surgery) were all recorded. Read More

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Characterization of Blue Light Treatment for Infected Wounds: Antibacterial Efficacy of 420, 455, and 480 nm Light-Emitting Diode Arrays Against Common Skin Pathogens Versus Blue Light-Induced Skin Cell Toxicity.

Photobiomodul Photomed Laser Surg 2021 May;39(5):339-348

Chair, Department of Virology and Microbiology, Centre for Biomedical Education and Research (ZBAF), University Witten/Herdecke, Witten, Germany.

To determine effective treatment strategies against bacterial infections of chronic wounds, we tested different blue light (BL)-emitting light-emitting diode arrays (420, 455, and 480 nm) against wound pathogens and investigated in parallel BL-induced toxic effects on human dermal fibroblasts. Wound infection is a major factor for delayed healing. Infections with and are clinically relevant caused by their ability of biofilm formation and their quickly growing antibiotics resistance. Read More

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Increasing conception rate by addition of a second prostaglandin injection in an Ovsynch and progesterone treatment programme for dairy cows not detected in oestrus before the start of the seasonal mating period.

N Z Vet J 2021 May 7:1-13. Epub 2021 May 7.

Cognosco, Anexa, Morrinsville, New Zealand.

Aims: To assess the effect on conception rate to first service, 3- and 6-week in-calf rates, final pregnancy rate and the hazard of pregnancy, of addition of a second prostaglandin (PG) injection 24 hours after the first, in a synchrony programme combining Ovsynch and progesterone in pasture-based dairy cows that had not been detected in oestrus before the start of the seasonal mating period.

Methods: This prospective, negative-controlled study was conducted using anoestrous cows (n = 1,411) from nine spring-calving dairy herds in the Waikato region of New Zealand. Ovaries of cows not detected in oestrus were examined by transrectal ultrasonography and the presence of a corpus luteum determined. Read More

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GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects.

Clin Pharmacol Drug Dev 2021 May 7. Epub 2021 May 7.

Galapagos, Mechelen, Belgium.

GLPG1205 is a modulator of GPR84, a G-protein-coupled receptor reported to be associated with several diseases. Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1205 in healthy subjects were evaluated in 2 randomized, double-blind, placebo-controlled, single-site, phase 1 studies. In study 1, 16 (aged 21-48 years) and 24 (24-50 years) healthy men received single doses of GLPG1205 10 to 800 mg, and GLPG1205 50, 100, or 200 mg once daily for 14 days, respectively, or placebo. Read More

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Personalise vitamin D using physiologically based pharmacokinetic modelling.

CPT Pharmacometrics Syst Pharmacol 2021 May 7. Epub 2021 May 7.

Beyond Consulting Ltd, 14 Tytherington Park Road, Macclesfield, Cheshire, UK, SK10 2EL.

Plasma concentration of Vitamin D metabolite 25-hydroxyvitamin D (25(OH)D ) is variable among individuals. The objective of this study is to establish an accurate model for 25(OH)D pharmacokinetics (PK) to support selection of a suitable dose regimen for an individual. We collated Vitamin D and 25(OH)D plasma PK data from reported clinical trials and developed a physiologically based pharmacokinetic (PBPK) model to appropriately recapitulate training data. Read More

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Efficient optimization of R50% when planning multiple cranial metastases simultaneously in single isocenter SRS/SRT.

J Appl Clin Med Phys 2021 May 7. Epub 2021 May 7.

Department of Radiation Medicine, University of Kentucky Chandler Medical Center, Lexington, KY, USA.

Simultaneous optimization of multiple Planning Target Volumes (PTVs) of varying size and location in the cranium is a non-trivial task. The rate of dose falloff around PTV structures is variable and depends on PTV characteristics such as the volume. The metric R50% is one parameter that can be used to quantify dose falloff achieved in a given treatment plan. Read More

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Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic.

Int Rev Immunol 2021 May 7:1-14. Epub 2021 May 7.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine that was developed about 100 years ago by Albert Calmette and Camille Guérin. Many countries have been using the vaccine for decades against tuberculosis (TB). The World Health Organization (WHO) recommends a single dose of BCG for infants in TB endemic as well as leprosy high risk countries, and globally almost 130 million infants are vaccinated yearly. Read More

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Radiobiological impact of Gadolinium neutron capture from proton therapy and alternative neutron sources using Topas-nBio.

Med Phys 2021 May 7. Epub 2021 May 7.

Department of Physics, Faculty of Science, Ryerson University, 350 Victoria St, Toronto, Ontario, Canada, M5B 2K3.

Purpose: A multi-scale investigation of the biological properties of gadolinium neutron capture (GdNC) therapy is conducted using Monte Carlo (MC) simulation code. The simulation results are used to quantify the amount of gadolinium dose enhancement produced from different neutron sources. The amount of dose enhancement is quantified as a result of the secondary neutron production from proton therapy scaled by measured data. Read More

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Erythropoietin Improves Poor Outcomes in Preterm Infants with Intraventricular Hemorrhage.

CNS Drugs 2021 May 6. Epub 2021 May 6.

Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Background: Intraventricular hemorrhage (IVH) is a common complication in preterm infants that has poor outcomes, especially in severe cases, and there are currently no widely accepted effective treatments. Erythropoietin has been shown to be neuroprotective in neonatal brain injury.

Objective: The objective of this study was to evaluate the protective effect of repeated low-dose recombinant human erythropoietin (rhEPO) in preterm infants with IVH. Read More

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Serum cortisol and adrenocorticotrophic hormone (ACTH) in infants receiving topical and subconjunctival corticosteroids following cataract surgery.

Graefes Arch Clin Exp Ophthalmol 2021 May 6. Epub 2021 May 6.

Ophthalmology Department, Faculty of Medicine, Cairo University, 16 Abd El-Hady Street Manial, Cairo, 114511, Egypt.

Purpose: Cushingoid features are occasionally encountered in infants after pediatric cataract surgery. The aim of this study is to evaluate whether the use of topical glucocorticoids (GCs) following congenital cataract surgery can result in endogenous adrenal suppression and/or systemic side effects similar to those seen with systemic steroids.

Methods: A prospective study was performed on 20 infants with bilateral congenital cataract. Read More

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Radiotherapy as a Single Modality in Primary Seminoma of the Prostate.

Cureus 2021 Apr 2;13(4):e14264. Epub 2021 Apr 2.

Medical Oncology, Grand River Regional Cancer Centre, Kitchener, CAN.

Extragonadal germ cell tumors (EGCTs) are uncommon, and those involving the prostate are rare. We report on a primary seminoma of the prostate in a 56-year-old male presenting with scrotal pain, urinary frequency and urgency, and erectile dysfunction. Digital rectal examination revealed a hard, markedly enlarged prostate projecting posteriorly into the rectum. Read More

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Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics.

Front Immunol 2021 20;12:639942. Epub 2021 Apr 20.

Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Kidney transplantation is currently the first choice of treatment for various types of end-stage renal failure, but there are major limitations in the application of immunosuppressive protocols after kidney transplantation. When the dose of immunosuppressant is too low, graft rejection occurs easily, while a dose that is too high can lead to graft loss. Therefore, it is very important to explore the immune status of patients receiving immunosuppressive agents after kidney transplantation. Read More

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Comparison of Multimaterial Decomposition Fat Fraction with DECT and Proton Density Fat Fraction with IDEAL IQ MRI for Quantification of Liver Steatosis in a Population Exposed to Chemotherapy.

Dose Response 2021 Apr-Jun;19(2):1559325820984938. Epub 2021 Apr 20.

IRCCS SDN, Napoli, Italy.

Introduction: Oncologic patients who develop chemotherapy-associated liver injury (CALI) secondary to chemotherapy treatment tend to have worse outcomes. Biopsy remains the gold standard for the diagnosis of hepatic steatosis. The purpose of this article is to compare 2 alternatives: Proton-Density-Fat-Fraction (PDFF) MRI and MultiMaterial-Decomposition (MMD) DECT. Read More

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Genetic Associations with Stable Warfarin Dose Requirements in Han Chinese Patients.

J Cardiovasc Pharmacol 2021 May 4. Epub 2021 May 4.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China Laiwu People's Hospital, Laiwu, Shandong 271100, China Laigang Hospital, Laiwu, Shandong 271126, China Shanghai Baio Technology Co., Ltd. Shanghai 200233, China Fudan University, Shanghai 200032, China The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China.

Abstract: Warfarin is a commonly prescribed anticoagulant for valvular heart disease that plays an important role in clinical management to prevent thrombotic events. In this study, we aim to perform a comprehensive study to investigate the genetic biomarkers of stable warfarin dose in the Han Chinese population. We performed an integrative study on 211 Han Chinese patients with valvular heart disease. Read More

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Transradial Neuroendovascular Procedures in Adolescents: Initial Single-Center Experience.

AJNR Am J Neuroradiol 2021 May 6. Epub 2021 May 6.

From the Divisions of Neuroradiology and Image-Guided Therapy (H.A., A.A.D., S.B., V.R., N.S., P.M.), Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Background And Purpose: The feasibility and safety of transradial angiography is not established outside the adult literature. The objective of this study was to assess the feasibility and safety of transradial access for neuroangiography in adolescents.

Materials And Methods: A retrospective case-control study was performed, comparing transradial neuroendovascular procedures in adolescents (age range, 10-18 years) with an age- and procedure-matched cohort of transfemoral neuroendovascular procedures. Read More

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Current Therapy and Emerging Intravesical Agents to Treat Non-Muscle Invasive Bladder Cancer.

Hematol Oncol Clin North Am 2021 Jun 18;35(3):513-529. Epub 2021 Apr 18.

Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Transurethral resection of bladder tumor remains the cornerstone of non-muscle invasive bladder cancer management, proper risk stratification, and appropriate selection of adjuvant therapy. A single, postoperative dose of intravesical chemotherapy is used for low-risk patients; patients with high-grade, high-risk disease should receive intravesical bacillus Calmette-Guérin (BCG) induction and maintenance therapy. For patients who develop BCG-unresponsive disease, cystectomy remains the standard of care. Read More

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The Role of Biological Effective Dose in Predicting Obliteration After Stereotactic Radiosurgery of Cerebral Arteriovenous Malformations.

Mayo Clin Proc 2021 May;96(5):1157-1164

Department of Neurological Surgery, Mayo Clinic, Rochester, MN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To determine whether biological effective dose (BED) was predictive of obliteration after stereotactic radiosurgery (SRS) for cerebral arteriovenous malformations (AVMs).

Patients And Methods: We studied patients undergoing single-session AVM SRS between January 1, 1990, and December 31, 2014, with at least 2 years of imaging follow-up. Excluded were patients with syndromic AVM, previous SRS or embolization, and patients treated with volume-staged SRS. Read More

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Comparison of liver exposure in CT-guided high-dose rate (HDR) interstitial brachytherapy versus SBRT in hepatocellular carcinoma.

Radiat Oncol 2021 May 6;16(1):86. Epub 2021 May 6.

Department of Radiation Oncology, University Hospital, LMU Munich, 81377, Munich, Germany.

Background: In unresectable hepatocellular carcinoma several local ablative treatments are available. Among others, radiation based treatments such as stereotactic body radiotherapy (SBRT) and high-dose rate interstitial brachytherapy (HDR BT) have shown good local control rates.

Methods: We conducted a dose comparison between actually performed HDR BT versus virtually planned SBRT to evaluate the respective clinically relevant radiation exposure to uninvolved liver tissue. Read More

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Immunogenicity and safety of two quadrivalent influenza vaccines in healthy adult and elderly participants in India - A phase III, active-controlled, randomized clinical study.

Hum Vaccin Immunother 2021 May 6:1-10. Epub 2021 May 6.

Established Pharmaceuticals Division, Abbott Healthcare Products B.V, Weesp, The Netherlands.

: This study was conducted to compare the immunogenicity and safety profile of two quadrivalent influenza vaccines (QIVs) in healthy adults (18-60 years) and elderly (>61 years) participants.: This phase III study was conducted from March 2018 to April 2018 across 12 sites in India. In this randomized, observer-blind, active-controlled study, 480 participants were randomized to receive a single dose of test vaccine (subunit, inactivated influenza vaccine; Influvac® Tetra, Abbott) (n = 240) or reference vaccine (split virion, inactivated influenza vaccine; VaxiFlu-4, Zydus Cadilla Healthcare) (n = 240). Read More

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Ketamine-induced generalized convulsive seizure during procedural sedation.

Arch Craniofac Surg 2021 Apr 20;22(2):119-121. Epub 2021 Apr 20.

Department of Plastic and Reconstructive Surgery, Bundang Jesaeng Hospital, Seongnam, Korea.

Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation for facial laceration in pediatric patients. The major benefits are its rapid onset of effects, relatively short half-life, and lack of respiratory depression. The known side effects of ketamine are hallucinations, dizziness, nausea, and vomiting. Read More

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A rabies virus vectored severe fever with thrombocytopenia syndrome (SFTS) bivalent candidate vaccine confers protective immune responses in mice.

Vet Microbiol 2021 Apr 21;257:109076. Epub 2021 Apr 21.

Department of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

The Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne hemorrhagic zoonotic disease, which is potentially fatal in human with mortality rates ranging from 16.2%-32%. The rabies virus (RABV) LBNSE vector expressing foreign antigens have shown considerable promise as vaccines against viral diseases, which is effective and safe. Read More

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A phase 2 trial of single low doses of rasburicase for treatment of hyperuricemia in adult patients with acute leukemia.

Leuk Res 2021 Apr 24;107:106588. Epub 2021 Apr 24.

Section of Leukemia, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Rasburicase can markedly and rapidly decrease uric acid (UA) levels, thereby preventing and treating tumor lysis syndrome. However, rasburicase is expensive, especially when used as per the manufacturer's recommended dosage of 0.2 mg/kg/day for up to 5 days. Read More

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Antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients - Prospective cohort study.

Clin Microbiol Infect 2021 May 3. Epub 2021 May 3.

Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Transplantation, Rabin Medical Center, Beilinson Campus, Petah-Tikva, Israel.

Objectives: We aimed to evaluate rates of antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients, and to identify factors associated with reduced immunogenicity.

Methods: A prospective cohort study including consecutive kidney transplant recipients in a single referral transplant center. Participants were tested for anti-spike (anti-S) antibodies 2-4 weeks following second vaccine dose. Read More

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Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice.

J Control Release 2021 May 3. Epub 2021 May 3.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1 Sho-machi, Tokushima 770-8505, Japan. Electronic address:

Recently, there is an increasing interest in exosomes or extracellular vesicles as potential candidates for delivering RNAs, proteins, genes, and anticancer agents. Engineering of exosome properties is rapidly evolving as a means of expanding exosome applications. PEGylation of exosomes is a technique used to improve their in vivo stability, circulation half-lives, and sometimes to allow the binding targeting ligands to the exosome exterior. Read More

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