11,385 results match your criteria simvastatin

Anti-hypercholesterolemic effect of extract.

F1000Res 2018 15;7:1798. Epub 2018 Nov 15.

Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, East Kalimantan, 75119, Indonesia.

High cholesterol levels (hypercholesterolemia) has been recognized to cause various disease, most notably the cardiovascular disease. Unfortunately, most anti-hypercholesterolemic drugs deliver several side effects for patients, by which medicinal plants have begun to attract attention for treating hypercholesterolemia. Among others, (J. Read More

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November 2018

Simvastatin nanoparticles loaded polymeric film as a potential strategy for diabetic wound healing: in vitro and in vivo evaluation.

Curr Drug Deliv 2021 Jul 20. Epub 2021 Jul 20.

Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.

Introduction: The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds.

Aim: Aim of the present study is to fabricate nanofilm embedded with simvastatin loaded chitosan nanoparticles (CS-SIM-NPs) has been reported herein to explore the efficacy of SIM in diabetic wound healing.

Methods: The NPs, prepared via ionic gelation, were 173nm ± 2. Read More

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Antioxidant Serine-(NSAID) Hybrids with Anti-Inflammatory and Hypolipidemic Potency.

Molecules 2021 Jul 2;26(13). Epub 2021 Jul 2.

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, 54124 Thessaloniki, Greece.

A series of L-serine amides of antioxidant acids, such as Trolox, ()-3-(3,5-di--butyl-4-hydroxyphenyl)acrylic acid (phenolic derivative of cinnamic acid) and 3,5-di--butyl-4-hydroxybenzoic acid (structurally similar to butylated hydroxytoluene), was synthesized. The hydroxy group of serine was esterified with two classical NSAIDs, ibuprofen and ketoprofen. The Trolox derivatives with ibuprofen (7) and ketoprofen (10) were the most potent inhibitors of lipid peroxidation (IC 3. Read More

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Improvement of Osseointegration by Ultraviolet and/or Simvastatin Treatment on Titanium Implants with or without Bone Graft Materials.

Materials (Basel) 2021 Jul 2;14(13). Epub 2021 Jul 2.

Department of Prosthodontics, Yonsei University College of Dentistry, Seoul 03722, Korea.

We evaluated and compared ultraviolet (UV) treatment and simvastatin (SIM) immersion effects on the osseointegration of sandblasted, large-grit, acid-etched (SLA) titanium dental implants at two different time points in rabbit tibias, with or without xenogenic bone graft materials. The surface alteration on simvastatin treatment titanium discs was analyzed using an infrared spectrometer. Implants were categorized into four groups according to the surface treatment type. Read More

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Simvastatin inhibites high glucose-induced renal tubular epithelial cells apoptosis by down-regulating miR-92a.

Pak J Pharm Sci 2021 Jan;34(1(Special)):411-415

Nephrology, Zhuji People's Hospital of Zhejiang Province, Zhuji, China.

This work aims to investigate the role of simvastatin (SIM) in renal tubular epithelial cells (HK-2) proliferation. The apoptosis model of HK-2 cells induced by high glucose was established; HK-2 cells were cultured in vitro and randomly divided into control group, model group, SIM low-dose group, SIM medium-dose group and SIM high-dose group. After 24 h culture, the inhibitory effect of SIM on high glucose- induced proliferation of HK-2 cells was evaluated by MTT method. Read More

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January 2021

Effects of simvastatin on white matter integrity in healthy middle-aged adults.

Ann Clin Transl Neurol 2021 Jul 18. Epub 2021 Jul 18.

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: The brain is the most cholesterol-rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol-lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol-rich brain white matter (WM) is largely unknown.

Methods: We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin-naïve, middle-aged adults during an 18-month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). Read More

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A Chemokine Regulatory Loop Induces Cholesterol Synthesis in Lung-Colonizing Triple-Negative Breast Cancer Cells to Fuel Metastatic Growth.

Mol Ther 2021 Jul 15. Epub 2021 Jul 15.

Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:

Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here, we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung resident fibroblasts to produce C-C motif chemokines 2/7 (CCL2/7), which in turn activate cholesterol synthesis in lung-colonizing TNBC cells and induce angiogenesis at lung metastatic sites. Read More

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When Should Statins Be Stopped?

Eur J Case Rep Intern Med 2021 15;8(7):002661. Epub 2021 Jun 15.

Hospital Pedro Hispano, Sra. da Hora, Portugal.

is a non-tuberculous mycobacterium that can cause skin infections in immunocompetent individuals. We report a case of skin infection by this agent in a woman with dyslipidaemia, that culminated in statin-induced rhabdomyolysis due to the combination of clarithromycin, ciprofloxacin and simvastatin.

Learning Points: Skin infection with is an increasing global problem among immunocompetent individuals. Read More

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First Reported Case of Rhabdomyolysis Associated with Concomitant Use of Cyclosporin, Diltiazem, and Simvastatin.

Indian J Nephrol 2021 Mar-Apr;31(2):173-175. Epub 2020 Nov 7.

Unit of Nephrology, Department of Medicine, Universiti Putra Malaysia, Malaysia.

Rhabdomyolysis is a syndrome with a wide range of symptoms ranging from asymptomatic raised serum creatinine kinase to life-threatening metabolic disturbances and acute kidney injury. A careful history taking and high clinical suspicion on drug-drug interaction are crucial to identify the etiology of rhabdomyolysis. Here, we present a case of rhabdomyolysis due to a rare drug-to-drug interaction of simvastatin, diltiazem, and cyclosporin in a patient with IgA nephropathy. Read More

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November 2020

The Role of Ophiopogonin D in Atherosclerosis: Impact on Lipid Metabolism and Gut Microbiota.

Am J Chin Med 2021 Jul 14:1-19. Epub 2021 Jul 14.

The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, P. R. China.

Gut microbiota has been proven to play an important role in many metabolic diseases and cardiovascular disease, particularly atherosclerosis. Ophiopogonin D (OPD), one of the effective compounds in , is considered beneficial to metabolic syndrome and cardiovascular diseases. In this study, we have illuminated the effect of OPD in ApoE knockout (ApoE[Formula: see text] mice on the development of atherosclerosis and gut microbiota. Read More

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Structure and Fate of Nanoparticles Designed for the Nasal Delivery of Poorly Soluble Drugs.

Mol Pharm 2021 Jul 14. Epub 2021 Jul 14.

Department of Medical Biotechnologies and Translational Medicine, LITA, University of Milan, Via Fratelli Cervi 93, Segrate, 20122 Milan, Italy.

Nanoparticles are promising mediators to enable nasal systemic and brain delivery of active compounds. However, the possibility of reaching therapeutically relevant levels of exogenous molecules in the body is strongly reliant on the ability of the nanoparticles to overcome biological barriers. In this work, three paradigmatic nanoformulations vehiculating the poorly soluble model drug simvastatin were addressed: (i) hybrid lecithin/chitosan nanoparticles (LCNs), (ii) polymeric poly-ε-caprolactone nanocapsules stabilized with the nonionic surfactant polysorbate 80 (PCL_P80), and (iii) polymeric poly-ε-caprolactone nanocapsules stabilized with a polysaccharide-based surfactant, i. Read More

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Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol.

Med Sci Monit 2021 Jul 14;27:e929346. Epub 2021 Jul 14.

Department of Clinical Laboratory, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China (mainland).

BACKGROUND Emodin has been widely used in traditional Chinese medicine, but few studies have tried to understand the mechanism of its anti-hypercholesterolemic effect. MATERIAL AND METHODS To delineate the underlying pathways, high-cholesterol diet (HCD)-fed Sprague-Dawley rats were orally administrated emodin or the lipid-lowering medicine simvastatin. Emodin was administered at 10, 30, or 100 mg/kg, while simvastatin was administered at 10 mg/kg. Read More

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Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes.

Nanomedicine 2021 Jul 10:102439. Epub 2021 Jul 10.

Department of Pharmacology, University, of Nevada, Reno, Reno, NV 89557. Electronic address:

Depletion of coenzyme Q (CoQ) is associated with disease, ranging from myopathy to heart failure. To induce a CoQ deficit, C2C12 myotubes were incubated with high dose simvastatin. This resulted in a concentration-dependent inhibition of cell viability. Read More

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Studying the Effect of Taking Statins before Infection in the Severity Reduction of COVID-19 with Machine Learning.

Biomed Res Int 2021 19;2021:9995073. Epub 2021 Jun 19.

Department of Infectious Diseases, Mazandaran University of Medical Sciences, P.O. Box: 48175-866, Sari, Iran.

Statins can help COVID-19 patients' treatment because of their involvement in angiotensin-converting enzyme-2. The main objective of this study is to evaluate the impact of statins on COVID-19 severity for people who have been taking statins before COVID-19 infection. The examined research patients include people that had taken three types of statins consisting of Atorvastatin, Simvastatin, and Rosuvastatin. Read More

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Utilization of drugs with reports on potential efficacy or harm on COVID-19 before, during, and after the first pandemic wave.

Pharmacoepidemiol Drug Saf 2021 Jul 9. Epub 2021 Jul 9.

German Institute for Drug Use Evaluation (DAPI), Berlin, Germany.

Purpose: Conflicting information on potential benefits of drugs as well as reports on hypothetical harm of commonly used drugs in COVID-19 treatment have challenged clinicians and healthcare systems. We analyzed the change in ambulatory drug utilization before, during, and after the first wave of the pandemic in 2020.

Methods: We explored dispensing data of nearly 19 000 pharmacies at the expense of the statutory health insurance funds covering 88% of Germany's population. Read More

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Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study.

Biomed Pharmacother 2021 Jul 8;139:111494. Epub 2021 May 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt. Electronic address:

This study set out to optimize simvastatin (SV) in lipid nanoparticles (SLNs) to improve bioavailability, efficacy and alleviate adverse effects. Simvastatin-loaded solid lipid nanoparticles (SV-SLNs) were prepared by hot-melt ultrasonication method and optimized by box-Behnken experimental design. Sixty Wister albino rats were randomly assigned into six groups and treated daily for 16 weeks: control group, the group fed with 20 g of high-fat diet (HFD), group treated with vehicle (20 mg/kg, P. Read More

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Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways.

Biomed Pharmacother 2021 Jul 6;141:111831. Epub 2021 Jul 6.

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

Obesity is a global epidemic disease that is closely associated with various health problems as Diabetes mellitus, cardiovascular, and metabolic disorders. Lycopene (LYC), a red-colored carotenoid, has demonstrated various promising therapeutic effects. Hence, the potential of LYC was studied against high fat diet (HFD)-induced obesity and metabolic disturbances in rats. Read More

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Impact of COPD exacerbations leading to hospitalization on general and disease-specific quality of life.

Respir Med 2021 Jun 29;186:106526. Epub 2021 Jun 29.

Lewis Katz School of Medicine at Temple University, Department of Thoracic Medicine and Surgery, Division of Pulmonary and Critical Care Medicine, 3401 North Broad Street Philadelphia, PA, 19140, USA. Electronic address:

Rationale: Acute exacerbations negatively impact quality of life in patients with chronic obstructive pulmonary disease (COPD), but the impact of hospitalized exacerbations on quality of life is not clear. We hypothesized that patients with hospitalized exacerbations would benefit from hospitalization and experience improvement in general and disease-specific quality of life (as measured by the St. George's respiratory questionnaire (SGRQ) and the medical outcomes study 36-item short form health survey (SF-36)) compared to those without exacerbations, or with non-hospitalized acute exacerbations. Read More

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Structural Characterization of Peptides From Huangjiu and Their Regulation of Hepatic Steatosis and Gut Microbiota Dysbiosis in Hyperlipidemia Mice.

Front Pharmacol 2021 15;12:689092. Epub 2021 Jun 15.

National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, China.

Hyperlipidemia is a chronic disorder that is difficult to cure and usually treated with long-term lipid-reducing drugs. Recent trends have led to the use of diet therapies or food-derived strategies in the treatment of such long-term diseases. The Chinese rice wine (huangjiu) contains a wide range of bioactive peptides that are produced during the multi-species fermentation process. Read More

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Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models.

Nanomedicine 2021 Jun 30;37:102434. Epub 2021 Jun 30.

Nanyang Technological University, School of Materials Science and Engineering, Singapore, Singapore; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Harvard University, MA, USA; Environmental Chemistry and Materials Centre, Nanyang Environment and Water Research Institution, Nanyang Technological University, Singapore.. Electronic address:

Atherosclerosis is a multifactorial disease triggered and sustained by risk factors such as high cholesterol, high blood pressure and unhealthy lifestyle. Inflammation plays a pivotal role in atherosclerosis pathogenesis. In this study, we developed a simvastatin (STAT) loaded nanoliposomal formulation (LIPOSTAT) which can deliver the drug into atherosclerotic plaque, when administered intravenously. Read More

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Baicalein inhibits the pharmacokinetics of simvastatin in rats regulating the activity of CYP3A4.

Pharm Biol 2021 Dec;59(1):880-883

Department of Emergency, Yidu Central Hospital of Weifang, Weifang, Shandong, China.

Context: Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear.

Objective: The interaction between baicalein and simvastatin was investigated to provide reference and guidance for the clinical application of the combination of these two drugs. Read More

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December 2021

Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity.

Cells 2021 Jun 29;10(7). Epub 2021 Jun 29.

Centre for Experimental and Clinical Infection Research, Institute for Experimental Virology, TWINCORE, 30625 Hannover, Germany.

The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is associated with the formation of lipid-rich membranous organelles and infectious particle assembly highjacks the very‑low-density lipoprotein (VLDL) secretory pathway. Hence, medications that interfere with the lipid metabolism of the cell, such as statins, may affect HCV infection. Here, we study the interplay between lipoprotein receptors, lipid homeostasis, and HCV infection by genetic and pharmacological interventions. Read More

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Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins.

Molecules 2021 Jun 9;26(12). Epub 2021 Jun 9.

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Špitálska 24, 813 72 Bratislava, Slovakia.

Statins have been widely used for the treatment of hypercholesterolemia due to their ability to inhibit HMG-CoA reductase, the rate-limiting enzyme of de novo cholesterol synthesis, via the so-called mevalonate pathway. However, their inhibitory action also causes depletion of downstream intermediates of the pathway, resulting in the pleiotropic effects of statins, including the beneficial impact in the treatment of cancer. In our study, we compared the effect of all eight existing statins on the expression of genes, the products of which are implicated in cancer inhibition and suggested the molecular mechanisms of their action in epigenetic and posttranslational regulation, and in cell-cycle arrest, death, migration, or invasion of the cancer cells. Read More

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Preliminary Investigation on Simvastatin-Loaded Polymeric Micelles in View of the Treatment of the Back of the Eye.

Pharmaceutics 2021 Jun 9;13(6). Epub 2021 Jun 9.

Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy.

There is increasing consensus in considering statins beneficial for age-related macular degeneration and in general, for immune and inflammatory mediated diseases affecting the posterior segment of the eye. However, all available data relate to oral administration, and safety and effectiveness of statins directly administered to the eye are not yet known, despite their ophthalmic administration could be beneficial. The aim was the development and the characterization of polymeric micelles based on TPGS or TPGS/poloxamer 407 to increase simvastatin solubility and stability and to enhance the delivery of the drug to the posterior segment of the eye via trans-scleral permeation. Read More

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Differentiating Co-Delivery of Bisphosphonate and Simvastatin by Self-Healing Hyaluronan Hydrogel Formed by Orthogonal "Clicks": An In-Vitro Assessment.

Polymers (Basel) 2021 Jun 26;13(13). Epub 2021 Jun 26.

Department of Fiber and Polymer Technology, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.

Due to its unique properties resembling living tissues, hydrogels are attractive carriers for the localized and targeted delivery of various drugs. Drug release kinetics from hydrogels are commonly controlled by network properties and the drug-network interactions. However, and simultaneously, the programmable delivery of multiple drugs with opposing properties (hydrophilicity, molecular weight, etc. Read More

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Association of Drug Application and Hydration Status in Elderly Patients.

Nutrients 2021 Jun 4;13(6). Epub 2021 Jun 4.

Institute for Bioanalysis, Coburg University of Applied Sciences and Arts, Friedrich-Streib-Str. 2, D-96450 Coburg, Germany.

Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. Mild cognitive impairment (MCI) or dementia increase the risk of dehydration and, in turn, dehydration decreases cognitive performance. The study aims to identify and assess differences in hydration status, taking into account patients' drug treatment and diseases, using bioelectrical impedance vector analysis (BIVA), thereby revealing unfavorable aspects of prognosis. Read More

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Effects of Alcoholic Extracts of Bangladeshi Mangrove Linn. (Acanthaceae) Leaf and Stem on Atherogenic Model of Wistar Albino Rats.

Evid Based Complement Alternat Med 2021 30;2021:7539037. Epub 2021 May 30.

Department of Biochemistry and Molecular Biology, Trust University, Barishal, Ruiya, Nobogram Road, Barishal 8200, Bangladesh.

Linn. (Acanthaceae) is a popular mangrove ethnomedicinal plant that cures several ailments, including asthma, diabetes, cancer, and many others. Our experiment was aimed at evaluating the anti-atherogenic effect of (leaf and stem) on a high-fat diet-induced atherogenic rat model. Read More

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Simvastatin reverses the harmful effects of high fat diet on titanium rod osseointegration in ovariectomized rats.

J Bone Miner Metab 2021 Jun 29. Epub 2021 Jun 29.

Department of Orthopedics, The Fifth Affiliated Hospital Lishui Municipal Central Hospital, Wenzhou Medical University, Lishui, Zhejiang, People's Republic of China.

Introduction: The objectives of the present study were to determine whether simvastatin (SIM) could reverse the harmful effects on titanium rod osseointegration in ovariectomized rats fed high-fat diet (HFD).

Materials And Methods: Ovariectomized female Sprague-Dawley rats were randomly allocated to three groups and received SIM treatment plus HFD for 12 weeks. We then evaluated the microstructure parameters, histological parameters, biomechanical parameters, bone turnover, and blood lipid level. Read More

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Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review.

Arh Hig Rada Toksikol 2021 Jun 28;72(3):114-128. Epub 2021 Jun 28.

University of Zagreb School of Medicine, Department of Medical Chemistry, Biochemistry, and Clinical Chemistry, Zagreb, Croatia.

Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of adverse drug reactions (ADRs) due to drug-drug interactions. The risk is further increased in patients with chronic diseases/comorbidities who are more susceptible because of their genetic setup or external factors. In that light, we present a case of a 46-year-old woman who had been experiencing acute renal and hepatic injury and myalgia over two years of concomitant treatment with diclofenac, atorvastatin, simvastatin/fenofibrate, and several other drugs, including pantoprazole and furosemide. Read More

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An association of ABCG8: rs11887534 polymorphism and HDL-cholesterol response to statin treatment in the Polish population.

Pharmacol Rep 2021 Jun 26. Epub 2021 Jun 26.

Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.

Background: Variation in lipid changes in response to statin treatment is associated with genetic polymorphism. Sterolin-1, encoded by ABCG5, and sterolin-2, encoded by ABCG8, together form a sterol transporter. There are some reports indicating association of rs11887534 (ABCG8:c. Read More

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